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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | 血管紧张素Ⅱ2型受体的基因多态性(+1675G/A)对已接受治疗高血压患者的左心室肥大和左心室构型的作用显示文摘已有报道显示血管紧张素Ⅱ2型受体的基因多态性(AGTR2+1675G/A)与左心室肥大(left ventric-ular hypertrophy,LVH)相关。研究者检验这种基因多态性是否影响已按高血压治疗指南治疗的原发性高血压和心血管疾病患者的LVH和左心室构型参数。 | 张玲玉 叶鹏 Huber M V ller H Jakob S Reibis R Do V Bol-brinker J Zergibel I Schmieder RE Treszl A Wegscheider K Kreutz R | 2010 | 中华高血压杂志2010，18，12： | 6 |
| 3 | How do fibroblasts translate mechanical signals into changes in excellular matrix production显示文摘 | Chiguet M Renedo A S Huber F | 2003 | Matrix Biol2003，22，1： | 1 |
| 4 | Sucrose-phosphate synthase and other sucrose metabolizing enzymes in fruit of various species 显示文摘 | Hubbard N L Pharr D M Huber S C | 1991 | Physiol Plant1991，82，： | 1 |
| 5 | Role of sucrose phosphate synthase in sucrose biosynthesis in ripening bananas and its relationship to the respiratory climacteric 显示文摘 | HUBBARD N L PARR D M HUBER S C | 1990 | Plant Physiol1990，94，1： | 1 |
| 6 | The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4显示文摘 | Brustle A Heink S Huber M | 2007 | Nat Immunol2007，8，9： | 1 |
| 7 | Differential response of nitrate reductase and sucrose phosphate synthase activation to inorganic and organic salts,in vitro and in situ显示文摘 | Huber S C Huber J L Kaider W M | 1994 | Plant Physiol1994，，92： | 1 |
| 8 | TGF -β lates the CD^+ CD25^T T cell pool and the expression of Foxp3 invivo 显示文摘 | Schramm C Huber S Protschka M | 2004 | Int Imnmnol2004，16，9： | 1 |
| 9 | Oxidation ofpharmaceuticals during ozonation and advanced oxidationprocesses显示文摘 | Huber M M Canonica S Park G Y | 2003 | Environmental Science and Technology2003，37，5： | 1 |
| 10 | TGF-bregulates the CD4+ CD25+ T cells pool and the expression of Foxp3 in vivo 显示文摘 | Sehamm C Huber S Protschka M | 2004 | Int Immunol2004，16，9： | 1 |
| 11 | Characterization of diurnal changes in activity of enzymes involved in sucrose biosynthesis显示文摘 | THOMAS W R JRPHILLIP S KERR HUBER S C | 1983 | Plant Physiol1983，73，： | 1 |
| 12 | Doppler sonography of breast tumours显示文摘 | Delorme S Huber S | 1998 | Anticancer Research1998，8，： | 1 |
| 13 | Role of sucrose phosphate synthase in sucrose biosynthesis in ripening bananas and its relationship to the respiratory climacteric显示文摘 | HUBBARD N L PHARR D M HUBER S C | 1990 | Plant Physiol1990，94，： | 1 |
| 14 | Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression显示文摘 | Huber JD Witt KA Hom S | 2001 | Am J Physiol Heart Circ Physiol2001，280，： | 1 |
| 15 | IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells 显示文摘 | Ali S Huber M Kollewe C | 2007 | Proc Nat Acad Sc U S A2007，104，18： | 1 |
| 16 | A new isolation procedure of nitrate from freshwater fornitrogen and oxygen isotope analysis 显示文摘 | Huber B Bemasconi S M Luster J Pannatier E G | 2011 | RapidCommunications in Mass Spectrometry2011，25，： | 1 |
| 17 | Ultra- sonographic guidance improves the suc- cess rate of interscalene brachial plexus blockade 显示文摘 | Kapral S GreherM Huber G | 2008 | Reg Anesth Pain Med2008，33，3： | 1 |
| 18 | The DNA damageinduced decrease of Bcl-2 is secondary to the activation of apoptotic effector caspases显示文摘 | Milosevic J Hoffarth S Huber C | | 0，，44： | 1 |
| 19 | Capillary flow as the cause of ring stains from dried liquid drops显示文摘 | Deegan R D Bakajin O Dupont T F Huber G Nagel S R Witten T A | | 0，，6653： | 1 |
| 20 | Thl7 cells express interleukin-10 receptor and are controlled by Foxp3- and Foxp3* regulatory D T cells in an interleukin-10 dependent manner显示文摘 | Huber S Gagliani N Esplugues E | 2011 | Immunity2011，34，4： | 1 |
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