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| 1 | Paleoproterozoic Potassic Granitoids in the Sushui Complex from the Zhongtiao Mountains,Northern China:Geochronology,Geochemistry and Petrogenesis显示文摘Paleoproterozoic potassic granitoids in the southern Sushui Complex from the Zhongtiao Mountains yielded SHRIMP zircon U-Pb ages of 1968–1944 Ma. Lithologically, the potassic granitoid series consists chiefly of monzodiorite, quartz monzonite and syenogranite. Their trace elements and Sm-Nd isotope characteristics indicate that they were derived from partial melting of Archean TTG rocks in an overthickened continental crust. Petrogenesis of this potassic granitoid series implies a collisional environment within the Trans-North China Orogen in the Paleoproterozoic, which supports a tectonic model of Eastern and Western Continental Blocks being amalgamated in the Paleoproterozoic. | TIAN Wei LIU Shuwen ZHANG Huafeng | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 14 |
| 2 | Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer显示文摘Metformin is currently a strong candidate anti-tumor agent in multiple cancers.However,its anti-tumor effectiveness varies among different cancers or sub-populations,potentially due to tumor heterogeneity.It thus remains unclear which hepatocellular carcinoma(HCC)patient subpopulation(s)can benefit from met-formin treatment.Here,through a genome-wide CRISPR-Cas9-based knockout screen,we find that DOCK1 levels determine the anti-tumor effects of met-formin and that DOCK1 is a synthetic lethal target of metformin in HCC.Mechanistically,metformin promotes DOCK1 phosphorylation,which activates RAC1 to facilitate cell survival,leading to metformin resistance.The DOCK1-selective inhibitor,TBOPP,potentiates anti-tumor activity by metformin in vitro in liver cancer cell lines and patient-derived HCC organoids,and in vivo in xenografted liver cancer cells and immunocompetent mouse liver cancer models.Notably,metformin improves overall survival of HCC patients with low DOCK1 levels but not among patients with high DOCK1 expression.This study shows that metformin effective-ness depends on DOCK1 levels and that combining metformin with DOCK1 inhibition may provide a promising personalized therapeutic strategy for met-formin-resistant HCC patients. | Junru Feng Hui Lu Wenhao Ma Wenjing Tian Zhuan Lu Hongying Yang Yongping Cai Pengfei Cai Yuchen Sun Zilong Zhou Jiaqian Feng Jiazhong Deng Ying Shu Kun Qu Weidong Jia Ping Gao Huafeng Zhang | 2022 | Protein & Cell2022，13，11： | 5 |
| 3 | Natural polypeptides treat pollution complex: Moistureresistant multi-functional protein nanofabrics for sustainable air filtration显示文摘有象优秀过滤效率, eco 友好,和环境稳定性那样的特征的绿多功能的空气过滤器的开发极其被要求探讨弄脏的空气的增加的担心。自然蛋白质例如酱油蛋白质和明胶,作为由于富有的功能的组的多功能的空气过滤材料是吸引人的候选人;然而,这些简历材料对潮湿脆弱,它在实践限制他们的宽广申请。在这个工作,从丰富的玉米导出的玉米朊的恐水病的蛋白质第一次被修改经由 electrospinning 生产高效的 nanofilters。玉米朊 nanofabrics 在无毒的溶剂和 co-electrospinning 代理人的帮助下被制作, poly (乙烯氧化物) 。结果表明基于玉米朊的 nanofabrics 为从 0.1 ~ 10 m 的不同尺寸的微粒事的同时的移动显示出高效率(>99.5%) 并且某些气体的有毒的化学药品(>70%) 。另外,到纤维素纸巾的优秀潮湿抵抗和好粘附用作空气过滤器底层的玉米朊 nanofabrics 表演。这研究基于象玉米朊那样的蛋白质为开发多功能的绿空气过滤器正在答应材料的恐水病的天赋表明那 nanofabrics。 | Huafeng Tian Xuewei Fu Min Zheng Yu Wang Yichao Li Aimin Xiang Wei-Hong Zhong | 2018 | Nano Research2018，11，8： | 5 |
| 4 | Microstructure and properties of glycerol plasticized soy protein plastics containing castor oil显示文摘 | Huafeng Tian Wenqian Wu Gaiping Guo Bagen Gaolun Qingqing Jia Aimin Xiang | 2011 | Journal of Food Engineering2011，，3： | 2 |
| 5 | Structure and properties of soy protein films plasticized with hydroxylamine显示文摘 | Huafeng Tian Dagang Liu Lina Zhang | 2009 | Journal of Applied Polymer Science2009，111，3： | 1 |
| 6 | Microstructure and mechanical properties of soy protein/agar blend films: Effect of composition and processing methods显示文摘 | Huafeng Tian Guozhi Xu Biao Yang | 2011 | Journal of Food Engineering2011，107，1： | 1 |
| 7 | Influence of polyol plasticizers on the properties of polyvinyl alcohol films fabrica- ted by melt processing显示文摘 | Wu Wenqian Tian Huafeng Xiang Aimin | 2012 | Journal of Polymers and The Envi- ronment2012，20，1： | 1 |
| 8 | Structure and proper- ties of soy protein films plasticized with hydroxylamine 显示文摘 | Tian Huafeng Liu Dagang Zhang Lina | 2009 | Journal of Applied Polymer Science2009，111，3： | 1 |
| 9 | Creation of hydrophobic materials fabricated from soy protein and natural rubber;Surface,interface,and properties显示文摘 | Tian Huafeng Zhang Lina Wu Qiangxian | 2010 | Macromolecular Materials and Engineering2010，295，5： | 1 |
| 10 | Improved flexibility and water resistance of soy protein thermoplastics containing waterborne polyurethane 显示文摘 | Tian Huafeng Wang Yixiang Zhang Lina | 2010 | Industrial Crops and Products2010，32，1： | 1 |
| 11 | Struc- ture and Properties of Soy Protein Platics with -Caprolac- tone/Glycerol as Binary Plasticizers 显示文摘 | CHEN Pu TIAN Huafeng ZHANG Lina | 2008 | Ind Eng Chem Res2008，47，23： | 1 |
| 12 | Structure andProperties of Soy Protein Films Plasticized withHydroxylamine显示文摘 | Tian Huafeng Liu Dagang Zhang Lina | 2009 | Journal of Applied Polymer Science2009，111，3： | 1 |
| 13 | Structure and properties of soy protein films plasticized with hydroxylamine显示文摘 | TIAN Huafeng LIU Dagang ZHANG Lina | 2009 | Journal of Applied Polymer Science2009，111，： | 1 |
| 14 | Tectonic Evolution and Key Geological Issues of the ProtoSouth China Sea显示文摘There are numerous controversies surrounding the tectonic properties and evolution of the Proto-South China Sea(PSCS).By combining data from previously published works with our geological and paleontological observations of the South China Sea(SCS),we propose that the PSCS should be analyzed within two separate contexts:its paleogeographic location and the history of its oceanic crust.With respect to its paleogeographic location,the tectonic properties of the PSCS vary widely from the Triassic to the mid-Late Cretaceous.In the Triassic,the Paleo-Tethys and the Paleo-Pacific Oceans were the major causes of tectonic changes in the SCS,while the PCSC may have been a remnant sea residing upon Tethys or Paleo-Pacific oceanic crust.In the Jurassic,the Meso-Tethys and the Paleo-Pacific oceans joined,creating a PSCS back-arc basin consisting of Meso-Tethys and/or Paleo-Pacific oceanic crust.From the Early Cretaceous to the midLate Cretaceous,the Paleo-Pacific Ocean was the main tectonic body affecting the SCS;the PSCS may have been a marginal sea or a back-arc basin with Paleo-Pacific oceanic crust.With respect to its oceanic crust,due to the subduction and retreat of the Paleo-Pacific plate in Southeast Asia at the end of the Late Cretaceous,the SCS probably produced new oceanic crust,which allowed the PSCS to formally emerge.At this time,the PSCS was most likely a combination of a new marginal sea and a remnant sea;its oceanic crust,which eventually subducted and became extinct,consisted of both new oceanic crust and remnant oceanic crust from the Paleo-Pacific Ocean.In the present day,the remnant PSCS oceanic crust is located in the southwestern Nansha Trough. | TIAN Zhiwen TANG Wu WANG Pujun ZHAO Zhigang SUN Xiaomeng TANG Huafeng | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 1 |
| 15 | Structure and proper- ties of soy protein films plasticized with hydroxylamine 显示文摘 | Tian Huafeng Liu Dagang Zhang Lina | 2009 | Journal of Applied Polymer Science2009，111，3： | 1 |
| 16 | Structure and Properties of Soy Protein Films Plasticized With Hy- droxyamine 显示文摘 | Huafeng Tian Dagang Liu Lina Zhang | 2009 | Journal of Applied Polymer Science2009，111，3： | 1 |
| 17 | Role of starch nanocrystals and cellulose whiskers in synergistic reinforcement of waterborne polyurethane显示文摘 | Wang Yixiang Tian Huafeng Zhang Lina | 2010 | Carbohydrate Polymers2010，80，3： | 1 |
| 18 | Characteristics of the Density and Magnetic Susceptibility of Rocks in Northern Borneo and their Constraints on the Lithologic Identification of the Mesozoic Rocks in the Southern South China Sea显示文摘Based on the volume magnetic susceptibility and specific gravity measurements and mineral and lithologic identification results for 540 samples,the rock type,density,and magnetic susceptibility of rocks from northern Borneo were analyzed,and the applicability of gravity and magnetic data to the lithologic identification of the Mesozoic strata in the southern South China Sea was assessed accordingly.The results show that there are 3 types and 25 subtypes of rocks in northern Borneo,mainly intermediate-mafic igneous rocks and exogenous clastic sedimentary rocks,with small amounts of endogenous sedimentary rocks,felsic igneous rocks,and metamorphic rocks.The rocks that are very strongly-strongly magnetic and have high-medium densities are mostly igneous rocks,tuffaceous sandstones,and their metamorphic equivalents.The rocks that are weakly magnetic-non-magnetic and have medium-very low densities are mostly conglomerates,sandstones,siltstones,mudstones,and coal.The rocks that are weakly magnetic-diamagnetic and have highmedium densities are mostly limestones and siliceous rocks.The Cenozoic rocks are characterized by low densities and medium susceptibilities;the Mesozoic rocks are characterized by medium densities and medium-high susceptibilities;and the pre-Mesozoic rocks are characterized by high densities and low magnetism.Based on these results and the distribution characteristics of the various rock types,it was found that the pre-Mesozoic rocks produce weak regional gravity anomalies;the Mesozoic sedimentary rocks produce negative regional gravity anomalies;whereas the Mesozoic igneous rocks produce positive regional gravity anomalies;and the Cenozoic igneous rocks produce positive regional gravity anomalies.The regional high magnetic anomalies in the southern part of the South China Sea originate from the Mesozoic mafic igneous rocks and their metamorphic equivalents;and the regional medium magnetic anomalies may be produced by the felsic igneous rocks and their metamorphic equivalents.Accordingly,the identification of the Mesozoic lithology in the southern South China Sea shows that the Mesozoic sedimentary rocks are distributed over a large area of the southern South China Sea.Thus,it is concluded that the Mesozoic strata in this area have the potential for oil and gas exploration. | TANG Huafeng ZHAO Zhigang TIAN Zhiwen LU Baoliang TANG Wu HE Kailun ZHU Chenxi WANG Pujun | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 1 |
| 19 | Influence of Polyol Plasticizers on the Properties of Polyvinyl Alcohol Films Fabricated by Melt Processing显示文摘 | Wu Wenqian Tian Huafeng Xiang Aimin | 2012 | Journal of Polymers and theEnvironment2012，20，1： | 1 |
| 20 | Role ofstarch nanocrystals and cellulose whiskers in synergisticreinforcement of waterborne polyurethane显示文摘 | Wang Yixiang Tian Huafeng Zhang Lina | 2010 | CarbohydratePolymers2010，80，3： | 1 |
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