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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Continuous quality and shelf life monitoring of retail-packed fresh cod loins in comparison with conventional methods显示文摘 | Nga T.T. Mai María Gudjónsdóttir Hélène L. Lauzon Kolbrún Sveinsdóttir Emilía Martinsdóttir Hubert Audorff Werner Reichstein Dietrich Haarer Sigurdur G. Bogason Sigurjón Arason | 2010 | Food Control2010，，6： | 2 |
| 3 | Flow processes in a radiant tube burner: Isothermal flow 显示文摘 | TSIOUMANIS N BRAMMER J G HUBERT J | 2008 | Fuel2008，87，1： | 1 |
| 4 | Effects of concomitant verbal recall on order effects in personality impression formation 显示文摘 | Anderson N Hubert S | 1963 | Journal of Verbal Learning and Verbal Behavior1963，2，56： | 1 |
| 5 | Transforming growth factor-betal-mediated Slug and Snail transcription factor up-regulation reduces the density of Langerhans cells in epithelial metaplasia by affecting E-cadherin ex-pression 显示文摘 | Hefts M Hubert P Kholod N | 2008 | Am J Pathol2008，，172： | 1 |
| 6 | A genetic map for Brassica oleracea based on RFLP markers detected with expressed DNA sequences and mapping of resistance genes to race 2 of Plasmodiophora brassicae (Woronin)显示文摘 | Landry B S Hubert N Crete R | 1992 | Genome1992，35，3： | 1 |
| 7 | Predictive value of viral load and other markers for progression to clinical AIDS after CD4+ cell count falls below 200/micro L显示文摘 | Carre N Boufassa F Hubert JB | 1998 | Int J Epidemion1998，27，5： | 1 |
| 8 | The cross-talk between den-dritic and regulatory T cells:good or evil?显示文摘 | Hubert P Jacobs N Caberg JH | 2007 | J Leukoc Biol2007，82，4： | 1 |
| 9 | Role of the CLOCK protein in the mammalian circadian mechanism 显示文摘 | Gekakis N Staknis D Hubert BN | 1998 | Science1998，280，： | 1 |
| 10 | Chalcopyrite thin film solar cells by electrodeposition 显示文摘 | LINCOT D GUILLEMOLESA J F TAUNIER S GUIMARD D SICX-KURDI J CHAUMONT A ROUSSEL O RAMDANI O HUBERT C FAUVARQUE J P BODEREAU N PARISSI L PANHELEUX P FANOUILLERE P NAGHAVI N GRAND P P BENFARAH M MOGENSEN P KERREC O | 2004 | Solar Energy2004，77，： | 1 |
| 11 | High interaction alginate - hyaluronate associations by hyaluronate deacetylation for the preparation of effident biomaterials显示文摘 | Oerther S Maurin A Payan E Hubert P I.apicque F Presle N etal | | 0，，： | 1 |
| 12 | A genetic map for Brassica oleracea based on RFLP markers detected with expressed DNA sequences and mapping of resisance genes to race 2 of Plasmodiophora brassicae (Woronin)显示文摘 | Landry B S Hubert N Crete R | 1992 | Genome1992，35，： | 1 |
| 13 | A genetic map for Brassica napus based on restriction fragment length polymorphisms detected with expressed DNA sequences 显示文摘 | Landry B S Hubert N Etoh T | 1991 | Genome1991，34，4： | 1 |
| 14 | In vitro hepatoprotective and antioxidant activities of crude extract and i- solated compounds from Ficus gnaphalocarpa显示文摘 | Hubert D J Dawe A Florence N T | 2011 | Inflammop- harmacology2011，19，1： | 1 |
| 15 | 白细胞端粒长度缩短较动脉粥样硬化的临床表现提前出现:血液和肌肉模型显示文摘白细胞端粒长度与动脉粥样硬化性心血管病(atherosclerotic cardiovascular disease,ASCVD)相关。目前还不清楚这种关系是否源于出生时天生较短的白细胞端粒长度(leukocy tetelomere length,LTL)和(或)之后较快的LTL消耗。LTL代表高增殖性造血系统中的端粒长度,而骨骼肌中的端粒长度(muscle tetelomere length,MTL)代表最低限度复制的组织。 | Benetos A Toupance S Gautier S Labat C Kimura M Rossi PM Settembre N Hubert J Frimat L Bertrand B Boufi M Flecher X Sadoul N Eschwege P Kessler ML Tzanetakou IP Doulamis IP Konstantopoulos PS Tzani AI Korou LM Gkogkos A Perreas KG Menenakos E Samanidis G Vasiloglou-Gkanis M Kark JD Malikov S Verhulst S Aviv A 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，1： | 1 |
| 16 | Colchicines poisoning:case report of two suicide显示文摘 | Deveaux Marc Hubert N Demarly C | 2004 | Forensic Sci Int2004，143，： | 1 |
| 17 | Reduction of pain and fracture incidence after kyphoplasty: 1-year outcomes of a prospective controlled trial of patients with primary osteoporosis显示文摘 | Ingo A. Grafe Katharina Fonseca Jochen Hillmeier Peter-Jürgen Meeder Martin Libicher Gerd N?ldge Hubert Bardenheuer Walter Pyerin Linus Basler Christel Weiss Rod S. Taylor Peter Nawroth Christian Kasperk | 2005 | Osteoporosis International2005，，12： | 1 |
| 18 | A simple and rapid DNA microextraction methodfor plant,animal and insect suitable for RAPD and other PCR analyses显示文摘 | CHEUNG W Y,HUBERT N,LANDRY B S | 1993 | PCR Methodsand Applications1993，3，1： | 1 |
| 19 | Comparison of the genetic maps of Brassica napus and Brassica oleracea 显示文摘 | Cheung W Y Champagne G Hubert N | 1997 | Theor Appl Genet1997，94，： | 1 |
| 20 | A genetic map for Brassicae olerace based on RFLFP markers detected with expressed DNA sequences and mapping resist ance gene to race 2 of Plasmodiophora brassicae显示文摘 | LANDERY B S HUBERT N CRET R | 1992 | Genome1992，35，： | 1 |
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