5篇
您的检索式：作者名="Huping Wang"
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| 1 | Baicalin extracted from Huangqin(Radix Scutellariae Baicalensis) induces apoptosis in gastric cancer cells by regulating B cell lymphoma(Bcl-2)/Bcl-2-associated X protein and activating caspase-3 and caspase-9显示文摘OBJECTIVE:To evaluate the effects of baicalin in human gastric cancer cells, including apoptosis-inducing effects, and to investigate its underlying mechanisms of action.METHODS:Cell proliferation and apoptosis assays were performed to investigate the anti-proliferation effects of baicalin in human gastric cancer BGC-823 and MGC-803 cells.Real time-quantitative polymerase chain reaction and Western blotting analysis were performed to elucidate the molecular mechanisms underlying the anti-tumor properties of baicalin.RESULTS:In BGC-823 and MGC-803 gastric cancer cells treated with 80, 120, and 160 μmol/L baicalin for 48 h, a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay showed that baicalin significantly inhibited cell proliferation in a dose-dependent manner, while flow cytometric analysis demonstrated that baicalin could induce apoptosis, also in a dose-dependent manner.Moreover, baicalin up-regulated the expression of caspase-3, caspase-9, and B cell lymphoma(Bcl-2)-associated X protein and down-regulated the expression of Bcl-2 at both the m RNA and protein level.CONCLUSION:Baicalin has potential as a therapeutic agent for gastric cancer by inducing apoptosis in cancer cells. | Wang Hongwei Li Hailong Chen Fengqin Luo Jun Gu Jing Wang Huping Wu Hongyan Xu Yan | 2017 | Journal of Traditional Chinese Medicine2017，37，2： | 13 |
| 2 | Expression of CD18 on the neutrophils of patients with diabetic retinopathy显示文摘 | Huping Song Lili Wang Yannian Hui | 2007 | Graefe’s Archive for Clinical and Experimental Ophthalmology2007，，1： | 1 |
| 3 | Localized solutions to interval linear equations 显示文摘 | Wei Li Huping Wang Qing Wang | 2012 | journal of computational and applied mathematics2012，，15： | 1 |
| 4 | Expression of CD18 on the neutrophils of patients with diabetic retinopathy显示文摘 | Huping Song Lili Wang Yannian Hui | 2007 | Graefe’s Archive for Clinical and Experimental Ophthalmology2007，，1： | 1 |
| 5 | Sister chromatid exchange and DNA damage in human lymphocytes induced by air-dust in Lanzhou City: involvement in free radicals显示文摘The air-dust samples collected from petro-chemical industrial region in the suburb of Lanzhou and from a certain rural region 64 km away from the city were extracted, with a mixed solvent (benzene: hexane: isopropanol=7:2:1) for 8 hours. A strong free radical signal at g= 2.00 of air-dust itself and a hyperfine splitting EPR signal of extract from air-dust have been detected. The sister chromatid exchange frequency (SCE) was increased by extracts of both dusts from the industrial region and from the rural region. If a chemical is able to increase SCE up to twice as high as the control, this chemical is considered to be mutagenic and/or carcinogenic. The double SCE frequency concentration is 23 μg/ml for the dust extract obtained from the industrial region and 47μg/ml for that from the rural region. Extracts were able to damage to DNA template. Results indicated that the mutagenicity and/or carcinogenicity of the extracts obtained from the petro-chemical industrial region were stronger than that of | Zheng Rongliang, Wang Xiaoxuan, Hu Huping Fan Zhanru and Zhang YuzhanLaboratory of Biophysics,Department of Biology,Lanshou University,Lanshou 730000,China. | 1991 | Journal of Environmental Sciences1991，3，2： | 0 |
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