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| 1 | Multispherical interactions and their effects on the Tibetan Plateau's earth system: a review of the recent researches显示文摘The Tibetan Plateau(TP) is a regional Earth system showing very strong interactions among its lithosphere, hydrosphere, cryosphere, biosphere, atmosphere, and anthrosphere. hese interactions manifest TP's impact on surrounding regions and relect TP's response to the global change. Quantifying the multispherical interactions is critically important to understand the TP environment. Our recent years researches including the ongoing program entitled ‘Tibetan Multi-Spheres Interactions and heir Resource-Environment Signiicance(TIMI)', the completed program entitled. ‘Paleo-Altitudes of Tibetan Plateau and Environment(PATE)', as well as the other relating projects have focused on multidisciplinary research approaches and emphasized on three major pathways: Eurasia-Indian plates collision on deep-Earth dynamics, uplit impact on Earth's mantle–crust dynamics, and contemporary interface on land surface and atmospheric dynamics. Our researches have taken in situ measurement as priority and developed several platforms of data acquisition and analysis, including the platforms of water-phase transformations, and ecosystem observations. Our ield investigations have been conducted to obtain data about stratum, paleontology, paleoenvironment, genetic diferentiation of animals and plants. We have developed conceptual and mathematical models for crust uplit formation, paleoclimate, glacial melt,water–air interface lux, vegetation climate, and soil erosion. We have also assessed the anthropogenic impacts on environment. Our researches have achieved new and reliable redating of the mantle–crust interaction and initial formation of the TP, found the interaction between tectonics and uplit of the TP and resultant paleoaltitude acting as a spreading source; discovered the interaction between the westerlies and Indian monsoon acting as a control chain that dominates the TP's contemporary environment. he scientiic results can play fundamental roles in supporting the TP's resource exploration and societal sustainable development. | Tandong Yao Fuyuan Wu Lin Ding Jimin Sun Liping Zhu Shilong Piao Tao Deng Xijun Ni Hongbo Zheng Hua Ouyang | 2015 | National Science Review2015，2，4： | 35 |
| 2 | Detrital zircon U-Pb ages of Late Cenozoic sediments from the Yangtze delta:Implication for the evolution of the Yangtze River显示文摘Detrital zircon grains of Late Cenozoic sediments dated back to ca.3.6 Ma from core DY03 in the Yangtze delta were dated by LA-ICP-MS,in order to investigate the sedimentary provenance and to find some clue for the evolution of the Yangtze River.Most of the detrital zircon U-Pb ages are distributed at 100 300 Ma,350 550 Ma,600 1000 Ma,1400 2000 Ma and 2200 2800 Ma,which correspond well with the main tectonic and magmatic events in the Yangtze drainage.The detrital zircon age patterns show distinct difference between the 3 samples below 189.8 m and other 6 above 189.8 m.43% 55% zircons in the 3 samples below 189.8 m fall within Cretaceous,while ages from 150 to 2800 Ma are distributed with no obvious peaks,which indicate the sedimentary provenance may be limited to the lower Yangtze drainage.The 6 samples above 189.8 m show similar age patterns,and the ages are relatively evenly distributed,indicating the sedimentary provenance broadened distinctly.All 6 samples deposited later than ca.3.2 Ma show age information from the upper Yangtze drainage (including the Emeishan large igneous province),indicating that the Three Gorges may have already been cut through by then. | JIA JunTao ZHENG HongBo HUANG XiangTong WU FuYuan YANG ShouYe | 2010 | Chinese Science Bulletin2010，55，15： | 20 |
| 3 | Mapping coalmine goaf using transient electromagnetic method and high density resistivity method in Ordos City, China显示文摘The research about subsurface characteristics by using transient electromagnetic method(TEM) and high density resistivity method(HDRM) were already conducted in Ordos. The objective of this research is to detect coalmine goaf areas based on rock resistivity. The data processing using wavelet transform, three point smoothing, RES2 DINV and Maxwell processing software to obtain 2D resistivity structure. The results showed that the layers with maximum resistivity values(30e33 U m on Line 1, 30e31 U m on Line 2, 32e40 U m on Line3) are founded at station 1e7, and 14e20 on Line 1,13e18 on Line 2, and 8e13 and 16e20 on Line 3 which is predicted as goaf layer, and the minimum resistivity values(20e26 U m of TEM, 45e75 U m of HDRM) at the other layers. This resistivity difference was caused by the geology and characteristics of the study area which is located close by the cleugh with rich coal, so the goaf area distinguishable with aquifer layer and coal seam. The results were also significant accidents and serious destruction of ecological environment. | Guiju Wu Guangliang Yang Hongbo Tan | 2016 | Geodesy and Geodynamics2016，7，5： | 14 |
| 4 | Overview of 5G security technology显示文摘The 5 th-generation mobile communication system(5 G) has higher security requirements than previous systems. Accordingly, international standard organizations, operators, and equipment manufacturers are focusing extensively on 5 G security technology. This paper analyzes the security requirements of 5 G business applications, network architecture, the air interface, and user privacy. The development trends of5 G security architecture are summarized, with a focus on endogenous defense architecture, which represents a new trend in 5 G security development. Several incremental 5 G security technologies are reviewed, including physical layer security, lightweight encryption, network slice security, user privacy protection, and block chain technology applied to 5 G. | Xinsheng JI Kaizhi HUANG Liang JIN Hongbo TANG Caixia LIU Zhou ZHONG Wei YOU Xiaoming XU Hua ZHAO Jiangxing WU Ming YI | 2018 | Science China(Information Sciences)2018，61，8： | 14 |
| 5 | Basement of the South China Sea Area:Tracing the Tethyan Realm显示文摘华南海( SCS )和邻近的区域的地下室能被划分成六个部门(区域)在 Beibu 海湾的古生代的 Erathem 指责graben 的地下室分割,在 Yinggehai 的古生代的 Erathem 罢工滑倒拉开流水,在东方海南的古生代的 Erathem 差错消沉,在北 Xisha ( Paracel )的古生代的 Erathem rifted ,古生代的 Erathem 罢工滑倒在在 Nansha 岛延长的南部的 Xisha ,和古生代中生代的 Erathem 延长( Spratly )水。在 SCS 和 Yunkai 大陆人区域的新生代前地下室在在新生代前时期的 Tethyan 构造领域以内是同时代的。他们在 Paleo-Tethyan 构造领域的背景上被形成,并且是东方 Tethyan multi-island-ocean 系统的重要部件。东方 Paleo-Tethys 构造领域,北方 Yunkai,诺思海南,和南方海南海盆的三个分支,演变为北方 Yunkai,诺思海南,和南方海南缝术地区分别地。这为新生代前地下室显示出本地化的一个特殊特征。 Qiongnan (即南方海南)华南海的北边缘上的缝术地区能被认为 Paleo-Tethys 的主要海洋盆的痕迹,并且与 Longmucuo-Shuanghu beltBitu 带 Changning-Menglian-Bentong-Raub 带的缝术地区连接了,华南海的西方上的 Bitu-Changning-MenglianChing Mai beltChanthaburi-Raub-Bentong 带的南方延期,并且与 Lianhua-Taidong 缝术地区(沿着在台湾的纵的山谷的东方方面的一个差错) Hida Qiongbei (诺思海南) 缝术地区可以向东沿着 Wangwu-Wenjiao 差错地区延长了,并且深与 Lufeng-Dapu-Zhenghe-Shangyu (Lianhuashan ) 连接通过珍珠河嘴盆的差错地区。Meso-Tethys 在华南海的南方上发展了。Nansha 马槽可以被认为 Meso-Tethys 的北架的痕迹。 Meso-Tethys 的海洋的外壳向南沿着 subduction-collision-thrust 有 subducted 有华南海的西方上的 Yarlung Zangbo-Mytkyina-Bago 地区的到那些的subduction杆反面的 Nansha 马槽的南部的边缘,并且 Meso-Tethyan (例如 Meso-Tethys 的北 Chichibu 海洋)在在西南日本的侏罗记早的白垩纪地球组的外部带的缝术地区 Butsozo 构造的线,在华南海的东方上。 | LIU Hailing ZHENG Hongbo WANG Yanlin LIN Qiujin WU Chaohua ZHAO Meisong DU Yunkong | 2011 | Acta Geologica Sinica(English Edition)2011，85，3： | 13 |
| 6 | CPSF30-L-mediated recognition of mRNA m^(6)A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis显示文摘N6-methyladenosine(m^(6)A),a ubiquitous internal modification of eukaryotic mRNAs,plays a vital role in almost every aspect of mRNA metabolism.However,there is little evidence documenting the role of m^(6)A in regulating alternative polyadenylation(APA)in plants.APA is controlled by a large protein-RNA complex with many components,including CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR30(CPSF30).In Arabidopsis,CPSF30 has two isoforms and the longer isoform(CPSF30-L)contains a YT512-B Homology(YTH)domain,which is unique to plants.In this study,we showed that CPSF30-L YTH domain binds to m^(6)A in v itro.In the cpsf30-2 mutant,the transcripts of many genes including several important nitrate signaling-related genes had shifts in polyadenylation sites that were correlated with m^(6)A peaks,indicating that these gene transcripts carrying m^(6)A tend to be regulated by APA.Wild-type CPSF30-L could rescue the defects in APA and nitrate metabolism in cpsf30-2,but m^(6)A-binding-defective mutants of CPSF30-L could not.Taken together,our results demonstrated that m^(6)A modification regulates APA in Arabidops is and revealed that the m^(6)A reader CPSF30-L affects nitrate signaling by controlling APA,shedding new light on the roles of the m^(6)A modification during RNA 3-end processing in nitrate metabolism. | Yiteng Hou Jing Sun Baixing Wu Yangyang Gao Hongbo Nie Zhentian Nie Shuxuan Quan Yong Wang Xiaofeng Cao Sisi Li | 2021 | Molecular Plant2021，14，4： | 12 |
| 7 | A high strength, anti-fouling, self-healable, and thermoplastic supramolecular polymer hydrogel with low fibrotic response显示文摘The fibrotic response plays an important role in the performance and longevity of implantable devices. Thus, development of effective anti-inflammatory and anti-fibrosis biomaterial implants has become an urgent task. In this work, we developed a novel supramolecular polymer hydrogel through the copolymerization of N-acryloyl glycinamide(NAGA) and carboxybetaine acrylamide(CBAA) in the absence of any chemical crosslinker, which the mechanical properties being tunable through changing the monomer concentration and the monomer ratio over a broad scope. The hydrogel possessed the superior mechanical performances: high tensile strength(~1.13 MPa), large stretchability(~1200%), and excellent compressive strength(~9 MPa) at high monomer concentration and NAGA/CBAA ratio. Introduction of CBAA could promote the self-healability, thermoplasticity of suparmolecular polymer hydrogels at lower temperatures, meanwhile dramatically improving anti-fouling property.Histological analysis and in vitro cytotoxicity assays testified the excellent biocompatibility of the hydrogel. This high strength supramolecular polymer hydrogel with integrated multiple functions holds promising potentials as a scaffold biomaterial for treating degenerated soft supporting tissues. | WANG HongBo LI HaoFei WU YuanHao YANG JianHai LIU WenGuang | 2019 | Science China(Technological Sciences)2019，62，4： | 11 |
| 8 | Placement Optimization of Caching UAV-Assisted Mobile Relay Maritime Communication显示文摘Recently, due to the deployment flexibility of unmanned aerial vehicles(UAVs), UAV-assisted mobile relay communication system has been widely used in the maritime communication. However, the performance of UAV-assisted mobile relay communication system is limited by the capacity of wireless backhaul link between base station and UAV. In this paper, we consider a caching UAV-assisted decode-and-forward relay communication system in a downlink maritime communication. For the general case with multiple users, the optimal placement of UAV is obtained by solving the average achievable rate maximization problem through the one-dimensional linear search. For a special case with single user, we derive a semi closedform expression of the optimal placement of UAV. Simulation results confirm the accuracy of analytical results and show that the optimal placement of UAV and the average achievable rate significantly depend on the cache capacity at UAV. We also show the difference between the performances of the air-to-ground model and the air-to-sea model. | Jun Zhang Fengzhu Liang Bin Li Zheng Yang Yi Wu Hongbo Zhu | 2020 | China Communications2020，17，8： | 10 |
| 9 | A Study on Inhibitors for the Prevention of Hydrate Formation in Gas Transmission Pipeline显示文摘气体水化物通常在油和气体的交通和处理期间被形成,导致插煤气的管道和设备。三个热力学的计算公式被分析处理这个问题。降低禁止者 |¤ T 的凝固点被用来计算天然气水合物的形成温度。因为它由一个人使用类型并且什么禁止者的集中的是不有限的,这被认为是一条好途径。而且,凝固点降低的率能容易被测量。在一个反应堆的严峻的甲醇和单音乙烯的乙二醇的结果显示出那补充说到反应堆的 10% 禁止者能阻止水合物形成。运动禁止者在现在的研究被赞成。他们被划分成二种类型,聚合物和表面活跃的代理人。他们的特征,机制,和申请前景独立被讨论。聚合物禁止者展出更好的效率。VC-713 inhibiter 的领域申请的结果也在这篇文章被给。在实践,热力学的禁止者和运动禁止者的联合给更好的结果。给词调音:天然气水合物;热力学的禁止者;运动禁止者;聚合物; | Ming Wu Shumiao Wang Hongbo Liu | 2007 | Journal of Natural Gas Chemistry2007，16，1： | 9 |
| 10 | The 5.5 cal ka BP climate event, population growth, circumscription and the emergence of the earliest complex societies in China显示文摘The emergence of complex society is a milestone in the history of human society evolution. China is one of the few regions in the world where the earliest complex society appeared; however, its driving mechanisms remain unresolved. On the base of available evidence from both archaeology and Holocene climate, in combination with agency theory, this study attempts to address the driving mechanisms for the simultaneous emergence of complex societies in multiple areas of China around 5.5 cal ka BP. It is hypothesized that three factors, including climate change, population growth, and circumscription, jointly act and cause regional population-resource imbalance and trigger inter-group conflicts and wars. Such competitions provide the opportunity for some power-pursuing agents to break the restriction of social leveling mechanism and to become the centralized decision-making leaders, which further lead to the emergence of incipient large-scale complex societies. Increase in extreme climate events during 6.0–5.0 cal ka BP cooling period causes frequent occurrence of resource stress and increase in the frequency of inter-group competitions, which creates conditions for the legitimation, institutionalization, and persistence of centralized leadership, and finally leads to the formation of persistent institutionalized inequity. Our research result can explain not only the process and mechanism of complex society formation, but also two phenomena which cannot be reasonably explained by previous theories, that are, why the earliest complex societies in China emerge around 5.5 cal ka BP, and why they appear simultaneously in multiple regions. | WU WenXiang ZHENG HongBo HOU Mei GE QuanSheng | 2018 | Science China Earth Sciences2018，61，2： | 8 |
| 11 | Spatial and temporal distribution of Neolithic sites in coastal China:Sea level changes, geomorphic evolution and human adaption显示文摘The East China coastal plain is one of the most important Neolithic culture areas in China, where rich archaeological sites including those producing the earliest domesticated rice are observed. It is also a place where landscape has experienced dramatic evolution during the Holocene when both sea level and climate changed, such that it is an ideal place for studying human-environment interaction. This study investigated over 2000 sites of pre-history and Shang and Zhou Dynasties, with 655 of which being Neolithic ages, by using DEM and GIS methods. The results suggest that the spatial and temporal distribution of Neolithic sites has largely been controlled by landscape evolution(particularly changes in coastal line), which ultimately governed by sea level changes. During early Holocene, Neolithic sites sparsely distributed in the intermountain basins of east Zhejiang Province, far from the influence of ocean. Over the period of 9–7 ka, the coastal plain(including the shelf) was largely submerged,only the feet of low hills to the south and southwest of the study area, and islands protruding the estuary, cradled limited number of settlements with characteristic 'maritime components'. At about 7 ka, sea level rise decelerated prominently, while sediments supply in the drainage remained high value, the combination of which led to land formation and propagation. Vast space during this period facilitated the growth of settlements in both size and number. In the mean time, however, the coastal plain was vulnerable to extreme environmental events such as storms and flooding owning to its geomorphic nature, which exerted great influence on the rise and fall of Neolithic culture. | ZHENG HongBo ZHOU YouSheng YANG Qing HU ZhuJun LING GuangJiu ZHANG JuZhong GU ChunGuang WANG YingYing CAO YeTing HUANG XianRong CHENG Yue ZHANG XiaoYu WU WenXiang | 2018 | Science China Earth Sciences2018，61，2： | 7 |
| 12 | A novel RHT-TBD approach for weak targets in HPRF radar显示文摘A novel approach, which can handle ambiguous data from weak targets, is proposed within the randomized Hough transform track-before-detect(RHT-TBD) framework. The main idea is that, without the pre-detection and ambiguity resolution step at each time step, the ambiguous measurements are mapped by the multiple hypothesis ranging(MHR) procedure. In this way, all the information, based on the relativity in time and pulse repetition frequency(PRF) domains, can be gathered among different PRFs and integrated over time via a batch procedure. The final step is to perform the RHT with all the extended measurements, and the ambiguous data is unfolded while the detection decision is confirmed at the end of the processing chain.Unlike classic methods, the new approach resolves the problem of range ambiguity and detects the true track for targets. Finally, its application is illustrated to analyze and compare the performance between the proposed approach and the existing approach. Simulation results exhibit the effectiveness of this approach. | Hongbo YU Guohong WANG Wei WU Shuncheng TAN | 2016 | Science China Earth Sciences2016，59，12： | 6 |
| 13 | A hybrid LES (Large Eddy Simulation)/assumed sub-grid PDF (Probability Density Function) model for supersonic turbulent combustion显示文摘A hybrid LES (Large Eddy Simulation)/assumed sub-grid PDF (Probability Density Function) closure model has been devel-oped for supersonic turbulent combustion. Scalar transport equations for all species in a given chemical kinetic mechanism were solved, which are necessary in the supersonic combustion where the non-equilibrium chemistry is essentially involved. The clipped Gaussian PDF of temperature and multivariate ? PDF of composition were used to close the sub-grid chemical sources that appear in the conservation equations. The sub-grid variances of temperature and composition were constructed based on scale similarity approach. A semi-implicit approach based on the PDF model was proposed to tackle the resulting numerical stiffness associated with finite rate chemistry. The model was applied to simulate a supersonic, coaxial H2-air burner, where both the mean and rms (root mean square) results were compared with the experimental data. In general, good agree-ments were achieved, which indicated that the present sub-grid PDF method could work well in simulating supersonic turbu-lent combustion. Moreover, the calculation showed that the sub-grid fluctuations of temperature and major species in the combustion region were of the order of 10%-20% of their rms, while the sub-grid fluctuation of hydroxyl might be as high as 40%-50% of its rms. | WANG HongBo QIN Ning SUN MingBo WU HaiYan WANG ZhenGuo | 2011 | Science China(Technological Sciences)2011，54，10： | 6 |
| 14 | Lx2-32c,a novel semi-synthetic taxane,exerts antitumor activity against prostate cancer cells in vitro and in vivo显示文摘Tubulin has been shown to be an effective target for the development of cytotoxic agents against prostate cancer. Previously, we reported that Lx2-32 c is an anti-tubulin agent with high binding affinity to tubulin. In this study, we investigated the potential of Lx2-32 c to act as an effective cytotoxic agent in the treatment of prostate cancer. MTT assays showed that Lx2-32 c was cytotoxic to all tested prostate cancer cell lines. The Lx2-32c-treated cells typically exhibited a rounded morphology associated with the onset of apoptosis, as evidenced by immunocytochemical staining. Human prostate cancer cell lines treated with Lx2-32 c arrest in the G2/M phase of the cell cycle and the treatment is associated with an increased ratio of cells in the sub-G0/G1 phase as determined by flow cytometry. Furthermore, expression of the cleaved form of poly(ADP-ribose) polymerase in prostate cancer cell lines treated with Lx2-32 c was shown by Western blotting assay. Xenograft implants of LNCa P and PC3-derived tumors in nude mice showed that Lx2-32 c treatment significant inhibited tumor growth with effects equivalent to those of docetaxel. These findings demonstrate the potential of Lx2-32 c as a candidate antitumor agent for the treatment of prostate cancer. | Guangyao Lv Dengjun Sun Jingwen Zhang Xiaoxia Xie Xiaoqiong Wu Weishuo Fang Jingwei Tian Chunhong Yan Hongbo Wang Fenghua Fu | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 6 |
| 15 | Nonlinear analysis of combustion oscillations in a cavity-based supersonic combustor显示文摘Combustion oscillations in a supersonic combustor with hydrogen injection upstream of a cavity flameholder are investigated using nonlinear analysis based on experimental measurements.Time series of both flamefront and wall pressure are acquired,and the state space reconstruction approach is adopted to characterize the nonlinear behavior of the combustion oscillations.Three overall equivalence ratios,0.038,0.076 and 0.11,are considered.The existence of a chaotic source in the present combustion system is demonstrated.The correlation dimension and the largest Lyapunov exponent tend to become larger with the increasing equivalence ratio,indicating a more complicated and unstable combustion system.In particular,it is found that the correlation dimension for the highest equivalence ratio is much greater than those of the two lower equivalence ratios.Two possible reasons responsible for the observed nonlinear behaviors are identified.One is the shock-related instabilities and the other is the transition of combustion stabilization mode between the cavity and jet-wake stabilized mode. | WANG HongBo WANG ZhenGuo SUN MingBo WU HaiYan | 2013 | Science China(Technological Sciences)2013，56，5： | 5 |
| 16 | Sr-Nd isotope stratification along water depth:An example from Datong hydrological station of Yangtze River显示文摘This study examines the effects of hydrologic sorting and mixing of sources on the Sr-Nd isotopic compositions of suspended sediments at different water depths. The samples were collected from three layers (surface, middle and bottom) at Datong hydrological station of Yangtze River during the flood season of 2010. Our results show that, 87 Sr/ 86 Sr values decrease from surface to bottom, ranging from 0.730332 to 0.720857. ε Nd (0) values range from 14.75 to 10.09, with surface sediments being the most negative. The isotope composition at the middle layer can best represent the mean isotopic composition of the total suspended sediments transported by a river. It is believed that the stratification of Sr-Nd isotope is attributable to mixing of sediments from different sources due to hydrological sorting. Sediments from the upper stream are found to be coarser, and tend to contribute more to the lower water column. Although Sr-Nd isotope is a well acknowledged tool to trace sediment provenance, the current study suggests that the grain size of the samples and the sampling locations should be taken into consideration when applying this method to provenance study. | LUO Chao ZHENG HongBo WU WeiHua WANG Ping CHEN YuLiang WEI XiaoChun | 2012 | Chinese Science Bulletin2012，57，34： | 4 |
| 17 | Gravity distribution characteristics and their relationship with the distribution of earthquakes and tectonic units in the Northe South seismic belt, China显示文摘The Northe South Seismic Belt(NSSB) is a Chinese tectonic boundary with a very complex structure, showing a sharp change in several geophysical field characteristics. To study these characteristics and their relationship with the distribution of earthquakes and faults in the study area, we first analyze the spatial gravity anomaly to achieve the Bouguer gravity anomaly(EGM2008 BGA) and the regional gravity survey Bouguer gravity anomaly.Next, we ascertain the Moho depth and crustal thickness of the study area using interface inversion with the control points derived from the seismic and magnetotelluric sounding profiles achieved in recent years. In this paper, we summarize the relief, trend, Moho gradient, and crustal nature, in addition to their relationship with the distribution of earthquakes and faults in the study area. The findings show that earthquakes with magnitudes greater than Ms7.0 are mainly distributed in the Moho Bouguer anomaly variation belt and faults. The results of the study are important for future research on tectonic characteristics, geological and geophysical surveys, and seismicity patterns. | Wu Guiju Tan Hongbo Zou Zhengbo Yang Guangliang Shen Chongyang | 2015 | Geodesy and Geodynamics2015，6，3： | 4 |
| 18 | Genome architecture and tetrasomic inheritance of autotetraploid potato显示文摘Potato(Solanum tuberosum)is the most consumed non-cereal food crop.Most commercial potato cultivars are autotetraploids with highly heterozygous genomes,severely hampering genetic analyses and improvement.By leveraging the state-of-the-art sequencing technologies and polyploid graph binning,we achieved a chromosome-scale,haplotype-resolved genome assembly of a cultivated potato,Cooperation-88(C88).lntra-haplotype comparative analyses revealed extensive sequence and expression differences in this tetraploid genome.We identified haplotype-specific pericentromeres on chromosomes,suggesting a distinct evolutionary trajectory of potato homologous centromeres.Furthermore,we detected double reduction events that are unevenly distributed on haplotypes in 1021 of 1034 selfing progeny,a feature of autopolyploid inheritance.By distinguishing maternal and paternal haplotype sets in C88,we simulated the origin of heterosis in cultivated tetraploid with a survey of 3110 tetra-allelic loci with deleterious mutations,which were masked in the heterozygous condition bytwo parents.This study provides insights into the genomic architecture of autopolyploids and will guide their breeding. | Zhigui Bao Canhui Li Guangcun Li Pei Wang Zhen Peng Lin Cheng Hongbo Li Zhiyang Zhang Yuying Li Wu Huang Mingwang Ye Daofeng Dong Zhukuan Cheng Peter VanderZaag Evert Jacobsen Christian W.B.Bachem Suomeng Dong Chunzhi Zhang Sanwen Huang Qian Zhou | 2022 | Molecular Plant2022，15，7： | 4 |
| 19 | Application of regional citrate anticoagulation in patients at high risk of bleeding during intermittent hemodialysis:a prospective multicenter randomized controlled trial显示文摘Objective:Safe and effective anticoagulation is essential for hemodialysis patients who are at high risk of bleeding.The purpose of this trial is to evaluate the effectiveness and safety of two-stage regional citrate anticoagulation(RCA)combined with sequential anticoagulation and standard calcium-containing dialysate in intermittent hemodialysis(IHD)treatment.Methods:Patients at high risk of bleeding who underwent IHD from September 2019 to May 2021 were prospectively enrolled in 13 blood purification centers of nephrology departments,and were randomly divided into RCA group and saline flushing group.In the RCA group,0.04 g/mL sodium citrate was infused from the start of the dialysis line during blood draining and at the venous expansion chamber.The sodium citrate was stopped after 3 h of dialysis,which was changed to sequential dialysis without anticoagulant.The hazard ratios for coagulation were according to baseline.Results:A total of 159 patients and 208 sessions were enrolled,including RCA group(80 patients,110 sessions)and saline flushing group(79 patients,98 sessions).The incidence of severe coagulation events of extracorporeal circulation in the RCA group was significantly lower than that in the saline flushing group(3.64%vs.20.41%,P<0.001).The survival time of the filter pipeline in the RCA group was significantly longer than that in the saline flushing group((238.34±9.33)min vs.(221.73±34.10)min,P<0.001).The urea clearance index(Kt/V)in the RCA group was similar to that in the saline flushing group with no statistically significant difference(1.12±0.34 vs.1.08±0.34,P=0.41).Conclusions:Compared with saline flushing,the two-stage RCA combined with a sequential anticoagulation strategy significantly reduced extracorporeal circulation clotting events and prolonged the dialysis time without serious adverse events. | Xiaoyan TANG Dezheng CHEN Ling ZHANG Ping FU Yanxia CHEN Zhou XIAO Xiangcheng XIAO Weisheng PENG Li CHENG Yanmin ZHANG Hongbo LI Kehui LI Bizhen GOU Xin WU Qian YU Lijun JIAN Zaizhi ZHU Yu WEN Cheng LIU Hen XUE Hongyu ZHANG Xin HE Bin YAN Liping ZHONG Bin HUANG Mingying MAO | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，11： | 4 |
| 20 | Trajectory prediction of cyclist based on dynamic Bayesian network and long short-term memory model at unsignalized intersections显示文摘Cyclist trajectory prediction is of great significance for both active collision avoidance and path planning of intelligent vehicles.This paper presents a trajectory prediction method for the motion intention of cyclists in real traffic scenarios.This method is based on dynamic Bayesian network(DBN)and long short-term memory(LSTM).The motion intention of cyclists is hard to predict owing to potential large uncertainties.The DBN is used to infer the distribution of cyclists’intentions at intersections to improve the prediction time.The LSTM with encoder-decoder is used to predict the cyclists’trajectories to improve the accuracy of prediction.Therefore,the DBN and LSTM are adopted to guarantee prediction accuracy and improve the prediction time.The experiment results are presented to show the effectiveness of the predict strategies. | Hongbo GAO Hang SU Yingfeng CAI Renfei WU Zhengyuan HAO Yongneng XU Wei WU Jianqing WANG Zhijun LI Zhen KAN | 2021 | Science China(Information Sciences)2021，64，7： | 4 |
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