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| 1 | Prevalence of metabolic syndrome and risks of abnormal serum alanine aminotransferase in Hispanics: a population-based study 显示文摘 | Pan JJ Qu Huiqi Rentfro A | 2011 | PLoS One2011，6，21： | 1 |
| 2 | One step synthesis of efficient red emissive carbon dots and their bovine serum albumin composites with enhanced multi-photon fluorescence for in vivo bioimaging显示文摘Efficient red emissive carbon dots(CDs)in aqueous solutions are very scarce for high performance bioimaging applications.In this work,we report a one-step solvothermal treatment to synthesize pure red emissive CDs(FA-CDs)from citric acid and urea in formic acid without complicated purification procedures.Photoluminescence quantum yield(PLQY)of 43.4%was observed in their dimethyl sulfoxide solutions.High PLQY up to 21.9%in aqueous solutions was achieved in their bovine serum albumin(BSA)composites(FA-CDs@BSA)with significantly enhanced multiphoton fluorescence.The strong surface electron-withdrawing structure of FA-CDs caused by the high content of C=O groups contributes for their pure red emission.Owing to the significantly enhanced single and multi-photon red fluorescence and enlarged particle sizes after composing with BSA,in vivo tumor imaging and two-photon fluorescence imaging of blood vessels in mouse ear have been realized via intravenous injection of FA-CDs@BSA aqueous solutions. | Huiqi Zhang Gang Wang Zhiming Zhang Josh Haipeng Lei Tzu-Ming Liu Guichuan Xing Chu-Xia Deng Zikang Tang Songnan Qu | 2022 | Light(Science & Applications)2022，11，5： | 0 |
| 3 | Genetic correlations between COVID-19 and a variety of traits and diseases显示文摘The ongoing coronavirus disease(COVID-19)outbreak has posed an extraordinary threat to global public health.Patients with certain underlying medical conditions,such as obesity,hypertension,and diabetes are at increased risk for poor outcome in COVID-19.1 Given the high genetic heritability of the aforementioned conditions,their shared genetic factors may play a crucial role in the severity of COVID-19.Indeed,a recent genome-wide association study(GWAS)of COVID-19 has reported two genomic loci associated with severe COVID-19,indicating a strong genetic influence on the severity of COVID-19. | Xiao Chang Yun Li Kenny Nguyen Huiqi Qu Yichuan Liu Joseph Glessner Patrick M.A.Sleiman Hakon Hakonarson | 2021 | The Innovation2021，2，2： | 0 |
| 4 | Supramolecular Assemblies of Three New Metronidazole Derivatives Constructed with Various Dihydroxy-benzoic Acids via Hydrogen Bonds显示文摘Metronidazole(MTZ)is an important antibiotic,which has been widely applied to cure protozoal and bacterial diseases for human beings or animals.Herein,three novel drug supramolecular crystals constructed by MTZ with 2.5-dihydroxy-benzoic acid(2.5-DHBA)(1),2.6-dihydroxy-benzoic acid(2.6-DHBA)(2)and 3,5-dihydroxy-benzoic acid(3.5-DHBA)(3),respectively,have been discovered.The hydrogen bonds of N-H…O(O-H…N).C-H…O and O-H…O play important roles in the 3D supramolecular framework formation for crystals 1-3.Interestingly.due to the vary locations of the substituent groups,the two-dimensional layers in crystals 1 or 2 are constructed via intermolecular hydrogen bonds between MTZ and 2,5-DHBA or 2.6-DHBA,while in crystal 3 water molecules play a significant role except the intermolecular hydrogen bonds between MTZ and 3,5-DHBA.In addition,five synthons of I R^22(8),ⅡR3(9)in crystal 1,ⅢR1(4),ⅣR2(8)in crystal 2 andⅤR2(7)in crystal 3 formed through various hydrogen bonds are founded in this work.Systematic studies of syntheses,crystal structures and thermal analysis are reported. | QU Huiqi PAN Longhai SUN Yuexin WANG Lei LI Yanyan ZHANG Mingjuan ZHANG Zhaoxiang LIN Haifeng | 2020 | Chemical Research in Chinese Universities2020，36，6： | 0 |
| 5 | Structure-guided engineering of transcriptional activator XYR1 for inducer-free production of lignocellulolytic enzymes in Trichoderma reesei显示文摘The filamentous fungus Trichoderma reesei is widely used for the production of lignocellulolytic enzymes in industry.XYR1 is the major transcriptional activator of cellulases and hemicellulases in T.reesei.However,rational engineering of XYR1 for improved lignocellulolytic enzymes production has been limited by the lack of structure information.Here,alanine 873 was identified as a new potential target for the engineering of XYR1 based on its structure predicted by AlphaFold2.The mutation of this residue to tyrosine enabled significantly enhanced production of xylanolytic enzymes in the medium with cellulose as the carbon source.Moreover,xylanase and cellulase production increased by 56.7-and 3.3-fold,respectively,when glucose was used as the sole carbon source.Under both conditions,the improvements of lignocellulolytic enzyme production were higher than those in the previously reported V821F mutant.With the enriched hemicellulases and cellulases,the crude enzymes secreted by the A873Y mutant strain produced 51%more glucose and 52%more xylose from pretreated corn stover than those of the parent strain.The results provide a novel strategy for engineering the lignocellulolytic enzyme-producing capacity of T.reesei,and would be helpful for understanding the molecular mechanisms of XYR1 regulation. | Qinqin Zhao Zezheng Yang Ziyang Xiao Zheng Zhang Jing Xing Huiqi Liang Liwei Gao Jian Zhao Yinbo Qu Guodong Liu | 2023 | Synthetic and Systems Biotechnology2023，8，4： | 0 |
| 6 | The highly dispersed Co-based nanoparticles encapsulated into porous N-doping carbon polyhedral with the low content of Ru modification as a promising cathode catalyst for long-life Li-O_(2)batteries显示文摘Lithium(Li)-O_(2)batteries have triggered worldwide interest due to their ultrahigh theoretical energy density.However,it is a long shot for the grand-scale applications of Li-O_(2)battery at current stage owing to its significant polarization,inferior cycling life,and irreversible decomposition of Li2O_(2).Herein,a facile way of preparing the highly dispersed Co-based nanoparticles encapsulated into porous N-doping carbon polyhedral with the low content of Ru modification(LRu@HDCo-NC)is explored through the pyrolysis of Co/Zn based zeolitic imidazole frameworks(ZIFs)containing Ru-based ligands.Even with the very small amount of Ru introduction(1.8%),LRu@HDCo-NC still exhibits the superior oxygen evolution reaction/oxygen reduction reaction(OER/ORR)performance and also inhibits side reactions in Li-O_(2)battery because of the abundant pores,plentiful surface N heteroatoms,and highly dispersed metal-based sites which are induced by the volatilization of Zn,and conductive/stable carbon skeleton derived from ZIFs.When applied in Li-O_(2)batteries,LRu@HDCo-NC cathode delivers a high discharge capacity of 15,973 mAh·g^(-1)at 200 mA·g^(-1),good capacity retention at higher rate(12,362 mAh·g^(-1)at 500 mA·g^(-1))and outstanding stability for>300 cycles with low voltage polarization of<2.3 V under a cut-off capacity of 1,000 mAh·g^(-1)at 500 mA·g^(-1).More critically,a series of ex situ and in situ characterization technologies disclose that the LRu@HDCo-NC cathodes can effectively promote the reversible reactions in Li-O_(2)batteries. | Yiru Ma Huiqi Qu Zhenzhen Chi Xiaoqiang Liu Yueqin Yu Ziyang Guo Lei Wang | 2022 | Nano Research2022，15，4： | 0 |
| 7 | Graphdiyne scaffold anchored highly dispersed ruthenium nanoparticles as an efficient cathode catalyst for rechargeable Li-CO_(2) battery显示文摘Lithium (Li)-CO_(2) battery is rising as an attractive energy-storage system with the competence of CO_(2) conversion/fixation. However, its practical development is seriously hindered by the high overpotential. Herein, a rational design on a highly catalytic Li-CO_(2) battery electrode built by graphdiyne powder as a multi-functional laminar scaffold with anchored highly dispersed Ru nanoparticles is explored. The strong interaction between the abundant acetylenic bond sites of graphdiyne scaffold and Ru nanoparticles can effectively promote the electrochemical progress and reduce the voltage polarization. The unique channels architecture of the cathodic catalyst with enough space not only accelerates CO_(2) diffusion and electrons/Li+ transport, but also allows a large amount of accommodation for discharged product (Li2CO3) to assure an advanced capacity. The corresponding Li-CO_(2) battery displays an advanced discharged capacity of 15,030 mAh/g at 500 mA/g, great capacity retention of 8873 mAh/g at 2 A/g, high coulombic efficiency of 97.6% at 500 mA/g and superior life span for 120 cycles with voltage gap of 1.67 V under a restricted capacity of 1000 mAh/g at 500 mA/g. Ex/in-situ studies prove that synergy between Ru nanoparticles and acetylene bonds of GDY can boost the round-trip CO_(2)RR and CO_(2)ER kinetics. | Yiru Ma Huiqi Qu Wenna Wang Ziyang Guo Yueqin Yu Feng Liu Bin Yu Minge Tian Zhenjiang Li Bin Li Lei Wang | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
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