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| 1 | E2FBP1 antagonizes the p16^(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability显示文摘Cellular senescence is an irreversible cell cycle arrest triggered by the activation of oncogenes or mitogenic signaling as well as the enforced expression of tumor suppressors such as p53, p16 INK4A and promyelocytic leukemia protein (PML) in normal cells. E2F-binding protein 1 (E2FBP1), a transcription regulator for E2F, induces PML reduction and suppresses the formation of PML-nuclear bodies, whereas the down-regulation of E2FBP1 provokes the PML-dependent premature senescence in human normal fibroblasts. Here we report that the depletion of E2FBP1 induces the accumulation of PML through the Ras-dependent activation of MAP kinase signaling. The cellular levels of p16 INK4A and p53 are elevated during premature senescence induced by depletion of E2FBP1, and the depletion of p16 INK4A , but not p53 rescued senescent cells from growth arrest. Therefore, the premature senescence induced by E2FBP1 depletion is achieved through the p16 INK4A -Rb pathway. Similar to human normal fibroblasts, the growth inhibition induced by E2FBP1 depletion is also observed in human tumor cells with intact p16 INK4A and Rb. These results suggest that E2FBP1 functions as a critical antagonist to the p16 INK4A -Rb tumor suppressor machinery by regulating PML stability. | Yayoi Fukuyo Akiko Takahashi Eiji Hara Nobuo Horikoshi Tej K. Pandita Takuma Nakajima | 2011 | International Journal of Oral Science2011，3，4： | 11 |
| 2 | Characteristics of microwaves on second generation nitrogen-doped TiO 2 nanoparticles and their effect on photoassisted processes显示文摘 | Satoshi Horikoshi Yuya Minatodani Hideki Sakai Masahiko Abe Nick Serpone | 2010 | Journal of Photochemistry & Photobiology A: Chemistry2010，，1： | 2 |
| 3 | Development and evaluation of FSSG: frequency scale for the symptoms of GERD显示文摘 | Motoyasu Kusano Yasuyuki Shimoyama Sayaka Sugimoto Osamu Kawamura Masaki Maeda Keiko Minashi Shiko Kuribayashi Tatsuya Higuchi Hiroaki Zai Kyoko Ino Tsutomu Horikoshi Tadashi Sugiyama Munetoshi Toki Tsuneo Ohwada Masatomo Mori | 2004 | Journal of Gastroenterology2004，，9： | 2 |
| 4 | Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population 显示文摘 | Horikoshi M Hara K ho C | 2007 | Diabetologia2007，50，12： | 1 |
| 5 | Cellulases of an alkalophilic Bacillus strain isolated from soil显示文摘 | HORIKOSHI K NAKAO M KURONO Y | 1984 | Can J Mierobiol1984，30，： | 1 |
| 6 | Evaluation of hepatic lesions and hepatic parenchyma using diffusion-weighted reordered turboFLASH magnetic resonance images显示文摘 | Moteki T Horikoshi H Oya N | 2002 | J Magn Reson Imaging2002，15，5： | 1 |
| 7 | Diffusion tensor tractography predicts motor functional outcome in patients with spontaneous intracerebral hemorrhage显示文摘 | Yoshioka H Horikoshi T Aoki S | 2008 | Neurosurgery2008，62，10： | 1 |
| 8 | Pharmacokinetic study of S-1,a novel oral fluorouracil antitumor drug显示文摘 | Hirata K Horikoshi N Aiba K | 1999 | Clin Cancer Res1999，5，8： | 1 |
| 9 | NAD(P) H : quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin aensitivity显示文摘 | Traver RD Horikoshi T Danenberg KD | 1992 | Cancer Res1992，52，4： | 1 |
| 10 | Urinary levels of interleukin-8(IL-8)and disease activity in patients with IgA nephropathy显示文摘 | Huang F Horikoshi S Kurusu A | 2001 | Clin Lab Anal2001，15，1： | 1 |
| 11 | Characterization of three β-Mannanse sofanofan alkalophilic Bacillussp显示文摘 | AKINO T KATO C HORIKOSHI K | 1958 | Agric Biol Chem1958，52，： | 1 |
| 12 | Photodegrada- tion of tetrahalobisphenol - A (X = C1, Br) flame retard- ants and delineation of factors affecting the process显示文摘 | Horikoshi S Miura T Kajitani M | 2008 | Appl Catal B- Environ2008，84，34： | 1 |
| 13 | Production of β-mannosidase and β-mannanase by an alkalophilic Bacillus sp.显示文摘 | Toshiro Akino Nobuyuki Nakamura Koki Horikoshi | 1987 | Applied Microbiology and Biotechnology1987，，4： | 1 |
| 14 | Activation of in- variant NKT cells with glyeolipid ligand a-galactosylceram- ide ameliorates glueose-6-phosphate isomerase peptide-in- duced arthritis显示文摘 | Horikoshi M Goto D Segawa S | 2012 | PLoS One2012，7，51： | 1 |
| 15 | Genetic and antigenic diversity among noroviruses 显示文摘 | Hansman GS Natori K Shirato - Horikoshi H | 2006 | J Gen Virol2006，87，4： | 1 |
| 16 | Photocatalyzed N-demethylation and degradation of methylene blue in titania dispersions exposed to concentrated sunlight 显示文摘 | Zhang T Y Oyama T Horikoshi S | 2002 | Solar Energy Mater Solar Cells2002，73，3： | 1 |
| 17 | : A new microbial world-Extremophiles显示文摘 | | 1997 | Extremophiles1997，1，： | 1 |
| 18 | Geldanamycin and its anti-cancer activities显示文摘 | Fukuyo Y Hunt C R Horikoshi N | 2010 | Cancer Lett2010，290，1： | 1 |
| 19 | In vitro magnetite formation by urease dependent reaction显示文摘 | Hamaya T Horikoshi K | 1989 | Agric Biol Chem1989，53，3： | 1 |
| 20 | Enhanced photocurrent generation and photooxidation of benzene sulfonate in a continuous flow reactor using hybrid TiO2 thin films immobilized on OTE electrodes显示文摘 | Horikoshi S Satou Y Hidaka H | 2001 | J Photochem Photobio A:Chem2001，146，： | 1 |
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