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| 1 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 2 | On the Complete Convergence for Weighted Sums of Dependent Random Variables under Condition of Weighted Integrability 显示文摘 | Baek J I Ko M H Kim T S | 2008 | J Korean Math Soc2008，45，1： | 1 |
| 3 | Galactosylated chitosan/ DNA nanoparticles prepared using water-soluble chitosan as a gene carrier显示文摘 | Kim T H Park I K Nah J W | 2004 | Biomaterials2004，25，3： | 1 |
| 4 | Behavior of double skin composite wall subjected to in- plane cyclic loading显示文摘 | Eom T S Park H G Lee C H Kim J H Chang I H | 2009 | Journal of Structural Engineering ASCE2009，135，10： | 1 |
| 5 | Preparation and characterization of fouling-resistant TiO2 selfassembled nanocomposite membranes 显示文摘 | Bae T H Kim I C Tak T M | 2006 | Journal of Membrane Science2006，275，12： | 1 |
| 6 | Effects of lactate dehydrogenase suppression and glycerol-3-phosphate dehydrogenase overexpression on cellular metabolism显示文摘 | Jeong D W Cho I T Kim T S | 2006 | Mol Cell Biochem2006，2，14： | 1 |
| 7 | PAMAM-PEG-PAMAM : Novel triblock copolymer as a biocompatible and efficient gene delivery carrier 显示文摘 | KIM T I SEO H J CHOI J S | 2004 | Biomacromolecules2004，5，6： | 1 |
| 8 | Theoretical study on fabrication of functionally graded material with density gradient by a centrifugal solid-particle method显示文摘 | OGAWA T WATANABE Y SATO H KIM I S FUKUI Y | 2006 | Composites Part A2006，37，12： | 1 |
| 9 | Comparison of Two Physical SensorModels for Satellite Images: Position - Rotation Modeland Orbit-Attitude Model 显示文摘 | KIM T DOWMAN I | 2006 | The Photogrammetric Re-cord2006，21，114： | 1 |
| 10 | Entrepreneurship in Ja- pan and silicon valley: a comparative study显示文摘 | Suzuki K I Kim S H Bae Z T | 2002 | Techn- ovaton2002，22，10： | 1 |
| 11 | Comparison of phenoliccomposi tions between common and tartary buckwheat (Fagopyrum) sprouts显示文摘 | Kim S J Zaidul I S M Suzuki T Mukasa Y Hashimoto N Takigawa S Noda T Endo M C and Yamauchi H | | 0，，04： | 1 |
| 12 | Identification and characterization of microorganisms from earthworm viscera for the conversion of fish wastes into liquid fertilizer显示文摘 | KIM J K DAO V T KONG I S | 2010 | Bioresour Technol2010，101，14： | 1 |
| 13 | Analysis of magnetization of mag- net in the rotor of line start permanent magnet motor 显示文摘 | LEE C K KWON B I KIM B T | 2003 | IEEE Transactions on Magnetic2003，39，3： | 1 |
| 14 | Synthesis and electrochemical performance of reduced graphene oxide/maghemite composite anode for lithium ion batteries显示文摘 | KIM I T MAGASINSKI A JACOB K | 2013 | Carbon2013，52，： | 1 |
| 15 | Directconverison of cellulose into polyols or H2 over P t/N a (H )-Z S M -5 显示文摘 | YOU S J BEAK I G KIM Y T JEONG K E CHAE H J KIM T W KIM C U KIM T J CHUNG Y M OH S H PARK E D | | Korean J Chem Eng0，28，3： | 1 |
| 16 | A study on dewatering characteristics of the industrial waste water sludge using fry-drying technology 显示文摘 | OHM T I CHAE J S KIM J E | 2008 | Korea Society of Waste Management2008，，25： | 1 |
| 17 | Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasponin Ⅲ in the streptozotocin-induced diabetic rat and their antioxidant activity in vitro显示文摘 | Lee K T Sohn I C Kim D H | 2000 | Arch Pharm Res2000，23，5： | 1 |
| 18 | Airway gene transfer using cationic emulsion as a mucosal gene carrier显示文摘 | Kim T W Chung H Kwon I C | 2005 | J Gene Med2005，7，6： | 1 |
| 19 | Effects of lactate dehydrogenase suppression and glycerol-3-phosphate dehydrogenase overexpression on cellular metabolism显示文摘 | Jeong D W Cho I T Kim T S | 2006 | Mol Cell Biochem2006，2，14： | 1 |
| 20 | Isolation and characterization of a low phytic acid rice mutant reveals a mutation in the rice orthologue of maize MIK 显示文摘 | Kim S I Andaya J W Newman J W Goyal S S Tai T H | 2008 | Theoretical and Applied Genetics2008，117，： | 1 |
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