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| 1 | Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development显示文摘Immune checkpoints are the crucial regulators of immune system and play essential roles in maintaining self-tolerance,preventing autoimmune responses,and minimizing tissue damage by regulating the duration and intensity of the immune response.Furthermore,immune checkpoints are usually overexpressed in cancer cells or noninvasive cells in tumor tissues and are capable of suppressing the antitumor response.Based on substantial physiological analyses as well as preclinical and clinical studies,checkpoint molecules have been evaluated as potential therapeutic targets for the treatment of multiple types of cancers.In the last few years,extensive evidence has supported the immunoregulatory effects of traditional Chinese medicines(TCMs).The main advantage of TCMs and natural medicine is that they usually contain multiple active components,which can act on multiple targets at the same time,resulting in additive or synergistic effects.The strong immune regulation function of traditional Chinese medicine on immune checkpoints has also been of great interest.For example,Astragalus membranaceus polysaccharides can induce anti-PD-1 antibody responses in animals,and these antibodies can overcome the exhaustion of immune cells under tumor immune evasion.Furthermore,many other TCM molecules could also be novel and effective drug candidates for the treatment of cancers.Therefore,it is essential to assess the application of immune checkpoints in the development of new drugs and TCMs.In this review,we focus on research progress in the field of immune checkpoints based on three topics:(1)immune checkpoint targets and pathways,(2)development of novel immune checkpoint-based drugs,and(3)application of immune checkpoints in the development of TCMs. | Yuli Wang Xingyan Zhang Yuyan Wang Wenjing Zhao Huling Li Lixing Zhang Xinping Li Tiejun Zhang Hongbing Zhang He Huang Changxiao Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 3 |
| 2 | Experimental Study of Effect of Perfluorohexyloctane to Retina显示文摘Objective: To investigate the effect of perfluorohexvloctane to the retina of rabbit eyes.Methods: Perfluoroh-exyloctane (experimental group) or BSS(control group) intovitreous cavities of fifteen vitrectomized New Zealand white rabbits. A slit-lampbiomicroscope and an indirect ophthalmoscope were used to examine all the eyes pre- andpostoperation. Histopathological examination was performed after the rabbits weresacrificed. Results:Perfluorohexyloctane was injected into the vitreous cavity forming a single largeclear globe. No retinal detachment and cataract were found. The edema of outer plexiformlayer was significant, and then get thin, inner nuclear layer and ganglion cell bodies hada darker cytop: lasm and nucleoplasm. Conclusions: Perfluorohexyloctane in vitreous cavity had significant side effects on retinaAs a silicone solvent, it should be removed out completely after injection. We don′trecommend to use it as a new intraocular temponade. | Chunfang Li, Xiaoyan Ding, Lin Lu, Guanguang Feng, Huling ZhengZhongshan Ophthalmic center, Sun Yet-san University, Guangzhou, 510060 , China | 2002 | Eye Science2002，18，1X： | 2 |
| 3 | Persulfate oxidation regeneration of granular activated carbon: Reversible impacts on sorption behavior 显示文摘 | HUTSON A KO S HULING S G | 2012 | Chemosphere2012，89，10： | 1 |
| 4 | Virtual reality for persistent pain: a new direction for behavioral pain management显示文摘 | Keefe FJ Huling DA Coggins MJ | 2012 | Pain2012，153，11： | 1 |
| 5 | Multi-sensor Tracking of a Maneuvering Target in Clutter显示文摘 | Hules A Bar-Shalom Y | 1989 | IEEE Transactions on Aerospace and Electronic Systems1989，25，2： | 1 |
| 6 | Contaminant ad-sorption and oxidation via Fenton reaction显示文摘 | Huling S G Arnold R G Sierka R A | 2000 | Journal of Envi- ronmental Engineering2000，126，7： | 1 |
| 7 | Plasama-sprayed wear-resistant ceramic and cermet coating materials 显示文摘 | Ding Chuanxian Huang Bingtang Lin Huling | 1984 | Thin Solid Film1984，118，： | 1 |
| 8 | ln-situ regeneration of saturated granular activated carbon by an iron oxide nanocata- lyst显示文摘 | Chin C A Hristovski K Huling S | 2013 | Water Research2013，47，4： | 1 |
| 9 | 显示文摘 | Jha A K Hule R A Jiao T | 2009 | Macromolecules2009，42，2： | 1 |
| 10 | Effect and mechanism of persulfate activated by different methods for PAHs removal in soil显示文摘 | Dan Zhao Xiaoyong Liao Xiulan Yan Scott G. Huling Tuanyao Chai Huan Tao | 2013 | Journal of Hazardous Materials2013，，： | 1 |
| 11 | Changes in Local Immune Functions in Mooren's Ulcer显示文摘Purpose: To the investigate changes in local immune functions of the cornea and the adjacent conjunctiva, and their roles in the mechanism of the disease. Method: The cornea and adjacent bulbar conjunctiva taken from 14 patients with Mooren’s ulcer were stained immunohistochemically for CD3, CD4, CD8, HLA-DR, GD1 and CD25.Result: An aberrant expression of HLA-DR antigen by a large number of kerato-conjunctival epithelial cells and keratocytes in the corneal stroma was found. The CD4 + /CD8+ ratio is significantly higher than normal control. Conclusion: The aberrant expression of MHC- II antigen in the resident cells at the peripheral cornea and the adjacent conjunctiva, along with a raised local TH/ Ts ratio leading to an excessive autoimmune reactivity is possibly the direct cause of Mooren’s ulcer. Eye Science 1996; 12: 33-35. | Zheng Wang, Jiaqi Chen, Huling ZhengZhongshan Ophthalmic Center, Sun Yat-sen Unicersity of Medical Sciences, Guangzhou 510060,China | 1996 | Eye Science1996，16，1： | 1 |
| 12 | Epitactic nucleation of spinel in aluminosilicate gels and its effect on mullite crystallization 显示文摘 | HULING J C MESSING G L | 1991 | J Am Ceram Soc1991，74，10： | 1 |
| 13 | A kinematic model for an adiabatic transfer line catalytic cracking reactor显示文摘 | SHAH Y T HULING G P PARASKOS J A | 1977 | Ind Eng Chem Proc Des Dev1977，16，1： | 1 |
| 14 | ZHURong-hua,ZHAOXu-yuan,DINGJing-song显示文摘 | YAOJin-cheng QUYan-hui HuLing LIHuan-de | | 中国药学0，，： | 1 |
| 15 | Are ducks contributing to the endemicity of highly pathogenic H5N1 influenza virus in Asia? 显示文摘 | STURM-RAMIREZ K M HULES D J GOVORKOV A | 2005 | J Virol2005，79，11： | 1 |
| 16 | Influence of peat on Fenton oxidation 显示文摘 | HULING S G ARNOLD R G SIERKA R A | 2001 | Water Research2001，35，7： | 1 |
| 17 | Contaminant adsorption and oxidation via Fenton reaction显示文摘 | HULING S G AMOLD R G SIERKA R A | 2000 | Journal of Environmenta/Engineering2000，126，7： | 1 |
| 18 | Measurement of hydroxyl radical activity in a soll slurry using the spin trap ct- (4-Pyridyl-l-oxide)- N-tert-butylnitrone 显示文摘 | Huling S G Arnold R G Sierka R A | 1998 | Environmen- tal Science and Technology1998，32，21： | 1 |
| 19 | Repeated reductlve and oxidative treatments of granular activated carbon 显示文摘 | HULING S G JONES P K ELA W P | 2005 | Journal of Environmental Engineering2005，131，2： | 1 |
| 20 | Fenton-driven chemical regeneration of MTBE-spent GAC 显示文摘 | Huling S G Jones P K Ela W P | 2005 | Water Research2005，39，10： | 1 |
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