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| 1 | Observation and analysis of near-surface atmospheric aerosol optical properties in urban Beijing显示文摘Year-round measurements of the mass concentration and optical properties of fine aerosols(PM_(2.5)) from June 2009 to May 2010 at an urban site in Beijing were analyzed.The annual mean values of the PM_(2.5) mass concentration,absorption coefficient(Ab),scattering coefficient(Sc) and single scattering albedo(SSA)at 525 nm were 67±66μg/m^3,64 ±62 Mm^(-1),360 ±405 Mm^(-1) and 0.82 ±0.09,respectively.The bulk mass absorption efficiency and scattering efficiency of the PM_(2.5) at 525 nm were 0.78 m^2/g and 5.55 m^2/g,respectively.The Ab and Sc showed a similar diurnal variation with a maximum at night and a minimum in the afternoon,whereas SSA displayed an opposite diurnal pattern.Significant increases in the Ab and Sc were observed in pollution episodes caused by the accumulation of pollutants from both local and regional sources under unfavorable weather conditions.Aerosol loadings in dust events increased by several times in the spring,which had limited effects on the Ab and Sc due to the low absorption and scattering efficiency of dust particles.The frequency of haze days was the highest in autumn because of the high aerosol absorption and scattering under unfavorable weather conditions.The daily PM_(2.5)concentration should be controlled to a level lower than 64 μg/m^3 to prevent the occurrence of haze days according to its exponentially decreased relationship with visibility. | Junshan Jing Yunfei Wu Jun Tao Huizheng Che Xiangao Xia Xiaochun Zhang Peng Yan Deming Zhao Leiming Zhang | 2015 | Particuology2015，13，1： | 16 |
| 2 | Effect of deleted pancreatic cancer locus 4 gene transfection on biological behaviors of human colorectal carcinoma cells显示文摘AIMS: To investigate the effect of deleted pancreatic cancer locus 4 (DPC4) gene transfection on biological behaviors of human colorectal carcinoma cells and the role of DPC4 gene in colorectal carcinogenesis.METHODS: PcDNA3.1-DPC4 plasmid was re-constructed by gene-recombination technology. SW620 cells, a human colorectal carcinoma cell line, were transfected with PcDNA3.1-DPC4 plasmid using lipofectamine transfecting technique. Transfected cells were selected with G418.Expression of Smad4 protein was detected in cells transfected with DPC4 gene by immunohistochemistry and Western blot. Biological characterristics of transfected cells were evaluated by population-doubling time and cloning efficiency. Alterations of percentage of S phage cells (S%) and apoptosis rate were determined by flowcytometry.RESULTS: PcDNA3.1-DPC4 plasmid was constructed successfully. SW620 cells transfected with PcDNA3.1-DPC4plasmid (DPC4+-SW620 cells) showed a strong intracellular expression of Smad4 protein, and the positive signal was localized in cytoplasm and nuclei, mainly in cytoplasm,where the expressions of Smad4 protein in SW620 cells transfected with PcDNA3.1 plasmid (PcDNA3.1-SW620 cells)and non-transfected SW620 cells (SW620 cells) were weaker than those in DPC4+-SW620 cells. The populationdoubling time in DPC4+-SW620 cells (116 h) was significantly longer than that in SW620 cells (31 h) and PcDNA3.1-Sw620 cells (29 h) (P<0.01). The cloning efficiencies of DPC4+-SW620 cells (12%) were markedly lower than those of SW620 cells (69%) and PcDNA3.1-Sw620 cells (67%) (P<0.01). Compared with SW620 cells and PcDNA3.1-Sw620 cells, the G0-G1% of DPC4+-SW620cells was obviously higher and the S% was markedly lower (P<0.05). Apoptosis rate of DPC4+-SW620 cells was significantly higher than that of SW620 cells and PcDNA3.1-SW620 cells.CONCLUSION: PcDNA3.1-DPC4 plasmid can be successfully re-constructed and stably transfected into human SW620 cells, thereby the cells can steadily express Smad4. DPC4protein may regulate proliferation of colorectal carcinoma cells by inhibiting cell growth and inducing cell apoptosis. | De-ShengXiao Ji-FangWen Jing-HeLi Zhong-LiangHu HuiZheng Chun-YanFu | 2005 | World Journal of Gastroenterology2005，11，3： | 11 |
| 3 | Hepatocyte transformation and tumor development induced by hepatitis C virus NS3 c-terminal deleted protein显示文摘AIM: To study the effect of hepatitis C virus nonstructural protein 3 c-terminal deleted protein (HCV NS3-5') on hepatocyte transformation and tumor development.METHODS: QSG7701 cells were transfected with plasmid pRcHCNS3-5' (expressing HCV NS3 c-terminal deleted protein) by lipofectamine and selected in G418. The expression of HCV NS3 gene and protein was determined by PCR and immunohistochemistry respectively. Biological behavior of transfected cells was observed through cell proliferation assay, anchorage-independent growth and tumor development in nude mice. The expression of HCV NS3 and c-mycproteins in the induced tumor was evaluated by immunohistochemistry.RESULTS: HCV NS3 was strongly expressed in QSG7701 cells transfected with plasmid pRcHCNS3-5' and the positive signal was located in cytoplasm. Cell proliferation assay showed that the population doubling time in pRcHCNS3-5' transfected cells was much shorter than that in pRcCMV and nontransfected cells (24 h, 26 h, 28 h respectively). The cloning ratio of cells transfected with pRcHCNS3-5; pRcCMV and nontransfected cells was 33 %, 1.46 %, 1.11%, respectively,the former one was higher than that in the rest two groups (P<0.01). Tumor development was seen in nude mice inoculated with pRcHCNS3-5' transfected cells after 15 days.HE staining showed its feature of hepatocarcinoma, and immunohistochemistry confirmed the expressions of HCV NS3and c-mycproteins in tumor tissue. The positive control group inoculated with HepG2 also showed tumor development, while no tumor developed in the nude mice injected with pRcCMV and non-transfected cells after 40 days.CONCLUSION: 1.HCV NS3 c-terminal deleted protein has transforming and oncogenic potential. 2. Human liver cell line QSG7701 may be used as a good model to study HCV NS3 pathogenesis. | Qiong-QiongHe Rui-XueCheng YiSun De-YunFeng Zhu-ChuChen HuiZheng | 2003 | World Journal of Gastroenterology2003，9，3： | 10 |
| 4 | Effect of hepatitis C virus nonstructural protein NS3 on proliferation and MAPK phosphorylation of normal hepatocyte line显示文摘AIM: To study the effect of hepatitis C virus nonstructural region 3 (HCV NS3) pro, in on proliferation and transformation of normal human liver cell line.METHODS: QSG7701 cells were transfected with pRcHCNS3-5; pRcHCNS3-3' and pRcCMV using lipofectamine transfecting technique and selected with G418 method. Expression of HCV NS3 protein was determined by immunohistochemistry. Biologic characteristics of transfected cells were evaluated by population doubling time and soft agar assays. Activation of MAPK was analyzed using Western blot with phosphospecific monoclonal antibody against dually phosphorylated MAPK.RESULTS: QSG7701 cells transfected with pRcHCNS3-5' showed strong intracellular expression of HCVNS3 protein,and the positive signal was localized in cytoplasm. The expressing strength of HCVNS3 protein in pRcHCNS3-3'-transfected cells was weaker than that in pRcHCNS3-5'-transfected cells. The population doubling time in the transfected cells with pRcHCNS3-5' (12 h) was much shorter than those with pRcHCNS3-3; pRcCMV and normal cells (24, 26, 28 h, respectively) (P<0.01). The transfected cells with pRcHCNS3-5' showed much more anchorage independent colonies than that in those with pRcHCNS3-3' and pRcCMV (P<0.01). The cloning efficiencies of transfected cells with pRcHCNS3-5', pRcHCNS3-3',pRcCMV and controls were 33%, 1.33%, 1.46%, 1.11% respectively. The level of phosphorylated MlAPK in the cells with pRcHCNS3-5' was much higher than that in those with pRcHCNS3-3'and pRcCMV and normal cells (P<0.01). CONCLUSION: The results suggest that (1) QSG7701 cells are a better human liver cell line for investigating the pathogenesis of HCV NS3 protein. (2) 5' region of the HCV genome segment encoding HCV NS3 is involved in cell growth and cell phenotype. (3) HCV NS3 N-terminalpeptide may up-regulate the activation of rMAPK, but not affect the expression of MAPK. | De-YunFeng YiSun Rui-XueCheng Xiao-MingOuyang HuiZheng | 2005 | World Journal of Gastroenterology2005，11，14： | 8 |
| 5 | Comparison of Two Air Pollution Episodes over Northeast China in Winter 2016/17 Using Ground-Based Lidar显示文摘This study analyzes and compares aerosol properties and meteorological conditions during two air pollution episodes in 19–22(E1) and 25–26(E2) December 2016 in Northeast China. The visibility, particulate matter(PM) mass concentration, and surface meteorological observations were examined, together with the planetary boundary layer(PBL) properties and vertical profiles of aerosol extinction coefficient and volume depolarization ratio that were measured by a ground-based lidar in Shenyang of Liaoning Province, China during December 2016–January 2017.Results suggest that the low PBL height led to poor pollution dilution in E1, while the high PBL accompanied by low visibility in E2 might have been due to cross-regional and vertical air transmission. The PM mass concentration decreased as the PBL height increased in E1 while these two variables were positively correlated in E2. The enhanced winds in E2 diffused the pollutants and contributed largely to the aerosol transport. Strong temperature inversion in E1 resulted in increased PM2.5 and PM10 concentrations, and the winds in E2 favoured the southwesterly transport of aerosols from the North China Plain into the region surrounding Shenyang. The large extinction coefficient was partially attributed to the local pollution under the low PBL with high ground-surface PM mass concentrations in E1,whereas the cross-regional transport of aerosols within a high PBL and the low PM mass concentration near the ground in E2 were associated with severe aerosol extinction at high altitudes. These results may facilitate better understanding of the vertical distribution of aerosol properties during winter pollution events in Northeast China. | Yanjun MA Hujia ZHAO Yunsheng DONG Huizheng CHE Xiaoxiao LI Ye HONG Xiaolan LI Hongbin YANG Yuche LIU Yangfeng WANG Ningwei LIU Cuiyan SUN | 2018 | Journal of Meteorological Research2018，32，2： | 5 |
| 6 | Estimation and inter-comparison of dust aerosols based on MODIS, MISR and AERONET retrievals over Asian desert regions显示文摘This study presents detailed analysis of spatiotemporal variations and trend of dust optical properties i.e., Aerosol Optical Depth(AOD) and Angstrom component over Asian desert regions using thirteen years of data(i.e., 2001–2013) retrieved from Aerosol Robotic Network(AERONET), Moderate Resolution Imaging Spectroradiometer(MODIS) and Multi-angle Imaging Spectroradiometer(MISR). These regions include Solar Village, Dunhuang and Dalangzadgad and are considered as origin of desert aerosols in Asia. Mann–Kendall trend test was used to show the trend of AOD. The relationship of AOD with weather parameters and general AOD trend over different wavelengths has also been shown. AOD's trend has been observed significant throughout the year in Solar Village, while in Dunhuang and Dalanzadgad the significant trend has been found only in peak period(March–June).Analysis show high values of AOD and low values of angstrom in Solar Village during peak period. In Chinese desert regions, high values of AOD have been found during peak period and low values in pre-peak period. Significant relationship has been observed between AOD and average temperature in Solar Village and Dalanzadgad whereas rainfall and wind speed showed no significant impact on AOD in all desert regions. | Ammara Habib Bin Chen Bushra Khalid Saichun Tan Huizheng Che Tariq Mahmood Guangyu Shi Muhammad Tahir Butt | 2019 | Journal of Environmental Sciences2019，31，2： | 5 |
| 7 | Case study of longwave contribution to dust radiative effects over East Asia显示文摘In order to evaluate the impacts of LW contribution to aerosol radiative effects over East Asia,a dust longwave radiative parameterization scheme is integrated into the online mesoscale dust forecasting model GRAPES_CUACE/dust.A case modeling study shows that about half at surface and one third at TOA of the dust negative shortwave radiative forcing are cancelled by its positive longwave forcing over the dust affected area.In the dust layer,longwave radiation emitting by dust cools the atmosphere,which counteracts about 17%of shortwave heating of atmosphere during daytime and results in cooling of atmosphere simply during nighttime.At the same time,the atmosphere beyond the dust layer is warmed because of absorbing the LW radiation emitted by dust layer.Dust longwave contribution exerts more evident impact on the air temperature in lower atmosphere and surface.The surface air temperature cooling rate resulting from the dust solar radiation is cancelled about 40%by dust longwave warming at daytime.At nighttime,dust longwave contribution warms land and sea surface.The online calculation of dust LW radiation reduces about 15%relative errors of predicted AOD based on the dust model with only SW radiative feedback.This case study result suggests that dust longwave contribution has important impacts on the earth-atmosphere energy process,especially on the surface and in the lower atmosphere and should not be neglected in the study of dust radiation effects. | WANG Hong SHI GuangYu ZHU Jing CHEN Bin CHE HuiZheng ZHAO TianLiang | 2013 | Chinese Science Bulletin2013，58，30： | 4 |
| 8 | Applying the WRF Double-Moment Six-Class Microphysics Scheme in the GRAPES_Meso Model: A Case Study显示文摘This study incorporated the Weather Research and Forecasting(WRF) model double-moment 6-class(WDM6) microphysics scheme into the mesoscale version of the Global/Regional Assimilation and Pr Ediction System(GRAPES_Meso). A rainfall event that occurred during 3–5 June 2015 around Beijing was simulated by using the WDM6, the WRF single-moment 6-class scheme(WSM6), and the NCEP 5-class scheme, respectively. The results show that both the distribution and magnitude of the rainfall simulated with WDM6 were more consistent with the observation. Compared with WDM6, WSM6 simulated larger cloud liquid water content, which provided more water vapor for graupel growth, leading to increased precipitation in the cold-rain processes. For areas with the warmrain processes, the sensitivity experiments using WDM6 showed that an increase in cloud condensation nuclei(CCN)number concentration led to enhanced CCN activation ratio and larger cloud droplet number concentration(Nc) but decreased cloud droplet effective diameter. The formation of more small-size cloud droplets resulted in a decrease in raindrop number concentration(Nr), inhibiting the warm-rain processes, thus gradually decreasing the amount of precipitation. For areas mainly with the cold-rain processes, the overall amount of precipitation increased; however, it gradually decreased when the CCN number concentration reached a certain magnitude. Hence, the effect of CCN number concentration on precipitation exhibits significant differences in different rainfall areas of the same precipitation event. | Meng ZHANG Hong WANG Xiaoye ZHANG Yue PENG Huizheng CHE | 2018 | Journal of Meteorological Research2018，32，2： | 3 |
| 9 | RELATIONSHIP BETWEEN HORIZONTAL EXTINCTION COEFFICIENT AND PM_(10) CONCENTRATION IN XI'AN,CHINA,DURING 1980-2002显示文摘Based on daily visibility data obtained from 1980-2002 and air pollution index data from 2001-2004 in Xi’an, long-term variations and relationships for daily horizontal extinction coefficient and mass concentration of PM10 have been evaluated. A decreasing trend was found in horizontal extinction coefficient during the past 23 years, with higher values observed in 1980s relative to 1990s, and the highest and lowest values in winter and summer, respectively. Significant correlation and similar seasonal variations existed between horizontal extinction coefficient and PM10 concentration, suggesting the high influence of PM10 to the visibility drop at a site in the Guanzhong Plain of central China during the past two decades. | Huizheng Che Xiaoye Zhang Yang Li Zijiang Zhou Zhenlin Chen | 2006 | China Particuology2006，4，6： | 3 |
| 10 | Effects of droplet size and spray volume parameters on droplet deposition of wheat herbicide application by using UAV显示文摘With the characteristic of flexible and precise,unmanned aerial vehicles(UAVs)for low volume applications are increasing substantially and quickly around the globe.However,little attention has been paid to the study of wheat herbicides with UAV,especially the research on the spray volume and droplet size of the herbicide sprayed by UAVs.The objectives of this study were to compare the droplet deposition from a typical commercial UAV under four different spray volumes of 7.5 L/hm2,15.0 L/hm2,22.5 L/hm2,and 30.0 L/hm2 and three different volume median diameter(VMD)of 150μm,200μm,and 300μm during winter wheat weeding period.DepositScan software was used to analyze droplet deposition parameters including the percentage of spray coverage and the number of droplets in various sampling positions.The test results showed that the droplet deposition waseffected by each factor andtheirinteractions.When the spray volume was 7.5 L/hm2,the effect of VMD on the percentage of spray coverage was not significant.However,these variation rules were changed to smaller droplets with greater coverage when the spray volume higher than 15.0 L/hm2.In all treatments,the number of droplets increased with decreasing VMD or increasing spray volume.The maximum percentage of spray coverage and the number of droplets that were achieved under the VMD of 150μm and the spray volume of 30.0 L/hm2 were 12.8%and 40.0 droplets/cm2,respectively.The variation coefficients of the percentage of spray coverage and the number of droplets were 29.0%-73.3%and 20.2%-54.1%,respectively.The most uniform deposition was achieved under the spray volume of 15.0 L/hm2and the VMD of 150μm.The results revealed the effect of droplet size and spray volume parameters on droplet deposition,which was useful for guiding farmers on how to use UAVs for weeding in winter wheat fields. | Changfeng Shan Guobin Wang Haihong Wang Yingjie Xie Huizheng Wang Shilong Wang Shengde Chen Yubin Lan | 2021 | International Journal of Agricultural and Biological Engineering2021，14，1： | 3 |
| 11 | Research Progress on Estimation of the Atmospheric Boundary Layer Height显示文摘Atmospheric boundary layer height(ABLH)is an important parameter used to depict characteristics of the planetary boundary layer(PBL)in the lower troposphere.The ABLH is strongly associated with the vertical distributions of heat,mass,and energy in the PBL,and it is a key quantity in numerical simulation of the PBL and plays an essential role in atmospheric environmental assessment.In this paper,various definitions and methods for deriving and estimating the ABLH are summarized,from the perspectives of turbulent motion,PBL dynamics and thermodynamics,and distributions of various substances in the PBL.Different methods for determining the ABLH by means of direct observation and remote sensing retrieval are reviewed,and comparisons of the advantages and disadvantages of these methods are presented.The paper also summarizes the ABLH parameterization schemes,discusses current problems in the estimation of ABLH,and finally points out the directions for possible future breakthroughs in the ABLHrelated research and application. | Hongsheng ZHANG Xiaoye ZHANG Qianhui LI Xuhui CAI Shaojia FAN Yu SONG Fei HU Huizheng CHE Jiannong QUAN Ling KANG Tong ZHU | 2020 | Journal of Meteorological Research2020，34，3： | 3 |
| 12 | Optical and Radiative Properties of Aerosols during a Severe Haze Episode over the North China Plain in December 2016显示文摘The optical and radiative properties of aerosols during a severe haze episode from 15 to 22 December 2016 over Beijing, Shijiazhuang, and Jiaozuo in the North China Plain were analyzed based on the ground-based and satellite data, meteorological observations, and atmospheric environmental monitoring data. The aerosol optical depth at 500 nm was < 0.30 and increased to > 1.4 as the haze pollution developed. The ?ngstr?m exponent was > 0.80 for most of the study period. The daily single-scattering albedo was > 0.85 over all of the North China Plain on the most polluted days and was > 0.97 on some particular days. The volumes of fine and coarse mode particles during the haze event were approximately 0.05–0.21 and 0.01–0.43 μm3, respectively—that is, larger than those in the time without haze. The daily absorption aerosol optical depth was about 0.01–0.11 in Beijing, 0.01–0.13 in Shijiazhuang, and0.01–0.04 in Jiaozuo, and the average absorption ?ngstr?m exponent varied between 0.6 and 2.0. The aerosol radiative forcing at the bottom of the atmosphere varied from –23 to –227, –34 to –199, and –29 to –191 W m–2 for the whole haze period, while the aerosol radiative forcing at the top of the atmosphere varied from –4 to –98, –10 to –51,and –21 to –143 W m–2 in Beijing, Shijiazhuang, and Jiaozuo, respectively. Satellite observations showed that smoke,polluted dust, and polluted continental components of aerosols may aggravate air pollution during haze episodes. The analysis of the potential source contribution function and concentration-weighted trajectory showed that the contribution from local emissions and pollutants transport from upstream areas were 190–450 and 100–410 μg m^(–3), respectively. | Yu ZHENG Huizheng CHE Leiku YANG Jing CHEN Yaqiang WANG Xiangao XIA Hujia ZHAO Hong WANG Deying WANG Ke GUI Linchang AN Tianze SUN Jie YU Xiang KUANG Xin LI Enwei SUN Dapeng ZHAO Dongsen YANG Zengyuan GUO Tianliang ZHAO Xiaoye ZHANG | 2017 | Journal of Meteorological Research2017，31，6： | 2 |
| 13 | Recent Progress in Atmospheric Chemistry Research in China: Establishing a Theoretical Framework for the “Air Pollution Complex”显示文摘Atmospheric chemistry research has been growing rapidly in China in the last 25 years since the concept of the“air pollution complex”was first proposed by Professor Xiaoyan TANG in 1997.For papers published in 2021 on air pollution(only papers included in the Web of Science Core Collection database were considered),more than 24000 papers were authored or co-authored by scientists working in China.In this paper,we review a limited number of representative and significant studies on atmospheric chemistry in China in the last few years,including studies on(1)sources and emission inventories,(2)atmospheric chemical processes,(3)interactions of air pollution with meteorology,weather and climate,(4)interactions between the biosphere and atmosphere,and(5)data assimilation.The intention was not to provide a complete review of all progress made in the last few years,but rather to serve as a starting point for learning more about atmospheric chemistry research in China.The advances reviewed in this paper have enabled a theoretical framework for the air pollution complex to be established,provided robust scientific support to highly successful air pollution control policies in China,and created great opportunities in education,training,and career development for many graduate students and young scientists.This paper further highlights that developing and low-income countries that are heavily affected by air pollution can benefit from these research advances,whilst at the same time acknowledging that many challenges and opportunities still remain in atmospheric chemistry research in China,to hopefully be addressed over the next few decades. | Tong ZHU Mingjin TANG Meng GAO Xinhui BI Junji CAO Huizheng CHE Jianmin CHEN Aijun DING Pingqing FU Jian GAO Yang GAO Maofa GE Xinlei GE Zhiwei HAN Hong HE Ru-Jin HUANG Xin HUANG Hong LIAO Cheng LIU Huan LIU Jianguo LIU Shaw Chen LIU Keding LU Qingxin MA Wei NIE Min SHAO Yu SONG Yele SUN Xiao TANG Tao WANG Tijian WANG Weigang WANG Xuemei WANG Zifa WANG Yan YIN Qiang ZHANG Weijun ZHANG Yanlin ZHANG Yunhong ZHANG Yu ZHAO Mei ZHENG Bin ZHU Jiang ZHU | 2023 | Advances in Atmospheric Sciences2023，40，8： | 2 |
| 14 | Cloning of Rabbit HPRT Gene Using the Recombineering System显示文摘次黄嘌呤 phosphoribosyltransferase ( HPRT )在嘌呤的新陈代谢的抢救起一个重要作用,并且在 manystudies.To 为变异的选择用作一条其他的小径在兔子便于它的申请,我们用联合的一条途径克隆 cDNA 和兔子 HPRT 基因的 genomic DNA 生物信息学并且重新结合 ering 方法。由为 218 氨基酸的蛋白质包含一个编码序列的 1449 bp 组成的 cDNAis。兔子 HPRT 基因的推出的氨基酸顺序与人,老鼠,猪和牛 HPRT 基因分享 98%,97%,98% 和 94% 身份, respectively.Reverse 抄写聚合酶链反应分析证明这基因无所不在地在成年兔子的纸巾被表示。兔子 HPRT 基因在长度跨越约 48 kb 并且由在克隆大尺寸的基因兔子 HPRT 基因表演克隆 recombine ering 系统的实用性的九 exons.The 组成。这个系统可以便于为克隆大尺寸的基因或在定序的 genomic 充满大差距从细菌的人工的染色体 DNA 克隆的潜水艇。 | Jianjun SHI Donghui CAI Xuejin CHEN Huizheng SHENG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，8： | 2 |
| 15 | Robust prediction of hourly PM_(2.5) from meteorological data using LightGBM显示文摘Retrieving historical fine particulate matter(PM_(2.5))data is key for evaluating the long-term impacts of PM_(2.5) on the environment,human health and climate change.Satellite-based aerosol optical depth has been used to estimate PM_(2.5),but estimations have largely been undermined by massive missing values,low sampling frequency and weak predictive capability.Here,using a novel feature engineering approach to incorporate spatial effects from meteorological data,we developed a robust Light GBM model that predicts PM_(2.5) at an unprecedented predictive capacity on hourly(R^(2)=0.75),daily(R^(2)=0.84),monthly(R^(2)=0.88)and annual(R^(2)=0.87)timescales.By taking advantage of spatial features,our model can also construct hourly gridded networks of PM_(2.5).This capability would be further enhanced if meteorological observations from regional stations were incorporated.Our results show that this model has great potential in reconstructing historical PM_(2.5) datasets and real-time gridded networks at high spatial-temporal resolutions.The resulting datasets can be assimilated into models to produce long-term re-analysis that incorporates interactions between aerosols and physical processes. | Junting Zhong Xiaoye Zhang Ke Gui Yaqiang Wang Huizheng Che Xiaojing Shen Lei Zhang Yangmei Zhang Junying Sun Wenjie Zhang | 2021 | National Science Review2021，8，10： | 2 |
| 16 | Hepatitis B screening, prophylaxis and re‐activation in the era of rituximab‐based chemotherapy显示文摘 | JorgeMéndez‐Navarro Kathleen E.Corey HuiZheng Lydia L.Barlow Jae YoungJang WenyuLin HongZhao Run‐XuanShao Steven L.McAfee Raymond T.Chung | 2011 | Liver International2011，，3： | 2 |
| 17 | Haze trends over the capital cities of 31 provinces in China, 1981–2005显示文摘 | Huizheng Che Xiaoye Zhang Yang Li Zijiang Zhou John J. Qu Xianjun Hao | 2009 | Theoretical and Applied Climatology (-)2009，，3： | 1 |
| 18 | Effects of Chronic Stress and Phenytoin on the Long-term Potentiation (LTP) in Rat Hippocampal CA1 Region显示文摘To investigate the changes of LTP in hippocampal CA1 region induced by chronic stress and the effect of phenytoin on them, thirty-two adult male Sprague-Dawley rats were randomly divided equally into four groups: control group, control-phenytoin group, stress-saline group and stress-phenytoin group. Isolated hippocampal slices of rats were used to observe the changes of long-term potentiation (LTP) in hippocampal CA1 field using electrophysiological technique. Amplitude of population spike (PS) and field excitatory postsynaptic potentials (fEPSPs) slope were used to indicate the changes of LTP. High-frequency stimulation (HFS) was applied to Schaffer collaterals of hippocampal CA3 field, and the changes of PS amplitude and fEPSPs slope in CA1 field were observed. The results showed that the LTP induction rate, the increases of PS amplitude and fEPSPs slope after HFS in control and stress-phenytoin groups were significantly greater than those in stress-saline group (P<0.05). There were no significant differences between control group and stress- phenytoin group or between control and control-phenytoin groups in these indexes (P>0.05). It is suggested that chronic stress can damage the development of LTP in hippocampal CA1 field, while phenytoin can protect the LTP of stressed hippocampal slices in normal state. | HuiZHENG QuanYANG Chong-TaoXU | 2004 | Acta Biochimica et Biophysica Sinica2004，36，5： | 1 |
| 19 | Spatial and temporal distribution of the cloud optical depth over China based on MODIS satellite data during 2003–2016显示文摘The cloud optical depth(COD) is one of the important parameters used to characterize atmospheric clouds. We analyzed the seasonal variations in the COD over East Asia in 2011 using cloud mode data from the AERONET(Aerosol Robotic Network) ground-based observational network. The applicability of the MODIS(Moderate Resolution Imaging Spectroradiometer) COD product was verified and compared with the AERONET cloud mode dataset. There was a good correlation between the AERONET and the MODIS. The spatial and temporal distribution and trends in the COD over China were then analyzed using MODIS satellite data from 2003 to 2016. The seasonal changes in the AERONET data and the time sequence variation of the satellite data suggest that the seasonal variations in the COD are significant. The result shows that the COD first decreases and then increases with the season in northern China, and reaches the maximum in summer and minimum in winter.However, the spatial distribution change is just the opposite in southern China. The spatial variation trend shows the COD in China decreases first with time and gradually increases after 2014. And the trend of COD in the western and central China is consistent with that in China. While the trend of COD shows a continuously increasing over time in northeast China and the Pearl River Delta. | Xiaopan Li Huizheng Che Hong Wang Xiang'ao Xia Quanliang Chen Ke Gui Hujia Zhao Linchang An Yu Zheng Tianze Sun Zhizhong Sheng Chao Liu Xiaoye Zhang | 2019 | Journal of Environmental Sciences2019，31，6： | 1 |
| 20 | Identification and characterization of multiple subtypes of muscarinic acetylcholine receptors and their physiological functions in canine hearts 显示文摘 | Hong S HuiZheng W Zhiguo W | 1999 | Molecular Pharmacol1999，55，： | 1 |
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