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| 1 | ^11C-PIBPET和^18F-FDGPET显像诊断阿尔茨海默病与遗忘型轻度认知损害的临床价值显示文摘目的应用11C-PIB PET和18F-FDG PET显像研究阿尔茨海默病和遗忘型轻度认知损害患者β-淀粉样蛋白(Aβ)沉积与葡萄糖代谢之间的关系,联合载脂蛋白E(ApoE)基因型进一步探讨遗忘型轻度认知损害与阿尔茨海默病的相关性。方法利用PET显像对阿尔茨海默病(14例)、遗忘型轻度认知损害(10例)和正常对照者(5例)脑组织Aβ沉积和葡萄糖代谢变化进行分析,采用聚合酶链反应-限制性片段长度多态性方法对ApoE基因型进行分析。结果阿尔茨海默病组患者11C-PIB标准化摄取比值在下顶叶、颞叶外侧、额叶、后扣带回皮质和楔前叶、枕叶和纹状体均高于正常对照组(P<0.05);遗忘型轻度认知损害组患者脑组织11C-PIB结合水平呈双峰形。11C-PIB+aMCI亚组与阿尔茨海默病组、11C-PIB-aMCI亚组与正常对照组之间11C-PIB标准化摄取比值差异均无统计学意义(P>0.05)。18F-FDG PET显像显示,3/5例11C-PIB+aMCI亚组患者双侧顶叶、颞叶和楔前叶代谢减低,其中2例ApoEε4等位基因携带者随访期间进展至阿尔茨海默病;3/5例11C-PIB-aMCI亚组患者双侧额叶和前扣带回代谢减低。结论11C-PIB PET显像是筛查具有阿尔茨海默病病理特点的遗忘型轻度认知损害患者的有效工具。具有阿尔茨海默病病理特征的遗忘型轻度认知损害患者可伴有顶叶、颞叶外侧皮质和楔前叶代谢减低,其中ApoEε4等位基因携带者更易进展至阿尔茨海默病痴呆。 | Shi Zhihong Wang Ying Liu Shuai Liu Shuling Z hou Yuying Wang Jinhuan Cai Li Gao Shuo Ji Yong | 2014 | 中国现代神经疾病杂志2014，14，3： | 8 |
| 2 | Application of spline wavelet transform in differential of electroanalytical signal显示文摘Investigating characteristics of spline wavelet, we found that if the two-order spline function, the derivative function of the three-order B spline function, is used as the wavelet base function, the spline wavelet transform has both the property of denoising and that of differential. As a result, the relation between the spline wavelet transform and the differential was studied in theory. Experimental results show that the spline wavelet transform can well be applied to the differential of the electroanalytical signal. Compared with other kinds of wavelet transform, the spline wavelet transform has a characteristic of differential. Compared with the digital differentia] and simulative differential with electronic circuit, the spline wavelet transform not only can carry out denoising and differential for a signal, but also has the advantages of simple operation and small quantity of calculation, because step length, RC constant and other kinds of parameters need not be selected. Compared with | ZHANG Shuling ZHENG Jianbin GU Wenliang ZHANG Hongquan HOU Xun GAO Hong | 2001 | Chinese Science Bulletin2001，46，7： | 3 |
| 3 | Simulation of cavity flow by the lattice Boltzmann method 显示文摘 | Hou Shuling Zou Qisu Chen Shiyi | 1995 | Journal of Computational Physics1995，118，2： | 1 |
| 4 | Evaluation of Two Lattice Boltzmann Models for Multiphase Flows显示文摘 | Shuling Hou Xiaowen Shan Qisu Zou Gary D. Doolen Wendy E. Soll | 1997 | Journal of Computational Physics1997，，2： | 1 |
| 5 | Autologous transplantation of adipose-derived mesenchymal stem cellsameliorates streptozotocin-induced diabetic nephropathy in rats by inhibitingoxidative stress, pro-inflammatory cytokines and the p38 MAPK signaling pathway显示文摘 | Yan Fang Xiaohong Tian Shuling Bai Jun Fan Weijian Hou Hao Tong Dehua Li | 2012 | International Journal of Molecular Medicine2012，，1： | 1 |
| 6 | LIFU-responsive nanomedicine enables acoustic droplet vaporization-induced apoptosis of macrophages for stabilizing vulnerable atherosclerotic plaques显示文摘Due to the high risk of tearing and rupture,vulnerable atherosclerotic plaques would induce serious cardiovascular and cerebrovascular diseases.Despite the available clinical methods can evaluate the vulnerability of plaques and specifically treat vulnerable plaques before a cardiovascular event,but the efficiency is still low and undesirable.Herein,we rationally design and engineer the low-intensity focused ultrasound(LIFU)-responsive FPD@CD nanomedicine for the highly efficient treatment of vulnerable plaques by facilely loading phase transition agent perfluorohexane(PFH)into biocompatible PLGA-PEG-PLGA nanoparticles(PPP NPs)and then attaching dextran sulphate(DS)onto the surface of PPP NPs for targeting delivery.DS,as a typical macrophages-targeted molecule,can achieve the precise vaporization of NPs and subsequently controllable apoptosis of RAW 264.7 macrophages as induced by acoustic droplet vaporization(ADV)effect.In addition,the introduction of DiR and Fe3O4 endows nanomedicine with near-infrared fluorescence(NIRF)and magnetic resonance(MR)imaging capabilities.The engineered FPD@CD nanomedicine that uses macrophages as therapeutic targets achieve the conspicuous therapeutic effect of shrinking vulnerable plaques based on in vivo and in vitro evaluation outcomes.A reduction of 49.4%of vascular stenosis degree in gross pathology specimens were achieved throughout the treatment period.This specific,efficient and biosafe treatment modality potentiates the biomedical application in patients with cardiovascular and cerebrovascular diseases based on the relief of the plaque rupture concerns. | Jingxin Hou Jun Zhou Meiqi Chang Guangcheng Bao Jie Xu Man Ye Yixin Zhong Shuling Liu Junrui Wang Wei Zhang Haitao Ran Zhigang Wang Yu Chen Dajing Guo | 2022 | Bioactive Materials2022，7，10： | 1 |
| 7 | Autologous transplantation of adipose-derived mesenchymal stem cellsameliorates streptozotocin-induced diabetic nephropathy in rats by inhibitingoxidative stress, pro-inflammatory cytokines and the p38 MAPK signaling pathway显示文摘 | Yan Fang Xiaohong Tian Shuling Bai Jun Fan Weijian Hou Hao Tong Dehua Li | 2012 | International Journal of Molecular Medicine2012，，1： | 1 |
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