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| 1 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 2 | 高血压患者血清磷酸盐与新发高尿酸血症风险的关系显示文摘血清磷酸盐与新发高尿酸血症的关系仍不确定。该研究对中国脑卒中一级预防试验(China stroke primary prevention trial,CSPPT)的尿酸亚组研究进行事后分析,旨在评估血清磷酸盐与新发高血尿酸症的风险之间的关系。研究包括基线尿酸水平正常(<357μmol/L)的参与者共10612人。主要观察指标是新发高血尿酸症,其定义为男性血尿酸浓度≥417或女性≥357μmol/L。在中位数为4.4年的随访期间,1663名(15.7%)参与者发生了新发高尿酸血症。 | 刘莉(译) 叶鹏(摘、审校) Cao J Zhang J Li Q Jiang C Song Y Liu C Liu L Wang B Li J Zhang Y Cui Y Huo Y Wang X Tang G Xu X Qin X | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 3 | Nanoindentafion tests on single crystal copper thin film with an AFM显示文摘 | Liang Y C Cheng K | 2003 | Journal of Harbin Institute of Technology (New Series)2003，10，3： | 1 |
| 4 | Expression of milk-derived antihypertensive peptide in Escherichia coli 显示文摘 | LV G S HUO G C FU X Y | 2003 | J Dairy Sci2003，86，： | 1 |
| 5 | A Physical Model for On-Chip Spiral Inductors With Accurate Substrate Modeling显示文摘 | Huo X Philip C H Kevin J C | 2006 | IEEE Trans Electron Devices2006，53，12： | 1 |
| 6 | 2013, Antigenic and genetic characterization of a European avian-like H1N1 swine influenza virus from a boy in China in 2011显示文摘 | Qi x Cui L Jiao Y Pan Y Li X Zu R Huo X Wu B Tang F Song Y Zhou M Wang H Cardona C J Xing Z | 2013 | Archives of Virology2013，158，1： | 1 |
| 7 | Comparison of sensitiza- tion between fl-lactoglobulin and its hydrolysates显示文摘 | DUAN C C HUO G C YANG L J | 2012 | AsianPac J Aller- gy Immunol2012，30，1： | 1 |
| 8 | Pioglitazone suppresses the lipopolysaccharide-induced production of inflammatory factors in mouse macrophages by inactivating NF-kappaB显示文摘 | Ao C Huo Y Qi L | 2010 | Cell Biol Int2010，34，7： | 1 |
| 9 | Spatial distribution, potential risk as- sessment, and source apportionment of polycyclic aromatic hydrocarbons (PAHs) in sediments of Lake Chaohu, China显示文摘 | LI C C HUO S L YU Z Q | 2014 | Environmental science and pollution research2014，21，12： | 1 |
| 10 | CO dissociation on clean and hydrogen precovered Fe(111) surfaces 显示文摘 | Huo C F REN J~ LI Y W | 2007 | Journal of Catalysis2007，249，2： | 1 |
| 11 | Research progress on laser surface modification of titanium alloys显示文摘 | Tian Y S Chen C Z Li S T Huo Q H | 2005 | Applied Surface Science2005，242，12： | 1 |
| 12 | Critical role ofmacrophage12/15lipoxygenase for atherosclerosis in apolipoprotein E-deficientmice显示文摘 | HUO Y ZHAO L H YMAN M C | 2004 | Circulation2004，110，14： | 1 |
| 13 | Reciprocal repression between microRNA-133and calcineurin regulates cardiac hypertrophy:a novel mechanism for pro-gressive cardiac hypertrophy显示文摘 | Dong DL Chen C Huo R | 2010 | Hypertension2010，55，4： | 1 |
| 14 | A novel liquid-phase strategy for organic synthesis using organic ions as soluble supports 显示文摘 | Huo C Chan T | 2010 | Chemical Society Re- views2010，39，8： | 1 |
| 15 | Studies on the Effectiveness of NaFeEDTA-Forti ]ed Soy Sauce in Controlling Iron Deciency: A Population-Based Intervention Trial 显示文摘 | Chen J Zhao X Zhang X Yin S Piao J Huo J Yu B Qu N Lu Q Wang S Chen C | 2005 | Food and NutritionBulletin2005，26，2： | 1 |
| 16 | Synthesis of 13- cyclodextrin modified ehitosan-poly ( acrylic acid ) nanoparticles and use as drug carriers 显示文摘 | Wang X Chen C J Huo D | 2012 | CarbohydratePolymers2012，90，1： | 1 |
| 17 | Optimization of multiple objective gate assignments显示文摘 | YAN Shang-yao HUO C M | 2001 | Transportation Research Part A: Policy and Practice2001，35，5： | 1 |
| 18 | Multilevel SIFT- Matching for Large-Size VHR Image Registration 显示文摘 | Huo C Pan C Huo L | 2012 | IEEE Geoscience and Remote Sensing Letters2012，9，2： | 1 |
| 19 | Lower Limb Wearable Robots for Assistance and Rehabilitation: A State of the Art 显示文摘 | Huo W Mohammed S Moreno J C | 2014 | IEEE SYSTEMS JOURNAL2014，，： | 1 |
| 20 | Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders,age of onset and suicidal behavior显示文摘 | HONG C J HUO S J YEN F C | 2003 | Neuropsychobiology2003，48，4： | 1 |
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