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| 1 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 2 | Impaired brachial artery endothelial function is not predicted by elevated triglycerides显示文摘 | Schnell GB Robertson A Houston D | 1999 | J Am Coil Cardiol1999，33，7： | 1 |
| 3 | Fas ligand expressed in colon cancer is not associated with increased apoptosis of tumor cells in vivo显示文摘 | Houston A Walsron-Lynch F D Bennett M N et aI | 2003 | Int J Cancer2003，1，10： | 1 |
| 4 | Cancellation and focus:The Role of Shared and Unique Features in the Choice Process显示文摘 | HOUSTON D A SHERMAN S T | 1995 | Journal of Experimental Social Psychology1995，31，4： | 1 |
| 5 | Feature Matching,Unique Features,and the Dynamics of the Choice Process:Predecision Conflict and Postdecision Satisfaction显示文摘 | HOUSTON D A SHERMAN S T BAKER S M | 1991 | Journal of Experimental Social Psychology1991，27，5： | 1 |
| 6 | A polymor phism in the 5'-Untranslated region of the porcine cholecys- tokinin type A receptor gene affects feed in take and growth 显示文摘 | Houston R D Haley C S Archibald A L | 2006 | Genetics Sociaety of America2006，10，： | 1 |
| 7 | Verbal paired- associate learning by APOE genotype in non-demented older adults: fMRI evidence of a right hemispheric compensatory response 显示文摘 | Han S D Houston W S Jake A J | 2007 | Neurobiology of Aging2007，28，2： | 1 |
| 8 | 1993 nm Photodissociation Dynamic of Nitromethane 显示文摘 | Moss D B Trentelman K A Houston P L | 1992 | J Chem Phys1992，96，1： | 1 |
| 9 | Are pollination bags needed for controlled pollination programs with yellowpolar? 显示文摘 | Houston D B Joehlin K A | 1989 | Silvae Genetica1989，38，34： | 1 |
| 10 | A melanocortin-4 receptor (MC4R)polymorphism is associated With performance traits in divergently selected Large White pig populations显示文摘 | Houston R D Cameron N D Rance K A | 2004 | Anim Genet2004，35，5： | 1 |
| 11 | Vitamin D polymorplism bone mineral density and osteoporotic vertebral fracture: studies in a UK population显示文摘 | HOUSTON L A GRANTS F A REID D M | 1996 | Bone1996，18，： | 1 |
| 12 | Var-iation in alluvia-I derived soils as measured by landsat hematicmapper显示文摘 | THOMPSON D R HENDERSON K E HOUSTON A G | 1984 | Soil Science Society of America Journal1984，48，： | 1 |
| 13 | A melanocortin 4 receptor ( MIC4R ) polymorphism is associated with per- formance traits in divergently selected large white pig pop ulations显示文摘 | Houston R D Cameron N D Rance K A | 2004 | Animal Genetics2004，35，5： | 1 |
| 14 | A polymorphism in the 5'- untranslated region of the porcine cholecystokinin type A receptor genc affects feed intake and growth 显示文摘 | HOUSTON R D HALEY C S ARCHIBALD A L | 2006 | Genetics2006，174，3： | 1 |
| 15 | A melanocortin- 4 receptor(MC4R) polymorphism is associated with performance traits in divergently selected large white pig populations 显示文摘 | Houston R D Cameron N D Rance K A | 2004 | Animal Genetics2004，35，： | 1 |
| 16 | Canine urolithiasis:a look at over 16000 urolith submissions to the Canadian Veterinary Urolith Centre from February 1998 to April 2003显示文摘 | Houston D M Moore A E P Favrin M G | 2004 | Canadian Veterinary Journal2004，45，3： | 1 |
| 17 | Weighty concerns:the growing prevalence of obesity among older adults显示文摘 | HOUSTON D K NICKLAS B J ZIZZA C A | 2009 | J Am Diet Assoc2009，109，11： | 1 |
| 18 | Transmission of BSE by blood transfusion in sheep显示文摘 | HOUSTON F FOSTER J D CHONG A | 2000 | Lancet2000，356，4： | 1 |
| 19 | A melanocortin-4 receptor (MC4R) polymorphism is associated with performance traits in divergently selected Large White pig populations 显示文摘 | Houston R D Cameron N D Rance K A | 2004 | Anita Genet2004，35，5： | 1 |
| 20 | Canine urolitbiasis :a look at over 16 000 urolith submissions to the Canadian Veterinary Urolith Centre from February 1998 to April 2003 显示文摘 | Houston D M Moore A E Favrin M G | 2004 | Can Vet J2004，45，3： | 1 |
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