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| 1 | Visual characterization of targeted effect of holo-transferrin-tagged dihydroartemisinin on human breast cancer cells显示文摘Targeted drugs could significantly reduce cytotoxic effect and increase therapeutic activity. Dihydroartemisinin (DHA) has been shown to be effective in killing cancer cells. However, it exhibits non-targeted property. Holo-transferrin (TF) is a suitable drug-carrier to target cancer cells, because cancer cells need iron uptake by the TF-mediated mechanism to maintain their uncontrolled growth. Furthermore, TF receptors (TF-R) are highly expressed on cancer cell surfaces. In this paper, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to evaluate the different killing effect of 4-(12-Dihydroartemisininoxy) Benzoic Acid Hydrozide-transferrin (DBAH-TF) on human breast cancer cells (MCF-7) cells and human normal breast (HNB) cells, and atomic force microscopy (AFM) was used to visually observe the targeted effect of DBAH-TF on MCF-7 cells. MTT results show that DBAH-TF is 172 times more potent than DHA in killing MCF-7 cells, while the cytotoxic effect of DBAH-TF on HNB cells is merely 1/33 to DHA. Also, the killing effect of DBAH-TF on MCF-7 cells is 286 times that on HNB cells, showing targeted effect. Moreover, there are distinct differences in ultrastructures of cellular surfaces after DBAH-TF and DHA treatment. Through AFM imaging, many characteristic holes were observed on the cancer cell surface after being effected by DBAH-TF, which differ from the holes with irregular shapes affected by DHA. These results visually show that the DBAH-TF targeted drug has more potent killing effect on MCF-7 cells compared with DHA. | XIE WeiLing YANG PeiHui ZENG Xin WANG Hui CAI HuaiHong CAI JiYe | 2010 | Chinese Science Bulletin2010，55，22： | 4 |
| 2 | Expression of miR-126 and miR-508-5p in endothelial progenitor cells is associated with the prognosis of chronic heart failure patients显示文摘 | Liu Qiang Li Hong Wang Ningfu Chen Huaihong Wang Jing | 2013 | International Journal of Cardiology2013，，： | 2 |
| 3 | Pathway of cytotoxicity induced by folic acid modified selenium nanoparticles in MCF-7 cells显示文摘 | Jiang Pi Hua Jin RuiYing Liu Bing Song Qing Wu Li Liu JinHuan Jiang Fen Yang HuaiHong Cai Jiye Cai | 2013 | Applied Microbiology and Biotechnology2013，，3： | 1 |
| 4 | Cinobufacini-induced HeLa cell apoptosis enhanced by curcumin显示文摘When used in combination with certain chemotherapies, curcumin has been shown to increase apoptosis in several cancer cell lines. Here, we report the combined effects of curcumin and cinobufacini on human cervical carcinoma cells. The aim of this study was to examine whether curcumin could enhance apoptosis induced by cinobufacini. 3-(4,5-Dimethylthiazol-2-y1)-2,5- diphenytetrazolium bromide (MTT) assays revealed that the growth and proliferation of HeLa cells could be inhibited by 75% after a combined treatment of 25 μg/mL cinobufacini and 8 μg/mL curcumin. The combined treatment is 3 times more effective than treatment with 25 μg/mL cinobufacini alone. Annexin V-FITC/PI staining, morphological changes and immunofluorescence verified a significant enhancement in cinobufacini-induced apoptosis when cells were also exposed to curcumin. The data showed that the proportion of early apoptotic cells significantly increased from 15.43% in cells treated only with 25 μg/mL cinobufacini to 49.2% in cells treated with 25 μg/mL cinobufacini and 8 μg/mL curcumin. Moreover, compared with treatment of only 25 μg/mL cinobufacini, ROS production increased 1.7-fold, the intracellular free Ca 2+ concentration increased 1.5-fold, and the mitochon- drial membrane potential decreased by 20% in the combined treatment. Simultaneously, the atomic force microscopy (AFM) re- sults suggest that cells treated with a combination of cinobufacini and curcumin varied significantly in shape and ultrastructure. Collapsed cells with leaking cytoplasm, blebbing pores and emerging apoptotic bodies were prevalent. The nanoparticle size increased from 70 nm when the cells were treated with 25 μg/mL cinobufacini to 190 nm when the cells were treated with 25 μg/mL cinobufacini and 8 μg/mL curcumin. The size increase resulted in the cell membrane becoming considerably rough. These results can improve our understanding of combination treatments. Specifically, the combination of cinobufacini and curcumin may potentially find use as a novel cervical carcinoma treatment. Additionally, AFM is a powerful tool that can be used to explore cellular morphologies and ultrastructures. | LIU Li JIN Hua OU JinLai JIANG JinHuan PI Jiang KE ChangHong YANG Fen QIAO DongJuan CAI HuaiHong CAI JiYe | 2013 | Chinese Science Bulletin2013，58，21： | 1 |
| 5 | Highly sensitive detection of chromium (III) ions by resonance Rayleigh scattering enhanced by gold nanoparticles显示文摘 | CHEN Min CAI Huaihong YANG Fen | 2014 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2014，118，： | 1 |
| 6 | Author correction to‘Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy'[Acta Pharm Sin B 13(2023)1303-1317]显示文摘The authors regret that there is an error in the article Fig.4G due to the mistake of copying and pasting in the process of assembling figures and negligence in the proofreading.Although it does not affect the conclusion,it is an obvious error.The authors have now modified as below.The authors apologize for any inconvenience caused to the journal and readers. | Xueqin Huang Bingbing Sheng Hemi Tian Qiuxia Chen Yingqi Yang Brian Bui Jiang Pi Huaihong Cai Shanze Chen Jianglin Zhang Wei Chen Haibo Zhou Pinghua Sun | 2023 | Acta Pharmaceutica Sinica B2023，13，10： | 0 |
| 7 | Man-object, Interpersonal and Man-machine Relationships——An Ethical Perspective on Artificial Intelligence显示文摘Traditional social ethics has always been centered on human relationships. In recent years, modern ethics began to systematically reflect the relationships between humans and objects, and the future ethics will need to account for the relationships between humans and intelligent machines. This is mainly because humans may be overtaken by machines in intelligence through which humans gain dominance over all other natural objects. On the ethical thinking of the man-machine relationship, an idea is to be inclined to do subtraction rather than addition. Specifically, we should give priority to and focus on limiting the means and abilities of intelligent machines rather than how to cultivate and set the value judgments of their friendliness. In other words, we should concentrate on how to limit the development of intelligent machines to specialization and miniaturization, especially keeping them within the scope of non-violence. | He Huaihong Zhuang Qiuyue | 2019 | Contemporary Social Sciences2019，4，3： | 0 |
| 8 | Study on Correlation Between Light Particles and Fragments in 25MeV/u ^(40)Ar+^(115)In Reaction显示文摘Study on Correlation Between Light Particles and Fragments in 25MeV/u^(40)Ar+^(115)In Reaction￥ZhouJianqun;ZhanWenlong;GuoZhon... | Zhou Jianqun Zhan Wenlong Guo Zhongyan Xi Hongfei Wang Jinchuan Luo Yongfeng Zhao Youxilong Let Huaihong and Fend Enpu | 1994 | IMP & HIRFL Annual Report1994，，0： | 0 |
| 9 | High Resolution Position Sensitive Silicon Detector显示文摘High Resolution Position Sensitive Silicon Detector￥WangJinchuan;ZhanWenlong;GuoZhongyan;XiHongfei;ZhouJianqun;ZhaoYouxiong;L... | Wang Jinchuan Zhan Wenlong Guo Zhongyan Xi Hongfei Zhou Jianqun Zhao Youxiong Luo Yongfeng and Lei Huaihong | 1994 | IMP & HIRFL Annual Report1994，，0： | 0 |
| 10 | Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy显示文摘In situ and real-time monitoring of responsive drug release is critical for the assessment of pharmacodynamics in chemotherapy.In this study,a novel pH-responsive nanosystem is proposed for real-time monitoring of drug release and chemo-phototherapy by surface-enhanced Raman spectroscopy(SERS).The Fe3O4@Au@Ag nanoparticles(NPs)deposited graphene oxide(GO)nanocomposites with a high SERS activity and stability are synthesized and labeled with a Raman reporter 4-mercaptophenylboronic acid(4-MPBA)to form SERS probes(GO-Fe3O4@Au@Ag-MPBA).Furthermore,doxorubicin(DOX)is attached to SERS probes through a pH-responsive linker boronic ester(GO-Fe3O4@Au@Ag-MPBA-DOX),accompanying the 4-MPBA signal change in SERS.After the entry into tumor,the breakage of boronic ester in the acidic environment gives rise to the release of DOX and the recovery of 4-MPBA SERS signal.Thus,the DOX dynamic release can be monitored by the real-time changes of 4-MPBA SERS spectra.Additionally,the strong T2 magnetic resonance(MR)signal and NIR photothermal transduction efficiency of the nanocomposites make it available for MR imaging and photothermal therapy(PTT).Altogether,this GO-Fe3O4@Au@Ag-MPBA-DOX can simultaneously fulfill the synergistic combination of cancer cell targeting,pH-sensitive drug release,SERS-traceable detection and MR imaging,endowing it great potential for SERS/MR imaging-guided efficient chemo-phototherapy on cancer treatment. | Xueqin Huang Bingbing Sheng Hemi Tian Qiuxia Chen Yingqi Yang Brian Bui Jiang Pi Huaihong Cai Shanze Chen Jianglin Zhang Wei Chen Haibo Zhou Pinghua Sun | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 0 |
| 11 | Signal-on bimodal sensing glucose based on enzyme product-etching MnO_(2)nanosheets for detachment of MoS_(2)quantum dots显示文摘The sensitive and rapid detection of blood glucose is very important for monitoring and managing diabetes.Herein,a fluorescent/magnetic bimodal sensing strategy is proposed for glucose detection using a multifunction-responsive nanocomposite(MoS_(2)QDs-MnO_(2)NS).MoS_(2)QDs act as fluorescent probes,and MnO_(2)nanosheets are used as both quenchers and recognizers in this sensing platform.In the presence of glucose-mediated enzyme product(H_(2)O_(2)),MnO_(2)nanosheet is etched,thus releasing MoS_(2)QDs and Mn^(2+)ions,which causes the significantly enhancement of fluorescent and magnetic signals.Furthermore,MoS_(2)QDs-MnO_(2)NS-based fluorescent test paper is constructed for H_(2)O_(2)sensing with the naked eyes.Under optimal conditions,the dual linear ranges of 20-300μmol/L and 40-250μmol/L toward glucose detection are obtained for the fluorescent and magnetic mode,respectively.Furthermore,this bimodal assay exhibits good reproducibility and acceptable accuracy in glucose detection of clinical samples,demonstrating great versatility and flexibility of multifunctional probes in glucose detection. | Lingzhi Chen Xueqin Huang Xueyi Zeng Guiting Fang Weijian Chen Haibo Zhou Xing Zhong Huaihong Cai | 2021 | Chinese Chemical Letters2021，32，6： | 0 |
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