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| 1 | Impact of tumor location on clinical outcomes of gastric endoscopic submucosal dissection显示文摘AIM:To determine whether there is a correlation between the location of the lesion and endoscopic submucosal dissection(ESD)outcome.METHODS:From January 2008 to December 2010,ESD of 1443 gastric tumors was performed.En bloc resection rate,complete resection rate,procedure time and complication rate were analyzed according to the tumor location.RESULTS:The rates of en bloc resection and complete resection were 91%(1318/1443)and 89%(1287/1443),respectively.The post-ESD bleeding rate was 4.3%,and perforation rate was 2.7%.Tumors located in the upper third of the stomach were associated with a longer procedure time and significantly higher rates of incomplete resection,piecemeal resection,and perforation than tumors below the upper third of the stomach.Posterior wall lesions had significantly longer procedure times and higher rates of incomplete resection and piecemeal resection than lesions in other locations.In multivariate analysis,posterior wall lesions and upper third lesions were significantly associated with incomplete resection and perforation,respectively.In post-ESD bleeding analysis,location was not a significant related factor.CONCLUSION:More advanced endoscopic techniques are required during ESD for lesions located in the upper third or posterior wall of the stomach to decrease complications and improve therapeutic outcomes. | Ji Young Yoon Choong Nam Shim Sook Hee Chung Wan Park Hyunsoo Chung Hyuk Lee Sung Kwan Shin Sang Kil Lee Yong Chan Lee Jun Chul Park | 2014 | World Journal of Gastroenterology2014，20，26： | 10 |
| 2 | Hwangryunhaedoktang exerts anti-inflammation on LPS-induced NO production by suppressing MAPK and NF-κB activation in RAW264.7 macrophages显示文摘OBJECTIVE: This study aimed to evaluate whether Hwangryunhaedoktang(HHT), a herbal compound, has an inhibitory effect on lipopolysaccharide(LPS)-induced inflammation in RAW264.7 macrophages.METHODS: The effects of HHT were evaluated by confirming nitric oxide(NO) production and expression of inducible NO synthase(iN OS) and mitogen-activated protein kinases(MAPKs) in LPS-stimulated RAW264.7 macrophages via the Griess assay, Western blotting, and real-time reverse transcription quantitative polymerase chain reaction. Western blot analyses and luciferase assays were used to evaluate whether HHT has an effect on the phosphorylation and translocation of nuclear factor-κB(NF-κB). The secretion and expression of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) were determined via enzyme-linked immunosorbent assay and Western blot analyses.RESULTS: HHT suppressed LPS-induced NO production and expression of iN OS in a dose-dependent manner. Additionally, MAPKs activation was also attenuated via inhibition of phosphorylation of extracellular signal-regulated kinases 1/2, c-Jun N-terminal kinase and p38 which were related to inflammatory pathway. Furthermore, HHT also effectively attenuated NF-κB activation and its translocation to the nucleus, a process that is closely linked to inflammation. LPS normally induced the expression of inflammatory cytokines such as TNF-α and IL-6, but the secretion and expression of TNF-α and IL-6 were significantly attenuated by pretreating the cells with HHT.CONCLUSION: HHT suppressed LPS-induced NO production by blocking the activation of NF-κB and MAPK signaling pathways in RAW264.7 macrophages. Furthermore, HHT may have an anti-inflammatory effect by suppressing the LPS-induced secretion of TNF-α and IL-6. Therefore, the traditional herbal formula HHT might be a useful potential therapeutic agent for inflammation. | Byung Hyuk Han Yun Jung Lee Jung Joo Yoon Eun Sik Choi Seung Namgung Xian Jun Jin Da Hye Jeong Dae Gill Kang Ho Sub Lee | 2017 | Journal of Integrative Medicine2017，15，4： | 5 |
| 3 | Akt is negatively regulated by the MULAN E3 ligase显示文摘serine/threonine kinase Akt 在多重细胞的进程工作,包括房间幸存和肿瘤开发。否定地调整 Akt 的机制的研究集中了于调停 dephosphorylation 的 inactivation。在这研究,我们识别了 Akt 的一个否定管理者, MULAN,它拥有一个戒指手指领域和 E3 ubiquitin ligase 活动。Akt 被发现直接与 MULAN 交往并且是由在 vitro 并且在 vivo 的 MULAN 的 ubiquitinated。另外的分子的试金证明 phosphorylated Akt 由 MULAN 是为和 MULAN 和 ubiquitination 的相互作用的一个真实目标。功能的研究的结果建议由 MULAN 的 Akt 的降级压制房间增长和生存能力。这些数据提供卓见进 Akt ubiquitination 发信号网络。 | Seunghee Bae Sun-Yong Kim Jin Hyuk Jung Yeongmin Yoon Hwa Jun Cha Hyunjin Lee Karam Kim Jongran Kim In-Sook An Jongdoo Kim Hong-Duck Um In-Chul Park Su-Jae Lee Seon Young Nam Young-Woo Jin Jae Ho Lee Sungkwan An | 2012 | Cell Research2012，22，5： | 3 |
| 4 | Expression of survivin and clinical correlation in patients with breast cancer显示文摘 | Doo Min Sohn Sung Yong Kim Moo Jun Baek Cheol Wan Lim Min Hyuk Lee Moo Sik Cho Tae Yoon Kim | 2006 | Biomedicine & Pharmacotherapy2006，，6： | 2 |
| 5 | Meta‐analysis: Is sequential therapy superior to standard triple therapy for H elicobacter pylori infection in A sian adults?显示文摘 | Hyuk Yoon Dong Ho Lee Nayoung Kim Young Soo Park Cheol Min Shin Kyu Keun Kang Dong Hyun Oh Dong Kee Jang Jun‐Won Chung | 2013 | J Gastroenterol Hepatol2013，，12： | 2 |
| 6 | The optimal duration of preoperative biliary drainage for periampullary tumors that cause severe obstructive jaundice显示文摘 | Jun Hyuk Son Jaihwan Kim Sang Hyub Lee Jin-Hyeok Hwang Ji Kon Ryu Yong-Tae Kim Yong Bum Yoon Jin-Young Jang Sun-Whe Kim Jai Young Cho Yoo-Seok Yoon Ho-Seong Han Sang Myung Woo Woo Jin Lee Sang Jae Park | 2013 | The American Journal of Surgery2013，，1： | 1 |
| 7 | Performance of a diffusion barrier under a fuel–clad chemical interaction (FCCI)显示文摘 | Jun Hwan Kim Ho Jin Ryu Jong Hyuk Baek Seok Jin Oh Byoung Oon Lee Chan Bock Lee Young Soo Yoon | 2009 | Journal of Nuclear Materials2009，，2： | 1 |
| 8 | Regeneration-associated macrophages: a novel approach to boost intrinsic regenerative capacity for axon regeneration显示文摘Axons in central nervous system(CNS) do not regenerate spontaneously after injuries such as stroke and traumatic spinal cord injury.Both intrinsic and extrinsic factors are responsible for the regeneration failure.Although intensive research efforts have been invested on extrinsic regeneration inhibitors,the extent to which glial inhibitors contribute to the regeneration failure in vivo still remains elusive.Recent experimental evidence has rekindled interests in intrinsic factors for the regulation of regeneration capacity in adult mammals.In this review,we propose that activating macrophages with pro-regenerative molecular signatures could be a novel approach for boosting intrinsic regenerative capacity of CNS neurons.Using a conditioning injury model in which regeneration of central branches of dorsal root ganglia sensory neurons is enhanced by a preceding injury to the peripheral branches,we have demonstrated that perineuronal macrophages surrounding dorsal root ganglia neurons are critically involved in the maintenance of enhanced regeneration capacity.Neuron-derived chemokine(C-C motif) ligand 2(CCL2) seems to mediate neuron-macrophage interactions conveying injury signals to perineuronal macrophages taking on a soley pro-regenerative phenotype,which we designate as regeneration-associated macrophages(RAMs).Manipulation of the CCL2 signaling could boost regeneration potential mimicking the conditioning injury,suggesting that the chemokine-mediated RAM activation could be utilized as a regenerative therapeutic strategy for CNS injuries. | Min Jung Kwon Hyuk Jun Yoon Byung Gon Kim | 2016 | Neural Regeneration Research2016，11，9： | 1 |
| 9 | The optimal duration of preoperative biliary drainage for periampullary tumors that cause severe obstructive jaundice显示文摘 | Jun Hyuk Son Jaihwan Kim Sang Hyub Lee Jin-Hyeok Hwang Ji Kon Ryu Yong-Tae Kim Yong Bum Yoon Jin-Young Jang Sun-Whe Kim Jai Young Cho Yoo-Seok Yoon Ho-Seong Han Sang Myung Woo Woo Jin Lee Sang Jae Park | 2013 | The American Journal of Surgery2013，，1： | 1 |
| 10 | Fully automated synthesis of [ 18 F]fluoromisonidazole using a conventional [ 18 F]FDG module显示文摘 | Seung Jun Oh Dae Yoon Chi Christoph Mosdzianowski Jung Young Kim Hee Seop Gil Se Hun Kang Jin Sook Ryu Dae Hyuk Moon | 2005 | Nuclear Medicine and Biology2005，，8： | 1 |
| 11 | IgG4-related sclerosing esophagitis: a case report显示文摘 | Hyuk Lee Mee Joo Tae Jun Song Sun Hee Chang Hanseong Kim Yeon Soo Kim Ji Yoon Ryoo | 2011 | Gastrointestinal Endoscopy2011，，4： | 1 |
| 12 | Hydrogen production by catalytic decomposition of methane over activated carbons: kinetic study显示文摘 | Myung Hwan Kim Eun Kyoung Lee Jin Hyuk Jun Sang Jun Kong Gui Young Han Byung Kwon Lee Tae-Jin Lee Ki June Yoon | 2003 | International Journal of Hydrogen Energy2003，，2： | 1 |
| 13 | Hyaluronic acid modified biodegradable scaffolds for cartilage tissue engineering显示文摘 | Yoo Hyuk Sang Lee Eun Ah Yoon Jun Jin | 2005 | Biomaterials2005，26，： | 1 |
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