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| 1 | Developing DNA methylation-based diagnostic biomarkers显示文摘An emerging paradigm shift for disease diagnosis is to rely on molecular characterization beyond traditional clinical and symptom-based examinations. Although genetic alterations and transcription signature were first introduced as potential biomarkers, clinical implementations of these markers are limited due to low reproducibility and accuracy. Instead, epigenetic changes are considered as an alternative approach to disease diagnosis. Complex epigenetic regulation is required for normal biological functions and it has been shown that distinctive epigenetic disruptions could contribute to disease pathogenesis. Disease-specific epigenetic changes, especially DNA methylation, have been observed,suggesting its potential as disease biomarkers for diagnosis. In addition to specificity, the feasibility of detecting disease-associated methylation marks in the biological specimens collcted noninvasively,such as blood samples, has driven the clinical studies to validate disease-specific DNA methylation changes as a diagnostic biomarker. Here, we highlight the advantages of DNA methylation signature for diagnosis in different diseases and discuss the statistical and technical challenges to be overcome before clinical implementation. | Hyerim Kim Xudong Wang Peng Jin | 2018 | Journal of Genetics and Genomics2018，45，2： | 4 |
| 2 | Therapeutic gene editing: delivery and regulatory perspectives显示文摘 | Gayong SHIM Dongyoon KIM Gyu Thae PARK Hyerim JIN Soo-Kyung SUH Yu-Kyoung OH | 2017 | Acta Pharmacologica Sinica2017，38，6： | 3 |
| 3 | Claudin 4-targeted nanographene phototherapy using a Clostridium perfringens enterotoxin peptidephotosensitizer conjugate显示文摘 | Gayong SHIM Mi-Gyeong KIM Hyerim JIN Jinyoung KIM Yu-Kyoung OH | 2017 | Acta Pharmacologica Sinica2017，38，6： | 2 |
| 4 | Automatic control of workflow processes using ECA rules显示文摘 | Joonsoo Bae Hyerim Bae Suk Ho Kang Yeongho Kim | 2004 | IEEE2004，16，8： | 1 |
| 5 | A document-process association model for workflow management 显示文摘 | Hyerim Bae Yeongho Kim | 2002 | Computers in Industry2002，47，2： | 1 |
| 6 | Quench distribution in superconducting fault current limiters at various voltages 显示文摘 | KIM Hyerim CHOI Hyosang LIM Haeryong | 2001 | Cryogenics2001，41，2： | 1 |
| 7 | The KDM4B–CCAR1–MED1 axis is a critical regulator of osteoclast differentiation and bone homeostasis显示文摘Bone undergoes a constant and continuous remodeling process that is tightly regulated by the coordinated and sequential actions of bone-resorbing osteoclasts and bone-forming osteoblasts.Recent studies have shown that histone demethylases are implicated in osteoblastogenesis;however,little is known about the role of histone demethylases in osteoclast formation.Here,we identified KDM4B as an epigenetic regulator of osteoclast differentiation.Knockdown of KDM4B significantly blocked the formation of tartrate-resistant acid phosphatase-positive multinucleated cells.Mice with myeloid-specific conditional knockout of KDM4B showed an osteopetrotic phenotype due to osteoclast deficiency.Biochemical analysis revealed that KDM4B physically and functionally associates with CCAR1 and MED1 in a complex.Using genome-wide chromatin immunoprecipitation(ChIP)-sequencing,we revealed that the KDM4B–CCAR1–MED1 complex is localized to the promoters of several osteoclast-related genes upon receptor activator of NF-κB ligand stimulation.We demonstrated that the KDM4B–CCAR1–MED1 signaling axis induces changes in chromatin structure(euchromatinization)near the promoters of osteoclast-related genes through H3K9 demethylation,leading to NF-κB p65 recruitment via a direct interaction between KDM4B and p65.Finally,small molecule inhibition of KDM4B activity impeded bone loss in an ovariectomized mouse model.Taken together,our findings establish KDM4B as a critical regulator of osteoclastogenesis,providing a potential therapeutic target for osteoporosis. | Sun-Ju Yi You-Jee Jang Hye-Jung Kim Kyubin Lee Hyerim Lee Yeojin Kim Junil Kim Seon Young Hwang Jin Sook Song Hitoshi Okada Jae-Il Park Kyuho Kang Kyunghwan Kim | 2021 | Bone Research2021，9，3： | 1 |
| 8 | A document-process association model for workflow management显示文摘 | HYERIM Bae YEONGHO Kim | 2002 | Computer in Industry2002，47，2： | 1 |
| 9 | Development of a liposome-based immunochromatographic strip assay for the detection of Salmonella 显示文摘 | Shruti Shukla Hyerim Leem Myunghee Kim | 2011 | Anal Bioanal Chem2011，401，8： | 1 |
| 10 | Micro-Locational Fine Dust Prediction Utilizing Machine Learning and Deep Learning Models显示文摘Given the increasing number of countries reporting degraded air quality,effective air quality monitoring has become a critical issue in today’s world.However,the current air quality observatory systems are often prohibitively expensive,resulting in a lack of observatories in many regions within a country.Consequently,a significant problem arises where not every region receives the same level of air quality information.This disparity occurs because some locations have to rely on information from observatories located far away from their regions,even if they may be the closest available options.To address this challenge,a novel approach that leverages machine learning and deep learning techniques to forecast fine dust concentrations was proposed.Specifically,continuous location features in the form of latitude and longitude values were incorporated into our models.By utilizing a comprehensive dataset comprising weather conditions,air quality measurements,and location properties,various machine learning models,including Random Forest Regression,XGBoost Regression,AdaBoost Regression,and a deep learning model known as Long Short-Term Memory(LSTM)were trained.Our experimental results demonstrated that the LSTM model outperforms the other models,achieving the best score with a root mean squared error of 23.48 in predicting fine dust(PM10)concentrations on an hourly basis.Furthermore,the fact that incorporating location properties,such as longitude and latitude values,enhances the overall quality of the regression models was discovered.Additionally,the implications and contributions of our research were discussed.By implementing our approach,the cost associated with relying solely on existing observatories can be substantially reduced.This reduction in costs can pave the way for economically efficient fine dust observation systems,ensuring more widespread and accurate air quality monitoring across different regions. | Seoyun Kim Hyerim Yu Jeewoo Yoon Eunil Park | 2024 | Computer Systems Science & Engineering2024，48，2： | 0 |
| 11 | Central retinal artery occlusion in eosinophilic granulomatosis with polyangiitis(Churg-Strauss Syndrome):the first case report in South Korea显示文摘Dear Editor,I am Dr.Jungyul Park from the Department of Ophthalmology,Pusan National University Hospital,Busan,Korea.I am writing to present a case of eosinophilic granulomatosis with polyangiitis(EGPA)with central retinal artery occlusion(CRAO).It provides important information about the relationship between ANCA and CRAO in a patient who was diagnosed with EGPA who had ophthalmic symptoms.We believe that our study makes a significant contribution to the literature because to our knowledge,the literature of EGPA with CRAO are rare worldwide and this is even the first case of EGPA with CRAO in Republic of Korea. | Jungyul Park Up Huh Hee-young Choi Seunggeun Lee Miyeun Han Sungwoon Chung Hyerim Kim | 2021 | International Journal of Ophthalmology(English edition)2021，14，6： | 0 |
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