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| 1 | Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation显示文摘Accumulating evidence suggests that a reduction in the number of Foxp3^(+) regulatory T cells(Tregs)contributes to the pathogenesis of acute graft-versus-host disease(aGVHD),which is a major adverse complication that can occur after allogeneic hematopoietic stem cell transplantation(allo-HSCT).However,the precise features and mechanism underlying the defects in Tregs remain largely unknown.In this study,we demonstrated that Tregs were more dramatically decreased in bone marrow compared with those in peripheral blood from aGVHD patients and that bone marrow Treg defects were negatively associated with hematopoietic reconstitution.Tregs from aGVHD patients exhibited multiple defects,including the instability of Foxp3 expression,especially in response to IL-12,impaired suppressor function,decreased migratory capacity,and increased apoptosis.Transcriptional profiling revealed the downregulation of Lkb1,a previously identified critical regulator of murine Treg identity and metabolism,and murine Lkb1-regulated genes in Tregs from aGVHD patients.Foxp3 expression in human Tregs could be decreased and increased by the knockdown and overexpression of the Lkb1 gene,respectively.Furthermore,a loss-of-function assay in an aGVHD murine model confirmed that Lkb1 deficiency could impair Tregs and aggravate disease severity.These findings reveal that Lkb1 downregulation contributes to multiple defects in Tregs in human aGVHD and highlight the Lkb1-related pathways that could serve as therapeutic targets that may potentially be manipulated to mitigate aGVHD. | Xiuhua Su Qianqian Wang Wei Guo Xiaolei Pei Qing Niu Maolan Liu Yuanyuan Liu Song Chen Sizhou Feng Yi He Donglin Yang Rongli Zhang Qiaoling Ma Weihua Zhai Aiming Pang Jialin Wei Yong Huang Yuechen Luo Mingzhe Han Xiaoming Feng Erlie Jiang | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 2 | Effect of Surface-modified Clay on the Thermal Stability and Insulation of Polyorganosiloxane Foam显示文摘 | ZHANG Chunling HUANG Rong HOU Jiazi LI Aiming HOU Xiaoman GU Xiaoyan | 2016 | Chemical Research in Chinese Universities2016，32，5： | 2 |
| 3 | Critical flux and chemical cleaning- in-place during the long term operation of a pilot-scale submergcd membrane bioreactor for municipal wastewater treatment 显示文摘 | Wei C H Huang X Ben Aim R | 2011 | Water Research2011，45，： | 1 |
| 4 | PREVALENCE OF SOLENOPSIS INVICTA (HYMENOPTERA: FORMICIDAE) VENOM ALLERGIC REACTIONS IN MAINLAND CHINA显示文摘 | Xu Yijuan Huang Jun Zhou Aiming Zeng Ling | 2012 | The Florida Entomologist2012，，4： | 1 |
| 5 | Tribophy- sieal properties of polyerystalline bulk Ti3 AIC2 显示文摘 | ZHAI H X HUANG Z Y AIM X | 2005 | Journal of the American Ceramic Society2005，，： | 1 |
| 6 | Critical flux and chemical cleaning-in-place during the long-term operation of a pilot-scale submerged membrane bioreactor for municipal wastewater treatment 显示文摘 | WEI Chunhua HUANG Xia AIM R B | 2011 | Water Res2011，45，2： | 1 |
| 7 | Critical flux and chemical cleaning-in-place during the longterm operation of a pilot-scale submerged membrane bioreactor for municipal wastewater treatment显示文摘 | Chun-Hai Wei Xia Huang Roger Ben Aim | 2011 | Water Research2011，45，： | 1 |
| 8 | Microstructural evolution and modelling of the hot compression of a TC6 titanium alloy显示文摘 | Miaoquan Li Aiming Xiong Weichao Huang Hairong Wang Shaobo Su Lichuang Shen | 2002 | Materials Characterization2002，，3： | 1 |
| 9 | Synthesis and property of nanosized palladium catalysts protected by polymer/silica 显示文摘 | Huang Aiming Liu Yinfeng Chen Lai et al | 2002 | J Appl Polym Sci2002，85，5： | 1 |
| 10 | 显示文摘 | Liu Y F Huang Aiming Chen J | 2003 | J Appl Polym Sci2003，89，： | 1 |
| 11 | Microstructural evolution and modelling of the hot compression of TC6 titanium alloy 显示文摘 | Li Miaoquan Xiong Aiming Huang Weichao | 2003 | Materials Characterization2003，，49： | 1 |
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