|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | In vivo theranostics with near-infraredemitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration显示文摘Carbon dots that exhibit near-infrared fluorescence(NIR CDs)are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents.Despite progress in the synthesis of NIR CDs,there remains a key obstacle to using them as an in vivo theranostic agent.This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy(PTT)in mouse models(conversion efficiency of 59%)and can be readily visualized by photoluminescence and photoacoustic imaging.The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting.Contrary to all other nanomaterials that have been tested in biomedicine,they are excreted through the body’s renal filtration system.Moreover,after intravenous injection,NIR CDs are accumulated in tumor tissue via passive targeting,without any active species such as antibodies.Due to their accumulation in tumor tissue without the need for intratumor injection,high photothermal conversion,excellent optical and photoacoustic imaging performance,and renal excretion,the developed CDs are suitable for transfer to clinical biomedical practice. | Xin Bao Ye Yuan Jingqin Chen Bohan Zhang Di Li Ding Zhou Pengtao Jing Guiying Xu Yingli Wang Kateřina Holá Dezhen Shen Changfeng Wu Liang Song Chengbo Liu Radek Zbořil Songnan Qu | 2018 | Light(Science & Applications)2018，7，1： | 13 |
| 2 | Ultra-strong phosphorescence with 48% quantum yield from grinding treated thermal annealed carbon dots and boric acid composite显示文摘Metal-free room-temperature phosphorescence(RTP)materials are of great significance for many applications;however,they usually exhibit low efficiency and weak intensity.This article reports a new strategy for the preparation of a high-efficiency and strong RTP materials from crystalline thermal-annealed carbon dots(CDs)and boric acid(BA)composite(g-t-CD@BA)through grinding-induced amorphous to crystallization transition.Amorphous thermal-annealed CDs and BA composite(t-CD@BA)is prepared following a thermal melting and super-cooling route,where the CDs are fully dispersed in molten BA liquid and uniformly frozen in an amorphous thermal annealed BA matrix after super-cooling to room temperature.Upon grinding treatment,the fracture and fragmentation caused by grinding promote the transformation of the high-energy amorphous state to the lower energy crystalline counterparts.As a result,the CDs are uniformly in situ embedded in the BA crystal matrix.This method affords maximum uniform embedding of the CDs in the BA crystals,decreases nonradiative decay,and promotes intersystem crossing by restraining the free vibration of the CDs,thus producing strong RTP materials with the highest reported phosphorescence quantum yield(48%).Remarkably,RTP from g-t-CD@BA powder is strong enough to illuminate items with a delay time exceeding 9 s. | Qijun Li Zhenxiao Zhao Shuai Meng Yuchen Li Yunyang Zhao Bohan Zhang Zikang Tang Jing Tan Songnan Qu | 2022 | SmartMat2022，3，2： | 2 |
| 3 | Near-infrared chemiluminescent carbon nanogels for oncology imaging and therapy显示文摘Carbon nanogels(CNGs)with dual ability of reactive oxygen species(ROS)imaging and photodynamic therapy have been designed with selfassembled chemiluminescent carbonized polymer dots(CPDs).With efficient deep-red/near-infrared chemiluminescence(CL)emission and distinctive photodynamic capacity,the H2O2-driven chemiluminescent CNGs are further designed by assembling the polymeric conjugate and CL donors,enabling an in vitro and in vivo ROS bioimaging capability in animal inflammation models and a high-performance therapy for xenograft tumors.Mechanistically,ROS generated in inflammatory sites or tumor microenvironment can trigger the chemically initiated electron exchange luminescence in the chemical reaction of peroxalate and H2O2,enabling in vivo CL imaging.Meanwhile,part of the excited-state electrons will transfer to the ambient H2O or dissolved oxygen and in turn lead to the type I and type II photochemical ROS production of hydroxyl radicals or singlet oxygen,endowing the apoptosis of tumor cells and thus enabling cancer therapy.These results open up a new avenue for the design of multifunctional nanomaterials for bioimaging and antienoplastic agents. | Chenglong Shen Tianci Jiang Qing Lou Wenbo Zhao Chaofan Lv Guangsong Zheng Hangrui Liu Pengfei Li Lingling Dai Kaikai Liu Jinhao Zang Feng Wang Lin Dong Songnan Qu Zhe Cheng Chongxin Shan | 2022 | SmartMat2022，3，2： | 1 |
| 4 | Amplified Spontaneous Green Emission and Lasing Emission From Carbon Nanoparticles显示文摘 | Songnan Qu Xingyuan Liu Xiaoyang Guo Minghui Chu Ligong Zhang Dezhen Shen | 2014 | Adv Funct Mater2014，，18： | 1 |
| 5 | A Biocompatible Fluorescent Ink Based on Water‐Soluble Luminescent Carbon Nanodots显示文摘 | Songnan Qu Xiaoyun Wang Qipeng Lu Xingyuan Liu Lijun Wang | 2012 | Angew Chem Int Ed2012，，49： | 1 |
| 6 | Generating long-wavelength absorption bands with enhanced deep red fluorescence and photothermal performance in fused carbon dots aggregates显示文摘Carbon dots(CDs)with long-wavelength absorptions and emissions are highly desired for biological applications.Herein,we report a new supra-CDs strategy to construct long-wavelength absorption bands based on fused CDs aggregates(f-CDAs)through a concentration-induced interparticle dehydration process among green emissive CDs(r-CDs)under solvothermal treatment.The obtained fused f-CDAs exhibit an obvious absorption band in 550-700 nm and significantly enhanced deep red fluorescence in N,N-dimethylformamide with photoluminescence quantum yields of 15.6% and high photothermal conversion efficiency up to 26.1%in water.Benefiting from the high photothermal performance,in vivo tumor photothermal therapy has been realized via intratumoral injection of f-CDAs under 655 nm laser irradiated at 0.5 W/cm^(2). | Jun Wu Josh Haipeng Lei Bingchen He Chu-Xia Deng Zikang Tang Songnan Qu | 2021 | Aggregate2021，2，6： | 1 |
| 7 | One step synthesis of efficient red emissive carbon dots and their bovine serum albumin composites with enhanced multi-photon fluorescence for in vivo bioimaging显示文摘Efficient red emissive carbon dots(CDs)in aqueous solutions are very scarce for high performance bioimaging applications.In this work,we report a one-step solvothermal treatment to synthesize pure red emissive CDs(FA-CDs)from citric acid and urea in formic acid without complicated purification procedures.Photoluminescence quantum yield(PLQY)of 43.4%was observed in their dimethyl sulfoxide solutions.High PLQY up to 21.9%in aqueous solutions was achieved in their bovine serum albumin(BSA)composites(FA-CDs@BSA)with significantly enhanced multiphoton fluorescence.The strong surface electron-withdrawing structure of FA-CDs caused by the high content of C=O groups contributes for their pure red emission.Owing to the significantly enhanced single and multi-photon red fluorescence and enlarged particle sizes after composing with BSA,in vivo tumor imaging and two-photon fluorescence imaging of blood vessels in mouse ear have been realized via intravenous injection of FA-CDs@BSA aqueous solutions. | Huiqi Zhang Gang Wang Zhiming Zhang Josh Haipeng Lei Tzu-Ming Liu Guichuan Xing Chu-Xia Deng Zikang Tang Songnan Qu | 2022 | Light(Science & Applications)2022，11，5： | 0 |
| 8 | Polyetherimide functionalized carbon dots with enhanced red emission in aqueous solution for bioimaging显示文摘Red emissive carbon dots(CDs)are highly desired for biological applications.However,serious luminescence quenching of red emissive CDs in aqueous solution greatly hinders their application in high performance biological imaging.Herein,we reported a facile strategy to realize enhanced red emission of CDs in aqueous solution by surface modification with polyetherimide(PEI)via microwave heating method.High photoluminescence quantum yield(PLQY)of 25%was realized from the PEI functionalized CDs(CDs@PEI)in aqueous solution.The proposed PEI functionalization strategy not only protects the red emission against water molecules quenching,but also reverses the surface charges from negativity to positivity to promote cellular uptake of CDs,leading to clear cell imaging in red fluorescence region.More important,CDs@PEI exhibits much better photostability than commercial red emissive dye(MitoT racker red)in cell fluorescent imaging.Potential application of CDs@PEI on fast staining of cells for clonogenic assay has also been demonstrated. | Liming Wang Bingzhe Wang Enshan Liu Yunyang Zhao Bingchen He Chunfei Wang Guichuan Xing Zikang Tang Yinning Zhou Songnan Qu | 2022 | Chinese Chemical Letters2022，33，8： | 0 |
| 9 | Toward Rational Design of Carbon Nanodots with High Photothermal Efficiency for Tumor Photothermal Therapy显示文摘Comprehensive Summary Carbon nanodots(CDs)with high photothermal performance are ideal candidates for tumor photothermal therapy(PTT).Herein,we investigated the photothermal performance of CDs synthesized from urea and citric acid via solvothermal method in dimethyl sulfoxide(DMSO)at different temperatures.Photothermal conversion efficiency(PCE)of up to 61.3%was obtained in the CDs synthesized at 150℃(150-CDs),which is much better than the CDs synthesized at 180℃(180-CDs).By analyzing the morphologies,chemical structures,and absorption spectra of these CDs,we found that the photothermal effect of the CDs was due to the lattice vibration of their carbonized cores. | Enshan Liu Jun Wu Tao Liang Bohan Zhang Zikang Tang Songnan Qu | 2023 | Chinese Journal of Chemistry2023，41，16： | 0 |
| 10 | Narrow-bandwidth emissive carbon dots:A rising star in the fluorescent material family显示文摘Fluorescent carbon dots(CDs)have recently become a research hotspot in multidisciplinary fields owing to their distinctive advantages,including outstanding photoluminescence properties,high biocompatibility,low toxicity,and abundant raw materials.Among the promising CDs,narrow‐bandwidth emissive CDs with high color purity have emerged as a rising star in recent years because of their significant potential applications in bioimaging,information sensing,and photoelectric displays.In this review,the state-of-the-art advances of narrow-bandwidth emissive CDs are systematically summarized,and the factors influencing the emission bandwidth,preparation methods,and applications of narrow-bandwidth emissive CDs are described in detail.Besides,existing challenges and future perspectives for achieving high-performance narrow-bandwidth emissive CDs are also discussed.This overview paper is expected to generate more interest and promote the rapid development of this significant research area. | Biao Zhao Huanyu Ma Mengyun Zheng Kunxiang Xu Chao Zou Songnan Qu Zhan'ao Tan | 2022 | Carbon Energy2022，4，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员