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| 1 | 【特刊综述】睾酮和雌二醇检测方法面临的挑战和取得的进展显示文摘在患者护理、公共卫生、科学研究过程中类固醇激素的检测方法需要正确而精准,因为这些检测的标准可以保证所有的临床机构和研究机构的结果具有可比性。本文陈述了目前有关检验结果易变的主要问题以及最近美国疾病预防控制中心(CDc)针对提升检验效果所做的工作。目前,睾酮和雌二醇的检测方法还无法达到高度的正确性和精准性。虽然类固醇激素检测方法已经有了长足的进步,但是实验室内部和实验室之间的检测差异仍然未能得到相应的改善。检测标准和特异性的差异被认为是测量精度变异性的来源。最终认为,类固醇激素检测的不准确性似乎是由综合因素造成的,其中不一致的检验标准和缺乏特异性被认为是产生结果变异的两个主要因素。目前,同一批次内的化验结果也变异较大,特别是在样本浓度低的情况下。2007至2011年间的质谱分析法和CDC参考方法之间的平均绝对偏差下降了50%,由此可以看出CDC激素标准化测试程序正在提高临床化验的准确性。这种测试程序可以为CDC参考方法提供追朔源头的途径,从而减少产生测量结果变异的因素。 | Hubert W Vesper Julianne C Botelho Yuesong Wang | 2014 | Asian Journal of Andrology2014，16，2： | 3 |
| 2 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | The Lancet . 2005 (9454)2005，，： | 2 |
| 3 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | 2005 (9454)2005，，9454： | 1 |
| 4 | Expulsion of dummy transmitters by rainbow trout 显示文摘 | Chisholm I M Hubert W A | 1985 | Trans Am Fish Soc1985，114，： | 1 |
| 5 | Determination and on-line clean-up of (fluoro)quinolones in bovine milk using column-switching liquidchromatography fluorescence detection显示文摘 | Clare Ho Della W M Sin Hubert P 0 Tang | 2004 | Journal ofChromatography A2004，1061，： | 1 |
| 6 | CART peptides as modulators of dopamine and psychostimula nts and interactions with the mesolimbic dopaminergic system 显示文摘 | Hubert G W Jones D C Moffett M C Rogge G Kuhar M J | 2008 | Biochem Pharmacol2008，75，： | 1 |
| 7 | Frequency-and Time-Domain BEM Analysis of Rigid Track on a Halfspace with Vibration Barriers显示文摘 | Hubert W Friedrich K Pflanz G | 2001 | Meccanica2001，36，4： | 1 |
| 8 | A simple and rapid DNA microextraction methodfor plant,animal and insect suitable for RAPD and other PCR analyses显示文摘 | CHEUNG W Y,HUBERT N,LANDRY B S | 1993 | PCR Methodsand Applications1993，3，1： | 1 |
| 9 | Comparison of the genetic maps of Brassica napus and Brassica oleracea 显示文摘 | Cheung W Y Champagne G Hubert N | 1997 | Theor Appl Genet1997，94，： | 1 |
| 10 | Influence of cooking process on phenolic marker compounds of vegetables显示文摘 | Andlauer W Stumpf C Hubert A | 2003 | Intemational J Vitmin and Nutri2003，73，： | 1 |
| 11 | Vesicle-directed growth of silica显示文摘 | Hubert D H W Jung M Frederik P M | 2000 | Adv Mater2000，12，： | 1 |
| 12 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | The Lancet2005，，9454： | 1 |
| 13 | Vesicle-directed growth of silica显示文摘 | Hubert D H W Jung M Frederik P M | 2000 | Advanced Materials2000，12，17： | 1 |
| 14 | Vesicle templating显示文摘 | HUBERT D H W JUNG M GERMAN A L | 2000 | Adv Mater2000，12，： | 1 |
| 15 | High extraction efficiency for POPs in real contaminated soil samples using accelerated solvent extraction 显示文摘 | Hubert A Wenzel K D Manz M Weissflog L Engewald W Schuurmann G | 2000 | Analyitical Chemistry2000，72，6： | 1 |
| 16 | On the Kolmogorov-Smirnov test for normality with mean and variance unknown显示文摘 | Hubert W L | 1967 | Journal of the American Statistical Association1967，62，318： | 1 |
| 17 | In vivo calibration of microdialysis probes for exogenous compounds显示文摘 | Menacherry S Hubert W Justice JJ | 1992 | Anal Chem1992，64，6： | 1 |
| 18 | Comparison of the genetic maps of Brassica napus and Brassica oleracea 显示文摘 | Cheung W Y Champagne G Hubert N | 1997 | Theor Appl Genet1997，94，： | 1 |
| 19 | Patency of autogenous and polytet-rafluoroethylene upper extremity arteriovenous hemodialysis accessed: a systematic review 显示文摘 | HUBERT S CARTER J W CARTER R L | 2003 | J Vasc Surg2003，38，5： | 1 |
| 20 | Fructoligosaccha- rides enhance mineral apparent absorption and counteract the deleterious effects of phytic acid on mineral homeosta- sis in rats显示文摘 | Hubert W Lopez C Acoudray M | 2000 | Nutr Biochem2000，11，10： | 1 |
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