3篇
您的检索式：作者名="Huibing Lu"
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| 1 | Asymmetric Michael Reaction of Aldehydes with 13 - Nitroalkenes Catalyzed by Pyrrolidine - Camphor Derived OrganiC atalysts Bearing Hydrogen - Bond Donors 显示文摘 | Jiang Weng Huibing Ai Renshi Luo Gui Lu | 2012 | Chirality2012，24，： | 1 |
| 2 | Molybdenum Oxynitride Atomic Nanoclusters Bonded in Nanosheets of N-Doped Carbon Hierarchical Microspheres for Efficient Sodium Storage显示文摘Transition metal nitrides have attracted considerable attention as great potential anode materials due to their excellent metallic conductivity and high theoretical specific capacity.However,their cycling performance is impeded by their instability caused by the reaction mechanism.Herein,we report the engineering and synthesis of a novel hybrid architecture composed of MoO2.0N0.5 atomic nanoclusters bonded in nanosheets of N-doped carbon hierarchical hollow microspheres(MoO2.0N0.5/NC)as an anode material for sodium-ion batteries.The facile self-templating strategy for the synthesis of MoO2.0N0.5/NC involves chemical polymerization and subsequent one-step calcination treatments.The design is benefi-cial to improve the electrochemical kinetics,buffer the volume variation of electrodes during cycling,and provide more interfacial active sites for sodium uptake.Due to these unique structural and compositional merits,these MoO2.0N0.5/NC exhibits excellent sodium storage performance in terms of superior rate capability and stable long cycle life.The work shows a feasible and effective way to design novel host candidates and solve the long-term cycling stability issues for sodium-ion batteries. | Xiaona Pan Baojuan Xi Huibing Lu Zhengchunyu Zhang Xuguang An Jie Liu Jinkui Feng Shenglin Xiong | 2022 | Nano-Micro Letters2022，14，10： | 1 |
| 3 | Thymidylate synthase confers pemetrexed resistance of non-small cell lung cancer cells by EGFR/PI3K/AKT pathway显示文摘Chemotherapy drug resistance is the main cause leading to the relapse and metastasis of non-small cell lung cancer(NSCLC)patients.Our study aimed to investigate the mechanism of pemetrexed resistance in NSCLC.Firstly,the pemetrexed(PEM)-resistant PC-9 and A549 lung adenocarcinoma cell lines(PC-9/PEM and A549/PEM)were established.The expression of thymidylate synthase(TS)in PC-9/PEM,A549/PEM,A549,and PC-9 cells were analyzed by qRT-PCR and western blot.Then,cell viability,colony formation,migration,and invasion were performed on PEM-resistant cells transfected with TS siRNA.The role of EGFR in PEM resistance of PEM-resistant cells was investigated using EGFR siRNA.The effects of gefitinib and EGFR siRNA on EGFR/PI3K/AKT pathway and downstream signaling Cyclin D1 and E2F1 in PEM-resistant cells were analyzed.Results showed that the protein level of TS was significantly increased in A549/PEM and PC-9/PEM.TS knockdown inhibited the potency of proliferation,colony-forming potential,migration,and invasion in PEM-resistant cells.EGFR knockdown abrogated the resistance to PEM of PEM-resistant cells and suppressed the migration and invasion of PEM-resistant cells.Gefitinib treatment and EGFR knockdown respectively inhibited the EGFR/PI3K/AKT pathway and downregulated Cyclin D1 and E2F1 in PEM-resistant cells.Thus,TS might be a predictive marker for PEM resistance in NSCLC.Inhibition of the EGFR pathway abrogated the resistance to PEM and inhibited the EGFR/PI3K/AKT and downstream signaling of PEM-resistant NSCLC cell lines. | DAN ZHANG HAIJING LIU ZHENNAN YI YUANYUAN LU YANYAN CHEN WEIQIANG SU HUIBING LIN ZHIHUI ZHANG WEI LEI | 2021 | BIOCELL2021，45，3： | 0 |
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