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| 1 | Measurement of circulating levels of VEGF-A,-C,and -D and their receptors,VEGFR-1 and -2 in gastric adenocarcinoma显示文摘AIM: To analyze the serum levels and prognostic significance of vascular endothelial growth factor (VEGF) -A,-C,and -D,and their receptors,VEGFR-1 and -2 in gastric adenocarcinomas. METHODS: The serum levels of VEGF family members were measured in 76 control subjects and 76 patients with gastric adenocarcinoma using an enzyme-linked immunosorbent assay (ELISA). These measurements were correlated with clinco-pathological features and survival rates. RESULTS: The serum levels of VEGF-A and its receptor,VEGFR-1,were signifi cantly higher in patients with gastric cancer than in healthy donors (t = 2.3,P = 0.02 and t = 4.2,P < 0.0001,respectively). In contrast,the serum levels of VEGF-D were signif icantly higher in control subjects than in patients (t = 2.9,P = 0.004). There was no significant difference in serum levels of VEGF-C and VEGFR-2 between patients and controls. VEGF-C was associated with advanced tumor stage and presence of metastasis. VEGFR-1 was associated with metastasis,advanced overall stage,tumor differentiation and survival. VEGFR-2 levels were associated with poor tumor differentiation. There was no significant prognostic value for any of the VEGF family members or their receptors except for VEGFR-1 where high levels were associated with a poor overall survival. CONCLUSION: Serum VEGF levels vary significantly in the same cohort of patients with variable clinico-pathological features and prognostic values. The simultaneous measurement of VEGF receptors levels in sera may overcome the limitations of a single biomarker assay. | Mansour S Al-Moundhri A Al-Shukaili M Al-Nabhani B Al-Bahrani IA Burney A Rizivi SS Ganguly | 2008 | World Journal of Gastroenterology2008，14，24： | 32 |
| 2 | 25-羟维生素D和甲状旁腺激素与高血压的相关性显示文摘有研究证实,维生素D缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素D缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高血压的进展。目前还没有前瞻性研究同时评估维生素D和PTH水平与高血压发病的关系。该研究分析多民族动脉粥样硬化研究的前瞻性数据,发现低水平25羟维生素D[25(OH)D]和高水平PTH与高血压发病相关,特别是在肥胖人群中。但在校正混杂因素后,25(OH)D水平与高血压发病的相关性无统计学意义,而PTH水平与高血压发病仍然相关。鉴于维生素D缺乏和PTH过量在人群中是普遍现象,该研究对于更好地了解高血压发病机制,在人群中开展高血压预防工作有重要意义。 | van Ballegooijen AJ Kestenbaum B Sachs MC de Boer IH Siscovick DS Hoofnagle AN Ix JH Visser M Brouwer IA 练桂丽 叶鹏 | 2014 | 中华高血压杂志2014，22，6： | 10 |
| 3 | 干扰素调节因子5通过损伤胞葬作用控制动脉粥样硬化病变中的坏死核心形成显示文摘髓系细胞是动脉粥样硬化病变发展和易损斑块形成的核心。动脉吞噬细胞吸收凋亡细胞(胞葬作用)的能力受损,可促进病变生长并建立坏死核心。干扰素调节因子(interferon regulatory factor,IRF)5是髓系细胞功能的重要调节因子。该研究试图确定IRF5是否影响动脉粥样硬化病变的形成和表型。方法:通过两种互补模型,研究IRF5在动脉粥样硬化中的作用: | Seneviratne AN Edsfeldt AO Cole JE Kassiteridi C Swart M Park I Green P Khoyratty TE Saliba DG Goddard ME Sansom SN Goncalves I Krams R Udalova IA Monaco C 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 9 |
| 4 | 异烟肼预防性治疗对机体抗结核分枝杆菌免疫反应的影响:随机、对照和探索性研究显示文摘背景:异烟肼的预防性治疗(isoniazid preventive therapy,IPT)已被证明在高危人群中的有效性,如HIV病毒感染者和新近感染结核者,IPT可以减少70%以上的患者发展成为活动性结核的风险,并降低了25%死亡率。已有的研究证实异烟肼对活动性肺结核患者具有将Th2通路的免疫反应逆转为具有保护作用的Th1免疫反应的作用,本研究观察IPT对结核潜伏感染的患者是否具有类似的效果并对宿主起到长期的免疫保护作用。 | Biraro IA Egesa M, Kimuda S 何亦凡 沙巍 | 2015 | 中国防痨杂志2015，37，12： | 8 |
| 5 | Identification of carbonyl sulfide and sulfur dioxide in porcine coronary artery by gas chromatography/mass spectrometry, possible relevance to EDHF 显示文摘 | Balazy M Abu - Yousef IA Harpp DN | 2003 | Biochem Biophys Res Commun2003，311，3： | 1 |
| 6 | The novel antimicrobial peptide beta3-defensin is produced by the amnion:a possible role of the fetal membranes in innate immunity of the amniotic cavity 显示文摘 | Buhimschi IA Jabr M Buhimschi CS | 2004 | Am J Obstet Gynecol2004，191，5： | 1 |
| 7 | Expression of anglogenesis factors and selected vascular wall matrix proteins in intracranial saccular aneurysms 显示文摘 | Skirgaudas M Awad IA Kim J | 1996 | Neurosurgery1996，39，3： | 1 |
| 8 | Role of laccase and low molecular weight metab olites from Tramctes versicolor in dye decolorizat ion显示文摘 | Diego Moldes Mar'ia Fern'andez-Fern'andez M 'Angeles San- rom'an | 2012 | The Scientif- ic World Journal2012，，2012： | 1 |
| 9 | Volume and densities of chronic subclural haematoma obtained from CT imaging as predictors of postoperative recurrence: a prospective study of 107 operated patients显示文摘 | Stanisic M Hald J Rasmussen IA | 2013 | Acta Neurochir2013，155，2： | 1 |
| 10 | Increased matenal plasma leptin in early pregnancy and risk of gestational diabetes mellitus 显示文摘 | Qiu c Will iams M A Vadachkor ia S | 2004 | Obstet Gynecol2004，103，3： | 1 |
| 11 | Autoantibodies to the glutamate receptor kill neurons via activation of the receptor ion channel 显示文摘 | Levite M Fleidervish IA Schwarz A | 1999 | J Autoimmun1999，13，1： | 1 |
| 12 | Tacrolimus pharmacogenetics: the CYP3A5*1 allele predicts low dose-normalized tacrolimus blood concentrations in whites and South Asians显示文摘 | MACPHEE IA FREDERICKS S MOHAMED M | 2005 | Transplantation2005，79，： | 1 |
| 13 | Histone deacetylase 1 regulates retinal neurogene- sis in zebrafish by suppressing Wnt and Notch signaling path- ways 显示文摘 | Yamaguctd M Tonou-Fujimori N Komori A Maeda R Nojima Y IA H | 2005 | Development2005，132，13： | 1 |
| 14 | Laparoscopic ovar- ian transposition before pelvic irradiation: a Saudi tertiary center experience显示文摘 | A1-Badawi IA AI-Aker M AISubhi J | 2010 | Int J Gynecol Cancer2010，20，： | 1 |
| 15 | Relation betweensingle serum progesterone assay and viability of the first trimester pregnancy显示文摘 | Abdelazim IA Elezz AA Elsherbiny M | 2012 | Springerplus2012，1，1： | 1 |
| 16 | Toxoplasma gondii: humoral and cellular immune response of BALB/c mice immu- nized via intranasal route with rTgROP2 显示文摘 | Igarashi M Zulpo DL Cunha IA | 2010 | Rev Bras Parasitol Vet2010，19，4： | 1 |
| 17 | Effect of ethanol on tone of isolated smooth muscle of the the pulmonary artery 显示文摘 | Jakupi M Dreshaj IA Mandura I | 1991 | Plucne Bolesti1991，43，12： | 1 |
| 18 | 显示文摘 | P'EREZ-RUIZ T MART'INEZ-LOZANO C GARC'IA M D | 2007 | J Chromatogr: A2007，1164，12： | 1 |
| 19 | Complex regional pain syndrome (reflex sympathetic dystrophy and causalgia):management with the calcium channel blocker nifedipine and/or the alpha-sympathetic blocker phenoxybenzamine in 59 patients显示文摘 | Muizelaar JP Kleyer M Hertogs IA | 1997 | Clin Neurol Neurosurg1997，99，1： | 1 |
| 20 | Clinical and radiographic outcomes of the treatment of adolescent idiopathic scoliosis with segmental pedicle screws and combined local autograft and allograft bone for spinal fusion: a retrospective case series显示文摘 | Yang X Xu H IA M Gu S Fang X Wang J | 2010 | BMC Musculoskelet Disord2010，11，： | 1 |
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