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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | BMP-6 inhibits microRNA-21 expression in breast cancer through repressing 6EF1 and AP-1显示文摘 | Jun Du Shuang Yang Di An Fen Hu Wei Yuan Chunli Zhai Tianhui Zhu | 2009 | Cell Research2009，19，4： | 44 |
| 3 | Tree ring based streamflow reconstruction for the Upper Yellow River over the past 1234 years显示文摘We established a Juniperus przewalski tree ring width chronology, based on tree ring cores collected from the A’nyêmaqên Mountains. Statistical analysis showed that the chronology was highly correlated with instrumental streamflow records from previous August to current July from the Tangnaihai Station in the upper reaches of the Yellow River, with a correlation coefficient of 0.656. Streamflow for the upper reaches of the Yellow River was reconstructed for the past 1234 years. Low flow periods for the 11-year averaged streamflow reconstruction were definite as lower than mean plus 1 standard deviation, and high flow periods were higher than mean minus 1 standard deviation. Over the past 1234 years, high flows occurred 18 times, and low flows occurred 12 times. The main low flow periods were identified as AD 1140–1156, AD 1295–1309, AD 1473–1500, and AD 1820–1847, and the main high flow periods were identified as AD 846–873, and AD 1375–1400. Extremely low streamflow over the reconstruction period was seen during the late 15th century, coinciding with a widespread drought phenomenon, which took place in the northeastern Tibetan Plateau over the same period. Reconstructed streamflow shows significant low-frequency variability, which is in line with drought variability of neighboring regions, as inferred from tree rings and other proxies. Multi-taper spectral analysis suggests the existence of significant periods of 2–5, 22, 35–38, 55–62, and 114–227 years, particularly significant for cyclic variations of years 159 and 36. | GOU XiaoHua DENG Yang CHEN FaHu YANG MeiXue FANG KeYan GAO LinLin YANG Tao ZHANG Fen | 2010 | Chinese Science Bulletin2010，55，36： | 37 |
| 4 | Effect of nuclear factor kappa B on intercellular adhesion molecule-1 expression and neutrophil infiltration in lung injury induced by intestinal ischemia/reperfusion in rats显示文摘瞄准:为了在肺损害的致病调查原子因素 kappa B (NF-kappaB ) 的角色,导致了旁边肠的 ischemia/reperfusion (I/R ) ,和它细胞间的粘附 molecule-1 (ICAM-1 ) 上的效果表示和嗜中性的渗入。方法:24 只 Wistar 老鼠随机被划分成控制, I/R 和吡咯烷 dithiocarbamate (PDTC ) 处理组,在各个的 n=8。I/R 组和 PDTC 治疗组织为 2 h 为 1 h 和灌注堵塞的收到的优异 mys 伤寒动脉(SMA ) 。PDTC 组在外科前与 2% 100 mg/kg PDTC 1 h 的腹膜内注射被管理。肺组织学和支气管 alveolus 肺液体(BALF ) 蛋白质是 assayed。浆液 IL-6,肺 malondialdehyde (MDA ) 和象 NF-kappaB 和 ICAM-1 的表示水平一样的 myeloperoxidase (军邮局) 被测量。结果:肺损害由肠的 I/R 导致了,被浮肿,出血和嗜中性的渗入以及由 BALF 的重要升起描绘蛋白质。比作控制组,在 I/R 显著地增加的浆液 IL-6 和肺 MDA 和军邮局的层次组织(P=0.001 ) 。NF-kappaB p65 和 ICAM-1 的强壮的积极表示被观察。在 PDTC 的管理以后,象 NF-kappaB 和 ICAM-1 一样的浆液 IL-6,肺 MDA 和军邮局的水平显著地减少了(P<0.05 ) 什么时候与 I/R 相比组。结论:NF-kappaB 的激活在肠的 I/R 直在调整嗜中性的渗入和肺 ICAM-1 表示上面导致的肺损害的致病起一个重要作用。NF-kappaB 的一个禁止者能阻止肺损害的 PDTC 通过禁止 NF-kappaB 的活动由肠的 I/R 导致了。 | Xiao-Feng Tian Ji-Hong Yao Ying-Hua Li Xue-Song Zhang Bing-An Fen Chun-Ming Yang Shu-Sen Zheng | 2006 | World Journal of Gastroenterology2006，12，3： | 28 |
| 5 | Clinical significance of serum intercellular adhesion molecule-1 detection in patients with hepatocellular carcinoma显示文摘INTRODUCTION Since the late 1980s,studies on the expression ofintercellular adhesion molecule-1(ICAM-1)inpatients with malignancies have demonstrated thatICAM-1 may strongly express in two forms in suchdiseases:membranous one on the surface of tumorcells(membrane-bound ICAM-1)and soluble one incirculation(soluble ICAM-1,sICAM-1). | Ming Hui Mei Jing Xu Qin Fen Shi Jing Hong Yang Qian CHen Li Ling Qin Department of Hepatobiliary Surgery, Institute of Hepatobiliary Surgery,Guilin Medical College,Guilin 541001,Guangxi Province,China | 2000 | World Journal of Gastroenterology2000，6，3： | 20 |
| 6 | Carbon Fluxes and Sinks:the Consumption of Atmospheric and Soil CO_2 by Carbonate Rock Dissolution显示文摘大陆人区域的碳酸盐岩石露头盖子 9%16% 并且溶解的无机的碳(DIC ) 的主要来源在河边被转移到海洋,后果他们的溶解。当前的评价建议流动在 0.10.6 PgC/a 之间掉落。拿中间的值(0.3 PgC/a ) ,它等于陆上的植被网络碳的 18% 当前的估计下沉, 38% 土壤碳下沉。在中国,从碳酸盐岩石溶解的碳流动被估计是 0.016 PgC/a,它占 21% , 87.5%150% 和 2.3 次森林,灌木和草地分别地捕捞碳水池,以及土壤碳水池流动的 23%40% 。碳酸盐溶解对环境、气候的变化敏感,率密切与降水正在被相关,温度,另外与土壤和植被盖子。水里的 HCO3 被水生植物光合作用影响,被变换成文档和停靠港的 HCO3 部分地结果,它可以由碳酸盐岩石溶解提高碳隐遁的潜力。这碳的可能的周转时间粗略地等于海水周期(2000a ) 的。由碳酸盐岩石溶解的 atmospheric/soil CO2 的举起因此在全球碳周期起一个重要作用,是最重要的水池之一。主要研究需要是更好从碳酸盐矿物质降水与海洋的来源相比评估这个水池的网效果。 | CAO Jianhua YUAN Daoxian Chris GROVES HUANG Fen YANG Hui LU Qian | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 20 |
| 7 | Utilization of polysaccharides as depressants for the flotation separation of copper/lead concentrate显示文摘The interaction mechanism between dextrin and minerals has been investigated through micro-flotation, adsorption density measurements, Fourier transform infrared ray (FTIR) spectroscopic studies and dissolution tests. Dextrin shows a good depressing action towards galena but not chalcopyrite. FTIR spectroscopic studies indicate that dextrin chemically adsorbed on galena surface in alkaline pH range. Dissolution tests confirm leaching action of metal ions from chalcopyrite and galena surfaces, and dextrin-lead ion interaction. Adsorption measurements present that the higher adsorption density of O-isopropyl-N-ethyl thionocarbamate (IPETC) onto chalcopyrite than that onto galena, and IPETC adsorbed on galena decrease with increasing dextrin concentrations in the presence of dextrin, attesting the flotation results. | Qin Wenqing Wei Qian Jiao Fen Yang Congren Liu Ruizeng Wang Peipei Ke Lifang | 2013 | International Journal of Mining Science and Technology2013，23，2： | 16 |
| 8 | Propofol protects against blood-spinal cord barrier disruption induced by ischemia/reperfusion injury显示文摘Propofol has been shown to exert neuroprotective effects on the injured spinal cord.However,the effect of propofol on the blood-spinal cord barrier(BSCB) after ischemia/reperfusion injury(IRI) is poorly understood.Therefore,we investigated whether propofol could maintain the integrity of the BSCB.Spinal cord IRI(SCIRI) was induced in rabbits by infrarenal aortic occlusion for 30 minutes.Propofol,30 mg/kg,was intravenously infused 10 minutes before aortic clamping as well as at the onset of reperfusion.Then,48 hours later,we performed histological and m RNA/protein analyses of the spinal cord.Propofol decreased histological damage to the spinal cord,attenuated the reduction in BSCB permeability,downregulated the m RNA and protein expression levels of matrix metalloprotease-9(MMP-9) and nuclear factor-κB(NF-κB),and upregulated the protein expression levels of occludin and claudin-5.Our findings suggest that propofol helps maintain BSCB integrity after SCIRI by reducing MMP-9 expression,by inhibiting the NF-κB signaling pathway,and by maintaining expression of tight junction proteins. | Li-jie Xie Jin-xiu Huang Jian Yang Fen Yuan Shuang-shuang Zhang Qi-jing Yu Ji Hu | 2017 | Neural Regeneration Research2017，12，1： | 14 |
| 9 | A Novel Hierarchical Porous 3D Structured Vanadium Nitride/Carbon Membranes for High-performance Supercapacitor Negative Electrodes显示文摘Transition-metal nitrides exhibit wide potential windows and good electrochemical performance, but usually experience imbalanced practical applications in the energy storage field due to aggregation, poor circulation stability, and complicated syntheses. In this study, a novel and simple multiphase polymeric strategy was developed to fabricate hybrid vanadium nitride/carbon(VN/C) membranes for supercapacitor negative electrodes, in which VN nanoparticles were uniformly distributed in the hierarchical porous carbon 3D networks. The supercapacitor negative electrode based on VN/C membranes exhibited a high specific capacitance of 392.0 F g^(-1) at 0.5 A g^(-1) and an excellent rate capability with capacitance retention of 50.5% at 30 A g^(-1). For the asymmetric device fabricated using Ni(OH)_2//VN/C membranes, a high energy density of 43.0 Wh kg^(-1) at a power density of800 W kg^(-1) was observed. Moreover, the device also showed good cycling stability of 82.9% at a current density of 1.0 A g^(-1) after 8000 cycles. This work may throw a light on simply the fabrication of other high-performance transition-metal nitridebased supercapacitor or other energy storage devices. | Yage Wu Yunlong Yang Xiaoning Zhao Yongtao Tan Ying Liu Zhen Wang Fen Ran | 2018 | Nano-Micro Letters2018，10，4： | 13 |
| 10 | miR-223 and miR-142 attenuate hematopoietic cell proliferation, and miR-223 positively regulates miR-142 through LMO2 isoforms and CEBP-β显示文摘miR-142 和 miR-223 作为造血的特定的 microRNAs 被识别了。miR-223 在 myeloid 系开发有关键功能。然而, miR-142 的功能仍然保持不清楚。在这研究,我们发现那 miR-142, miR-223 稀释了造血的房间,和那 miR-223 的增长通过 LMO2-L/-S isoforms 和 CEBP- 尾的起来调整的 miR-142 表示。miR-223 否定地 post-transcriptionally 调整了 LMO2-L/-S isoforms 和 CEBP- 尾,当 CEBP- 尾断然调整了 LMO2-L/-S isoforms 并且否定地两个都 LMO2-L/-S isoforms 调整了 miR-142 时。这些结果揭示一条新奇 miR-223 鈥擟E BP-尾鈥擫M O2 鈥攎i R-142 规章的小径,它在造血作用有枢轴的功能。 | Wei Sun Wenwen Shen Shuang Yang Fen Hu Huihui Li Tian-Hui Zhu | 2010 | Cell Research2010，20，10： | 12 |
| 11 | New insights into the effect of Tris-HCl and Tris on corrosion of magnesium alloy in presence of bicarbonate,sulfate,hydrogen phosphate and dihydrogen phosphate ions显示文摘In vitro degradation is an important approach to screening appropriate biomedical magnesium(Mg) alloys at low cost. However, corrosion products deposited on Mg alloys exert a critical impact on corrosion resistance. There are no acceptable criteria on the evaluation on degradation rate of Mg alloys. Understanding the degradation behavior of Mg alloys in presence of Tris buffer is necessary. An investigation was made to compare the influence of Tris-HCl and Tris on the corrosion behavior of Mg alloy AZ31 in the presence of various anions of simulated body fluids via hydrogen evolution, p H value and electrochemical tests.The results demonstrated that the Tris-HCl buffer resulted in general corrosion due to the inhibition of the formation of corrosion products and thus increased the corrosion rate of the AZ31 alloy. Whereas Tris gave rise to pitting corrosion or general corrosion due to the fact that the hydrolysis of the amino-group of Tris led to an increase in solution p H value, and promoted the formation of corrosion products and thus a significant reduction in corrosion rate. In addition, the corrosion mechanisms in the presence of Tris-HCl and Tris were proposed. Tris-HCl as a buffer prevented the formation of precipitates of HCO_3^-, SO_4^(2-),HPO_4^(2-) and H_2PO_4^- ions during the corrosion of the AZ31 alloy due to its lower buffering p H value(x.x).Thus, both the hydrogen evolution rate and corrosion current density of the alloy were approximately one order of magnitude higher in presence of Tris-HCl than Tris and Tris-free saline solutions. | Lan-Yue Cui Yan Hu Rong-Chang Zeng Yong-Xin Yang Dan-Dan Sun Shuo-Qi Li Fen Zhang En-Hou Han | 2017 | Journal of Materials Science & Technology2017，33，9： | 12 |
| 12 | A static pressure sensitive receptor APJ promote H9c2 cardiomyocyte hypertrophy via PI3K-autophagy pathway显示文摘这研究被设计调查 APJ 受体是否在静态的导致压力的 cardiomyocyte hypertrophyand 充当一个传感器调查 PI3K-autophagy 小径的机制。左室的肥大老鼠模型是腹的主动脉的确定的 bycoarctation。H9c2 老鼠 cardiomyocytes 面对被给 bya 的静态的压力是有教养的定做的压力孵卵器。结果表明 apelin/APJ 系统, PI3K, Akt 和他们的 phosphorylationwere 的表达式显著地在操作组增加了。静态的压力起来调整在 cardiomyocytes 的 APJ 表示, PI3K phosphorylation, Akt phosphorylation, LC3-II/I 和 beclin-1 表示。APJ shRNA pGPU6/Neo-rat-399, PI3K 禁止者 LY294002, Akt 禁止者 1701-1 分别地堵住了 APJ, PI3K phosphorylation, Akt phosphorylation, LC3-II/I 和 beclin-1 表示的起来规定。而且,静态的压力增加了直径,体积,房间的蛋白质内容,和这些能是 reversedwhen 房间分别地与 pGPU6/Neo-rat-399, LY294002,和 autophagy 禁止者 3-methyladenine 被对待。Theseresults 建议了那静态的压力起来调整 APJ 表情由 PI3K-autophagypathway 支持 cardiomyocyte 肥大。 | Feng Xiei Wei Liu Fen Feng Xin Li Li Yang Deguan Lv Xuping Qin Lanfang Li Linxi Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，8： | 10 |
| 13 | 生物合理设计光系统Ⅱ抑制剂研究(Ⅱ)3-苯甲氨基-2-氰基-3-甲硫基丙烯酸乙酯的晶体及分子结构显示文摘合成了具有良好光合作用抑制活性的标题化合物,测定了其晶体结构.确定了该类化合物的顺反构型,阐明了苯环与氨基间亚甲基对化合物抑制活性的重要作用,解释了氨基氢与酯羰基氧间没有形成氢键的原因. | LIU Hua Yin *, YANG Guang Fu, LU Rong Jian, TAN Hui Fen, YANG Hua Zheng (The Institute of Elemento Organic Chemistry, National Elemento Organic Chemistry Key Laboratory, Nankai University, Tianjin, 300071) LAI Lu Hua (The Institute of Physical Chemist | 1998 | 高等学校化学学报1998，19，6： | 10 |
| 14 | Application and interpretation of current autophagy inhibitors and activators显示文摘Autophagy 是主要细胞内部的降级系统,细胞质的材料被送到并且在 lysosome 降级了。作为为细胞质的蛋白质和细胞器的质量控制机制, autophagy 在许多人的疾病起重要作用,包括 neurodegenerative 疾病,癌症,心血管的疾病,糖尿病和传染、煽动性的疾病。ATG 基因的发现和涉及调整 autophagy 的发信号的小径的解剖极大地在这条 lysosomal 降级小径的出现和发展上充实我们的知识。除了它在降级的角色, autophagy 可以也支持与 apoptosis 不同的规划房间死亡的一种类型,称为的类型 II 规划了房间死亡。由于在房间死亡和疾病的特性的 autophagy 的双角色,在各种各样的疾病的 autophagy 的准确机制要求更多的调查。autophagy 禁止者和使活跃之物的申请将帮助我们在人的疾病理解 autophagy 的规定,并且提供卓见进指向 autophagy 的药的使用。在这评论,我们在 autophagy 禁止者和使活跃之物上总结最近的研究并且在人的疾病治疗讨论他们的申请的可能性。 | Ya-ping YANG Li-fang HU Hui-fen ZHENG Cheng-jie MAO Wei-dong HU Kang-ping XIONG Fen WANG Chun-feng LIU | 2013 | Acta Pharmacologica Sinica2013，34，5： | 10 |
| 15 | Assessing the Effectiveness of a Cervical Cancer Screening Program in a Hospital-based Study显示文摘This study compared HPV testing and liquid-based cytology(LCT)as performance indicators for cervical cancer screening in a hospital-based study.A total of 61,193 outpatients were screened initially by LCT.Samples with screening results showing atypical squamous cells of undetermined significance(ASC-US)or worse were referred for colposcopy,and some | YANG Yi LANG Jing He WANG You Fang CHENG Xue Mei CAI Yu Pin LI Hui ZHU Bao Li ZHANG Rui Fen | 2015 | Biomedical and Environmental Sciences2015，28，1： | 10 |
| 16 | Oil Tea Soup Formula Optimization Based on Orthogonal Test and Fuzzy Mathematics Sensory Evaluation显示文摘 | Liao Fen Wen Ren-De Yang Liu Yang Ren-Gui He Quan-Guang Zhang Er-Zhen | 2017 | Journal of Food Science and Engineering2017，7，9： | 10 |
| 17 | Global significance of the carbon cycle in the karst dynamic system:evidence from geological and ecological processes显示文摘On the basis of proposing the existence of a karst carbon cycle and carbon sink at a watershed scale,this paper provides four pieces of evidence for;the integration of geology and ecology during the carbon cycle processes m the karst dynamic system,and estxmated the karst carbon sink effect using the methods of comparative monitoring of paired watersheds and the carbon stable isotope tracer technique.The results of the soil carbon cycle in Maocun,Guilin,showed that the soil carbon cycle in the karst area,the weathering and dissolution of carbonate rocks under the soil,resulted in a lower soil respiration of 25% in the karstoarea than in a non-karst area (sandstone and shale),and the carbon isotope results indicated that 13.46% of the heavy carbon of the hmestone is involved in the soil carbon cycle.The comparative monitoring results m paxred watersheds,suggesting that the HCO3 concentration m a karst spring is 10 times that of a rivulet in a non-karst area,while the concentration of inorganic carbon flux is 23.8 times.With both chemical stoichiometry and carbon stable isotopes,the proportion of carbon in karst springs derived from carbonate rocks was found to be 58.52% and 37.65% respectively.The comparison on carbon exchange and isotopes at the water-gas interface between the granite and carbonate rock basins in the Li River showed that the CO2 emission of the karst water is 10.92 times that of the allogenic water from the non-karst area,while the carbon isotope of HCO3^- in karst water is lighter by 8.62%.However,this does not mean that the karst water body has a larger carbon source effect.On the contrary,it means the karst water body has a greater karst carbon sink effect.When the karst subterranean stream in Zhaidi,Guilin,is exposed at the surface,carbon-rich karst water stimulated the growth of aquatic plants.The values of carbon stable isotopes in the same species of submerged plants gradually becomes heavier and heavier,and the 512 m flow process has a maximum range of 15.46%.The calculation results showed that 12.52% of inorganic carbon is converted into organic carbon.According to the data that has been published,the global karst carbon sink flux was estimated to be 0.53-0.58 PgC/a,equivalent to 31.18%-34.41% of the global forest carbon sink flux.In the meanwhile,the karst carbon sink flux in China was calculated to be 0.051 PgC/a,accounting for 68% of its forest carbon sink flux. | Jian-hua Cao Xia Wu Fen Huang Bill Hu Chris Groves Hui Yang Chun-lai Zhang | 2018 | China Geology2018，1，1： | 9 |
| 18 | Alleviation by abscisic acid of Al toxicity in rice bean is not associated with citrate efflux but depends on ABI5-mediated signal transduction pathways显示文摘Under conditions of aluminum(Al) toxicity,which severely inhibits root growth in acidic soils, plants rapidly alter their gene expression to optimize physiological fitness for survival. Abscisic acid(ABA) has been suggested as a mediator between Al stress and gene expression, but the underlying mechanisms remain largely unknown. Here,we investigated ABA-mediated Al-stress responses, using integrated physiological and molecular biology approaches.We demonstrate that Al stress caused ABA accumulation in the root apex of rice bean(Vigna umbellata [Thunb.] Ohwi &Ohashi), which positively regulated Al tolerance. However,this was not associated with known Al-tolerance mechanisms. Transcriptomic analysis revealed that nearly one-third of the responsive genes were shared between the Al-stress and ABA treatments. We further identified a transcription factor, ABI5, as being positively involved in Al tolerance. Arabidopsis abi5 mutants displayed increased sensitivity to Al, which was not related to the regulation of AtALMT1 and AtMATE expression. Functional categorization of ABI5-mediated genes revealed the importance of cell wall modification and osmoregulation in Al tolerance, a finding supported by osmotic stress treatment on Al tolerance. Our results suggest that ABA signal transduction pathways provide an additional layer of regulatory control over Al tolerance in plants. | Wei Fan Jia Meng Xu Pei Wu Zhi Xin Yang He Qiang Lou Wei Wei Chen Jian Fen Jin Shao Jian Zheng Jian Li Yang | 2019 | Journal of Integrative Plant Biology2019，61，2： | 9 |
| 19 | Relevant Factors of Estrogen Changes of Myopia in Adolescent Females显示文摘 | Juan-Fen Gong Hong-Li Xie Xin-Jie Mao Xue-Bo Zhu Zuo-Kai Xie Hai-Hong Yang Yang Gao Xiao-Feng Jin Yu Pan Fen Zhou | 2015 | Chinese Medical Journal2015，，5： | 9 |
| 20 | Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis显示文摘Cystathionine-γ-lyase(CSE),an enzyme associated with hydrogen sulfide(H2S)production,is an important endogenous regulator of inflammation.Jumonji domain-containing protein 3(JMJD3)is implicated in the immune response and inflammation.Here,we investigated the potential contribution of JMJD3 to endogenous CSE-mediated inflammation in rheumatoid arthritis(RA).Upregulated CSE and JMJD3 were identified in synovial fibroblasts(SFs)from RA patients as well as in the joints of arthritic mice.Knocking down CSE augmented inflammation in IL-1β-induced SFs by increasing JMJD3 expression.In addition,CSE−/−mice with collagen-induced arthritis(CIA)developed severe joint inflammation and bone erosion.Conversely,overexpressing CSE inhibited JMJD3 expression by the transcription factor Sp-1 and was accompanied by reduced inflammation in IL-1β-treated SFs.Furthermore,JMJD3 silencing or the administration of the JMJD3 inhibitor GSK-J4 significantly decreased the inflammatory response in IL-1β-treated SFs,mainly by controlling the methylation status of H3K27me3 at the promoter of its target genes.GSK-J4 markedly attenuated the severity of arthritis in CIA mice.In conclusion,suppressing JMJD3 expression by the transcription factor Sp-1 is likely responsible for the ability of CSE to negatively modulate the inflammatory response and reduce the progression of RA. | Weijun Wu Ming Qin Wanwan Jia Zheng Huang Zhongzheng Li Di Yang Mengwei Huang Chenxi Xiao Fen Long Jianchun Mao Philip K.Moore Xinhua Liu Yi Zhun Zhu | 2019 | Cellular & Molecular Immunology2019，16，8： | 9 |
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