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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Ontology-based search for interactive digital maps显示文摘 | HUBNER S SPITrEL R VISSER U | 2004 | IEEE Intelligent Systems2004，119，3： | 1 |
| 3 | A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity显示文摘 | Schneikert J Hubner S Martin E | 1999 | J Cell Biol1999，146，5： | 1 |
| 4 | A prospective study of personality characteristics,occupational stressors,and burnout among school psychology practitioners显示文摘 | MILLS L B HUBNER E S | 1998 | J Sch Psychol1998，36，1： | 1 |
| 5 | Ontology-based Search for Interactive Digital Maps显示文摘 | Hubner S Spittel R Visse U | 2004 | IEEE Intelligent Systems2004，19，3： | 1 |
| 6 | Plant--Rhizosphere- Microflora Association during phytoremediation of PAH- contaminated soil显示文摘 | Muratova A Hubner T Tischer S | 2003 | Int J Phytoremediation2003，5，2： | 1 |
| 7 | Preliminary development and validation of a multidimensional life satisfaction scale for children显示文摘 | HUBNER E S | 1994 | Psychological Assessment1994，6，2： | 1 |
| 8 | Ultrasound in the diagnosis of fractures in children 显示文摘 | Hubner U Schlicht W Outzen S | 2000 | J Boint Surg Br2000，82，： | 1 |
| 9 | A fast-track program redues complications and length of hospital stay after open colonic surgery显示文摘 | Muller S Zalunardo MP Hubner M | 2009 | Gastroenterology2009，136，3： | 1 |
| 10 | Azaindole derivatives with high affinity for the dopamine D4 receptor: Synthesis, ligand binding studies and comparison of molecular electrostatic potential maps显示文摘 | Lober S Hubner H Omeiner P | 1999 | Bioorganic & Medicinal Chemistry Letters1999，9，： | 1 |
| 11 | Systematic review of microsatel-lite instability and colorectal cancer prognosis显示文摘 | Popat S Hubner R Houlston RS | 2005 | J Clin Oncol2005，23，3： | 1 |
| 12 | Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes显示文摘 | Frank S Hubner G Breier G | 1995 | J Biol Chem1995，270，12： | 1 |
| 13 | Systematic review of mi- erosatellite instability and colorectal cancer prognosis显示文摘 | Popat S Hubner R Houlston RS | 2005 | J Clin Oncol2005，23，3： | 1 |
| 14 | A fast-trackprogram reduces complications and length of hospital stay afteropen colonic surgery显示文摘 | Muller S Zalunardo M P Hubner M | 2009 | Gastroenterology2009，136，3： | 1 |
| 15 | A fast-track program reduces complications and length of Hospital stay after open colonic surgery 显示文摘 | Muller S Zalunardo MP Hubner M | 2009 | Gastroenterology2009，136，3： | 1 |
| 16 | Regulation of vascular growth factor expression in cultured keratinocytes显示文摘 | Hubner G Breier G | 1995 | J Biol Chem1995，270，12： | 1 |
| 17 | Chromium adsorption by Lignin显示文摘 | Lalvani S B Hubner A Wiltowski T S | 2000 | Energy Source2000，22，1： | 1 |
| 18 | Plant-rhizosphere-microflora association during phytoremediation of PAH-contaminated soil显示文摘 | MURATOVA A HUBNER T TISCHER S | 2003 | International Journal of Phytoremediation2003，5，2： | 1 |
| 19 | A fast track program reduces complications and length of hospital stay after open co- Ionic surgery 显示文摘 | Muller S Zalunardo MP Hubner M | 2009 | Gastroenterology2009，136，3： | 1 |
| 20 | Experimental infection of calves with a gI, gE, US9 negative bovine herpesvirus type 5显示文摘 | Hubner S O Oliveira A P Franco A C | 2005 | Comp Immunol Microbiol Infect Dis2005，28，3： | 1 |
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