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| 1 | Elucidation of the ‘Honeycrisp’ pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus×domestica) pedigree-connected SNP data set显示文摘The apple(Malus×domestica)cultivar Honeycrisp has become important economically and as a breeding parent.An earlier study with SSR markers indicated the original recorded pedigree of‘Honeycrisp’was incorrect and‘Keepsake’was identified as one putative parent,the other being unknown.The objective of this study was to verify‘Keepsake’as a parent and identify and genetically describe the unknown parent and its grandparents.A multi-family based dense and high-quality integrated SNP map was created using the apple 8 K Illumina Infinium SNP array.This map was used alongside a large pedigree-connected data set from the RosBREED project to build extended SNP haplotypes and to identify pedigree relationships.‘Keepsake’was verified as one parent of‘Honeycrisp’and‘Duchess of Oldenburg’and‘Golden Delicious’were identified as grandparents through the unknown parent.Following this finding,siblings of‘Honeycrisp’were identified using the SNP data.Breeding records from several of these siblings suggested that the previously unreported parent is a University of Minnesota selection,MN1627.This selection is no longer available,but now is genetically described through imputed SNP haplotypes.We also present the mosaic grandparental composition of‘Honeycrisp’for each of its 17 chromosome pairs.This new pedigree and genetic information will be useful in future pedigree-based genetic studies to connect‘Honeycrisp’with other cultivars used widely in apple breeding programs.The created SNP linkage map will benefit future research using the data from the Illumina apple 8 and 20 K and Affymetrix 480 K SNP arrays. | Nicholas P Howard Eric van de Weg David S Bedford Cameron P Peace Stijn Vanderzande Matthew D Clark Soon Li Teh Lichun Cai James J Luby | 2017 | Horticulture Research2017，4，1： | 9 |
| 2 | Surface-bound myeloperoxidase is a ligand for recognition of late apoptotic neutrophils by human lung surfactant proteins A and D显示文摘Surfactant proteins A(SP-A)and D(SP-D),both members of the collectin family,play a well established role in apoptotic cell recognition and clearance.Recent in vitro data show that SP-A and SP-D interact with apoptotic neutrophils in a distinct manner.SP-A and SP-D bind in a Ca^(2+)-dependent manner to viable and early apoptotic neutrophils whereas the much greater interaction with late apoptotic neutrophils is Ca^(2+)-independent.Cell surface molecules on the apoptotic target cells responsible for these interactions had not been identified and this study was done to find candidate target molecules.Myeloperoxidase(MPO),a specific intracellular defense molecule of neutrophils that becomes exposed on the outside of the cell upon apoptosis,was identified by affinity purification,mass-spectrometry and western blotting as a novel binding molecule for SP-A and SP-D.To confirm its role in recognition,it was shown that purified immobilised MPO binds SP-A and SP-D,and that MPO is surface-exposed on late apoptotic neutrophils.SP-A and SP-D inhibit binding of an anti-MPO monoclonal Ab to late apoptotic cells.Fluorescence microscopy confirmed that anti-MPO mAb and SP-A/SP-D colocalise on late apoptotic neutrophils.Desmoplakin was identified as a further potential ligand for SP-A,and neutrophil defensin as a target for both proteins. | Anne Jäkel Howard Clark Kenneth B.M.Reid Robert B.Sim | 2010 | Protein & Cell2010，1，6： | 2 |
| 3 | Surfactant protein A (SP-A) binds to phosphatidylserine and competes with annexin V binding on late apoptotic cells显示文摘The role of surfactant protein A(SP-A)in the recognition and clearance of apoptotic cells is well established,but to date,it is still not clear which surface molecules of apoptotic cells are involved in the process.Here we present evidence that phosphatidylserine(PS)is a relevant binding molecule for human SP-A.The binding is Ca^(2+)-dependent and is not inhibited by mannose,suggesting that the sugar-binding site of the carbohydrate recognition domain(CRD)of SP-A is not involved.Flow cytometry studies on apoptotic Jurkat cells revealed apparent inhibition of annexin V binding by increasing concentrations of SP-A in late apoptotic but not early apoptotic cells,and this was consistent for Jurkat cells and neutrophils.Supporting these data,confocal microscopy results show a co-localisation of annexin V and SP-A in late apoptotic but not early apoptotic cells.However,we cannot conclude that this inhibition is exclusively due to the binding of SP-A to PS on the cell surface,as annexin V is not wholly specific for PS and SP-A also interacts with other phospholipids that might become exposed on the apoptotic cell surface. | Anne Jäkel Kenneth B.M.Reid Howard Clark | 2010 | Protein & Cell2010，1，2： | 2 |
| 4 | Energy Absorbed by Longitudinally Splitting a Tibialis Anterior Allograft:Implications for Double-Bundle Anterior Cruciate Ligament Reconstruction显示文摘 | Clark L Howard C Bisso LJ | 2010 | The Journal of Arthroscopic&Related Surgery2010，26，9： | 1 |
| 5 | 数字中间片的现状显示文摘 | Curtis Clark Howard Lwkk Jim Whittlesey 刘旭阳(译) 李铭(校) | 2009 | 现代电影技术2009，，7： | 1 |
| 6 | Immunity bovine viral diarrhea virus calves:the role of different T-cell sub-populations analysed by specific depletion in vivo with monoclonal antibodies显示文摘 | Clarke M C Sopp P | 1992 | Vet Immunolpathol1992，32，： | 1 |
| 7 | Antioxidant capacity and phenolic content in blueberries as affected by genotype and growing season显示文摘 | HOWARD L R CLARK J R BROWNMLLER C | 2003 | Journal of the Science of Food and Agriculture2003，83，： | 1 |
| 8 | The RASSF1 A tumor suppressor 显示文摘 | Howard Donninger Michele D Vos Geoffrey J Clark | 2007 | J Cell Sci2007，120，： | 1 |
| 9 | Antioxi-dant capacity and phenolic content in blueberries asaffected by genotype and growing season显示文摘 | Howard L R Clark J R Brownmiler C | 2003 | Jour-nal of the Science of Food and Agriculture2003，83，12： | 1 |
| 10 | Clear water radiances for atmospheric correction ofcoastal zone color scanner imagery 显示文摘 | Howard R Gordon Dennis K Clark | 1981 | Applied Optics1981，20，24： | 1 |
| 11 | Wear tests of steel knife blades 显示文摘 | John D V Alfred H P Howard F Clark | 2008 | Wear2008，265，78： | 1 |
| 12 | Autonomous driving in urban environments: Boss and the urban challenge 显示文摘 | URMSON C ANHALT J BAGNELL D BAKER C BITTNER R CLARK M N DOLAN J DUGGINS D GALATALI T GEYER C GITTLEMAN M HARBAUGH S HEBERT M HOWARD T M KOLSKI S KELLY A LIKHACHEV M MCNAUGHTON M MILLER N PETERSON K PILNICK B RAJKUMAR R RYBSKI P SALESKY B SEO Y W SINGH S SNIDER J STENTZ A WHITTAKER W WOLKOWICKI Z Z1GLAR J BAE H BROWN T DEMITRISH D LITKOUHI B NICKOLAOU J SADEKAR V ZHANG Wen-de STRUBLE J TAYLOR M DARMS M FERGUSON D | 2008 | Journal of Field Robotics2008，25，8： | 1 |
| 13 | Experimental infection of cattle in early pregnancy with a cytopathic strain of bovine virus diarrhoea virus显示文摘 | Brownlie J Clarke M C Howard C J | 1989 | Res Vet Sci1989，46，： | 1 |
| 14 | Experimental production of fatal mucosal disease in cattle显示文摘 | Brownlie J Clarke M C Howard C J | 1984 | Vet Rec1984，114，： | 1 |
| 15 | Biological formation of molecular hydrogen显示文摘 | CLARKE T GRAY HOWARD GEST | 1965 | Science1965，148，： | 1 |
| 16 | Entropy and information causality in general probabilistie theories 显示文摘 | Howard Barnum Jonathan Barrett Lisa Orloff Clark | 2010 | New Journal of Physics2010，3，： | 1 |
| 17 | Apolipoproteins as predic- tors of ischaemic stroek in patients with a previous transient ischae- mic attack显示文摘 | Bhatia M Howard SC Clark TG | 2006 | Cerebrovasc Dis2006，21，56： | 1 |
| 18 | Determination of carbohydrates in tobacco products by liquid chromatography-mass spectrometry/mass spectrometry: a comparison with ion chromatography and application to product discrimination 显示文摘 | Michelle B Clarke Dawit Z Bezabeh Caitlin T Howard | 2006 | J Agric Food Chem2006，，54： | 1 |
| 19 | Antloxidant capacity and phenolic content In blueberries as af- fected by genotype and growing sea- son显示文摘 | HOWARD LR CLARK JR BROWN- MILLER C | 2003 | Journal of the Science of Food and Agriculture2003，83，12： | 1 |
| 20 | Analysis of lung surfactant phosphatidylcholine metabolism in transgenic mice using stable isotopes显示文摘 | Anthony D. Postle Neil G. Henderson Grielof Koster Howard W. Clark Alan N. Hunt | 2011 | Chemistry and Physics of Lipids2011，，6： | 1 |
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