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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | Separation of fenoxaprop-p-ethyl biodegradation products by HPTLC显示文摘 | Song L Y Zhao Y C Hua R M | 2005 | J Planar Chromatogr2005，18，： | 1 |
| 3 | Kinetics and mechanism of the sonolytic degradation of CCl4 : Intermediates and byproducts显示文摘 | HUA I HOFFMANN M R | 1996 | Environ Sci Technol1996，30，： | 1 |
| 4 | Optimization of ultrasonic irradiation as an advanced oxidation technology显示文摘 | HUA L HOFMAM M R | 1997 | Environ Sci Technol1997，31，8： | 1 |
| 5 | Sonolytic Hydrolysis of p-Nitrophenyl Acetate: the Role of Supereritieal Water显示文摘 | Hua I Hoeehermer R H Hoffmann M R | 1995 | American Chemical Society1995，99，8： | 1 |
| 6 | Sonochemical degradation of PNP in a parallel - plant Near - field acoustical processor显示文摘 | Hua I Hochemer R H Hoffmann M R | 1995 | Envir Sci Teehnol1995，29，11： | 1 |
| 7 | Metathesis ofbutene to propeneon WO3 supported on MTS-9 titanium-silica: Effect of loading onselectivity of product and yield of propene 显示文摘 | Hua D R Chen S L Yuan G M | | Transition MetalChemistry0，，3： | 1 |
| 8 | Kinetics and mechanism of the sonolytic degradation of CCl4 :intermediates and byprod- ucts 显示文摘 | Hua I Hoffmann M R | 1996 | Environ Sci Technol1996，30，3： | 1 |
| 9 | Metathesis ofbutene to propeneand pentene over WO3/MTS-9 显示文摘 | Hua D R Chen S L Yuan G M | 2011 | Microporous and MesoporousMaterials2011，，： | 1 |
| 10 | Synthesis and characterizationof tungsten-incorporated mesoporous molecular sieve MCM-48 byone step 显示文摘 | Hua D R Chen S L Yuan G M | 2011 | Journal of Porous Materials2011，18，6： | 1 |
| 11 | The growth mechanism of copper nanowires and their properties in flexible, transparent conducting films显示文摘 | RATHMELL A R BERGIN S M HUA Y L | 2010 | Adv Mater2010，22，： | 1 |
| 12 | Optimization ofuhrasonic irradiation as an advanced oxidation technology 显示文摘 | HUA I HOFFMANN M R | 1997 | Environ Sci Techno1997，31，8： | 1 |
| 13 | Kinetics and mechanism of the sonolytic degradation of CCl4:intermediates and byproducts显示文摘 | Hua I Hoffmann M R | 1996 | Environ Sci Technol1996，30，3： | 1 |
| 14 | Structural characterisation of acid-and alkali-soluble polysac- charides in the fruiting body of Dictyophora indusiata and their immunomodulatory activities 显示文摘 | Hua Y L Gao Q Wen L R Yang B Tang J You L J Zhao M M | 2012 | Food Chemistry2012，132，2： | 1 |
| 15 | Tin-mesoporphyrin, a potent heme oxygenase inhibitor, for treatment of intracerebral hemorrhage: in vivo and in vitro studies显示文摘 | Wagner K R Hua Y de Courten Myers G M | 2000 | Cell Mol Biol ( Noisy-legrand)2000，46，3： | 1 |
| 16 | The growth mechanism of copper nanowires and their properties in flexible, transparent conducting films 显示文摘 | Rathmell A R Bergin S M Hua Y L | 2010 | Advanced Materials2010，22，32： | 1 |
| 17 | Optimization of ultrasonic irradiation as an advanced oxidation technology显示文摘 | Hua I Hoffmann M R | | 0，，31： | 1 |
| 18 | Fate of diclofenac in wetland mesocosms planted with Scirpus validus显示文摘 | Zhang D Q Hua T Gersberg R M | 2012 | Ecological Engineering2012，，49： | 1 |
| 19 | Optimization of ultrasonic irradiation as an advanced oxidation technology显示文摘 | Hua I Hoffmann M R | 1997 | Environ Sci Technol1997，31，8： | 1 |
| 20 | Application of ultrasonic irradiation for the degradation of chemical contaminants in water显示文摘 | Hoffmann M R Hua I Hochemer R | 1996 | Ultrasonics Sonochemistry1996，3，3： | 1 |
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