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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus显示文摘AIM: To compare the gene expression profile in a pair of HBV-infected twins.METHODS: The gene expression profile was compared in a pair of HBV-infected twins.RESULTS: The twins displayed different disease outcomes. One acquired natural immunity against HBV,whereas the other became a chronic HBV carrier. Eightyeight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RTPCR. However, upon HBV core antigen stimulation,TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins.CONCLUSION: TNF-αIP1 may play a role in the innate immunity against HBV. | Marie C Lin Nikki P Lee Ning Zheng Pai-Hao Yang Oscar G Wong Hsiang-Fu Kung Chee-Kin Hui John M Luk George Ka-Kit Lau | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 3 | Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression显示文摘 | Jason M Hui Archana Sud Geoffrey C Farrell Priyanka Bandara Karen Byth James G Kench Geoffrey W McCaughan Jacob George | 2003 | Gastroenterology2003，，6： | 2 |
| 4 | Mycobacteria in drinking water distribution systems:ecology and significance for human health显示文摘 | Vaerewijck M J M Huys G Palomino J C | | 0，，05： | 1 |
| 5 | Formation of Mg-Cu-Zn-Y bulk metallic glasses with compressive strength over gigapascal 显示文摘 | Li Z G Hui X Zhang C M | 2008 | Journal of Alloys and Compounds2008，454，1： | 1 |
| 6 | Guanxi and professional leadership in contemporary Sino-American joint ventures in mainland China显示文摘 | GRAEN G | 1997 | Leadership Quarterly1997，，8： | 1 |
| 7 | PCR detection,characterization,and distribution of virulence genes in Aeromonas spp 显示文摘 | Kingombe C I Huys G Tonolla M | 1999 | Appl Environ Microbiol1999，65，12： | 1 |
| 8 | 显示文摘 | NA N HU Yuping OUYANG Jin BAEYENS W R G DELANGHE J R TAES Y E C XIE Mengxia CHEN Huying YANG Yiping | 2006 | Talanta2006，69，4： | 1 |
| 9 | Strengthening and toughening of Mg-Cu-(Y,Gd)bulk metallic glasses by minor addition of Be显示文摘 | Li Z G Hui X Zhang C M | 2007 | Materials Letters2007，61，28： | 1 |
| 10 | Data mining for customer service support 显示文摘 | Hui S C Jha G | 2000 | Information & Management2000，38，1： | 1 |
| 11 | Lack of HIV testing and awareness of HIV infection among men who have sex with men, Beijing, China显示文摘 | Kyung Hee C Hui L Yaqi G | 2006 | AIDS Education and Prevention2006，18，1： | 1 |
| 12 | The possible role of hydrogen sulfide as a smoth muscle cell proliferation inhibitor in rat cultured cells显示文摘 | Du J Hui Y Cheng Y Bin G Jiang H Chen X Tang C | 2004 | Heart Vessels2004，19，2： | 1 |
| 13 | A Web-based intelligent fault diagnosis system for customer service support显示文摘 | HUI S C FONG A C M JHA G | 2001 | Engineering Applications of Artificial Intelligence2001，14，： | 1 |
| 14 | Film-pore diffusion modeling and contact tilne optimization for the adsorption of dyestuffs of pith显示文摘 | CHEN B HUI C W MCKAY G | 2001 | Chemical Engineering Journal2001，84，： | 1 |
| 15 | Beyondinsulin resistance in NASH:TNF-alpha or adiponectin?显示文摘 | HUI J M HODGE A FARRELL G C | 2004 | Hepatology2004，40，1： | 1 |
| 16 | An analytic network process approach to the selection of logistics service providers for air cargo显示文摘 | Yang Y H Hui Z V Leung L C Chen G | 2010 | The Journal of the Operational Research Society2010，61，9： | 1 |
| 17 | Characteristics of nano particles and their effect on the formation of nanostructures in air plasma spraying WC-17Co coating 显示文摘 | HUI C GUOQING G MINGJING T | 2009 | Surface & Coatings Technology2009，203，： | 1 |
| 18 | Release characteris- tics of three model drugs from ehitosan/eellulose acetate multimiero- spheres显示文摘 | Hui Yun Zhou X G C C Chen Guang Liu L J Y | 2006 | Bioehemieal Engineering Journal2006，31，3： | 1 |
| 19 | A Web-based Intelligent Fault Diagnosis System for Customer Service Support显示文摘 | Hui S C Fang A C M Jha G | 2001 | Engineering Applications of Artificial Intelligence2001，2，2： | 1 |
| 20 | 对空腹血糖和脑出血风险的前瞻性研究显示文摘尽管糖尿病已经被认为是缺血性脑卒中的一个独立危险因素,但空腹血糖水平和脑出血之间的研究较少且结果不一。该研究的目的是调查空腹血糖水平对脑出血风险的长期潜在影响。研究纳入唐山市开滦集团的受试者96110人,且在基础状态下(2006年)无心血管病和癌症。 | 黄洁 叶鹏 Jin C Li G Rexrode KM Gurol ME Yuan X Hui Y Ruan C Vaidya A Wang Y Wu S Gao X | 2017 | 中华高血压杂志2017，25，12： | 1 |
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