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| 1 | Hypothesis review:The direct interaction of food nanoparticles with the lymphatic system显示文摘Besides digestion and assimilation,there are other modes of direct interaction between food and human body.As it is known,the mucosal layer of the digestive tract interfaces with food after the digestion process.It has been demonstrated to uptake the micro-and nanoparticles via mucosa-associated lymphatic tissues(MALT).On the other hand,food is a typical polydisperse system and contains micro-and nanoparticles with different sizes and properties.Accordingly,it is hypothesized that food nanoparticles can directly interact with MALT and more specifically with the support of the preliminary experimental data from our research,that antioxidant nanoparticles can interact with the lymphatic vessels.This kind of interaction would be of great physiological importance.The confirmation of the hypothesis will establish a significant and novel approach to understand food system and provide answers to currently incomprehensible phenomena such as the biological functions of phytochemicals with low bioavailability.©2012 Production and hosting by Elsevier B.V.on behalf of Beijing Academy of Food Sciences. | Wei Lu Jingke Guo Jianwu Zhou Lijing Ke Shutao Liu Guanzhen Gao Huiqin Wang Wei Ding Pingfan Rao | 2012 | Food Science and Human Wellness2012，1，1： | 5 |
| 2 | Variation and heritability of morphological and physiological traits among Leymus chinensis genotypes under different environmental conditions显示文摘Intraspecific trait variation and heritability in different environmental conditions not only suggest a potential for an evolutionary response but also have important ecological consequences at the population, community, and ecosystem levels. However, the contribution of quantitative trait variation within a grassland species to evolutionary responses or ecological consequences is seldom documented. Leymus chinensis is an important dominant species in semi-arid grasslands of China, which has seriously suffered from drought and high temperature stresses in recent decades. In the present study, we measured variation and heritability of 10 quantitative traits, namely the number of tillers, maximum shoot height, number of rhizomes, maximum rhizome length, rhizome mass, aboveground mass, root mass, maximum net photosynthetic rate(Pmax), specific leaf area(SLA), and leaf length to leaf width ratio(LL/LW), for 10 genotypes of L. chinensis under one non-stress(Ck) condition and three environmental stress conditions(i.e., drought(Dr), high temperature(Ht), and both drought and high temperature(DrHt)). Result indicated that(1) the interaction of genotype and environmental condition(G×E) was significant for 6 traits but not significant for the other 4 traits as shown by two-way analysis of variance(ANOVA), suggesting that different selection forces were placed for different traits on the factors dominating phenotypic responses to different environmental conditions. Moreover, these significant G×E effects on traits indicated significantly different phenotypic adaptive responses among L. chinensis genotypes to different environmental conditions. Additionally, individuals could be grouped according to environmental condition rather than genotype as shown by canonical discriminant analysis, indicating that environmental condition played a more important role in affecting phenotypic variation than genotype;(2) by one-way ANOVA, significant differences among L. chinensis genotypes were found in all 10 traits under Ck and Dr conditions, in 8 traits under Dr Ht condition and only in 4 traits under Ht condition; and(3) all 10 traits showed relatively low or non-measurable broad-sense heritability(H_2) under stress conditions. However, the lowest H_2 value for most traits did not occur under DrHt condition, which supported the hypothesis of 'unfavorable conditions have unpredictable effects' rather than 'unfavorable conditions decrease heritability'. Results from our experiment might aid to improve predictions on the potential impacts of climate changes on L. chinensis and eventually species conservation and ecosystem restoration. | YANG Xue LI Junpeng ZHAO Tingting MO Lidong ZHANG Jianli REN Huiqin ZHAO Nianxi GAO Yubao | 2019 | Journal of Arid Land2019，11，1： | 4 |
| 3 | Detailed resume of RNA m^(6)A demethylases显示文摘N6-Methyladenosine(m^(6)A) is the most abundant internal modification in eukaryotic mRNA,playing critical role in various bioprocesses. Like other epigenetic modifications, m^(6)A modification can be catalyzed by the methyltransferase complex and erased dynamically to maintain cells homeostasis. Up to now, only two m^(6)A demethylases have been reported, fat mass and obesity-associated protein(FTO)and alkylation protein AlkB homolog 5(ALKBH5), involving in a wide range of mRNA biological progress, including mRNA shearing, export, metabolism and stability. Furthermore, they participate in many significantly biological signaling pathway, and contribute to the progress and development of cancer along with other diseases. In this review, we focus on the studies about structure, inhibitors development and biological function of FTO and ALKBH5. | Dandan Shen Bo Wang Ya Gao Lijuan Zhao Yaping Bi Jinge Zhang Ning Wang Huiqin Kang Jingru Pang Ying Liu Luping Pang Zhe-Sheng Chen Yi-Chao Zheng Hong-Min Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 3 |
| 4 | Deciphering Ascorbic Acid Regulatory Pathways in Ripening Tomato Fruit Using a Weighted Gene Correlation Network Analysis Approach显示文摘Genotype is generally determined by the co-expression of diverse genes and multiple regulatory pathways in plants.Gene co-expression analysis combining with physiological trait data provides very important information about the gene function and regulatory mechanism.L-Ascorbic acid(AsA),which is an essential nutrient component for human health and plant metabolism,plays key roles in diverse biological processes such as cell cycle,cell expansion,stress resistance,hormone synthesis,and signaling.Here,we applied a weighted gene correlation network analysis approach based on gene expression values and AsA content data in ripening tomato(Solanum lycopersicum L.)fruit with different AsA content levels,which leads to identifcation of AsA relevant modules and vital genes in AsA regulatory pathways.Twenty-four modules were compartmentalized according to gene expression profling.Among these modules,one negatively related module containing genes involved in redox processes and one positively related module enriched with genes involved in AsA biosynthetic and recycling pathways were further analyzed.The present work herein indicates that redox pathways as well as hormone-signal pathways are closely correlated with AsA accumulation in ripening tomato fruit,and allowed us to prioritize candidate genes for follow-up studies to dissect this interplay at the biochemical and molecular level. | Chao Gao Zheng Ju Shan Li Jinhua Zuo Daqi Fu Huiqin Tian Yunbo Luo Benzhong Zhu | 2013 | Journal of Integrative Plant Biology2013，55，11： | 3 |
| 5 | Study on electrocatalytic oxidation of L-cysteine at glassy carbon electrode by ( FcM ) TMA and its electrochemical kinetics 显示文摘 | GAO Zuoning YAO Huiqin LIU Wanyi | 2005 | Electroanal2005，17，： | 1 |
| 6 | Electrochemical oxidation of isoniazid catalyzed by (FcM) TMA at platinum electrode and its practical analytical application显示文摘 | GAO Zuoning HAN Xiaoxiao YAO Huiqin | 2006 | Anal and Bioanal Chem2006，385，： | 1 |
| 7 | Study on elec trocatalytic oxidation of L-cysteine at glassy carbon electrode by (FcM) TMA and its electrochemical kinetics显示文摘 | Gao Zuoning Yao Huiqin Liu Wanyi | 2005 | Electroanalysis2005，17，7： | 1 |
| 8 | Recent progress of quantum dots for energy storage applications显示文摘The environmental problems of global warming and fossil fuel depletion are increasingly severe,and the demand for energy conversion and storage is increasing.Ecological issues such as global warming and fossil fuel depletion are increasingly stringent,increasing energy conversion and storage needs.The rapid development of clean energy,such as solar energy,wind energy and hydrogen energy,is expected to be the key to solve the energy problem.Several excellent literature works have highlighted quantum dots in supercapacitors,lithium-sulfur batteries,and photocatalytic hydrogen production.Here,we outline the latest achievements of quantum dots and their composites materials in those energy storage applications.Moreover,we rationally analyze the shortcomings of quantum dots in energy storage and conversion,and predict the future development trend,challenges,and opportunities of quantum dots research. | Quan Xu Yingchun Niu Jiapeng Li Ziji Yang Jiajia Gao Lan Ding Huiqin Ni Peide Zhu Yinping Liu Yaoyao Tang Zhong-Peng Lv Bo Peng Travis Shihao Hu Hongjun Zhou Chunming Xu | 2022 | Carbon Neutrality2022，1，1： | 1 |
| 9 | Research Progress on Pharmacological Action and Clinical Application of Stephania Tetrandrae Radix显示文摘Stephania Tetrandrae Radix is one of the common traditional Chinese medicines,which has bitter and pungent taste as well as cold properties. It can subside edema,get rid of rheumatism and relieve pain. Therefore,it is mainly used for the treatment of rheumatism arthralgia,edema,dysuria,athlete's foot,swollen wet sores and other diseases in traditional Chinese medicine( TCM). Stephania Tetrandrae Radix is mainly composed of dual-benzyl isoquinoline alkaloids,including tetrandrine,fangchinoline and so on. Modern pharmacology research shows that Stephania Tetrandrae Radix and its main components have a wide range of pharmacological activity in the anti-inflammatory,anti-pathogenic microorganisms,anti-tumor,anti-hypertension,anti-arrhythmia,anti-myocardial ischemia,anti-fibrosis,anti-silicosis,inhibiting scar and other aspects,with broad application prospect. Stephania Tetrandrae Radix is often applied with compatibility of other Chinese medicines in clinically,and has achieved obvious effects in the treatment of rheumatoid arthritis,cardiovascular disease,cancer,hypertension,liver ascites and other diseases. There are some representative prescriptions,such as Fangji Fuling decoction,Fangji Huangqi decoction,Jijiao Lihuang pill,Xuanbi decoction,compound Hanfangji granule and so on. In this paper,the pharmacological effects and clinical applications of Stephania Tetrandrae Radix in the past ten years are reviewed,providing the reference for its further development and application. | Rong WANG Tengmao MA Fei LIU Huiqin GAO | 2018 | Medicinal Plant2018，9，3： | 0 |
| 10 | Deep Immunophenotyping of Human Whole Blood by Standardized Multi‑parametric Flow Cytometry Analyses显示文摘Immunophenotyping is proving crucial to understanding the role of the immune system in health and disease.High-through-put flow cytometry has been used extensively to reveal changes in immune cell composition and function at the single-cell level.Here,we describe six optimized 11-color flow cytometry panels for deep immunophenotyping of human whole blood.A total of 51 surface antibodies,which are readily available and validated,were selected to identify the key immune cell populations and evaluate their functional state in a single assay.The gating strategies for effective flow cytometry data analysis are included in the protocol.To ensure data reproducibility,we provide detailed procedures in three parts,including(1)instrument characterization and detector gain optimization,(2)antibody titration and sample staining,and(3)data acquisition and quality checks.This standardized approach has been applied to a variety of donors for a better understanding of the complexity of the human immune system. | Jian Gao Yali Luo Helian Li Yiran Zhao Jialin Zhao Xuling Han Jingxuan Han Huiqin Lin Feng Qian | 2023 | Phenomics2023，3，3： | 0 |
| 11 | Bio-inspired chiral self-assemblies promoted neuronal differentiation of retinal progenitor cells through activation of metabolic pathway显示文摘Retinal degeneration is a main class of ocular diseases.So far,retinal progenitor cell(RPC)transplantation has been the most potential therapy for it,in which promoting RPCs neuronal differentiation remains an unmet challenge.To address this issue,innovatively designed L/D-phenylalanine based chiral nanofibers(LPG and DPG)are employed and it finds that chirality of fibers can efficiently regulate RPCs differentiation.qPCR,western blot,and immunofluorescence analysis show that right-handed helical DPG nanofibers significantly promote RPCs neuronal differentiation,whereas left-handed LPG nanofibers decrease this effect.These effects are mainly ascribed to the stereoselective interaction between chiral helical nanofibers and retinol-binding protein 4(RBP4,a key protein in the retinoic acid(RA)metabolic pathway).The findings of chirality-dependent neuronal differentiation provide new strategies for treatment of neurodegenerative diseases via optimizing differentiation of transplanted stem cells on chiral nanofibers. | Na Sun Xiaoqiu Dou Zhimin Tang Dandan Zhang Ni Ni Jiajing Wang Huiqin Gao Yahan Ju Xiaochan Dai Changli Zhao Ping Gu Jing Ji Chuanliang Feng | 2021 | Bioactive Materials2021，6，4： | 0 |
| 12 | Case Study of Fog Predictability for an Event with Cold-Front Synoptic Pattern显示文摘Fog has recently become a frequent high-impact weather phenomenon along the coastal regions of North China. Accurate fog forecasting remains challenging due to limited understanding of the predictability and mechanism of fog formation associated with synoptic-scale circulation. One frequent synoptic pattern of fog formation in this area is associated with cold front passage(cold-front synoptic pattern, CFSP). This paper explored the predictability of a typical CFSP fog event from the perspective of analyzing key characteristics of synoptic-scale circulation determining fog forecasting performance and the possible mechanism. The event was ensemble forecasted with the Weather Research and Forecasting model. Two groups of ensemble members with good and bad forecasting performance were selected and composited. Results showed that the predictability of this case was largely determined by the simulated strengths of the cold-front circulation(i.e., trough and ridge and the associated surface high). The bad-performing members tended to have a weaker ridge behind a stronger trough, and associated higher pressure over land and a weaker surface high over the sea, leading to an adverse impact on strength and direction of steering flows that inhibit warm moist advection and enhance cold dry advection transported to the focus region. Associated with this cold dry advection, adverse synoptic conditions of stratification and moisture for fog formation were produced, consequently causing failure of fog forecasting in the focus region. This study highlights the importance of accurate synoptic-scale information for improved CFSP fog forecasting, and enhances understanding of fog predictability from perspective of synoptic-scale circulation. | HU Huiqin HUANG Fei ZHANG Shaoqing RUAN Chengqing GAO Shanhong LI Pengyuan | 2019 | Journal of Ocean University of China2019，18，2： | 0 |
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