|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mesenchymal stem cells derived from human placenta suppress allogeneic umbilical cord blood lymphocyte proliferation显示文摘ABSTRACTHuman placenta-derived mononuclear cells (MNC) were isolated by a Percoll density gradient and cultured in mesen-chymal stem cell (MSC) maintenance medium. The homogenous layer of adherent cells exhibited a typical fibroblast-like morphology, a large expansive potential, and cell cycle characteristics including a subset of quiescent cells. In vitrodifferentiation assays showed the tripotential differentiation capacity of these cells toward adipogenic, osteogenic andchondrogenic lineages. Flow cytometry analyses and immunocytochemistry stain showed that placental MSC was ahomogeneous cell population devoid of hematopoietic cells, which uniformly expressed CD29, CD44, CD73, CD105,CD166, laminin, fibronectin and vimentin while being negative for expression of CD31, CD34, CD45 and α-smoothmuscle actin. Most importantly, immuno-phenotypic analyses demonstrated that these cells expressed class I majorhistocompatibility complex (MHC-I), but they did not express MHC-II molecules. Additionally these cells could sup-press umbilical cord blood (UCB) lymphocytes proliferation induced by cellular or nonspecific mitogenic stimuli. Thisstrongly implies that they may have potential application in allograft transplantation. Since placenta and UCB arehomogeneous, the MSC derived from human placenta can be transplanted combined with hematopoietic stem cells(HSC) from UCB to reduce the potential graft -versus-host disease (GVHD) in recipients. | Chang Dong LI Wei Yuan ZHANG He Lian LI Xiao Xia JIANG Yi ZHANG Pei Hsien TANG Ning MAO | 2005 | Cell Research2005，15，7： | 36 |
| 2 | Recent upper gastrointestinal panendoscopy increases the risk of pyogenic liver abscess显示文摘AIM To investigate the association between a recent gastrointestinal(GI) endoscopy and the subsequent risk of pyogenic liver abscess(PLA).METHODS We designed a nested case control study. Using the Taiwan National Health Insurance Research Database, 2135 patients with a first diagnosis of PLA were identified from 1998 to 2011. Another 10675 patients without PLA matched by age and sex were selected as reference controls. We identified and compared the possible risk factors for PLA and GI endoscopies performed before the index date(when PLA was diagnosed) between the two cohorts. Multivariate analysis was conducted to examine the risk of PLA within the 90 d after the GI endoscopies.RESULTS Patients with a history of diabetes [adjusted odds ratio(a OR) = 4.92, 95%CI: 1.78-13.61], end-stage renal disease(a OR = 3.98, 95%CI: 1.45-10.91), biliary tract infection(a OR = 2.68, 95%CI: 2.11-3.40), liver cirrhosis(a OR = 2.19, 95%CI: 1.39-3.46), GI malignancies(a OR = 5.68, 95%CI: 4.23-7.64), appendicitis(a OR = 3.16, 95%CI: 2.27-4.41), diverticulitis(a OR = 1.64, 95%CI: 1.01-2.64), and recent endoscopic retrograde cholangiopancreatography(a OR = 27.04, 95%CI: 11.65-62.72) were significantly associated with an increased risk of PLA. After adjusting for the above risk factors and the frequency of outpatient department visits and abdominal ultrasounds during 90 d before the index date, an upper GI panendoscopy(a OR = 2.75, 95%CI: 2.05-3.69) but not a lower GI endoscopy(a OR = 1.07, 95%CI: 0.62-1.86) was significantly associated with PLA.CONCLUSION An upper GI panendoscopy performed before 90 d may increase the risk of PLA. | Ming-Jen Tsai Chin-Li Lu Ying C Huang Chung Hsien Liu Wan-Ting Huang Kai-Yuan Cheng Solomon Chih-Cheng Chen | 2017 | World Journal of Gastroenterology2017，23，16： | 8 |
| 3 | Gastric peritoneal carcinomatosis-a retrospective review显示文摘AIM To characterize patients with gastric peritoneal carcinomatosis(PC) and their typical clinical and treatment course with palliative systemic chemotherapy as the current standard of care.METHODS We performed a retrospective electronic chart review of all patients with gastric adenocarcinoma with PC diagnosed at initial metastatic presentation between January 2010 and December 2014 in a single tertiary referral centre.RESULTS We studied a total of 271 patients with a median age of 63.8 years and median follow-up duration of 5.1 mo. The majority(n = 217, 80.1%) had the peritoneum as the only site of metastasis at initial presentation. Palliative systemic chemotherapy was eventually planned for 175(64.6%) of our patients at initial presentation, of which 171 were initiated on it. Choice of first-line regime was in accordance with the National Comprehensive Cancer Network Guidelines for Gastric Cancer Treatment. Thesepatients underwent a median of one line of chemotherapy, completing a median of six cycles in total. Chemotherapy disruption due to unplanned hospitalizations occurred in 114(66.7%), while cessation of chemotherapy occurred in 157(91.8%), with 42 cessations primarily attributable to PC-related complications. Patients who had initiation of systemic chemotherapy had a significantly better median overall survival than those who did not(10.9 mo vs 1.6 mo, P < 0.001). Of patients who had initiation of systemic chemotherapy, those who experienced any disruptions to chemotherapy due to unplanned hospitalizations had a significantly worse median overall survival compared to those who did not(8.7 mo vs 14.6 mo, P < 0.001).CONCLUSION Gastric PC carries a grim prognosis with a clinical course fraught with disease-related complications which may attenuate any survival benefit which palliative systemic chemotherapy may have to offer. As such, investigational use of regional therapies is warranted and required validation in patients with isolated PC to maximize their survival outcomes in the long run. | Hwee Leong Tan Claramae Shulyn Chia Grace Hwei Ching Tan Su Pin Choo David Wai-Meng Tai Clarinda Wei Ling Chua Matthew Chau Hsien Ng Khee Chee Soo Melissa Ching Ching Teo | 2017 | World Journal of Gastrointestinal Oncology2017，9，3： | 6 |
| 4 | 皮肤病患者预防新型冠状病毒肺炎个人防护专家共识(第一版)显示文摘2019年12月以来,湖北省武汉市陆续出现新型冠状病毒感染引起的以肺部病变为主的新发呼吸道传染病,即新型冠状病毒肺炎(COVID-19),之后呈现快速蔓延.该病具有发病迅速、传染性强、病程变化快等特点,因此采取甲类传染病的预防、控制措施.当前全国正处于新型冠状病毒肺炎防控工作的紧张阶段,皮肤病患者多存在皮肤屏障功能受损情况,会增加易感性.因此,皮肤病患者的个人防护工作亦极为迫切.针对上述问题,我们组织美国、英国、澳大利亚,中国香港、中国澳门、中国台湾及中国多省市著名专家、教授联合编写了皮肤病患者个人防护专家共识,内容较为翔实,以满足当前抗击新型冠状病毒肺炎疫情工作的需要,帮助皮肤病患者更好地做好个人防护. | 无 邓列华 孙乐栋 曾凡钦 赵华 王宏伟 姜群 林泽 | 2020 | 暨南大学学报(自然科学与医学版)2020，41，2： | 4 |
| 5 | Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders显示文摘 | Elaine Y. Hsiao Sara W. McBride Sophia Hsien Gil Sharon Embriette R. Hyde Tyler McCue Julian A. Codelli Janet Chow Sarah E. Reisman Joseph F. Petrosino Paul H. Patterson Sarkis K. Mazmanian | 2013 | Cell2013，，7： | 3 |
| 6 | Ten‐Day Quadruple Therapy Comprising Proton‐Pump Inhibitor, Bismuth, Tetracycline, and Levofloxacin Achieves a High Eradication Rate for H elicobacter pylori Infection after Failure of Sequential Therapy显示文摘 | Ping‐I Hsu Wen‐Chi Chen Feng‐Woei Tsay Chih‐An Shih Sung‐Shuo Kao Huay‐Min Wang Hsien‐Chung Yu Kwok‐Hung Lai Hui‐Hwa Tseng Nan‐Jing Peng Angela Chen Chao‐Hung Kuo Deng‐Chyang Wu | 2014 | Helicobacter2014，，1： | 3 |
| 7 | Efficacy of texture analysis of pre-operative magnetic resonance imaging in predicting microvascular invasion in hepatocellular carcinoma显示文摘BACKGROUND Presence of microvascular invasion(MVI)indicates poorer prognosis postcurative resection of hepatocellular carcinoma(HCC),with an increased chance of tumour recurrence.By present standards,MVI can only be diagnosed postoperatively on histopathology.Texture analysis potentially allows identification of patients who are considered‘high risk’through analysis of pre-operative magnetic resonance imaging(MRI)studies.This will allow for better patient selection,improved individualised therapy(such as extended surgical margins or adjuvant therapy)and pre-operative prognostication.AIM This study aims to evaluate the accuracy of texture analysis on pre-operative MRI in predicting MVI in HCC.METHODS Retrospective review of patients with new cases of HCC who underwent hepatectomy between 2007 and 2015 was performed.Exclusion criteria:No preoperative MRI,significant movement artefacts,loss-to-follow-up,ruptured HCCs,previous hepatectomy and adjuvant therapy.Fifty patients were divided into MVI(n=15)and non-MVI(n=35)groups based on tumour histology.Selected images of the tumour on post-contrast-enhanced T1-weighted MRI were analysed.Both qualitative(performed by radiologists)and quantitative data(performed by software)were obtained.Radiomics texture parameters were extracted based on the largest cross-sectional area of each tumor and analysed using MaZda software.Five separate methods were performed.Methods 1,2 and 3 exclusively made use of features derived from arterial,portovenous and equilibrium phases respectively.Methods 4 and 5 made use of the comparatively significant features to attain optimal performance.RESULTS Method 5 achieved the highest accuracy of 87.8%with sensitivity of 73%and specificity of 94%.CONCLUSION Texture analysis of tumours on pre-operative MRI can predict presence of MVI in HCC with accuracies of up to 87.8%and can potentially impact clinical management. | Jordan Zheng Ting Sim Terrence Chi Hong Hui Tong Kuan Chuah Hsien Min Low Cher Heng Tan Vishal GShelat | 2022 | World Journal of Clinical Oncology2022，13，11： | 3 |
| 8 | Innovative PCDD/F-containing gas stream generating system applied in catalytic decomposition of gaseous dioxins over V 2 O 5 –WO 3 /TiO 2 -based catalysts显示文摘 | Chia Cheng Yang Shu Hao Chang Bao Zhen Hong Kai Hsien Chi Moo Been Chang | 2008 | Chemosphere2008，，6： | 2 |
| 9 | Microstructures and properties of cancellous bone of avascular necrosis of femoral heads显示文摘这研究的目的是调查显微镜的结构并且描绘大腿骨的头(ANFH ) 的 avascular 坏死的 cancellous 骨头。ANFH 的兔子模型被建立。组织病理学说的特征成功地被学习。类固醇注射组(S.G ) 和控制的组(C.G ) 之间的差别被检验,包括兔子, hematological 考试和三维的结构的重量。triglyceride (TG ) 什么时候在 S.G 增加了,被发现胆固醇(CHO ) 的血浆层次,高密度的脂蛋白(HDL ) 和在 S.G 的低密度的脂蛋白(LDL ) 是比在 C.G 的那些低的;但是骨头矿物质内容( BMC )和机关和织物的结构的模型索引( SMI )在大腿骨的头的 S.G 三维的结构显著地减少了用扫描的微计算断层摄影术( CT )被获得,机械模型被建立分析这些结构的变化的影响在上 cancellous 骨头的机械性质。大腿骨的头的关键词 Avascular 坏死 - Cancellous 骨头 - 微观结构 - 机械性质工程被中国(30470430 和 30400514 ) 的国家自然科学基础支持。 | Xuefeng Yao Peng Wang Ruchun Dai Hsien Yang Yeh | 2010 | Acta Mechanica Sinica2010，26，1： | 2 |
| 10 | 水力旋流器现象模型:粒子运动的数值解及验证显示文摘描述水力旋流器内多相流动的流体动力学方程组是现象模型的基础。该模型能适应较宽的工作范围,更重要的是在模型中包括了设备的几何尺寸。建立模型的工作包括预估水流的三维速度、湍流强度、固体颗粒与水流的相对速度,并最终定出分离效率。本研究在75mm水力旋流器中用激光多谱勒速度计(LDV)测量了水相的速度分布,并通过纳维尔—斯托克斯(Navier-stcks)预算了水流的三维速度,预测的速度分布与实测结果相当符合。接着,考查颗粒的受力平衡,用代数逼近法(algebraic slip approach)求出颗粒与水流的相对运动,同时从一系列单一粒度颗粒的运动导出了分离效率曲线。 | K. T. Hsien 徐继润 | 1989 | 国外金属矿选矿1989，，8： | 2 |
| 11 | 水库冲沙显示文摘由于修建新坝会遇到很多困难 ,用冲走水库淤积泥沙来维持水库使用寿命的做法已越来越受到重视。回顾了水库冲沙现状 。 | Hsien Wenshen 王新朋 | 2000 | 水利水电快报2000，21，14： | 2 |
| 12 | Efficacy of transient elastography in screening for large esophageal varices in patients with suspicious or proven liver cirrhosis显示文摘 | Huay‐Min WANG Gin‐Ho LO Wen‐Chi CHEN Ping‐I HSU Hsien‐Chung YU Chiun‐Ku LIN Hoi‐Hung CHAN Wei‐Lun TSAI Feng‐Woei TSAY Tsan‐Ping LIU E‐Ming WANG Kwok‐Hung LAI | 2012 | Journal of Digestive Diseases2012，，8： | 2 |
| 13 | Tumor‐Associated Macrophages Regulate Murine Breast Cancer Stem Cells Through a Novel Paracrine EGFR/Stat3/Sox‐2 Signaling Pathway显示文摘 | Jian Yang Debbie Liao Cong Chen Yan Liu Tsung‐Hsien Chuang Rong Xiang Dorothy Markowitz Ralph A. Reisfeld Yunping Luo | 2013 | STEM CELLS2013，，2： | 2 |
| 14 | Text mining techniques for patent analysis 显示文摘 | Yuen - Hsien Tseng Chi - Jen Lin Yu - I Lin | 2007 | Information Processing and Management: An International Journal2007，43，5： | 1 |
| 15 | Topological design for vibrating structures 显示文摘 | Ma Zheng-dong Kikuchi Noboru Cheng Hsien Chie | 1995 | Computer Methods in Applied Mechanics and Engineering1995，121，： | 1 |
| 16 | Novel alternating fluorene-based conjugated polymers containing oxadiazole pendants with various terminal groups显示文摘 | Sung Haiso Hsien Lin Hong Cheu | 2004 | Macromolecules2004，37，21： | 1 |
| 17 | Antimicrobial aitivities of six new oral cephem antibiotics显示文摘 | Chang SC Hsien WC luh K T | 1990 | J Formos Med Assoc1990，89，8： | 1 |
| 18 | Acute disseminated encephalomyelitis :a follow-up study in Taiwan显示文摘 | Lin CH Jeng JS Hsien ST | 2007 | J Neurol Neurosurg Psychiatry2007，78，2： | 1 |
| 19 | Two dimensional subsonic flow of compressible fluids显示文摘 | Hsien H S | 1939 | J Aeron Sci1939，6，： | 1 |
| 20 | Topological design for vibration structures显示文摘 | Ma Z D Kikuchi N Hsien C C | 1995 | Computer Methods in Applied Mechanics and Engineering1995，121，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员