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| 1 | Immunological Effects of Silica and Asbestos显示文摘Silicosis patients(SILs) and patients who have been exposed to asbestos develop not only respiratory diseases but also certain immunological disorders. In particular,SIL sometimes complicates autoimmune diseases such as systemic scleroderma,rheumatoid arthritis(known as Caplan syndrome) ,and systemic lupus erythematoses. In addition,malignant complications such as lung cancer and malignant mesothelioma often occurr in patients exposed to asbestos,and may be involved in the reduction of tumor immunity. Although silica-induced disorders of autoimmunity have been explained as adjuvant-type effects of silica,more precise analyses are needed and should reflect the recent progress in immunomolecular findings. A brief summary of our investigations related to the immunological effects of silica/asbestos is presented. Recent advances in immunomolecular studies led to detailed analyses of the immunological effects of asbestos and silica. Both affect immuno-competent cells and these effects may be associated with the pathophysiological development of complications in silicosis and asbestos-exposed patients such as the occurrence of autoimmune disorders and malignant tumors,respectively. In addition,immunological analyses may lead to the development of new clinical tools for the modification of the pathophysiological aspects of diseases such as the regulation of autoimmunity or tumor immunity using cell-mediated therapies,various cytokines,and molecule-targeting therapies. In particular,as the incidence of asbestos-related malignancies is increasing and such malignancies have been a medical and social problem since the summer of 2005 in Japan,efforts should be focused on developing a cure for these diseases to eliminate nationwide anxiety. | Takemi Otsuki Megumi Maeda Shuko Murakami Hiroaki Hayashi Yoshie Miura Masayasu Kusaka Takashi Nakano Kazuya Fukuoka Takumi Kishimoto Fuminori Hyodoh Ayako Ueki Yasumitsu Nishimura | 2007 | Cellular & Molecular Immunology2007，4，4： | 9 |
| 2 | Use of fusion imase of 131I-metaiodobenzyl-guanidine,SPECT,and magnetic resonance studies to identify a malignant pheochromocytoma显示文摘 | Fujita A Hyodoh H Kawamura Y | 2000 | Clin Nucl Med2000，25，： | 1 |
| 3 | Early-stage rheumatoid arthritis:prospective study of the effectiveness of MR imaging for diagnosis显示文摘 | Takeda A Hyodoh K | 2000 | Radiology2000，216，2： | 1 |
| 4 | Magnetic resonance angiographie localization of the artery of Adamkiewicz for spinal cord blood supply 显示文摘 | Kawaharada N Morishita K Hyodoh H | 2004 | Ann Thorac Surg2004，78，3： | 1 |
| 5 | High-flow arteriovenous malformation of the lower extremity: ethanolamine oleate sclerotherapy显示文摘 | Hyodoh H Fujita A Hyodoh K | 2001 | Cardiovasc Intervent Radiol2001，24，5： | 1 |
| 6 | Usefulness of preoperative detection of artery of Adamkiewicz with dynamic contrast-enhanced MR angiography显示文摘 | Hyodoh H Kawaharada N Akiba H | 2005 | Radiology2005，236，10： | 1 |
| 7 | Induction of CD69 antigen expression in peripheral blood mononuclear cells on exposure to silica, but not by asbestoa/ehrysotile-A 显示文摘 | WU P HYODOH F HATAYAMA T ctal | 2005 | Immunol Lett2005，98，1： | 1 |
| 8 | Assessment of dural arteriovenous fistulas of the cavernous sinuses on 3D dynamic MR angiography显示文摘 | Akiba H Tamakawa M Hyodoh H | 2008 | AJNR2008，29，9： | 1 |
| 9 | Use of fusion images of 131I metaiodobenzylguanidine,SPECT,and magnetic resonance studies to identify a malignant pheochromocytoma显示文摘 | Fujita A Hyodoh H Kawamura Y | 2000 | Clin Nucl Med2000，25，6： | 1 |
| 10 | Brachial plexus: normal anato- myand pathological conditions 显示文摘 | Hyodoh K Hyodoh H Akiba H | 2002 | Curt Probl Diagn Radiol2002，31，： | 1 |
| 11 | Early-stage rheumatoid arthritis:prospective study of the effectiveness of MR imaging for diagnosis显示文摘 | Sugimoto H Takeda A Hyodoh K | 2000 | Radiology2000，216，： | 1 |
| 12 | Double-subtraction maximum intensity projection MR angiography for detecting the artery of Adamkiewicz and differentiating it from the drainage vein显示文摘 | Hyodoh H Shirase R Akiba H | 2007 | J Magn Reson Imaging2007，26，2： | 1 |
| 13 | Early stage rheumatoidarthritis:prospective study of the effectiveness of MRimaging for diagnosis显示文摘 | Sugimoto H Takeda A Hyodoh K | 2000 | Radiology2000，216，5： | 1 |
| 14 | A retrospective study onthe transition of radiation dose rate and iodine distribution in pa-tients with I-131-treated well differentiated thyroid cancer to im-prove bed control shorten isolation periods显示文摘 | Yama N Sakata KI Hyodoh H | 2012 | Annals of NuclearMedicine2012，26，5： | 1 |
| 15 | Early-stage rheumatoid arthritis:prospective study of the effectiveness of MR imaging for diagnosis显示文摘 | Sugimoto H Takeda A Hyodoh K | | 0，，02： | 1 |
| 16 | Early-stage rheumatoid arthritis:prospective study of the effectiveness of MR imaging for diagnosis显示文摘 | Sugimoto H Takeda A Hyodoh K | 2000 | Radiology2000，216，： | 1 |
| 17 | Early - stage rheumatoid arthritis:prospective dy of the effectiveness of MR imaging for diagnosis显示文摘 | Sugimoto H Takeda A Hyodoh K | 2000 | Radiology2000，216，2： | 1 |
| 18 | Multi-step neoplastic transformation of normal human fibroblasts by 60 Co Gamma rays and Ha-ras onco genes显示文摘 | Namba M Nishitani K Hyodoh F | 1988 | Muat Res1988，199，： | 1 |
| 19 | Negplastic transformation of hu man diploid fibroblasts(KMST-6) by treatment with 60Co gamma rays显示文摘 | Namber M Nishitani K Hyodoh F | 1985 | Int J Cancer1985，35，： | 1 |
| 20 | Assessment of dural arteriovenous fistulas of the cavemous sinuses on 3D dynamic MR angiography显示文摘 | Akiba H Tamakawa M Hyodoh H | | 0，，09： | 1 |
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