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您的检索式：作者名="Huanfang Guo"
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| 1 | Prodrug design,synthesis and pharmacokinetic evaluation of(3'R,4'R)-3-hydroxymethyl-4-methyl-3',4'-di-O-(S)-camphanoyl-(t)-cis-khellactone显示文摘3-Hydroxymethyl-4-methyl-DCK(3,HMDCK)was discovered previously as a potent HIV non-nucleoside reverse transcriptase inhibitor(NNRTIs)(EC_(50):0.004 μM,TI:6225)with a novel mechanism of action.It exerts anti-HIV activity by inhibiting the production of HIV-1 double-stranded viral DNA from a single-stranded DNA intermediate,rather than blocking the generation of single-stranded DNA from a RNA template,which is the mechanism of action of current HIV-1 RT inhibitors.However,the insufficient metabolic stability of 3 limits its further clinical development.In the current study,a series of ester prodrugs of 3 was designed and synthesized to explore the new drug candidates as NNRTIs.The L-alanine ester prodrug 10 exhibited desirable pharmacokinetic properties in vitro and in vivo and showed improved oral bioavailability of 26%in rat,and would be a potential clinical candidate as a new anti-AIDS drug. | Huanfang Guo Xiaomei Zhuang Keduo Qian Lianqi Sun Xiaofeng Wang Hua Li Kuohsiung Lee Lan Xie | 2012 | Acta Pharmaceutica Sinica B2012，2，2： | 0 |
| 2 | In memoriam Professor Wei Jiang, one of the young editorial board members显示文摘It is with great sadness for us that Professor Wei Jiang, a young and well-known supramolecular chemist, passed away on Sunday25 December 2022. He created a series of supramolecular hosts including Oxatubarenes [1] and Naphthotubes [2] with inner functionalized groups [3–6] and applied them into materials, catalysis,molecular machines and drug recognition and delivery fields [7–10] during his independent research career. | Qiang Shi Liping Cao Yong Chen Huanfang Guo Yu Liu Tao Tu Feng Wang Junli Wang Leyong Wang Yongshu Xie Cheng Yang Xin Zhao | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
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