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| 1 | Targeting cancer stem cell pathways for cancer therapy显示文摘Since cancer stem cells(CSCs)were first identified in leukemia in 1994,they have been considered promising therapeutic targets for cancer therapy.These cells have self-renewal capacity and differentiation potential and contribute to multiple tumor malignancies,such as recurrence,metastasis,heterogeneity,multidrug resistance,and radiation resistance.The biological activities of CSCs are regulated by several pluripotent transcription factors,such as OCT4,Sox2,Nanog,KLF4,and MYC.In addition,many intracellular signaling pathways,such as Wnt,NF-κB(nuclear factor-κB),Notch,Hedgehog,JAK-STAT(Janus kinase/signal transducers and activators of transcription),PI3K/AKT/mTOR(phosphoinositide 3-kinase/AKT/mammalian target of rapamycin),TGF(transforming growth factor)/SMAD,and PPAR(peroxisome proliferator-activated receptor),as well as extracellular factors,such as vascular niches,hypoxia,tumor-associated macrophages,cancer-associated fibroblasts,cancer-associated mesenchymal stem cells,extracellular matrix,and exosomes,have been shown to be very important regulators of CSCs.Molecules,vaccines,antibodies,and CAR-T(chimeric antigen receptor T cell)cells have been developed to specifically target CSCs,and some of these factors are already undergoing clinical trials.This review summarizes the characterization and identification of CSCs,depicts major factors and pathways that regulate CSC development,and discusses potential targeted therapy for CSCs. | Liqun Yang Pengfei Shi Gaichao Zhao Jie Xu Wen Peng Jiayi Zhang Guanghui Zhang Xiaowen Wang Zhen Dong Fei Chen Hongjuan Cui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 12 |
| 2 | Nidus vespae protein inhibiting proliferation of HepG2 hepatoma cells through extracellular signal-regulated kinase signaling pathways and inducing G1 cell cycle arrest显示文摘蛋白质说出 NVP (1 ) 从巢 vespae 被孤立。T 他现在的学习的目的是阐明 NVP (1 ) 是否并且怎么调制 HepG2 房间的增长。在 6.6 μg/ml 的集中的 NVP (1 ) 能在阶段 G 1 逮捕房间周期并且禁止 cyclinB, cyclinD1 和 cyclinE 的 mRNA 表示。NVP (1 ) 压制了 cdk2 蛋白质表示,但是增加了 p27 和 p21 蛋白质表示。然而, NVP (1 ) 没改变 p16 蛋白质表示层次。NVP (1 ) 在由原子染色质冷凝作用显示了的 HepG2 房间支持了 apoptosis,并且另外,表明小径的细胞外的调整信号的 kinase (英皇家空军之阶级最低之兵) 被激活。而且,当 HepG2 房间是有英皇家空军之阶级最低之兵禁止者 PD98059 的 pretreated 时,津贴蛋白质表示水平被稀释。这些结果证明 NVP (1 ) 通过表明小径的英皇家空军之阶级最低之兵禁止 HepG2 的增长。NVP (1 ) 能是为肝癌症的潜在的药。 | Changdong Wang Peng Chen Hongjuan Jin Xu Yan Lu Gan Yi Li Shiyi Zhou Junli Chang Yuesheng Wang Guangxiao Yang Guangyuan He | 2008 | Acta Biochimica et Biophysica Sinica2008，40，11： | 11 |
| 3 | Preparation of nitrogen and sulfur co-doped ultrathin graphitic carbon via annealing bagasse lignin as potential electrocatalyst towards oxygen reduction reaction in alkaline and acid media显示文摘Renewable lignin used for synthesizing materials has been proven to be highly potential in specific electrochemistry.Here,we report a simple method to synthesize nitrogen and sulfur co-doped carbon nanosheets by using bagasse lignin,denoted as lignin-derived carbon(LC).By adjusting the ratio of nitrogen source and annealing temperature,we obtained the ultrathin graphitic lignin carbon(LC-4-1000)with abundant wrinkles with high surface area of 1208 m2g_1 and large pore volume of 1.40 cm3g_1.In alkaline medium,LC-4-1000 has more positive half-wave potential and nearly current density compared to commercial Pt/C for oxygen reduction reaction(ORR).More importantly,LC-4-1000 also exhibits comparable activity and superior stability for ORR in acid medium due to its high graphitic N ratio and a direct four electron pathway for ORR.This study develops a cost-effective and highly efficient method to prepare biocarbon catalyst for ORR in fuel cells. | Yixing Shen Feng Peng Yonghai Cao Jianliang Zuo Hongjuan Wang Hao Yu | 2019 | Journal of Energy Chemistry2019，28，7： | 5 |
| 4 | Temporal and spatial expression of MMP-2,-9,-14 and their inhibitors TIMP-1,-2,-3 in the corpus luteum of the cycling rhesus monkey显示文摘The corpus luteum (CL) is a transient endocrine organ that secretes progesterone to support early pregnancy. If implantation is unsuccessful, luteolysis is initiated. Extensive tissue re-modeling occurs during CL formation and luteolysis. In this study, we have studied the possible in-volvement of MMP-2, -9, -14, and their inhibitors, TIMP-1, -2, -3 in the CL of cycling rhesus monkey at various stages by in situ hybridization, immunohistochemistry and microscopic assessment. The re-sults showed that the MMP-2 mRNA and protein were mainly expressed in the endothelial cells at the early and middle stages of the CL development, while their expressions were observed in the luteal cells at the late stage during luteal regression. MMP-9 protein was detected in the CL at the early and middle stages, and obviously increased at the late stage. The expressions of MMP-14 and TIMP-1 mRNA were high at the early and late stages, and low at the middle stage. TIMP-2 mRNA was high throughout all the stages, the highest level could be observed at the late stage. The TIMP-3 produc-tion was detected throughout all the stages, but obviously declined during CL regression. MMP-9, -14 and TIMP-1, -2, -3 were mainly localized in the cytoplasm of the steroidogenic cells. The results suggest that the MMP/TIMP system is involved in regulation of CL development in the primate, and the coordinated expression of MMP-2, -14 and TIMP-1, -3 may have a potential role in the CL forma-tion and the functional maintaining, while the interaction of MMP-2, -9, -14 and TIMP-1, -2, -3 might also play a role in CL regression at the late stage of CL development in the primate. | CHEN Xinlei GAO Hongjuan GAO Fei WEI Peng HU Zhaoyuan LIU Yixun | 2006 | Science China(Life Sciences)2006，49，1： | 5 |
| 5 | Preparation of phosphorus-doped carbon nanospheres and their electrocatalytic performance for O_2 reduction显示文摘Phosphorus-doped carbon nanospheres without any metal residues were synthesized and characterized.The results revealed that the doping phosphorus atoms could significantly improve the electrocatalytic activity of graphitic carbon for the oxygen-reduction reaction(ORR) both in acidic and alkaline media,and the materials exhibited high electrocatalytic activity,long-term stability,and excellent tolerance to crossover effects especially in alkaline media.Quantum mechanics calculations with the density functional theory demonstrated that the changes in charge density and energetic characteristics of frontier orbitals for the P-doped graphene sheet could facilitate the ORR. | Ziwu Liu Feng Peng Hongjuan Wang Hao Yu Wenxu Zheng Xianyong Wei | 2012 | Journal of Natural Gas Chemistry2012，21，3： | 4 |
| 6 | The Effect of Thermal Exfoliation Temperature on the Structure and Supercapacitive Performance of Graphene Nanosheets显示文摘Graphene nanosheets(GSs) were prepared from graphite oxide by thermal exfoliation method. The effect of thermal exfoliation temperature on the structure and supercapacitive performance of GSs has been investigated. The results show that the GSs with pore sizes center around 4.0 nm. With an increase of thermal reduction temperature, the number of stacking layers and the structure disorder degree increase, while the oxygen-containing groups content, BET surface area,and electrical resistivity of GSs decrease. The results indicate that 673 K is the preferable thermal exfoliation temperature to acquire good supercapacitive performance. In this case, the GSs have the best supercapacitive performance(233.1 F g-1) in a 6 mol L-1KOH electrolyte. The prepared GSs at the preferable thermal exfoliation temperature have good rate performance and cycle stability. | Haiyang Xian Tongjiang Peng Hongjuan Sun Jiande Wang | 2015 | Nano-Micro Letters2015，7，1： | 3 |
| 7 | Host cell Rac1 GTPase facilitates Toxoplasma gondii invasion显示文摘Dear Editor,Toxoplasma gondii is broadly distributed worldwide,and infects nearly all warm-blooded animals(Montoya and Liesenfeld,2004).Its primary infections in pregnant women may lead to abortion,stillbirth and other conditions,and it also attributes largely to encephalitis,retinochoroiditis and other serious diseases in immunocompromised individuals(Moncada and Montoya,2012).Rac1 is a small GTPase in the Rho family that plays an important role in cytoskeleton reorganization(Hall,1998).Rac1 GTPase is reported to be activated by infection of Chlamydia pneumoniae(Zhang et al.,2014). | Haixia Wei Lijuan Zhou Shuizhen Wu Dongliang Li Shengqun Deng Hongjuan Peng | 2020 | Science China(Life Sciences)2020，63，4： | 2 |
| 8 | LncRNA MIR31HG controls the proliferation and metastasis of gastric cancer by c-CBL-mediated degradation of β-catenin显示文摘LncMIR31HG acts as a host gene for miR-31,also known as LncHIFCAR(long non-coding HIF-1 co-activating RNA),whose deregulation has been reported to promote the development of various human cancers,including lung cancer,colorectal cancer,etc.1,2 However,the biological functions and molecular mechanisms of MIR31HG in gastric cancer are unclear. | Wen Peng Jiayi Zhang Shenghao Wang Feng Wang a Kun Wang Rui Geng Xiangfei Ding Jingping Zhang Biao Li Xiaoxue Ke Muhan Lü Hongjuan Cui | 2023 | Genes & Diseases2023，10，3： | 1 |
| 9 | Syngas production by dry reforming of the mixture of glycerol and ethanol with CaCO3显示文摘The reduction of CO2 emission is crucial for the mitigation of climate change.A considerable amount of industrial CO2 can be absorbed in the form of carbonates through high-temperature sorption processes.In this regard,the efficient conversion of carbonates to value-added products will provide an economically viable method for the sustainable usage of carbon compounds.Herein,we report a promising solution involving the use of a glycerol and ethanol mixture as a hydrogen donor in the dry reforming process with CaCO3 to produce syngas.A series of metal active components,including Ni,Fe,Co,Cu,Pt,Pd,Ru,and Rh,was used to promote this reaction.Ni showed comparable performance with that of Pd,but outperformed Co,Fe,Cu,Rh,Ru,and Pt.Approximately 100%conversion of glycerol and ethanol,~92%selectivity of synthesis gas(H2 and CO),and a H2/CO ratio of^1.2 were achieved over CaCO3 containing10 wt%Ni(10Ni-CaCO3).Meanwhile,the CO2 concentration was less than 5 vol%,indicating that most of the CO2 captured by the carbonate can be transformed into chemicals;however,they cannot simply be emitted.The CO2 released from the decomposition of CaCO3 not only adjusted the ratio of H2 to CO but also eliminated cokes to guarantee the CO2 absorption-conversion cyclic stability in the absence of steam and at high temperatures. | Chengxiong Dang Shijie Wu Guangxing Yang Yonghai Cao Hongjuan Wang Feng Peng Hao Yu | 2020 | Journal of Energy Chemistry2020，29，4： | 1 |
| 10 | Hydrogen production via autothermal reforming of ethanol over noble metal catalysts supported on oxides显示文摘Hydrogen was produced over noble metal (Ir, Ru, Rh, Pd) catalysts supported on various oxides, including γ-Al2O3, CeO2, ZrO2 and La2O3, via the autothermal reforming reaction of ethanol (ATRE) and oxidative reforming reaction of ethanol (OSRE). The conversion of ethanol and selectivites for hydrogen and byproducts such as methane, ethylene and acetaldehyde were studied. It was found that lanthana alone possessed considerable activity for the ATRE reaction, which could be used as a functional support for ATRE catalysts. It was demonstrated that Ir/La2O3 prevented the formation of methane, and Rh/La2O3 encumbered the production of ethylene and acetaldehyde. ATRE reaction was carried out over La2O3-supported catalysts (Ir/La2O3) with good stability on stream, high conversion, and excellent hydrogen selectivity approaching thermodynamic limit under autothermal condition. Typically, 3.4 H2 molecules can be extracted from a pair of ethanol and water molecules over Ir(5wt%)/La2O3. The results presented in this paper indicate that Ir/La2O3 can be used as a promising catalyst for hydrogen production via ATRE reaction from renewable ethanol. | Hongqing Chen Hao Yu Yong Tang Minqiang Pan Guangxing Yang Feng Peng Hongjuan Wang Jian Yang | 2009 | Journal of Natural Gas Chemistry2009，18，2： | 1 |
| 11 | Noble-metal-based high-entropy-alloy nanoparticles for electrocatalysis显示文摘Since the two seminal papers were published independently in 2004, high-entropy-alloys(HEAs) have been applied to structural and functional materials due to the enhanced mechanical properties, thermal stability, and electrical conductivity. In recent years, HEA nanoparticles(HEA-NPs) were paid much attention to in the field of catalysis for the promoted catalytic activity. Furthermore, the various ratios among the metal components and tunable bulk and surface structures enable HEAs have big room to enhance the catalytic performance. Especially, noble-metal-based HEAs displayed significantly improved performance in electrocatalysis, where the ‘core effects’ were employed to explain the superior catalytic activity. However, it is insufficient to understand the essential mechanism or further guide the design of electrocatalysts. Structure–property relationship should be disclosed for the catalysis on HEA-NPs to accelerate the process of seeking high effective and efficient electrocatalysts. Therefore, we summarized the recent advances of noble-metal-based HEA-NPs applied to electrocatalysis, such as hydrogen evolution reaction, oxygen evolution reaction, oxygen reduction reaction, methanol oxidation reaction, ethanol oxidation reaction, formic acid oxidation reaction, hydrogen oxidation reaction, carbon dioxide reduction reaction and nitrogen reduction reaction. For each electrocatalytic reaction, the reaction mechanism and catalyst structure were presented, and then the structure–property relationship was elaborated. The review begins with the development, concept, four ‘core effect’ and synthesis methods of HEAs. Next,the electrocatalytic reactions on noble-metal-based HEA-NPs are summarized and discussed independently. Lastly, the main views and difficulties pertaining to structure–property relationship for HEAs are discussed. | Xianfeng Huang Guangxing Yang Shuang Li Hongjuan Wang Yonghai Cao Feng Peng Hao Yu | 2022 | Journal of Energy Chemistry2022，31，5： | 1 |
| 12 | Prepa- ration and characterization of Cu20/TiOz nano-nano het- erostructure photoeatalysts 显示文摘 | Huang Lei Peng Feng Wang Hongjuan | 2009 | Catal Commun2009，10，14： | 1 |
| 13 | Synthesis and characterization of sulfonated single-walled carbon nanotubes and their performance as solid acid catalyst显示文摘 | Hao Yu Yuguang Jin Zhili Li Feng Peng Hongjuan Wang | 2007 | Journal of Solid State Chemistry2007，，3： | 1 |
| 14 | Sulfonated carbon nanotubes as a strong protonic acid catalyst显示文摘 | Feng Peng Lei Zhang Hongjuan Wang Ping Lv Hao Yu | 2005 | Carbon2005，，11： | 1 |
| 15 | Mechanism study on adsorption of acidified multiwalled carbon nanotubes to Pb(II) 显示文摘 | Wang Hongjuan Zhou Ailin Peng Feng | 2007 | Journal of Colloid and Interface Science2007，316，： | 1 |
| 16 | Effect of the metal foam materials on the performance of methanol steam micro-reformer for fuel cells显示文摘 | Hao Yu Hongqing Chen Minqiang Pan Yong Tang Kai Zeng Feng Peng Hongjuan Wang | 2007 | Applied Catalysis A, General2007，，1： | 1 |
| 17 | Assessment and optimization of the mass-transfer limitation in a metal foam methanol microreformer显示文摘 | Hongqing Chen Hao Yu Yong Tang Minqiang Pan Feng Peng Hongjuan Wang Jian Yang | 2007 | Applied Catalysis A, General2007，，2： | 1 |
| 18 | Bi-functional particles for integrated thermo-chemical processes:Catalysis and beyond显示文摘Particulate materials possessing dual functionalities have received tremendous investigations in many fields,owing to their superiority over mono-functional counterparts and their potential for process integration and intensification.This review focuses on bi-functional catalytic particles which also serve as sorbents/adsorbents or heat suppliers in the scheme of various thermo-chemical processes,enabling inherent separation or energy conservation within single-step operation.Bi-functional particles applied for integration of reaction and separation including sorption-enhanced hydrogen production and integrated capture and catalytic conversion processes are reviewed in detail,providing insights into material design and key performance indicators.On the other hand,bi-functional particles applied for integration of reaction and non-thermal radiation heating,including electrothermal and photothermal assisted heterogeneously catalyzed reactions,are also reviewed,with emphasis on the material property and energy efficiency improvement.These bi-functional particles show broad adaptability and feasibility in various reactions operated in integrated and intensified schemes,affording huge potentials for further improving productivity and efficiency in thermo-chemical processes. | Hanke Li Chengxiong Dang Guangxing Yang Yonghai Cao Hongjuan Wang Feng Peng Hao Yu | 2021 | Particuology2021，19，3： | 1 |
| 19 | Prepa- ration and characterization of Cu20/TiO2 nano-nano heterostructure photocatalysts 显示文摘 | Huang Lei Peng Feng Wang Hongjuan | 2009 | Catal Commun2009，10，14： | 1 |
| 20 | sp2- and sp3-hybridized carbon materials as catalysts for aerobic oxidation of cyclohexane 显示文摘 | Cao Yonghai Luo Xianyu Yu Hao Peng Feng Wang Hongjuan Ning Guoqing | 2013 | Catalysis Science & Technology2013，3，： | 1 |
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