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| 1 | Prevalence of Atrial Fibrillation in China and Its Risk Factors显示文摘Objective To study the prevalence of atrial fibrillation(AF)and the relation with its risk factors in China.Methods A total of 19 363 participants(8635 males and 10 728 females) aged ≥35 years in geographically dispersed urban and rural regions of China were included in this cross-sectional survey.All participants received questionnaire,physical and blood examination.Echocardiography were performed for AF patients found in the survey.Results Of the 19 363 participants,199 were diagnosed with AF.The estimated age-standardized prevalence of AF was 0.78% in men and 0.76% in women.The prevalence of AF in participants aged <60 years was 0.41% in men and 0.43% in women,and was 1.83% in both men and women aged ≥60 years.About 19.0% of males and 30.9% of females with AF were diagnosed with valve disease.Age-and sex-adjusted multivariable logistic regression analysis revealed that myocardial infarction,left ventricular hypertrophy(LVH),obesity,and alcohol consumption were associated with a increased risk of AF(P<0.05).Conclusion The age standardized prevalence of AF is 0.77% in the participants enrolled in the present study.The number of AF cases aged ≥35 years is 5.26 million according to 2010 Chinese Census.Most risk factors for AF,identified mainly in Western countries,are also detected in China. | LI Ying WU Yang Feng CHEN Ke Ping LI Xian ZHANG Xing XIE Gao Qiang WANG Fang Zheng ZHANG Shu | 2013 | Biomedical and Environmental Sciences2013，26，9： | 48 |
| 2 | Microbial Community Characteristics in a Degraded Wetland of the Yellow River Delta显示文摘Five different sites with a soluble salt gradient of 3.0-17.7 g kg-1 dry soil from the coast to the inland were selected, and the microbial population size, activity and diversity in the rhizospheres of five common plant species and the adjacent bulk soils (non-rhizosphere) were compared in a degraded wetland of the Yellow River Delta, Shandong Province, China to study the effiects of soil environment (salinity, seasonality, depth, and rhizosphere) on microbial communities and the wetland's ecological function, thus providing basic data for the bioremediation of degraded wetlands. There was a significant negative linear relationship between the salinity and the total number of microorganisms, overall microbial activity, or culturable microbial diversity. Salinity adversely affected the microbial community, and higher salinity levels resulted in smaller and less active microbial communities. Seasonal changes were observed in microbial activity but did not occur in the size and diversity. The microbial size, activity and diversity decreased with increasing soil depth. The size, activity and diversity of culturable microorganisms increased in the rhizospheres. All rhizospheres had positive effiects on the microbial communities, and common seepweed had the highest rhizosphere effect. Three halophilic bacteria (Pseudomonas mendocina, Burkholderia glumae, and Acinetobacter johnsonii) were separated through BIOLOG identification, and common seepweed could be recommended for bioremediation of degraded wetlands in the Yellow River Delta. | WANG Zhen-Yu XIN Yuan-Zheng GAO Dong-Mei LI Feng-Min J. MORGAN XING Bao-Shan | 2010 | Pedosphere2010，20，4： | 28 |
| 3 | Biodegradation of Crude Oil in Contaminated Soils by Free and Immobilized Microorganisms显示文摘The effciencies of free and immobilized bacterial cultures of petroleum hydrocarbon degraders were evaluated and compared in this study. Hydrocarbon-degrading microbial communities with high tolerance to and high degrading ability of crude oil were obtained from the soil contaminated with crude oil in the Yellow River Delta. Then, the microbial cells were immobilized in sodium alginate (SA) beads and sodium alginate-diatomite (SAD) beads. The biodegradation of crude oil in soil by immobilized cells was compared with that by free cells at three inoculation concentrations, 1 × 104 colony forming units (cfu) kg-1 (low concentration, L), 5 × 104 cfu kg-1 (medium concentration, M), and 1 × 105 cfu kg-1 (high concentration, H). At 20 d after inoculation, the maximum degradation rate in the immobilized systems reached 29.8% (SAD-M), significantly higher (P < 0.05) than that of the free cells (21.1%), and the SAD beads showed greater degradation than the SA beads. Moreover, both microbial populations and total microbial activity reached significantly higher level (P < 0.05) in the immobilized systems than free cell systems at a same initial inoculation amount. The scanning electronic microscope (SEM) images also confirmed the advantages of the immobilized microstructure of SAD beads. The enhanced degradation and bacterial growth in the SAD beads indicated the high potential of SAD beads as an effective option for bioremediation of crude oil-contaminated soils in the Yellow River Delta. | WANG Zhen-Yu XU Ying WANG Hao-Yun ZHAO Jian GAO Dong-Mei LI Feng-Min B. XING | 2012 | Pedosphere2012，22，5： | 28 |
| 4 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 5 | Inducing apoptosis and upregulation of Bax and Fas ligand expression by allicin in hepatocellular carcinoma in Balb/c nude mice显示文摘 | ZHANG Zhi-mian ZHONG Ning GAO Hai-qing ZHANG Shang-zhong WEI Yuan XIN Hua MEI Xing HOU Huai-shui LIN Xi-yun SHI Qing | 2006 | Chinese Medical Journal2006，，5： | 24 |
| 6 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 7 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 8 | Clinical study of midazolam sequential with dexmedetomidine for agitated patients undergoing weaning to implement light sedation in intensive care unit显示文摘 | Xing Lu Jun Li Tong Li Jie Zhang Zhi-Bo Li Xin-Jing Gao Lei Xu | 2016 | Chinese Journal of Traumatology2016，19，2： | 20 |
| 9 | Effect of wide-narrow row arrangement in mechanical pot-seedling transplanting and plant density on yield formation and grain quality of japonica rice显示文摘Mechanical pot-seedling transplanting is an innovatively developed transplanting method that has the potential to replace mechanical carpet-seedling transplanting. However, the initial pot-seedling transplanting machine lacked optimized density spacing and limited yield potential for japonica rice. Therefore, ascertaining the optimized density by wide-narrow rows and the appropriate transplanting method for yield formation and grain quality of japonica rice is of great importance for high-quality rice production. Field experiments were conducted using two japonica rice cultivars Nanjing 9108 and Nanjing 5055 under three transplanting methods in 2016 and 2017: mechanical pot-seedling transplanting with wide-narrow row(K, average row spacing of 30 cm);equidistant row(D, 33 cm×12 cm);and mechanical carpet-seedling transplanting(T, 30 cm×12.4 cm). In addition, five different density treatments were set in K(K1–K5, from 18.62×10~4 to 28.49×10~4 hills ha^(–1)). The results showed that the highest yield was produced by a planting density of 26.88×104 hills ha^(–1) in mechanical pot-seedling transplanting with wide-narrow row with a greater number of total spikelets that resulted from significantly more panicles per area and slightly more grain number per panicle, as compared with equidistant row, and yield among density in wide-narrow row showed a parabolic trend. Compared with mechanical carpet-seedling transplanting, the treatment of the highest yield increased yield significantly, which was mainly attributed to the larger sink size with improved filled-grain percentage and grain weight, higher harvest index, and increased total dry matter accumulation, especially the larger amount accumulated from heading stage to maturity stage. With the density in wide-narrow row decreasing, processing quality, appearance quality, and nutrition quality were all improved, whereas amylose content and the taste value were decreased. Compared with mechanical carpet-seedling transplanting, mechanical pot-seedling transplanting improved processing quality and nutrition quality, but decreased amylose content and deteriorated appearance quality. These results suggested that mechanical pot-seedling transplanting with wide-narrow row coupling produced a suitable planting density of 26.88×10~4 hills ha^(–1) and may be an alternative approach to improving grain yield and quality for japonica rice. | HU Qun JIANG Wei-qin QIU Shi XING Zhi-peng HU Ya-jie GUO Bao-wei LIU Guo-dong GAO Hui ZHANG Hong-cheng WEI Hai-yan | 2020 | Journal of Integrative Agriculture2020，19，5： | 19 |
| 10 | Biphasic insulin aspart 30 improved glycemic control in Chinese patients with type 2 diabetes poorly controlled on oral glucose-lowering drugs: a subgroup analysis of the A1chieve study显示文摘 | Chen Liming Xing Xiaoyan Lei Minxiang Liu Jie Shi Yongquan Li Pengqiu Qin Guijun Li Chengjiang Li Yukun Wang Qing Gao Tianshu Hu Ling Wang Yangwei Yang Wenying | 2014 | Chinese Medical Journal2014，，2： | 19 |
| 11 | Properties and evaluation of amidoxime-based UHMWPE fibrous adsorbent for extraction of uranium from seawater显示文摘An amidoxime-based ultra-high molecular weight polyethylene(UHMWPE)fibrous adsorbent was successfully prepared by γ-irradiation-induced graft copolymerization of acrylonitrile(AN)and acrylic acid(AA),followed by amidoximation.The grafting of AN and AA on the UHMWPE fiber and the amidoximation of the grafted fiber were confirmed by Fourier transform infrared spectroscopy,scanning electron microscopy,and thermogravimetric analysis.The mechanical property of the original and modified UHMWPE fibers was compared by single-filament strength test.The adsorption property of the UHMWPE fibrous adsorbent was evaluated by adsorption test in uranyl nitrate solution and seawater.The surface of the modified UHMWPE fibers was covered by the grafting layer and became rough.The tensile strength of the amidoxime-based UHMWPE fibrous adsorbent was influenced by the absorbed dose and hydrochloric acid elution,but was independent of the grafting yield and amidoximation.The uranium adsorption amount of the amidoxime-based UHMWPE fibrous adsorbent after immersing in seawater for 42 days was 2.3 mg-U/g. | XING Zhe HU JiangTao WANG MouHua ZHANG WenLi LI ShiNeng GAO QianHong WU GuoZhong | 2013 | Science China Chemistry2013，56，11： | 17 |
| 12 | Pm21 from Haynaldia villosa Encodes a CC-NBS- LRR Protein Conferring Powdery Mildew Resistance in Wheat显示文摘 | Liping Xing Ping Hu Jiaqian Liu Kamil Witek Shuang Zhou Jiefei Xu Weihao Zhou Li Gao Zhenpu Huang Ruiqi Zhang Xiue Wang Peidu Chen Haiyan Wang Jonathan D.G. Jones Miroslava Karafiatova Jan Vrana Jan Baros Jaroslav Dolezel Yuanchun Tian Yufeng Wu Aizhong Cao | 2018 | Molecular Plant2018，11，6： | 16 |
| 13 | Clinical practice guidelines on liver transplantation for hepatocellular carcinoma in China(2018 edition)显示文摘Introduction Over 300000 people in China die each year of hepatocellular carcinoma(HCC),which accounts for approximately half of HCCrelated deaths worldwide.Liver transplantation(LT)is generally recognized as one of the most effective therapeutic approaches for end-stage liver diseases.Since the beginning of the second LT boom in the 1990s,LT in China has been developed rapidly with professional and large-scale trends,and it is approaching or has reached the level of developed countries in terms of quantity and quality.According to the China Liver Transplant Registry,the number of transplants for HCC accounted for 36.8%of the total number of LT cases during the past 5 years in the mainland of China.In order to develop an effective,safe and standardized protocol to guide the national LT practice,the clinical guidelines of LT for HCC was launched in 2014 by multidisciplinary experts from Chinese Society of Organ Transplantation,Chinese Medical Association and Chinese Association of Organ Transplantation,Chinese Medical Doctor Association.Recently,there have been new clinical and scientific advances in the field of LT and to keep abreast of these achievements,the original clinical practice guidelines need to be updated. | Xiao Xu Jun Chen Qiang Wei Zhi-Kun Liu a Zhe Yang Ming Zhang Guo-Ying Wang Jie Gao Zhao-Xu Yang Wen-Yuan Guo Tong-Hai Xing Zhou Shao Qin-Fen Xie Shu-Sen Zheng | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，4： | 14 |
| 14 | Resatorvid protects against hypoxic-ischemic brain damage in neonatal rats显示文摘Secondary brain damage caused by hyperactivation of autophagy and inflammatory responses in neurons plays an important role in hypoxic-ischemic brain damage(HIBD).Although previous studies have implicated Toll-like receptor 4(TLR4)and nuclear factor kappa-B(NF-κB)in the neuroinflammatory response elicited by brain injury,the role and mechanisms of the TLR4-mediated autophagy signaling pathway in neonatal HIBD are still unclear.We hypothesized that this pathway can regulate brain damage by modulating neuron autophagy and neuroinflammation in neonatal rats with HIBD.Hence,we established a neonatal HIBD rat model using the Rice-Vannucci method,and injected 0.75,1.5,or 3 mg/kg of the TLR4 inhibitor resatorvid(TAK-242)30 minutes after hypoxic ischemia.Our results indicate that administering TAK-242 to neonatal rats after HIBD could significantly reduce the infarct volume and the extent of cerebral edema,alleviate neuronal damage and neurobehavioral impairment,and decrease the expression levels of TLR4,phospho-NF-κB p65,Beclin-1,microtubule-associated protein l light chain 3,tumor necrosis factor-α,and interleukin-1βin the hippocampus.Thus,TAK-242 appears to exert a neuroprotective effect after HIBD by inhibiting activation of autophagy and the release of inflammatory cytokines via inhibition of the TLR4/NF-κB signaling pathway.This study was approved by the Laboratory Animal Ethics Committee of Affiliated Hospital of Yangzhou University,China(approval No.20180114-15)on January 14,2018. | Li-Jun Jiang Zhen-Xing Xu Ming-Fu Wu Gai-Qin Dong Li-Li Zhang Jun-Yan Gao Chen-Xi Feng Xing Feng | 2020 | Neural Regeneration Research2020，15，7： | 14 |
| 15 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 16 | Effects of velvet antler polypeptide on sexual behavior and testosterone synthesis in aging male mice显示文摘有低浆液睾丸激素层次的 Twenty-four-month-old 男 C57BL/6 老鼠是被使用为在性功能和睾丸激素合成上检验丝绒鹿角多肽(VAP ) 的效果的一个迟了发作的性腺机能减退(LOH ) 动物模型。这些鼠标每天在 100, 200,或 300 mg kg −1 身体重量的剂量由每日的 gavage 收到了 VAP 5 个连续星期(n = 10 个鼠标每剂量) 。控制动物(n = 10 ) 收到了车辆的一样的基于重量的体积。在浆液和睾丸的空隙的织物的性行为和睾丸激素层次在 VAP 的最后管理以后被测量。而且,调查 VAP 怎么在 vivo 影响性行为和睾丸激素合成的机制, steroidogenic 的表示尖锐规章的蛋白质(星),细胞色素 P450 胆固醇方面链劈开酶( P450scc ),并且 3 β ; -hydroxysteroid 脱氢酶( 3 β ;在 Leydig 房间的-HSD)被染色的 immunofluorescence 和量的即时 PCR 也测量。作为结果, VAP 在这些变老的雄的鼠标的性函数生产了重要改进。浆液睾丸激素水平和 intratesticular 睾丸激素(ITT ) 集中也在对待 VAP 的组增加了。星, P450scc,和 3 β 的表示; -HSD 也被发现与控制组相比在对待 VAP 的组被提高。我们的结果建议 VAP 在在老化男性鼠标改进性功能是有效的。性功能上的丝绒鹿角的效果由于睾丸激素合成的几限制率的酶的增加的表示(星, P450scc,和 3 β在 vivo 的睾丸激素合成的 -HSD) 和下列提升。 | Zhi-Jun Zang Hong-Feng Tang Ying Tuo Wei-Jie Xing Su-Yun Ji Yong Gao Chun-Hua Deng | 2016 | Asian Journal of Andrology2016，18，4： | 13 |
| 17 | Response to Hepatocarcinoma Hca-F of Mice Immunized with Heat Shock Protein 70 from Elemene Combo Tumor Cell Vaccine显示文摘为了分析有免疫力的反应到老鼠的鼠科的 hepatocarcinoma Hca-F,与热吃惊使免疫(HSP70 ) 蛋白质 70 源于 elemene 组合肿瘤 Hca-F 的房间疫苗(EC-TCV ) , HSP70 被自动数据处理从 EC-TCV 孤立亲密关系层析。老鼠 intraperitoneally 与 HSP70 被使免疫三次,怒气房间被取样。为房间,他们对 Hca-F 的增长和 cytotoxicity 与 MTT 试金被测量,他们的显型与流动 cytometry 被分析。有 HSP70 的使免疫的鼠标的怒气房间比与 EC-TCV 使免疫的鼠标的比正常控制鼠标,而是更少的有势力的对 Hca-F 和增长展出了更多的有势力 cytotoxicity。在三个组之中,在与 HSP70 (35.5%) 使免疫的老鼠的 T 淋巴细胞的百分比在正常老鼠与 6.25% 相比是最高的,并且 28.4% 与 EC-TCV 在老鼠使免疫。从 EC-TCV 导出的 HSP70 的免疫能得到有势力免疫者反应到 Hca-F。HSP70 是对 Hca-F 导致反肿瘤免疫者回答的元素之一。细胞与分子的免疫学。2006; 3 (4 ): 291-295。 | Lianying Guo Guangxia Shi Zhihong Gao Jie Shen Rong Xing Zhenchao Qian | 2006 | Cellular & Molecular Immunology2006，3，4： | 13 |
| 18 | Enhanced mechanical properties and degradation rate of Mg-Ni-Y alloy by introducing LPSO phase for degradable fracturing ball applications显示文摘In this work,as-cast Mg-Ni-Y alloys were proposed to develop a feasible material for fracturing balls,and their mechanical performance and corrosion behavior were systematically investigated.Long period stacking order(LPSO)phase was firstly introduced to improve both the mechanical properties and degradation rate of magnesium alloys.With the increase of LPSO phase,the compressive strength was improved significantly,while the elongation of the alloys decreased owing to the relatively brittle nature of LPSO phase.Due to the higher corrosion potential of LPSO phase,the LPSO phase can accelerate the corrosion process by providing more micro-couples.However,the LPSO phase would serve as the corrosion barrier between the corrosion medium and the matrix when the contents of LPSO phase are too high in Mg92.5Ni3Y4.5 and Mg87.5Ni5Y7.5 alloys.As-cast Mg97.5Ni1Y1.5 alloy with satisfactory mechanical properties and rapid degradation rate was successfully developed,exhibiting a high degradation rate of 6675 mm/a(93℃)in 3 wt.%KCl solution and a favorable ultimate compressive strength of 410 MPa.The degradation rate of Mg97.5Ni1Y1.5 alloy is 2-5 times of the current commercial magnesium alloy fracturing materials. | Jingfeng Wang Shiqing Gao Xiuying Liu Xing Peng Kui Wang Shijie Liu Weiyan Jiang Shengfeng Guo Fusheng Pan | 2020 | Journal of Magnesium and Alloys2020，8，1： | 13 |
| 19 | Progress in the stratigraphy and geochronology of the Shuidonggou site,Ningxia,North China显示文摘In the past years we carried out further stratigraphy division in field and it is found that rich stone artifacts can be found in fluvial-shallow lake-alluvial sediments on the terrace Ⅱ of Biangou River, in Shuidonggou site, Ningxia and they are SDG1, 2 and 7. More luminescence and AMS 14C dating in laboratory show that Paleolithic culture develops during the Upper Paleolithic period with ages of 35―20 ka. The Paleolithic culture of SDG 1 is a little earlier than that of SDG 2 similar to SDG 7. The sandy sediments on terrace Ⅱ of Biangou River deposits in the past 72―18 ka, corresponding to Last Glacial. SDG2 has a stable sedimentary environment, resulting in the continuous stratigraphy, thickest deposits and rich environment and culture information, which can be regarded as the important and classic paleoanthropological section of Late Pleistocene in this region. | LIU DeCheng WANG XuLong GAO Xing XIA ZhengKai PEI ShuWen CHEN FuYou WANG HuiMing | 2009 | Chinese Science Bulletin2009，54，21： | 13 |
| 20 | SREBP-1 is a novel mediator of TGFβ1 signaling in mesangial cells显示文摘Glomerular 矩阵累积是糖尿病的 nephropathy 的一个特点。最近的研究证明抄写因素 SREBP-1 的 overexpression 导致 glomerulosclerosis。TGF1 是 glomerulosclerosis 的一个关键 profibrotic 调停人,但是 SREBP-1 是否调整它的效果,是未知的。在肾 mesangial 房间并且在 vivo, TGF1 激活 SREBP-1。这要求发信号的 SCAP, S1P,和 PI3K/Akt,但是独立于 Smad3。TGF1 应答的记者 plasmid p3TP 勒克司的激活要求 SREBP-1a,然而并非 SREBP-1c,对邻近一个 Smad 有约束力的元素的一个电子盒子有约束力。SREBP-1a overexpression 独自激活 p3TP 勒克司。Smad3 为 SREBP-1a transcriptional 激活被要求, TGF1 导致在二个抄写因素之间的协会。由 acetyltransferase CBP 的 SREBP-1a K333 acetylation 为 Smad3 协会和 SREBP-1 transcriptional 活动被要求,并且也为 Smad3 transcriptional 活动被要求。因此, Smad3 和 SREBP-1a 激活合作地调整 TGF transcriptional 回答。SREBP-1 抑制为糖尿病的肾疾病提供新奇治疗学的策略。 | Guang Chen Tony Wang Lalita Uttarwar Richard vanKrieken Renzhong Li Xing Chen Bo Gao Ayesha Ghayur Peter Margetts Joan C. Krepinsky | 2014 | Journal of Molecular Cell Biology2014，8，6： | 13 |
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