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| 1 | Constitutive renal Rel/nuclear factor-κB expression in Lewis polycystic kidney disease rats显示文摘AIM:To determine the temporal expression and pattern of Rel/nuclear factor(NF)-κB proteins in renal tissue in polycystic kidney disease(PKD). METHODS: The renal expression of Rel/NF-κB proteins was determined by immunohistochemistry, immunofluorescence and immunoblot analysis in Lewis polycystic kidney rats(LPK, a genetic ortholog of human nephronopthsis-9) from postnatal weeks 3 to 20. At each timepoint, renal disease progression and the mR NA expression of NF-κB-dependent genes(TNFa and CCL2) were determined. NF-κB was also histologicaly assessed in human PKD tissue.RESULTS: Progressive kidney enlargement in LPK rats was accompanied by increased renal cell proliferation and interstitial monocyte accumulation(peaking at weeks 3 and 10 respectively), and progressive interstitial fibrosis(with a smooth muscle actin and Sirius Red deposition significantly increased compared to Lewis kidneys from weeks 3 to 6 onwards). Rel/NF-κB proteins(phosphorylated-p105, p65, p50, c-Rel and RelB) were expressed in cystic epithelial cells(CECs) of LPK kidneys as early as postnatal week 3 and sustained until latestage disease at week 20. From weeks 10 to 20, nuclear p65, p50, Rel B and cytoplasmic IκBa protein levels, and TNFa and CCL2 expression, were upregulated in LPK compared to Lewis kidneys. NF-κB proteins were consistently expressed in CECs of human PKD. The DNA damage marker γ-H2AX was also identified in the CECs of LPK and human polycystic kidneys. CONCLUSION: Several NF-κB proteins are consistently expressed in CECs in human and experimental PKD. These data suggest that the upregulation of both the canonical and non-canonical pathways of NF-κB signaling may be a constitutive and early pathological feature of cystic renal diseases. | Michelle HT Ta Kristina G Schwensen David Liuwantara David L Huso Terry Watnick Gopala K Rangan | 2016 | World Journal of Nephrology2016，5，4： | 2 |
| 2 | Outgrowth of a transformed population derived from normal human mesenehymal stem cell culture 显示文摘 | Wang Y Huso DL Harrington J | 2005 | Cytotherapy2005，7，： | 1 |
| 3 | Outgrowth of a transformed cell population derived from normal human BM mesenchymal stem cell culture 显示文摘 | Wang Y Huso DL Harrington J | 2005 | Cytotherapy2005，7，6： | 1 |
| 4 | IMC-EB10,an Anti-FLT3 Monoclonal Antibody,Prolongs Survival and Reduces Nonobese Diabetic/Severe Combined Immunodeficient Engraftment of Some Acute Lymphoblastic Leukemia Cell Lines and Primary Leukemic Samples显示文摘 | Piloto O Nguyen B Huso D | 2006 | Cancer Res2006，66，9： | 1 |
| 5 | Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment显示文摘 | Osburn WO Karim B Dolan PM Liu G Yamamoto M Huso DL | 2007 | Int J Cancer2007，121，9： | 1 |
| 6 | Combination bacteriolytic therapy for the treatment of experimental tumors显示文摘 | Dang LH 1 Bettegowda C Huso D L | 2001 | Proc Natl Acad Sci2001，98，15： | 1 |
| 7 | Nitric oxide synthase in cardiac sarcoplasmic retiealum 显示文摘 | Xu KY Huso D L DawsonT M | 1999 | Proc Natl Aead Sci U S A1999，96，2： | 1 |
| 8 | Combination bacteriolytic therapy for the treatment of experimental tumors 显示文摘 | Dang LH Bettegowda C Huso DL | 2001 | Proc Natl Aead Sci U S A2001，98，15： | 1 |
| 9 | Diaruption of Id1 reveals major differences in angiogenesis between transplanted and autochthonous tumors显示文摘 | Sikder H Huso D L Zhang H | 2003 | Cancer Cell2003，4，4： | 1 |
| 10 | Progressive cerebellar, auditory, and esophageal dysfunction of the frizzled-4 gene显示文摘 | Wang Y Huso D Cahill H | 2001 | J Neurosci2001，21，13： | 1 |
| 11 | Combination bacteriolytic therapy for the treatment of experimental tumors显示文摘 | Dang Lh Bettegowda C Huso DL | 2001 | Proc Natl Acad Sci U S A2001，98，15： | 1 |
| 12 | Use of downed wood by Townsend's Chipmunks (Tamias townsendii) in Western Oregon显示文摘 | Waldien D L Hayes J P Huso M M P | 2006 | Journal of mammalogy2006，87，3： | 1 |
| 13 | Habitat selection by juvenile Swainson' s thrushes (Catharus ustMatus ) in headwater riparian areas, Northwestern Oregon, USA 显示文摘 | JENKINS S R BETTS M G HUSO M M | 2013 | Forest Ecology and Management2013，305，1： | 1 |
| 14 | Combination baeteriolytic therapy for the treatment of experimental tumors显示文摘 | Dang L H Bettegowda C Huso D L | 2001 | Medical Science2001，98，15： | 1 |
| 15 | NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins 显示文摘 | Huang G N Huso D L Bouyain S | 2008 | Science2008，319，5862： | 1 |
| 16 | Combination baeteriolytic therapy for the treatment of experimental tumors 显示文摘 | DANG L H BETTEGOWDA C HUSO D L | 2001 | Proc Natl Acad Sci USA2001，98，26： | 1 |
| 17 | Use of downed wood by Townsend's Chipmunks Tamias townsendii in Western Oregon显示文摘 | WALDIEN D L HAYES J P HUSO M M P | 2006 | Journal of Mammalogy2006，87，3： | 1 |
| 18 | Outgrowth of a transformed cel population derived from normal human BM mesenchymal stem cel culture显示文摘 | Wang Y Huso DL Harrington J | | 0，，06： | 1 |
| 19 | Outgrowth of a transformed cell population derived from normal human BM mesenchymal stem cell culture显示文摘 | Wang Y Huso DL Harrington J | 2005 | Cytotherapy2005，7，6： | 1 |
| 20 | Incorporation of Cu acceptors in ZnO nanocrystals显示文摘 | Hlaing Oo W M McCluskey M D Huso J | | 0，，06： | 1 |
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