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| 1 | Obesity is an important determinant of severity in newly defined metabolic dysfunction-associated fatty liver disease显示文摘Background: The recently proposed definition of metabolic dysfunction-associated fatty liver disease(MAFLD) is based on the co-existence of hepatic steatosis with other metabolic disorders, including obesity and metabolic risk abnormalities such as hyperglycemia, high blood pressure and dyslipidemia. This study aimed to assess MAFLD severity according to the presence of metabolic abnormalities and obesity. Methods: Using transient elastography, hepatic steatosis and fibrosis severity were assessed by measuring the controlled attenuation parameter and liver stiffness measurement. A total of 1163 patients with MAFLD were categorized into the following four groups according to metabolic risk abnormalities and obesity presence: non-obese without metabolic risk abnormality group(Group 1;reference group);nonobese with metabolic risk abnormality group(Group 2);obese without metabolic risk abnormality group(Group 3);and obese with metabolic risk abnormality group(Group 4). A multiple logistic regression analysis was performed to determine severe hepatic steatosis and fibrosis risk in each group in both unadjusted and adjusted models. Results: In the adjusted model, the odds ratios(ORs) [95% confidence interval(CI)] for severe hepatic steatosis in Groups 2, 3, and 4 were 1.07(0.61-1.88), 2.43(1.44-4.08), and 4.07(2.56-6.48), respectively( P trend < 0.001). For liver fibrosis, compared with Group 1, Group 2 showed no significant increases in OR, whereas Groups 3 and 4(obese groups) showed significant increases(OR = 4.70, 95% CI: 1.24-17.82 and OR = 6.43, 95% CI: 1.88-22.02, respectively). Conclusions: Obesity, rather than metabolic abnormality, is the principal determinant of severe hepatic steatosis and fibrosis in patients with MAFLD. | Ji Hye Huh Kwang Joon Kim Seung Up Kim Bong-Soo Cha Byung-Wan Lee | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，3： | 2 |
| 2 | The Ratio of the Absolute Lymphocyte Count to the Absolute Monocyte Count Is Associated with Prognosis in Hodgkin’s Lymphoma: Correlation with Tumor-Associated Macrophages显示文摘 | Young Wha Koh Hyo Jeong Kang Chansik Park Dok Hyun Yoon Shin Kim Cheolwon Suh Heounjeong Go Ji Eun Kim Chul-Woo Kim Jooryung Huh | 2012 | The Oncologist2012，，6： | 2 |
| 3 | Antisense inhibition of coagulation factor Ⅺ prolongs APTT without increased bleeding risk in cynomolgus monkeys显示文摘 | Younis HS Crosby J Huh JI | 2012 | Blood2012，119，10： | 1 |
| 4 | Endothelium-dependent sensory non-adrenergic non-cholinergic vasodilatation in rat thoracic aorta: involvement of ATP and a role for NO显示文摘 | Park JI Shin CY Lee YW Huh IH Sohn UD | 2000 | J Pharm Pharmacol2000，52，4： | 1 |
| 5 | Adverse effects of perioperative transfusion on patients with stage III and IV gastric cancer显示文摘 | Woo Jin Hyung MD Sung Hoon Noh MD Dong Woo Shin MD Ji Hun J. Huh BA Bong J. Huh MD Seung Ho Choi MD Jin Sik Min MD | 2002 | Annals of Surgical Oncology2002，，1： | 1 |
| 6 | Distinct tumor stage-specific inhibitory effects of 2-methoxyestradiol in a breast cancer mouse model associated with Id-1 exprossion显示文摘 | Huh JI Calvo A Charles R | | 0，，07： | 1 |
| 7 | Inhibition of VEGF receptors significantly impairs mammary cancer growth in C3(1)/Tag transgenic mice through antiangiogenic and non-antiangiogenic mechanisms显示文摘 | Huh JI Calvo A Stafford J | 2005 | Oncogene2005，27，24： | 1 |
| 8 | Expression and purification of HuwentoxinI in baculovirus system显示文摘 | JI W J ZHANG X Y HUH C | 2005 | Protein Expres Purif2005，41，： | 1 |
| 9 | Evaluation of dynamic hardening models for BCC, FCC, and HCP metals at a wide range of strain rates显示文摘 | Hoon Huh Kwanghyun Ahn Ji Ho Lim Hyung Won Kim Lee Ju Park | 2014 | Journal of Materials Processing Tech2014，，7： | 1 |
| 10 | Hydrotropic polymer micelles containing acrylic acid moieties for oral delivery of paclitaxel显示文摘 | Sungwon Kim Ji Young Kim Kang Moo Huh Ghanashyam Acharya Kinam Park | 2008 | Journal of Controlled Release2008，，3： | 1 |
| 11 | Determining which patients require irradiation of the supraclavicular nodal area after surgery for N1 breast cancer 显示文摘 | Yu JI Park W Huh SJ | 2010 | Int J Radiat Oncol Biol Phys2010，78，4： | 1 |
| 12 | Comparison of efficacy between adjuvant chemotherapy and chemoradiation therapy for pancreatic cancer: AJCC stage-based approach显示文摘BACKGROUND The adjuvant treatment for patients with resected pancreatic cancer(PC)is not yet standardized.Because the prognosis differs according to the American Joint Committee on Cancer(AJCC)stage,a tailored approach to establish more aggressive treatment plans in high-risk patients is necessary.However,studies comparing the efficacy of adjuvant treatment modalities according to the AJCC stage are largely lacking.AIM To compare the efficacy of chemotherapy and chemoradiation therapy according to AJCC 8th staging system in patients with PC who underwent surgical resection.METHODS A total of 335 patients who underwent surgical resection and adjuvant treatment for PC were included.Patients were divided into three groups:Chemoradiation therapy(CRT)group,systemic chemotherapy(SCT)group and combined treatment of chemoradiation plus chemotherapy therapy(CRT-SCT)group.The primary outcomes were differences in overall survival(OS)between the three groups.The secondary outcomes were differences in recurrence-free survival,recurrence pattern and adverse events between the three groups.RESULTS Patients received CRT(n=65),SCT(n=62)and CRT-SCT(n=208).Overall median OS was 33.3 mo(95%confidence interval(CI):27.4-38.6).In patients with stage I/II,the median OS was 27.0 mo(95%CI:2.06-89.6)in the CRT group,35.8 mo(95%CI:26.9-NA)in the SCT group and 38.6 mo(95%CI:33.3-55.7)in the CRT SCT group.Among them,there was no significant difference in OS between the three groups.In 59 patients with stage III,median OS in the SCT group[19.0 mo(95%CI:12.6-NA)]and the CRT-SCT group[23.4 mo(95%CI:22.0-44.4)]was significantly longer than that in the CRT group[17.7 mo(95%CI:6.8-NA);P=0.011 and P<0.001,respectively].There were no significant differences in incidence of locoregional and distant recurrences between the three groups(P=0.158 and P=0.205,respectively).Incidences of grade 3 or higher hematologic adverse events were higher in the SCT and CRT-SCT groups than in the CRT group.CONCLUSION SCT and CRT-SCT showed significantly longer OS and recurrence-free survival than CRT in patients with AJCC stage III,while there was no significant difference in OS between the CRT,SCT and CRT-SCT groups in patients with AJCC stage I/II.Different adjuvant therapy according to AJCC stage can be applied in patients with PC. | Min Su You Ji Kon Ryu Gunn Huh Jung Won Chun Woo Hyun Paik Sang Hyub Lee Yong-Tae Kim | 2020 | World Journal of Clinical Oncology2020，11，9： | 1 |
| 13 | Probiotic suppression of the H. pylori -induced responses by conjugated linoleic acids in a gastric epithelial cell line显示文摘 | Sung Wook Hwang Nayoung Kim Jung Mogg Kim Chul Sung Huh Young Tae Ahn Se Hoon Park Cheol Min Shin Ji Hyun Park Mi Kyoung Lee Ryoung Hee Nam Hye Seung Lee Joo Sung Kim Hyun Chae Jung In Sung Song | 2012 | Prostaglandins Leukotrienes and Essential Fatty Acids (PLEFA)2012，，6： | 1 |
| 14 | The effect of photodynamic therapy using indole-3-acetic Acid and green light on acne vulgaris 显示文摘 | Huh SY Na JI Huh CH | 2012 | Ann Dermatol2012，24，1： | 1 |
| 15 | Robust Enhancement of Neural Differentiation from Human ES and iPS Cells Regardless of their Innate Difference in Differentiation Propensity显示文摘 | Dae-Sung Kim Jae Souk Lee Joong Woo Leem Yong Jun Huh Ji Young Kim Han-Soo Kim In-Hyun Park George Q. Daley Dong-Youn Hwang Dong-Wook Kim | 2010 | Stem Cell Reviews and Reports2010，，2： | 1 |
| 16 | miR‐206 regulates brain‐derived neurotrophic factor in Alzheimer disease model显示文摘 | Soon‐Tae Lee Kon Chu Keun‐Hwa Jung Jin Hee Kim Ji‐Young Huh Hyejin Yoon Dong‐Kyu Park Ji‐Yeon Lim Jeong‐Min Kim Daejong Jeon Hoon Ryu Sang Kun Lee Manho Kim Jae‐Kyu Roh | 2012 | Ann Neurol2012，，2： | 1 |
| 17 | Microvascu- lar decompression for hemifacial spasm: analyses of opera- tive complications in 1582 consecutive patients 显示文摘 | Ryoong Huh In Bo Han Ji Young Moon | 2008 | Surg Neurol2008，69，： | 1 |
| 18 | Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys显示文摘 | Younis HS Crosby J Huh JI | 2012 | Blood2012，119，10： | 1 |
| 19 | An eft- cient method of one - carbon elongation of aryl aldehydes via their dibromoalkene derivatives 显示文摘 | Dal Ho Huh Ji Sang Jeong Hee Bong Lee | 2002 | Tetrahedron2002，58，50： | 1 |
| 20 | Adverse effects of perioperative transfusion on patients with stage III and IV gastric cancer显示文摘 | Woo Jin Hyung MD Sung Hoon Noh MD Dong Woo Shin MD Ji Hun J. Huh BA Bong J. Huh MD Seung Ho Choi MD Jin Sik Min MD | 2002 | Annals of Surgical Oncology2002，，1： | 1 |
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