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| 1 | Structural basis of nucleic acid recognition and 6mA demethylation by human ALKBH1显示文摘Dear Editor,DNA N^6-methyladenine(6mA)modification is common in prokaryotes1 and eukaryotes,2 involving in gene regulation,transposon,stem cell differentiation,and human tumors.At present,it has been confirmed that 6mA is ubiquitous in the human genome,and[G/C]AGG[C/T]is the most prominent motif for 6mA modification.3 Human ALKBH1(hALKBH1),one of the nine human homologs of the AlkB family,is an Fe(Ⅱ)and aketoglutarate(α-KG)-dependent dioxygenase and highly conserved in mammals.AlkB family proteins can repair damaged DNA/RNA or other lesions. | Li-Fei Tian Yan-Ping Liu Lianqi Chen Qun Tang Wei Wu Wei Sun Zhongzhou Chen Xiao-Xue Yan | 2020 | Cell Research2020，30，3： | 7 |
| 2 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 3 | Robust video hashing based on representative-dispersive frames显示文摘This study proposes a robust video hashing for video copy detection.The proposed method,which is based on representative-dispersive frames(R-D frames),can reveal the global and local information of a video.In this method,a video is represented as a graph with frames as vertices.A similarity measure is proposed to calculate the weights between edges.To select R-D frames,the adjacency matrix of the generated graph is constructed,and the adjacency number of each vertex is calculated,and then some vertices that represent the R-D frames of the video are selected.To reveal the temporal and spatial information of the video,all R-D frames are scanned to constitute an image called video tomography image,the fourth-order cumulant of which is calculated to generate a hash sequence that can inherently describe the corresponding video.Experimental results show that the proposed video hashing is resistant to geometric attacks on frames and channel impairments on transmission. | NIE XiuShan LIU Ju SUN JianDe WANG LianQi YANG XiaoHui | 2013 | Science China(Information Sciences)2013，56，6： | 3 |
| 4 | Ameliorating the interfacial issues of all-solid-state lithium metal batteries by constructing polymer/inorganic composite electrolyte显示文摘Lithium metal is one of the most promising anodes for next-generation batteries due to its high capacity and low reduction potential.However,the notorious Li dendrites can cause the short life span and safety issues,hindering the extensive application of lithium batteries.Herein,Li_(7)La_(3)Zr_(2)O_(12)(LLZO)ceramics are integrated into polyethylene oxide(PEO)to construct a facile polymer/inorganic composite solid-state electrolyte(CSSE)to inhibit the growth of Li dendrites and widen the electrochemical stability window.Given the feasibility of our strategy,the designed PEO-LLZO-LiTFSI composite solid-state electrolyte(PLLCSSE)exhibits an outstanding cycling property of 134.2 mAh g^(-1) after 500 cycles and the Coulombic efficiency of 99.1%after 1000 cycles at 1 C in LiFePO_(4)-Li cell.When cooperated with LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NCM622)cathode,the PLL-CSSE renders a capacity retention of 82.4%after 200 cycles at 0.2 C.More importantly,the uniform dispersion of LLZO in PEO matrix is tentative tested via Raman and FT-IR spectra and should be responsible for the improved electrochemical performance.The same conclusion can be drawn from the interface investigation after cycling.This work presents an intriguing solid-state electrolyte with high electrochemical performance,which will boost the development of all-solid-state lithium batteries with high energy density. | Su Wang Qifang Sun Wenxiu Peng Yue Ma Ying Zhou Dawei Song Hongzhou Zhang Xixi Shi Chunliang Li Lianqi Zhang | 2021 | Journal of Energy Chemistry2021，30，7： | 2 |
| 5 | Industry experiment & effect of oxidation resistance coating for steel slab显示文摘Spraying test were conducted twice before steel slabs were put into the furnace and the effects of the oxidation resistance coating were investigated and verified.By comparing the change of slab weight,rolling force of the roughing mill & finishing mill,thickness of oxide film on the surface slabs by an XL-30 SEM and acid pickling speed of slabs with and without coating,it was found that the oxidization waste in the furnace decreased by 40 percent with the use of the coating and the corresponding yield capacity could increase by 0.2 percent at least.Besides,the thickness of oxide scale film on hot rolled products was reduced by 1.44 micrometers and the acid pickling time was shortened by 6s with the coating technology,while the total rolling force of RM & FM did not changed.Furthermore,the application prospect of this technology was also discussed in this paper. | XIA Xiaoming SUN Mingjun WANG Wei ZHAO Nan WEI Lianqi | 2012 | Baosteel Technical Research2012，6，4： | 2 |
| 6 | Immunomodulatory effectiveness of tacrolimus in preventing epidural scar adhesion after laminectomy in rat model显示文摘 | Lianqi Yan Xiaolei Li Jingcheng Wang Sun Yu Daxing Wang Jiaxiang Gu Jinshan He Hansheng Hu Gang Chen Qiang Wang Xinmin Feng | 2012 | European Journal of Pharmacology2012，，： | 1 |
| 7 | Prodrug design,synthesis and pharmacokinetic evaluation of(3'R,4'R)-3-hydroxymethyl-4-methyl-3',4'-di-O-(S)-camphanoyl-(t)-cis-khellactone显示文摘3-Hydroxymethyl-4-methyl-DCK(3,HMDCK)was discovered previously as a potent HIV non-nucleoside reverse transcriptase inhibitor(NNRTIs)(EC_(50):0.004 μM,TI:6225)with a novel mechanism of action.It exerts anti-HIV activity by inhibiting the production of HIV-1 double-stranded viral DNA from a single-stranded DNA intermediate,rather than blocking the generation of single-stranded DNA from a RNA template,which is the mechanism of action of current HIV-1 RT inhibitors.However,the insufficient metabolic stability of 3 limits its further clinical development.In the current study,a series of ester prodrugs of 3 was designed and synthesized to explore the new drug candidates as NNRTIs.The L-alanine ester prodrug 10 exhibited desirable pharmacokinetic properties in vitro and in vivo and showed improved oral bioavailability of 26%in rat,and would be a potential clinical candidate as a new anti-AIDS drug. | Huanfang Guo Xiaomei Zhuang Keduo Qian Lianqi Sun Xiaofeng Wang Hua Li Kuohsiung Lee Lan Xie | 2012 | Acta Pharmaceutica Sinica B2012，2，2： | 0 |
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