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| 1 | Fight for carbon neutrality with state-of-the-art negative carbon emission technologies显示文摘After the Industrial Revolution,the ever-increasing atmospheric CO_(2)concentration has resulted in significant problems for human beings.Nearly all countries in the world are actively taking measures to fight for carbon neutrality.In recent years,negative carbon emission technologies have attracted much attention due to their ability to reduce or recycle excess CO_(2)in the atmosphere.This review summarizes the state-of-the-art negative carbon emission technologies,from the artificial enhancement of natural carbon sink technology to the physical,chemical,or biological methods for carbon capture,as well as CO_(2)utilization and conversion.Finally,we expound on the challenges and outlook for improving negative carbon emission technology to accelerate the pace of achieving carbon neutrality. | Jiaju Fu Pan Li Yuan Lin Huitong Du Hongzhi Liu Wenlei Zhu Hongqiang Ren | 2022 | Eco-Environment & Health2022，1，4： | 1 |
| 2 | Recent advances in carbon-supported non-precious metal singleatom catalysts for energy conversion electrocatalysis显示文摘Non-precious metal single-atom catalysts(NPM-SACs)with unique electronic structures and coordination environments have gained much attention in electrocatalysis owing to their low cost,high atomic utilization,and high performance.NPM-SACs on carbon support(NPM-SACs/CS)are promising because of the carbon substrate with a large surface area,excellent electrical conductivity,and high chemical stability.This review provides an overview of recent developments in NPM-SACs/CS for the electrocatalytic field.First,the state-of-the-art synthesis methods and advanced characterization techniques of NPM-SACs/CS are discussed in detail.Then,the structural adjustment strategy of NPM-SACs/CS for optimizing electrocatalytic performance is introduced concisely.Furthermore,we provide a comprehensive summary of recent advances in developing NPM-SACs/CS for important electrochemical reactions,including carbon dioxide reduction reaction,hydrogen evolution reaction,oxygen evolution reaction,oxygen reduction reaction,and nitrogen reduction reaction.In the end,the existing challenges and future opportunities of NPM-SACs/CS in the electrocatalytic field are highlighted. | Li-Xia Liu Yangyang Ding Linan Zhu Jin-Cheng Li Huitong Du Xiang Li Zhaoyuan Lyu Dan Du Fuqiang Liu Yuanyuan Wang Wenlei Zhu Yuehe Lin | 2023 | National Science Open2023，2，2： | 1 |
| 3 | Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Envt cells in vivo显示文摘HIV-specific chimeric antigen receptor(CAR)T-cells have been developed to target HIV-1 infected CD4t T-cells that express HIV Env proteins.However,T cell exhaustion and the patient-specific autologous paradigm of CAR-T cell hurdled clinical applications.Here,we created HIV-specific CAR-T cells using human peripheral blood mononuclear cells and a 3BNC117-E27(3BE)CAR construct that enabled the expression of programmed cell death protein(PD-1)-blocking scFv E27 and the single-chain variable fragment of the HIV-1-specific broadly neutralizing antibody 3BNC117 to target native HIV Env.Compared with T cells expressing 3BNC117-CAR alone,3BE CAR-T cells showed greater cytotoxic activity against HIV Envt cells with stronger proliferation capability,higher killing efficiency,and enhanced cytokine secretion in the presence of HIV Env-expressing cells.Furthermore,we manufactured TCR-deficient 3BE CAR-T cells through gene editing and demonstrated that these CAR-T cells could effectively kill HIV Env^(+) cells in vivo without the occurrence of severe graft-versus-host disease(GvHD)in NSG mice.These data suggest that we have provided a feasible approach to the generation of“off-theshelf”anti-HIV CAR-T cells in combination with PD-1 checkpoint blockade immunotherapy,which can be a powerful therapeutic candidate for the functional cure of HIV. | Hanyu Pan Xinyi Yang Jing Wang Huitong Liang Zhengtao Jiang Lin Zhao Yanan Wang Zhiming Liang Xiaoting Shen Qinru Lin Yue Liang Jinglong Yang Panpan Lu Yuqi Zhu Min Li Pengfei Wang Jianqing Xu Hongzhou Lu Huanzhang Zhu | 2023 | Virologica Sinica2023，38，2： | 0 |
| 4 | Expert recommendations on data collection and annotation of two dimensional ultrasound images in azoospermic males for evaluation of testicular spermatogenic function in intelligent medicine显示文摘Testicular two-dimensional ultrasound is a testing modality that is often used to evaluate azoospermia and other related diseases.With the continuous development of deep learning in recent years,the combination of deep learning and testicular ultrasound appears unstoppable despite a lack of relevant standards.One of the major problems associated with the digitization of ultrasound images is the uneven quality of data however,and a standardized data source and acquisition process has not yet been developed.Such a standard could fill the current gap,and establish acquisition criteria for ultrasound images of testes during the male reproductive period,including grayscale ultrasound,shear wave elastography,and contrast-enhanced ultrasound.By following these guidelines the quality of testicular ultrasound images would be improved and standardized,which would lay a solid foundation for the standardization of testicular ultrasound images,and assist automated evaluation of testicular spermatogenic function of whole testis in azoospermic males. | Wanling Huang Yifan Xiang Yahan Yang Qing Tang Guangjian Liu Hong Yang Erjiao Xu Huitong Lin Zhixing Zhang Zhe Ma Zhendong Li Ruiyang Li Anqi Yan Haotian Lin Zhu Wang Chinese Association of Artificial Intelligence Medical Artificial Intelligence Branch of the Guangdong Medical Association | 2022 | Intelligent Medicine2022，2，2： | 0 |
| 5 | Recent progress on rational design of catalysts for fermentative hydrogen production显示文摘The increasingly severe energy crisis has strengthened the determination to develop environmentally friendly energy.And hydrogen has emerged as a candi-date for clean energy.Among many hydrogen generation methods,biohydrogen stands out due to its environmental sustainability,simple operating environ-ment,and cost advantages.This review focuses on the rational design of catalysts for fermentative hydrogen production.The principles of microbial dark fermen-tation and photo-fermentation are elucidated exhaustively.Various strategies to increase the efficiency of fermentative hydrogen production are summa-rized,and some recent representative works from microbial dark fermentation and photo-fermentation are described.Meanwhile,perspectives and discussions on the rational design of catalysts for fermentative hydrogen production are provided. | Yifan Chai Zhaoyuan Lyu Huitong Du Pan Li Shichao Ding Yujing Jiang Hua Wang Qianhao Min Dan Du Yuehe Lin Wenlei Zhu | 2022 | SusMat2022，2，4： | 0 |
| 6 | Associations between LMO1 gene polymorphisms and central nervous system tumor susceptibility显示文摘Importance:LIM domain only 1(LMO1)gene polymorphisms were previously found to be implicated in the risk of several cancers.No available studies were performed regarding the predisposing effect of LMO1 gene single nucleotide polymorphisms(SNPs)on central nervous system(CNS)tumor risk.Objective:We aimed to determine whether the LMO1 gene SNPs were associated with the risk of CNS tumor by applying a case-control study with 191 cases and 248 controls in China.Methods:The contributions of LMO1 gene SNPs to the risk of CNS tumor was evaluated by multinomial logistic regression.Results:Based on the calculations of odds ratio(OR)and 95%confidence interval(CI),we failed to detect a significant relationship between each LMO1 gene SNP(rs110419 A>G,rs4758051 G>A,rs10840002 A>G,rs204938 A>G,and rs2168101 G>T)and CNS tumor risk,respectively.A negative association was also found in the combined effects on these five SNPs and CNS tumor risk.The stratification analysis further demonstrated the individuals with rs204938 AG/GG genotype confer to increased risk of CNS tumor compared with those with an AA genotype in males(OR:1.74,95%CI:1.01-2.98,P=0.046).Interpretation:We concluded that LMO1 gene SNPs may not strong enough to influence the risk of CNS tumor in Chinese children.More studies are required to verify this association. | Huiran Lin Huitong Chen Ao Lin Xiaoping Liu Xiaokai Huang Jingying Zhou Li Yuan Zhenjian Zhuo | 2021 | Pediatric Investigation2021，5，4： | 0 |
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