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| 1 | Diagnostic and prognostic value of minor elevated cardiac troponin levels for percutaneous coronary intervention-related myocardial injury:a prospective,single-center and double-blind study显示文摘Cardiac troponin-I(cTnI) and-T(cTnT) are sensitive and specific markers of myocardial injury.However,the role of increased cTnI and cTnT in percutaneous coronary intervention(PCI)-related myocardial injury remains controversial.In this prospective,single-center and double-blind study,we aimed to determine the diagnostic and prognostic value of cTnI as well as cTnT(cTns) in PCI-related myocardial injury in a Chinese population.A total of 1,008 patients with stable angina pectoris and non-ST-segment elevation acute coronary syndrome were recruited.The levels of cTnI and cTnT were examined before and after PCI.All patients were followed up for26±9 months to observe the incidence of major adverse cardiac events(MACEs).Our results showed that postPCI cTnI and/or cTnT levels were increased to more than the 99^(th) percentile upper reference limit(URL) in 133(13.2%) patients,among which 22(2.2%) were more than 5×99^(th) percentile URL.By univariate analysis,an elevation in cTns after PCI was not an independent predictor of increased MACEs,HR 1.35(P = 0.33,95%CI:0.74-2.46).In conclusion,our data demonstrate that the incidence of PCI-related myocardial injury is not common in a Chinese population and minor elevated cTns levels may not be a sensitive prognostic marker for MACEs. | Min Zhang Huiwei He Ze-Mu Wang Zhihui Xu Ningtian Zhou Zhengxian Tao Bo Chen Chunjian Li Tiebing Zhu Di Yang Liansheng Wang Zhijian Yang | 2014 | The Journal of Biomedical Research2014，28，2： | 12 |
| 2 | Expression, purification, and functional characterization of recombinant PTD-SARA显示文摘为蛋白质是的受体激活(SARA ) 的 Smad 锚为在支持发信号的小径的 fibrotic 起一个重要作用的 Smad2/3 的一个有约束力的搭挡由转变生长 factor-1 (TGF-1 ) 开始了。C 终端 SARA 的 665750 aa 包括 Smad 有约束力的领域(SBD ) 。由通过 SBD 的直接相互作用, SARA 禁止 Smad2/3 phosphorylation 并且堵住在 Smad2/3 和 Smad4 之间的相互作用,从而制止纤维变性的过程。在这研究,我们基于 SBD 顺序构造了 SARA 肽 aptamer。recombinant SARA aptamer,与一个蛋白质 transduction 领域(PTD-SARA ) 熔化了,被克隆,从 E 净化了。coli,并且第一次描绘了。编码顺序的全身的 PTD-SARA,与 E 创造了。coli 赞成了 codons,被克隆进 pQE-30 向量,并且 recombinant plasmid 被转变成 M15 紧张。在 Isopropyl -D-1-Thiogalactopyranoside (IPTG ) 以后正式就职和 Ni2+ 亲密关系纯化, recombinant PTD-SARA 被定序的 immunoblotting 和蛋白质 N 终端进一步识别。Epifluorescence 显微镜学表明 recombinant PTD-SARA 比 SARA 更高效地被变成细胞质和原子核。而且, recombinant PTD-SARA 被发现 E-cadherin 和下面调整的水平到起来调整 -SMA 和 phospho-Smad3 的层次更高效地比 SARA (P < 0.05 ) 。我们的工作探索了一个方法获得 recombinant PTD-SARA 蛋白质。recombinant PTD-SARA 熔化蛋白质能进入 HK2 房间(使不朽的近似小管上皮的房间线) 更高效地比 SARA 蛋白质和颠倒被 TGF-1 比 SARA 蛋白质更有效地导致的肾的 epithelial-to-mesenchymal transdifferentiation 过程。Recombinant PDT-SARA 是可能的是肾的纤维变性的临床的预防和处理的一个潜在的候选人。 | Chen Huang Rui Du Peng Zhang Hua Meng Huiwei Jia Yang Song Man Li Yingqi Zhang Shiren Sun | 2011 | Acta Biochimica et Biophysica Sinica2011，43，2： | 4 |
| 3 | A survey on distributed optimisation approaches and applications in smart grids显示文摘Smart grid and smart metering technologies are transforming the utility industry and the customer experience in search of a new energy deal that supports a more collaborative,eco-friendly,stable,reliable and cost-efficient system as a whole.In order to unlock the full benefits,utilities need now to develop new technologies like distributed optimisation methods to excavate the latent value from the magnanimous data.This paper surveys recent advances of distributed optimisation and game algorithms with applications in power systems.In particular,this paper reviews distributed algorithms for model-based offline optimisation solution of dynamic economic dispatch problems,charging control problems for plug-in electric vehicles and risk-averse energy trading as well as model-free online algorithms for demand response problems. | Huiwei Wang Chaojie Li Jueyou Li Xing He Tingwen Huang | 2019 | Journal of Control and Decision2019，6，1： | 2 |
| 4 | Combining Structured and Flat Features by a Composite Kernel to Detect Hedges Scope in Biological Texts显示文摘 | ZHOU Huiwei HUANG Degen LI Xiaoyan YANG Yuansheng | 2011 | Chinese Journal of Electronics2011，20，3： | 2 |
| 5 | Relationship between urea mycoplasma infection during pregnancy and premature rupture of membranes,preg-nancy outcome显示文摘 | SHI Huiwei | 2011 | Chin Matern Child Health Care2011，26，11： | 1 |
| 6 | Research on evaluation of enterprises'technology innovation performance from the perspective of industrial cluster networks显示文摘 | XU YOULI LI HUIWEI | 2011 | Energy Procedia2011，5，： | 1 |
| 7 | Microstrcture evolution in SnBi and SnBiCu solderjoints under thermal aging显示文摘 | Miao Huiwei Du Jenggong | 2001 | Materials Chemistry and Physics2001，，3： | 1 |
| 8 | Effect of the hyaluronic acid-poloxamer hydrogel on skin-wound healing: in vitro and in vivo studies显示文摘Background: Recent research into skin injury and wound healing has focused mainly on post‐trauma hemostasis, infection prevention, dermal regeneration and angiogenesis. However, less attention has been paid to air permeability and moisture loss prevention which also play important roles in injury healing. Methods: In the present work, we prepared a hyaluronic acid‐poloxamer (HA‐POL) hydrogel and tested the therapeutic effect of the hydrogel on skin‐wound healing. Results: The HA‐POL hydrogel transformed from sol to gel at 30°C, close to body temperature, and had stable moisturizing properties. HA‐POL hydrogel promoted skin‐wound healing and increased protein accumulation in the wound area. HA‐POL hydrogel allowed greater air permeability than Band‐aid, a typical wound covering. Results from transwell assays showed that the HA‐POL hydrogel effectively isolated skin‐wounds from bacterial invasion. Conclusion: This work demonstrates the advantages of using HA‐POL gel materials in the treatment of cutaneous wounds. | Xiaojuan Li Aimin Li Fan Feng Qiyu Jiang Huiwei Sun Yantao Chai Ruichuang Yang Zhijie Wang Jun Hou Ruisheng Li | 2019 | Animal Models and Experimental Medicine2019，2，2： | 1 |
| 9 | Systematically investigating the key features of the DNase deactivated Cpf1 for tunable transcription regulation in prokaryotic cells显示文摘With a unique crRNA processing capability,the CRISPR associated Cpf1 protein holds great potential for multiplex gene regulation.Unlike the well-studied Cas9 protein,however,conversion of Cpf1 to a transcription regulator and its related properties have not been systematically explored yet.In this study,we investigated the mutation schemes and crRNA requirements for the DNase deactivated Cpf1(dCpf1).By shortening the direct repeat sequence,we obtained genetically stable crRNA co-transcripts and improved gene repression with multiplex targeting.A screen of diversity-enriched PAM library was designed to investigate the PAMdependency of gene regulation by dCpf1 from Francisella novicida and Lachnospiraceae bacterium.We found novel PAM patterns that elicited strong or medium gene repressions.Using a computational algorithm,we predicted regulatory outputs for all possible PAM sequences,which spanned a large dynamic range that could be leveraged for regulatory purposes.These newly identified features will facilitate the efficient design of CRISPR-dCpf1 based systems for tunable multiplex gene regulation. | Chensi Miao Huiwei Zhao Long Qian Chunbo Lou | 2019 | Synthetic and Systems Biotechnology2019，4，1： | 1 |
| 10 | Microstructure Evolution in SnBi and SnBiCu Solder Joints under Thermal Aging显示文摘 | Huiwei M Jenggong D | 2001 | Mate - rials Chemistry and Physics2001，71，： | 1 |
| 11 | Synchronization for an array of coupled stochastic discrete-time neural networks with mixed delays显示文摘 | Wang Huiwei Song Qiankun | 2011 | Neurocomputing2011，74，10： | 1 |
| 12 | Research on the 'three shells' cooperative support technology of large-section chambers in deep mines显示文摘The'three shells'cooperative support technology was proposed herein according to both the large deformation of the rock surrounding large-section chambers in deep mines and the precarious stability of the support structures therein.The development range of the plastic zone in the surrounding rock was controlled by a stress shell to reduce the difficulty of controlling the surrounding rock.Additionally,the residual strength of the rock mass in the plastic zone and the self-bearing capacity of the surrounding rock were improved by a reinforced load-bearing shell.Furthermore,a passive load-bearing shell could restore the triaxial stress state of the surrounding rock on the free surface,reduce the influence of the external environment on the surrounding rock,and reinforce the surrounding rock with the strength of the shell.Reasonable layouts of large-section chambers were determined by analyzing the control effect of the stress shell on the surrounding rock under three kinds of in situ stress fields.The orthogonal test method was applied to reveal the influences of different support parameters in the reinforced loadbearing shell and passive load-bearing shell on the surrounding rock stability.The surrounding rock control effect of the'three shells'collaborative support technology was analyzed through numerical simulation and field monitoring.The results show that the maximum displacement between the roof and floor of the coal preparation chamber in the Xinjulong coal mine was approximately 48 mm,and the maximum displacement between its two sides was approximately 65 mm,indicating that the technology proposed herein could meet the long-term control requirements of the surrounding rock stability for large-section chambers in deep mines. | Cheng Zhu Yong Yuan Wenmiao Wang Zhongshun Chen Shengzhi Wang Huiwei Zhong | 2021 | International Journal of Mining Science and Technology2021，31，4： | 1 |
| 13 | Thermal cycling test in Sn-Bi and Sn-Bi-Cu solder joints显示文摘 | Huiwei M Jenggong D | 2000 | J Mater Sci:Mater Electron2000，11，： | 1 |
| 14 | Microstrcture evolution in SnBi and SnBiCu solder joints under thermal aging 显示文摘 | Miao Huiwei Du Jenggong | 2001 | Materials Chemistry and Physics2001，71，： | 1 |
| 15 | Quantitative examination of the inhibitory activation of molecular targeting agents in hepatocellular carcinoma patient-derived cell invasion via a novel in vivo tumor model显示文摘Background: The outcomes for patients with advanced hepatocellular carcinoma(HCC) receiving sorafenib are far from satisfactory because of treatment resistance to sorafenib. However, the exact mechanism of resistance to sorafenib remains unclear and it is valuable to establish a novel mouse model to quantitatively analyze the inhibition rates of sorafenib on the invasive growth of HCC cells in the liver.Methods: HCC tissue microblocks derived from patients were cultured and mixed with hydrogel drops. Then, hydrogel drops containing microblocks of HCC tissue were attached onto the surface of the livers of nude mice to form lesions or nodules of HCC. The mice received molecular targeting agents through oral administration. Livers with tumor nodules were harvested for H&E staining(hematoxylin-eosin staining) analysis and H&E staining images were quantitatively analyzed using image J software. The invasive growth of HCC cells into the liver was calculated using the depth of the lesions compared with the total thickness of the liver.Results: Microblocks containing cells derived from HCC patients can form lesions in the liver of nude mice. Oral administration of molecular targeting agents inhibited the invasive growth of HCC cells in the liver of nude mice.Conclusions: The model established in this study involves the invasive growth of HCC cells in the liver of nude mice, and the model allows for the quantitative analysis of the inhibitory effect of molecular targeting agents on the invasion of HCC cells in vivo. | Huiwei Sun Fan Feng Hui Xie Xiaojuan Li Qiyu Jiang Yantao Chai Zhijie Wang Ruichuang Yang Ruisheng Li Jun Hou | 2019 | Animal Models and Experimental Medicine2019，2，4： | 1 |
| 16 | Porous mullite ceramics from natural clay produced by gel-casting显示文摘 | Yafei Liu Xingqin Liu HuiWei Guangyao Meng | 2001 | Ceramic International2001，27，1： | 1 |
| 17 | SERVQUAL Model Based Evaluation Analysis of Railway Passenger Transport Service Quality in China显示文摘Railway is the backbone of Chinese transportation system,but its poor quality of services for passengers cause complains now and then.This study first analyzed the influencing factors of service quality on railway passenger,and its quality characteristics was also explained,and finally we proposed an evaluation system of service quality on railway passenger transport.Through the statistical analysis and processing of the basic information from survey data from railway station,trains and the official website of the ticket purchase,the evaluation score of question naire was converted into the score in evaluation index system,which was based on SERVQUAL model.Finally,the evaluation index system was applied to the field test,and all levels of indicators and the overall evaluation of railway passenger transport service quality was obtained.The relevant results show that the evaluation model of this study is concise and practical,and the method has certain practicability and promotion value,which is beneficial to the department of management supervision in railway transportation. | Huiwei Niu Jiao Yao Jing Zhao Jin Wang | 2019 | Journal on Big Data2019，1，1： | 1 |
| 18 | RcDhn5, a cold acclimation‐responsive dehydrin from Rhododendron catawbiense rescues enzyme activity from dehydration effects in vitro and enhances freezing tolerance in RcDhn5‐overexpressing Arabidopsis plants显示文摘 | YanhuiPeng Jose L.Reyes HuiWei YongilYang DaleKarlson Alejandra A.Covarrubias Stephen L.Krebs AnaniaFessehaie RajeevArora | 2008 | Physiologia Plantarum2008，，4： | 1 |
| 19 | Acetolactate synthase gene proline (197) mutations confer tribenuron-methyl resistance in flixweed (descurainia sophia) populations from China显示文摘 | Hai Lancui Chao Xianzhang Shou Huiwei Hong Junzhang Xiang Juli Yan Qiuzhang Gui Qiwang | 2011 | Weed Science2011，59，3： | 1 |
| 20 | State estimation for neural networks with mixed interval time-varying delays显示文摘 | Wang Huiwei Song Qiankun | 2010 | Neurocomputing2010，73，： | 1 |
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