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| 1 | Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy显示文摘CD8^+T cell-mediated cancer clearance is often suppressed by the interaction between inhibitory molecules like PD-1 and PD-L1,an interaction acts like brakes to prevent T cell overreaction under normal conditions but is exploited by tumor cells to escape the immune surveillance.Immune checkpoint inhibitors have revolutionized cancer therapeutics by removing such brakes.Unfortunately,only a minority of cancer patients respond to immunotherapies presumably due to inadequate immunity.Antitumor immunity depends on the activation of the cGAS-STING pathway,as STING-deficient mice fail to stimulate tumor-infiltrating dendritic cells(DCs)to activate CD8^+T cells.STING agonists also enhance natural killer(NK)cells to mediate the clearance of CD8^+T cell-resistant tumors.Therefore STING agonists have been intensively sought after.We previously discovered that manganese(Mn)is indispensable for the host defense against cytosolic dsDNA by activating cGAS-STING.Here we report that Mn is also essential in innate immune sensing of tumors and enhances adaptive immune responses against tumors.Mn-insufficient mice had significantly enhanced tumor growth and metastasis,with greatly reduced tumor-infiltrating CD8^+T cells.Mechanically,Mn^2+promoted DC and macrophage maturation and tumor-specific antigen presentation,augmented CD8^+T cell differentiation,activation and NK cell activation,and increased memory CD8^+T cells.Combining Mn^2+with immune checkpoint inhibition synergistically boosted antitumor efficacies and reduced the anti-PD-1 antibody dosage required in mice.Importantly,a completed phase 1 clinical trial with the combined regimen of Mn^2+and anti-PD-1 antibody showed promising efficacy,exhibiting type I IFN induction,manageable safety and revived responses to immunotherapy in most patients with advanced metastatic solid tumors.We propose that this combination strategy warrants further clinical translation. | Mengze Lv Meixia Chen Rui Zhang Wen Zhang Chenguang Wang Yan Zhang Xiaoming Wei Yukun Guan Jiejie Liu Kaichao Feng Miao Jing Xurui Wang Yun-Cai Liu Qian Mei Weidong Han Zhengfan Jiang | 2020 | Cell Research2020，30，11： | 27 |
| 2 | Remote Sensing of Ecosystem Services:An Opportunity for Spatially Explicit Assessment显示文摘Ecosystem service is an emerging concept that grows to be a hot research area in ecology.Spatially explicit ecosystem service values are important for ecosystem service management.However,it is difficult to quantify ecosystem services.Remote sensing provides images covering Earth surface,which by nature are spatially explicit.Thus,remote sensing can be useful for quantitative assessment of ecosystem services.This paper reviews spatially explicit ecosystem service studies conducted in ecology and remote sensing in order to find out how remote sensing can be used for ecosystem service assessment.Several important areas considered include land cover,biodiversity,and carbon,water and soil related ecosystem services.We found that remote sensing can be used for ecosystem service assessment in three different ways:direct monitoring,indirect monitoring,and combined use with ecosystem models.Some plant and water related ecosystem services can be directly monitored by remote sensing.Most commonly,remote sensing can provide surrogate information on plant and soil characteristics in an ecosystem.For ecosystem process related ecosystem services,remote sensing can help measure spatially explicit parameters.We conclude that acquiring good in-situ measurements and selecting appropriate remote sensor data in terms of resolution are critical for accurate assessment of ecosystem services. | FENG Xiaoming FU Bojie YANG Xiaojun Lü Yihe | 2010 | Chinese Geographical Science2010，20，6： | 18 |
| 3 | Does Experience Facilitate Entry into New Export Destinations?显示文摘Using a large panel dataset that covers 116 countries and 5013 products over the period1998-2010,this study evaluates the effects of export experience on the geographic expansion of China s exports.The results suggest that past export experience in geographically close and culturally similar markets plays a crucial role in facilitating new market entry,and the positive spillover effects are more pronounced for incumbent and successful products.The results also indicate that spillovers from export experience are market-specific and productspecific,and they are limited to within the same product class and the same market,with little cross-group effects.Finally,there is no strong evidence that export experience is more important for differentiated products than for homogeneous products,and the positive spillover effects are remarkable for both categories of products. | Lili Wang Yong Zhao Xiaoming Feng | 2013 | China & World Economy2013，21，5： | 13 |
| 4 | GIS-based Analysis for Hotspot Identification of Tradeoff Between Ecosystem Services: A Case Study in Yanhe Basin, China显示文摘Although the quantification and valuation of ecosystem services have been studied for a long time, few studies have specifically focused on the quantification of tradeoffs between ecosystem services and tradeoff hotspots. Based on previous studies of ecosystem service assessment, we proposed a feasible method to analyze the tradeoffs between ecosystem services, including determination of their relationship, quantification of tradeoffs, and identification of tradeoff hotspots. Potential influencing factors were then further analyzed. The Yanhe Basin in the Loess Plateau was selected as an example to demonstrate the application process. Firstly, the amounts of net primary production(NPP) and water yield(WY) in 2000 and 2008 were estimated by using biophysical models. Secondly, correlation analysis was used to indicate the tradeoffs between NPP and WY. Thirdly, tradeoff index(TI_(NPP/WY)) was established to quantify the extent of tradeoffs between NPP and WY, and the average value of TI_(NPP/WY) is 24.4 g/(mm·m^2) for the Yanhe Basin between 2000 and 2008. Finally, the tradeoff hotspots were identified. The results indicated that the area of lowest tradeoff index concentrated in the middle part of the Yanhe Basin and marginal areas of the southern basin. Map overlapping was used for preliminary analysis to seek potential influencing factors, and the results showed that shrub was the best suited for growing in the Yanhe Basin, but also was a potential influencing factor for formulation of the tradeoff hotspots. The concept of tradeoff index could also be used to quantify the degree of synergy between different ecosystem services. The method to identify the tradeoff hotspots could help us to narrow the scope of study area for further research on the relationship among ecosystem services and concentrate on the potential factors for formation of tradeoff between ecosystem services, enhance the capacity to maintain the sustainability of ecosystem. | ZHENG Zhenmin FU Bojie FENG Xiaoming | 2016 | Chinese Geographical Science2016，26，4： | 12 |
| 5 | EGCG attenuates pro-inflammatory cytokines and chemokines production in LPS-stimulated L02 hepatocyte显示文摘内毒素 lipopolysaccharide (LPS ) 作为第二攻击在肝炎的煽动性的反应的加速起一个重要作用。能由指向 LPS 阻止发炎的混合物有潜在的治疗学的临床的申请。Epigallocatechin-3-gallate (EGCG ) 有有势力 hepatocyte 保护的效果和温和反肝炎病毒工作。这里,我们调查了 EGCG 是否在刺激 LPS 的 L02 hepatocytes 稀释了煽动性的反应的严厉。L02 hepatocytes 是有为 2 h 的 EGCG 的 pretreated,然后在 250 ng/ml 由 LPS 刺激了。 chemokine 的表示层次在表示并且藏匿的激活正常T房间( Rantes )和单核白血球之上调整了趋化性的 protein-1 ( MCP-1 ), 支持inflammatory cytokines 肿瘤坏死因素--(TNF-)并且干扰素--,粘附分子细胞间的粘附 molecule-1 ( ICAM-1 ),氧化剂压力分子氮的氧化物(没有),脉管的 endothelial 生长因素( VEGF ),和矩阵 metalloproteinase-2 ( MMP-2 )被连接酶的 immunosorbent 试金测试。全部的细胞外的调整信号的 kinase 1/2 (ERK1/2 ) 的表示, phospho-ERK1/2 (p-ERK1/2 ) , p-AKT,全部的 p38, phospho-p38 (p-p38 ) ,全部的 p65 和 phospho-p65 (p-p65 ) , IB, phospho-IB (p-IB ) 和 TNF 受体联系了因素 2 被西方的污点分析测试。我们的结果证明有 EGCG 的那个预告的处理能显著地减少 TNF- 的生产, Rantes, MCP-1, ICAM-1,不在以一种剂量依赖者方式的刺激 LPS 的 L02 hepatocytes 的 VEGF,和 MMP-2。EGCG 的效果可能与原子 factor-B (NF-B ) 和由 p-IB, p65, p-p65, p-p38, p-ERK1/2,和 p-AKT 的下面规定表明小径的激活 mitogen 的蛋白质 kinase (MAPK ) 的抑制有关。这些结果显示 EGCG 压制导致 LPS 的煽动性的反应和氧化剂应力并且由禁止 NF-B 和 MAPK 小径部分施加它的 hepatocyte 保护的活动。 | Qiaoli Liu Yun Qian Feng Chen Xiaoming Chen Zhi Chen Min Zhen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 11 |
| 6 | Image-guided locoregional non-intravascular interventional treatments for hepatocellular carcinoma: Current status显示文摘Hepatocellular carcinoma(HCC) is one of the most deadly and frequent cancers worldwide,although great advancement in the treatment of this malignancy have been made within the past few decades.It continues to be a major health issue due to an increasing incidence and a poor prognosis.The majority of patients have their HCC diagnosed at an intermediate or advanced stage in theUSA or China.Curative therapy such as surgical resection or liver transplantation is not considered anoption of treatment at these stages.Transarterial chemoembolization(TACE),the most widely used locoregional therapeutic approach,used to be the mainstay of treatment for cases with unresectable cancer entities.However,for those patients with hypovascular tumors or impaired liver function reserve,TACE is a suboptimal treatment option.For example,embolization does not result in complete coverage of a hypovascular tumor,and may rather promotes postoperative tumor recurrence,or leave residual tumor,in these TACE-resistance patients.In addition,TACE carries a higher risk of hepatic decompensation in patients with poor liver function or reserve.Non-vascular interventional locoregional therapies for HCC include radiofrequency ablation(RFA),microwave ablation(MWA),high-intensity focused ultrasound(HIFU),laser-induced thermotherapy(LITT),cryosurgical ablation(CSA),irreversible Electroporation(IRE),percutaneous ethanol injection(PEI),and brachytherapy.Recent advancements in these techniques have significantly improved the treatment efficacy of HCC and expanded the population of patients who qualify for treatment.This review embraces the current status of imaging-guided locoregional non-intravascular interventional treatments for HCCs,with a primary focus on the clinical evaluation and assessment of the efficacy of combined therapies using these interventional techniques. | Kun Qian Feng Zhang Stephen K.Allison Chuansheng Zheng Xiaoming Yang | 2021 | Journal of Interventional Medicine2021，4，1： | 11 |
| 7 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 8 | Deformation control of asymmetric floor heave in a deep rock roadway:A case study显示文摘In order to control asymmetric floor heave in deep rock roadways and deformation around the surrounding rock mass after excavation, in this paper we discuss the failure mechanism and coupling control countermeasures using the finite difference method(FLAC3D) combined with comparative analysis and typical engineering application at Xingcun coal mine. It is indicated by the analysis that the simple symmetric support systems used in the past led to destruction of the deep rock roadway from the key zone and resulted in the deformation of asymmetric floor heave in the roadway. Suitable reinforced support countermeasures are proposed to reduce the deformation of the floor heave and the potential risk during mining. The application shows that the present support technology can be used to better environmental conditions. The countermeasures of asymmetric coupling support can not only effectively reduce the discrepancy deformation at the key area of the surrounding rock mass, but also effectively control floor heave, which helps realize the integration of support and maintain the stability of the deep rock roadways at Xingcun coal mine. | Sun Xiaoming Wang Dong Feng Jili Zhang Chun Chen Yanwei | 2014 | International Journal of Mining Science and Technology2014，24，6： | 10 |
| 9 | Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism显示文摘Amycolatopsis mediterranei 被用于 rifamycin 的工业规模生产,它在 antimycobacterial 治疗起一个重要作用。作为类 Amycolatopsis 的首先定序的染色体, 236 715 底配对的包括 10 的紧张 U32 的染色体,最大的原核生物的染色体之一到目前为止曾经被定序。不同于在 streptomycetes 发现的线性拓扑学,这个染色体是圆形的,特别地类似于 Saccharopolyspora erythraea 和奴卡氏菌属 farcinica,在发展史和分类代表他们的靠近的关系。尽管在 A 预言了 9 228 编码蛋白质的基因。mediterranei 染色体 S 与那些分享了 orthologs 的最大的数字。erythraea,它被 Streptomyces coelicolor 而非 N 出人意料地跟随。farcinica,显示不同新陈代谢的特征经由改编演变到多样的生态的壁龛。除类似于那的一个核心区域以外在 streptomycetes 普通,有典型核心特征的一个新奇“伪核心”在非核心区域以内被定义,在 21 从 26 基因为第二等的代谢物生产聚类的总数被定位的地方。位于核心的 rifamycin 生合成基因簇为 rifamycin SV 的变换编码细胞色素 P450 酶必需品到 B,由比作 rifamycin 生产 B 紧张 S699 的高度相应的簇揭示了并且进一步由基因互补证实了。A 的 genomic 信息。mediterranei 表明在看起来复杂的规章的机制的控制下面不仅为各种各样的碳来源和无机的氮混合物的广泛的利用而且为新陈代谢的中介的有效 funneling 安排进第二等的抗菌素合成进程的一个新陈代谢的网络。 | Wei Zhao Yi Zhong Hua Yuan Jin Wang Huajun Zheng Ying Wang Xufeng Cen Feng Xu Jie Bai Xiaobiao Han Gang Lu Yongqiang Zhu Zhihui Shao Han Yan Chen Li Nanqiu Peng Zilong Zhang Yunyi Zhang Wei Lin Yun Fan Zhongjun Qin Yongfei Hu Baoli Zhu Shengyue Wang Xiaoming Ding Guo-Ping Zbao | 2010 | Cell Research2010，20，10： | 10 |
| 10 | Design of precision variable-rate spray system for unmanned aerial vehicle using automatic control method显示文摘In order to reduce the use of chemical pesticides in crop plant protection and improve the utilization efficiency of pesticides,it is necessary to study advanced application machinery and application techniques.The use of unmanned aerial vehicle(UAV)for pesticide spraying has the characteristics of less application,strong penetrability,wide applicability and flexible operation scheduling,and has gradually become one of the important development directions in the field of aviation plant protection.However,the operation process of the UAV is often affected by meteorological factors and human manipulation,resulting in poor actual operation with inaccurate spray volume and uneven application.Therefore,to improve the stability and uniformity of the application of the plant protection UAV under variable operating conditions,in this paper a real-time control method was proposed for the application flow rate,and a precision variable-rate spray system was designed based on single-chip microcomputer and micro diaphragm pump that can controls the flow rate of the pump in real time with the changes of the operating state.The response s-peed of the variable-rate spray system was tested.The average control response time of the system was 0.18 s,and the average stability time of the pump flow change was 0.75 s.The test results showed that the system has a quick response to the working state and the adjustment of the target flow of the pump can be quickly completed to realize the variable-rate spray function.The research results can provide a reference for the practical application of plant protection UAV variable-rate spray system. | Qi Lian Feng Tan Xiaoming Fu Ping Zhang Xin Liu Wei Zhang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，2： | 10 |
| 11 | Physical model test and numerical simulation on the failure mechanism of the roadway in layered soft rocks显示文摘To explore the failure mechanism of roadway in layered soft rocks,a physical model with the physically finite elemental slab assemblage(PFESA)method was established.Infrared thermography and a video camera were employed to capture thermal responses and deformation.The model results showed that layered soft roadway suffered from large deformation.A three-dimensional distinct element code(3 DEC)model with tetrahedral blocks was built to capture the characteristics of roadway deformation,stress,and cracks.The results showed two failure patterns,layer bending fracture and layer slipping after excavation.The layer bending fracture occurred at positions where the normal direction of layers pointed to the inside of the roadway and the layer slipping occurred in the ribs.Six schemes were proposed to investigate the effects of layered soft rocks.The results showed that the deformation of ribs was obviously larger than that of the roof and floor when the roadway passed through three types of strata.When the roadway was completely in a coal seam,the change of deformation in ribs was not obvious,while the deformation in the roof and floor increased obviously.These results can provide guidance for excavation and support design of roadways in layered soft rocks. | Xiaoming Sun Chengwei Zhao Yong Zhang Feng Chen Shangkun Zhang Kaiyuan Zhang | 2021 | International Journal of Mining Science and Technology2021，31，2： | 9 |
| 12 | Cordycepin protects renal ischemia/reperfusion injury through regulating inflammation,apoptosis,and oxidative stress显示文摘Cordycepin(3-deoxyadenosine)is a naturally occurring adenosine analog and one of the bioactive constituents isolated from Cordyceps sinensis,species of the fungal genus Cordyceps.It has traditionally been a prized Chinese folk medicine for the human well-being.However,the actions of cordycepin against renal ischemia/reperfusion injury(/R)are still unknown.In the present study,rats were subject to VR and cordycepin was intragastrically administered for seven consecutive days before surgery to investigate the effects and mechanisms of cordycepin against renal/R injury.The test results of kidney and peripheral blood samples of experimental animals showed that cordycepin significantly decreased serum blood urea nitrogen and creatinine levels and markedly attenuated cell injury.Mechanistic studies showed that cordycepin significantly regulated inflammation,apoptosis,and oxidative stress.These data provide new insights for investigating the natural product with the nephroprotective effect against I/R,which should be developed as a new therapeutic agent for the treatment of I/R in the future. | Feng Han Meng Dou Yuxiang Wang Cuixiang Xu Yang Li Xiaoming Ding Wujun Xue Jin Zheng Puxun Tian Chenguang Ding | 2020 | Acta Biochimica et Biophysica Sinica2020，52，2： | 9 |
| 13 | A Study on the Xenia Effect in Castanea henryi显示文摘The xenia effect results in pollen affecting the setting rate and the appearance and quality of fruits. To further understand this phenomenon,we investigated the xenia effect in Castanea henryi using the cultivars ‘Huali 1', ‘Huali 2', ‘Huali 3', and ‘Huangzhen' as materials. Twenty combinations of self-, cross-, and natural pollination were undertaken in a chestnut orchard in Chenzhou City, Hunan Province, China. Significant differences were observed among the pollination combinations in terms of the time of fruit ripening, rate of fruit setting, size of the barbed shell and nut, and content of soluble sugars, fats, proteins, amylose, and vitamin C. No significant differences were observed with regard to nut rate,content of total starch, and moisture content. The fruit quality of the 20 pollination combinations was evaluated using a subordinate function method,and showed that Huali 2 × Huali 3 was the best combination, and Huangzhen × Huangzhen was the most ineffective combination. Therefore, we recommend the combination of Huali 2 × Huali 3 for the future production of C. henryi. | ZHANG Xuhui YUAN Deyi ZOU Feng FAN Xiaoming TANG Jing ZHU Zhoujun | 2016 | Horticultural Plant Journal2016，2，6： | 9 |
| 14 | IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-κB/S6K signalings显示文摘Interleukin 37b (IL-37b ) 在压制有免疫力的回答起一个关键作用,部分由 modulating 树枝状的房间(DC ) 的功能。然而,精确机制大部分仍然是未知的。这里,我们在回答由 DC 导致了的 DC 成熟和 T 房间上调查了 IL-37b 的效果,并且探索了深奥发信号的小径。它被发现那 IL-37b 下面调整在 vitro 的 DC 上的 co-stimulatory 分子 CD80 和 CD86 的表情。同时,支持 inflammatory cytokines 的表情例如 TNF-6, 和 IL-6,被压制,当时 T 房间的表示禁止的 cytokine TGF- 在 IL-37b-treated DC 被增加。另外, T 房间上的 DC 的激活效果被 IL-37b 损害。我们进一步表明细胞外的调整单人赛的 kinase (英皇家空军之阶级最低之兵) ,原子 factor-B (NF-B ) ,和表明小径的 mTOR-S6K 涉及 IL-37b 导致的 DC 的抑制。这被化学禁止者的同样镇压的效果在 DC 在 IL-6 和 TNF- 的表情上对 NF-B,英皇家空军之阶级最低之兵,和 S6K 证实。在结论,这些结果证明 IL-37b 由在英皇家空军之阶级最低之兵, NF-B,和基于 S6K 的禁止的发信号小径包含在 T 房间 priming 压制了 DC 成熟和 immunostimulatory 能力。 | Wantong Wu Weiqiang Wang Yun Wang Wenwen Li Gang Yu Zhonglong Li Chunmin Fang Yue Shen Zhina Sun Ling Han Juan Yu Lijun Fang Song Chen Kui Dong Zhongchao Han Hanzhi Liu Yuechen Luo Xiaoming Feng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 15 | Assessment of different biomarkers provides valuable diagnostic standards in the evaluation of the risk of acute rejection显示文摘尖锐拒绝(AR ) 是为长期的拒绝在的一个强壮的风险因素肾移植接受者。AR 事件的精确、及时的诊断为疾病控制和预后是很重要的。因此,客观地评估了病人的有免疫力的地位在移植以后的治疗的地里是必要的。这纵的研究在外部血 mononuclear 房间( PBMC )和活体检视在 sera ,CD4+ T 房间的细胞内部的腺苷 triphosphate ( iATP )版本水平,和 granzyme B/perforin 表示调查了五 biomarkers ,人的白血球抗原( HLA ) -G5 和 sCD30 水平的实用性,总共肾的移植的 84 个案例的检测 AR 和 biomarkers 的决定。数据证明接受者与临床或证明的活体检视拒绝显著地增加了 CD4+ T 房间的 iATP 版本水平,并且提高了 sCD30,但是与稳定的接枝功能与个人相比在 sera 降低了 HLA-G5 水平。granzyme B 和 perforin 的表示层次也在 PBMC 和 AR 病人的接枝活体检视被提高。一起拿,我们鉴别 HLA-G5 的 sCD30, iATP, granzyme B, perforin,和 downregulation 的 upregulation 能提供珍贵诊断标准在 AR 的风险识别那些接受者。并且 iATP 可以比为预言接枝拒绝事件的其它是更好的 biomarker。 | Jin Zheng Xiaoming Ding Xiaohui Tian Zhankui Jin Xiaoming Pan Hang Yan Xinshun Feng Jun Hou Heli Xiang Li Ren Puxun Tian Wujun Xue | 2012 | Acta Biochimica et Biophysica Sinica2012，44，9： | 8 |
| 16 | Chiral Amino Acids-Derived Catalysts and Ligands显示文摘 | Xiaohua Liu Shunxi Dong Lili Lin Xiaoming Feng | 2018 | Chinese Journal of Chemistry2018，36，9： | 8 |
| 17 | Trade-offs and Synergies of Ecosystem Services in Karst Area of China Driven by Grain-for-Green Program显示文摘As an important means regulating the relationship between human and natural ecosystem,ecological restoration program plays a key role in restoring ecosystem functions.The Grain-for-Green Program(GFGP,One of the world’s most ambitious ecosystem conservation set-aside programs aims to transfer farmland on steep slopes to forestland or grassland to increase vegetation coverage)has been widely implemented from 1999 to 2015 and exerted significant influence on land use and ecosystem services(ESs).In this study,three ecological models(In VEST,RUSLE,and CASA)were used to accurately calculate the three key types of ESs,water yield(WY),soil conservation(SC),and net primary production(NPP)in Karst area of southwestern China from 1982 to 2015.The impact of GFGP on ESs and trade-offs was analyzed.It provides practical guidance in carrying out ecological regulation in Karst area of China under global climate change.Results showed that ESs and trade-offs had changed dramatically driven by GFGP.In detail,temporally,SC and NPP exhibited an increasing trend,while WY exhibited a decreasing trend.Spatially,SC basically decreased from west to east;NPP basically increased from north to south;WY basically increased from west to east;NPP and SC,SC and WY developed in the direction of trade-offs driven by the GFGP,while NPP and WY developed in the direction of synergy.Therefore,future ecosystem management and restoration policy-making should consider trade-offs of ESs so as to achieve sustainable provision of ESs. | WANG Xiaofeng ZHANG Xinrong FENG Xiaoming LIU Shirong YIN Lichang CHEN Yongzhe | 2020 | Chinese Geographical Science2020，30，1： | 8 |
| 18 | Three-dimensional porous superaerophobic nickel nanoflower electrodes for high-performance hydrazine oxidation显示文摘与高活动和稳定性发现便宜电极是关键的认识到燃料房间的实际应用程序。这里,我们报导制造三维(3D ) 多孔的镍 nanoflower (3D-PNNF ) 电极经由一在里面 situ 减小方法。3D-PNNF 电极有一个高表面区域,显示出紧密的绑定到 electroconductive 底层,并且最重要地,有 superaerophobic (水泡驱虫剂) 表面。因此,因为它的极端弱的煤气水泡的粘附和极端快的煤气水泡的版本, 3D-PNNF 电极的 electrocatalytic 肼氧化表演比商业 Pt/C 催化剂的高得多。而且, 3D-PNNF 电极出现了超离频甚至在高当前的密度下面的稳定性(为实际应用使它有希望的 260 妈 / 厘米 2), 。另外, superaerophobic nanostructures 的构造能也为另外的煤气的进化过程是有益的(例如,氢进化反应) 。 | Guang Feng Yun Kuang Yingjie Li Xiaoming Sun | 2015 | Nano Research2015，8，10： | 8 |
| 19 | Relay-intercropping soybean with maize maintains soil fertility and increases nitrogen recovery efficiency by reducing nitrogen input显示文摘Optimized nitrogen(N)management can increase N-use efficiency in intercropping systems.Legume-nonlegume intercropping systems can reduce N input by exploiting biological N fixation by legumes.Measurement of N utilization can help in dissecting the mechanisms underlying N uptake and utilization in legume-nonlegume intercropping systems.An experiment was performed with three planting patterns:monoculture maize(MM),monoculture soybean(SS),and maize-soybean relay intercropping(IMS),and three N application levels:zero N(NN),reduced N(RN),and conventional N(CN)to investigate crop N uptake and utilization characteristics.N recovery efficiency and 15N recovery rate of crops were higher under RN than under CN,and those under RN were higher under intercropping than under the corresponding monocultures.Compared with MM,IMS showed a lower soil N-dependent rate(SNDR)in 2012.However,the SNDR of MM rapidly declined from 86.8%in 2012 to 49.4%in 2014,whereas that of IMS declined slowly from 75.4%in 2012 to 69.4%in 2014.The interspecific N competition rate(NCRms)was higher under RN than under CN,and increased yearly.Soybean nodule dry weight and nitrogenase activities were respectively 34.2%and 12.5%higher under intercropping than in monoculture at the beginning seed stage.The amount(Ndfa)and ratio(%Ndfa)of soybean N2 fixation were significantly greater under IS than under SS.In conclusion,N fertilizer was more efficiently used under RN than under CN;in particular,the relay intercropping system promoted N fertilizer utilization in comparison with the corresponding monocultures.An intercropping system helps to maintain soil fertility because interspecific N competition promotes biological N fixation by soybean by reducing N input.Thus,a maize-soybean relay intercropping system with reduced N application is sustainable and environmentally friendly. | Qing Du Li Zhou Ping Chen Xiaoming Liu Chun Song Feng Yang Xiaochun Wang Weiguo Liu Xin Sun Junbo Du Jiang Liu Kai Shu Wenyu Yang Taiwen Yong | 2020 | The Crop Journal2020，8，1： | 7 |
| 20 | SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target显示文摘Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death.However,the origin of excessive damages caused by SARS-CoV-2 remains largely unknown.Here we show that the SARS-CoV-2 envelope(2-E)protein alone is able to cause acute respiratory distress syndrome(ARDS)-like damages in vitro and in vivo. | Bingqing Xia Xurui Shen Yang He Xiaoyan Pan Feng-Liang Liu Yi Wang Feipu Yang Sui Fang Yan Wu Zilei Duan Xiaoli Zuo Zhuqing Xie Xiangrui Jiang Ling Xu Hao Chi Shuangqu Li Qian Meng Hu Zhou Yubo Zhou Xi Cheng Xiaoming Xin Lin Jin Hai-Lin Zhang Dan-Dan Yu Ming-Hua Li Xiao-Li Feng Jiekai Chen Hualiang Jiang Gengfu Xiao Yong-Tang Zheng Lei-Ke Zhang Jingshan Shen Jia Li Zhaobing Gao | 2021 | Cell Research2021，31，8： | 7 |
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