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| 1 | Immunological Effects of Silica and Asbestos显示文摘Silicosis patients(SILs) and patients who have been exposed to asbestos develop not only respiratory diseases but also certain immunological disorders. In particular,SIL sometimes complicates autoimmune diseases such as systemic scleroderma,rheumatoid arthritis(known as Caplan syndrome) ,and systemic lupus erythematoses. In addition,malignant complications such as lung cancer and malignant mesothelioma often occurr in patients exposed to asbestos,and may be involved in the reduction of tumor immunity. Although silica-induced disorders of autoimmunity have been explained as adjuvant-type effects of silica,more precise analyses are needed and should reflect the recent progress in immunomolecular findings. A brief summary of our investigations related to the immunological effects of silica/asbestos is presented. Recent advances in immunomolecular studies led to detailed analyses of the immunological effects of asbestos and silica. Both affect immuno-competent cells and these effects may be associated with the pathophysiological development of complications in silicosis and asbestos-exposed patients such as the occurrence of autoimmune disorders and malignant tumors,respectively. In addition,immunological analyses may lead to the development of new clinical tools for the modification of the pathophysiological aspects of diseases such as the regulation of autoimmunity or tumor immunity using cell-mediated therapies,various cytokines,and molecule-targeting therapies. In particular,as the incidence of asbestos-related malignancies is increasing and such malignancies have been a medical and social problem since the summer of 2005 in Japan,efforts should be focused on developing a cure for these diseases to eliminate nationwide anxiety. | Takemi Otsuki Megumi Maeda Shuko Murakami Hiroaki Hayashi Yoshie Miura Masayasu Kusaka Takashi Nakano Kazuya Fukuoka Takumi Kishimoto Fuminori Hyodoh Ayako Ueki Yasumitsu Nishimura | 2007 | Cellular & Molecular Immunology2007，4，4： | 9 |
| 2 | Decrease in Serum Amyloid a Protein Levels Following Three-month Stays in Negatively Charged Particle-dominant Indoor Air Conditions显示文摘Objective The changes in serum adipokines and cytokines related to oxidative stress were examined during 3 months ‘Off to On' and ‘On to Off' periods using negatively charged particle-dominant indoor air conditions(NCPDIAC).Methods Seven volunteers participated in the study,which included ‘OFF to 3 months ON' periods(ON trials) for a total of 16 times,and ‘ON to 3 months OFF'(OFF trials) periods for a total of 13 times.Results With the exception of one case,serum amyloid A(SAA) levels decreased significantly during the ON trials.Conclusion Considering that SAA is an acute phase reactive protein such as C reactive protein(CRP),this observed decrease might indicate the prevention of cardiovascular and atherosclerotic changes,since an increase in high-sensitive CRP is associated with the subsequent detection of these events. | Suni Lee Shoko Yamamoto Yasumitsu Nishimura Hidenori Matsuzaki Kei Yoshitome Tamayo Hatayama Miho Ikeda YU Min Nagisa Sada Naoko Kumagai-Takei Takemi Otsuki | 2018 | Biomedical and Environmental Sciences2018，31，5： | 5 |
| 3 | Downregulation of microRNA-34 induces cell proliferation and invasionof human mesothelial cells显示文摘 | Norimitsu Tanaka Shinichi Toyooka Junichi Soh Kazunori Tsukuda Kazuhiko Shien Masashi Furukawa Takayuki Muraoka Yuho Maki Tsuyoshi Ueno Hiromasa Yamamoto Hiroaki Asano Takemi Otsuki Shinichiro Miyoshi | 2013 | Oncology Reports2013，，6： | 1 |
| 4 | Ex- pression levels of estrogen receptor - a, estrogen receptor - b, co- activators,and corepressors in breast cancer 显示文摘 | Junichi Kurebayashi Takemi Otsuki Hironori Kunisue | 2000 | Clin Cancer Res2000，6，： | 1 |
| 5 | Involvement of IL-10 and Bcl-2 in resistance against an asbestos-induced apoptosis of T cells显示文摘 | Yoshie Miura Yasumitsu Nishimura Hironobu Katsuyama Megumi Maeda Hiroaki Hayashi Maolong Dong Fuminori Hyodoh Masafumi Tomita Yoshinobu Matsuo Ayuko Uesaka Kozo Kuribayashi Takashi Nakano Takumi Kishimoto Takemi Otsuki | 2006 | Apoptosis2006，，10： | 1 |
| 6 | Biological Effects of Cloth Containing Specific Ore Powder in Patients with Pollen Allergy显示文摘Objective The custom-homebuilding company,Cosmic Garden Co.Ltd.,located in Okayama City,Japan was established in 1997 and uses specific natural ore powder(SNOP) in wall materials and surveys customers in order to improve allergic symptoms.Methods To investigate the biological effects of SNOP,patients with a pollen allergy were recruited to stay in a room surrounded by cloth containing SNOP(CCSNOP),and their symptoms and various biological parameters were compared with those of individuals staying in a room surrounded by control non-woven cloth(NWC).Each stay lasted 60 min.Before and immediately after the stay,a questionnaire regarding allergic symptoms,as well as POMS(Profile of Mood Status) and blood sampling,was performed.Post-stay minus pre-stay values were calculated and compared between CCSNOP and NWC groups.Results Results indicated that some symptoms,such as nasal obstruction and lacrimation,improved,and POMS evaluation showed that patients were calmer following a stay in CCSNOP.Relative eosinophils,non-specific Ig E,epidermal growth factor,monocyte chemotactic protein-1,and tumor necrosis factor-α increased following a stay in CCSNOP.Conclusion This ore powder improved allergic symptoms,and long-term monitoring involving 1 to 2 months may be necessary to fully explore the biological and physical effects of SNOP on allergic patients. | Suni LEE Hitoshi OKAMOTO Shoko YAMAMOTO Tamayo HATAYAMA Hidenori MATSUZAKI Naoko KUMAGAI-TAKEI Kei YOSHI-TOME Yasumitsu N1SHIMURA Toshiaki SATO Yasuzo KIRITA Yoshio FUJII Takemi OTSUKI | 2016 | Biomedical and Environmental Sciences2016，29，8： | 0 |
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