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| 1 | Dynamic immune profiling identifies the stronger graft-versus-leukemia (GVL) effects with haploidentical allografts compared to HLA-matched stem cell transplantation显示文摘Haploidentical stem cell transplantation(haplo-SCT)achieves superior or at least comparable clinical outcomes to HLA-matched sibling donor transplantation(MSDT)in treating hematological malignancies.To define the underlying regulatory dynamics,we analyzed time courses of leukemia burden and immune abundance of haplo-SCT or MSDT from multiple dimension.First,we employed two nonirradiated leukemia mouse models which carried human AML-ETO or MLL-AF9 fusion gene to establish haplo-identical and major histocompatibility(MHC)-matched transplantation models and investigated the immune cell dynamic response during leukemia development in vivo.We found that haplo-matching the MHCs of leukemia cells with recipient mouse T cells prolonged leukemic mice survival and reduced leukemia burden.The stronger graft-versus-leukemia activity in haplo-SCT group mainly induced by decreased apoptosis and increased cytotoxic cytokine secretion including tumor necrosis factor–α,interferon-γ,pore-forming proteins and CD107a secreted by T cells or natural killer cells.Furthermore,we conducted a prospective clinical trial which enrolled 135 patients with t(8;21)acute myeloid leukemia that displayed minimal residual disease before transplantation and underwent either haplo-SCT or MSDT.The results showed that the haplo-SCT slowed the kinetics of the leukemia burden in vivo and reduced the cumulative incidence of relapse compared with MSDT.Ex vivo experiments showed that,1 year after transplantation,cytotoxic T lymphocytes from the haplo-SCT group had higher cytotoxicity than those from the MSDT group during the same period.Our results unraveled the role of immune cells in superior antileukemia effects of haplo-SCT compared with MSDT. | Huidong Guo Ying-Jun Chang Yan Hong Lan-Ping Xu Yu Wang Xiao-Hui Zhang Ming Wang Huan Chen Yu-Hong Chen Feng-Rong Wang Wei-Han Yu-Qian Sun Chen-Hua Yan Fei-Fei Tang Xiao-Dong Mo Kai-Yan Liu Xiao-Jun Huang | 2021 | Cellular & Molecular Immunology2021，18，5： | 11 |
| 2 | Novel nanoporous binary Ag-Ni electrocatalysts for hydrazine oxidation显示文摘From an aqueous mixture of Ag(I)-EDTA complex and Ni(II) nitrate, silver and nickel particles were co-deposited on the surface of titanium substrates by the hydrothermal method using hydrazine hydrate as a reduction agent. The prepared titanium-supported nano-scale Ag and Ag-Ni particles (nano Ag/Ti, nano Ag86Ni14/Ti, nano Ag77Ni23/Ti, and nano Ag74Ni26/Ti) exhibit nanoporous 3D network textures. Their electrocatalytic activity towards hydrazine oxidation in alkaline solutions was evaluated by cyclic voltammetry and chronoamperometry. The results show that the four samples present a low onset potential of ca. -0.60 V vs. SCE and considerably high and stable anodic current densities for hydrazine oxidation. Among them, the nano Ag86Ni14/Ti electrode exhibits the highest anodic current density towards hydrazine oxidation, showing an increment of electro-active sites on the nano Ag86Ni14/Ti due to the addition of Ni to Ag particles. | YI Qingfeng, LI Lei, YU Wenqiang, LIU Xiaoping, ZHOU Zhihua, and NIE Huidong School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China | 2010 | Rare Metals2010，29，1： | 3 |
| 3 | Microstructure control of organic semiconductors via UV-ozone for high-sensitivity NO2 detection显示文摘Developing high sensitive organic semiconductors(OSCs)in organic thin-film transistors(OTFTs)is the key for OTFT based gas sensors.Herein,we report a simple processing route of highly sensitive OSCs for high performance OTFT based nitrogen dioxide(NO2)sensors,where the active OSC layer is based on ultraviolet-ozone(UVO)treated poly(3-hexylthiophene-2,5-diyl)(P3HT).Compared to conventional P3HT based OTFT sensors,the reported device exhibits a remarkable improvement of the gas response from 350%to 30000%.The studies in morphologies,chemical compositions and microstructures of the UVOtreated films reveal that a large number of carrier traps generated in the P3HT films is the decisive reason for the enhancement of sensing performance.Moreover,the optimized device shows great potential of practical applications on the stand points of sensitivity,selectivity,reusability and the ability of recovery,as well as limit of detection of~7.3 ppb.This simple method provides an innovative understanding for the role of the carrier traps in sensing performance and demonstrates a bright future for developing high performance OTFT gas sensors. | HOU SiHui FAN HuiDong WU MengGe YU XinGe YU JunSheng | 2021 | Science China(Technological Sciences)2021，64，5： | 2 |
| 4 | Development of a rapid test kit for SARS-CoV-2:an example of product design显示文摘We present an example of applying'need-driven'product design principle to the development of a rapid test kit to detect SARS-COV-2(COVID-19).The tests are intended for use in the field and,longer term,for home use.They detect whether a subject is currently infected with the virus and is infectious.The urgent need for large numbers of tests in field setting imposes constraints such as short test time and lack of access to specialist equipment,laboratories and skilled technicians to perform the test and interpret results.To meet these needs,an antigen test based on RT-LAMP with colorimetric readout was chosen.Direct use of swab sample with no RNA extraction was explored.After extensive experimental study(reported elsewhere),a rapid test kit has been fabricated to satisfy all design criteria. | Zhanfeng Cui Hong Chang Hui Wang Boon Lim Chia-Chen Hsu Yejiong Yu Huidong Jia Yun Wang Yida Zeng Mengmeng Ji Weizhi Liu Catriona Inverarity Wei E.Huang | 2020 | Bio-Design and Manufacturing2020，3，2： | 1 |
| 5 | Jupiter system exploration trajectory design: Summary of the winning solution at CTOC10显示文摘This paper presents the methods and results submitted by the winning team from Harbin Institute of Technology of the 10th China Trajectory Optimization Competition(CTOC10).The problem posed by CTOC10 requires exploring the Jupiter system using a combined spacecraft.The exploration mission consists of the detection of Jupiter’s magnetic field and an exploration of the Galilean moons.The mission is completed through three steps:problem analysis,orbital design process,and data processing.The orbital design process is mainly divided into four parts,namely,repeating groundtrack orbit design,gravity-assisted orbit design,initial orbit parameter selection,and local optimization adjustment.The designed orbit is then evaluated using a heuristic optimization algorithm applied during the data processing.Finally,six full-coverage observations of Jupiter’s magnetic field are realized under the constraints of fuel and time.The final index of the submitted result is 357.8067. | Haiyang Zhang Yabo Hu Zichen Fan Jie Lv Huidong Ma Ze Yu Mingying Huo Gang Zhang | 2021 | Astrodynamics2021，5，1： | 1 |
| 6 | Facile construction of aggregation-induced emission molecular liquids via Piers-Rubinsztajn reaction for green fluorescent ink显示文摘Solvent-free luminescent molecular liquids(LMLs), which exhibit nonvolatile fluidic nature and active optoelectronic properties, were widely used. For further development, we introduced siloxane units into AIE molecules, designed and synthesized TPE derivatives with siloxane side chains via facile Piers-Rubinsztajn reaction. The obtained AIE molecular liquids exhibit unique photophysical properties. Compared with the obtained alkyl TPE-solids, siloxane TPE show liquid state, which proves that the siloxane units have stronger liquefaction effect than alkyl. Viscosity test shows that siloxane TPE-liquids has far more lower viscosity and better fluidity than the long-chain alkyl molecular liquids in previous research. All those properties are attributed to the weak interaction between flexible molecular chains of siloxane. Besides,fluorescence test shows temperature responsiveness of siloxane TPE-liquids. We developed this lowviscosity nonvolatile AIE molecular liquid as green fluorescent ink. | Rong Fu Longyue Yu Junying Zhang Huidong Yu Shengyu Feng Xing-Dong Xu | 2022 | Chinese Chemical Letters2022，33，4： | 0 |
| 7 | Petrological evidence of kaolinite transformation to dawsonite显示文摘Clay minerals,especially authigene kaolinite,are abundant in the dawsonite-bearing sandstone from the Gudian and Qian'an regions in the southern Songliao Basin. The relationship between dawsonite and kaolinite has been investigated based on drilling data from 50 wells in the Jilin Oil Field and petrological characteristics analyses on 23 core samples from the Gudian and Qian'an regions. The study revealed a negative relationship between the content of dawsonite and kaolinite,suggesting that kaolinite was replaced by the dawsonite. Combined with thermodynamics and geochemical analysis published previously,it is concluded that kaolinite is unstable under CO2 -rich environments and can transform into dawsonite. | GUI Lily LIU Li YU Miao LIU Na YANG Huidong ZHANG Yongmei | 2012 | Global Geology2012，15，2： | 0 |
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