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| 1 | Hepatocellular carcinoma in cirrhotic patients with portal hypertension:Is liver resection always contraindicated?显示文摘AIM:To analyze the outcome of hepatocellular car-cinoma(HCC)resection in cirrhosis patients,related to presence of portal hypertension(PH)and extent of hepatectomy.METHODS:A retrospective analysis of 135 patients with HCC on a background of cirrhosis was submitted to curative liver resection.RESULTS:PH was present in 44(32.5%)patients.Overall mortality and morbidity were 2.2% and 33.7%,respectively.Median survival time in patients with or without PH was 31.6 and 65.1 mo,respectively(P=0.047);in the subgroup with Child-Pugh class A cirrhosis,median survival was 65.1 mo and 60.5 mo,respectively(P=0.257).Survival for patients submitted to limited liver resection was not significantly different in presence or absence of PH.Conversely,median survival for patients after resection of 2 or more segments with or without PH was 64.4 mo and 163.9 mo,respectively(P=0.035).CONCLUSION:PH is not an absolute contraindication to liver resection in Child-Pugh class A cirrhotic patients,but resection of 2 or more segments should not be recommended in patients with PH. | Andrea Ruzzenente Alessandro Valdegamberi Tommaso Campagnaro Simone Conci Silvia Pachera Calogero Iacono Alfredo Guglielmi | 2011 | World Journal of Gastroenterology2011，17，46： | 20 |
| 2 | Hepatocellular carcinoma:Surgical perspectives beyond the barcelona clinic liver cancer recommendations显示文摘The barcelona clinic liver cancer(BCLC)staging system has been approved as guidance for hepatocellular carcinoma(HCC)treatment guidelines by the main Western clinical liver associations.According to the BCLC classification,only patients with a small single HCC nodule without signs of portal hypertension or hyperbilirubinemia should undergo liver resection.In contrast,patients with intermediate-advanced HCC should be scheduled for palliative therapies,even if the lesion is resectable.Recent studies report good short-term and long-term outcomes in patients with intermediate-advanced HCC treated by liver resection.Therefore,this classification has been criticised because it excludes many patients who could benefit from curative resection.The aim of this review was to evaluate the role of surgery beyond the BCLC recommendations.Safe liver resection can be performed in patients with portal hypertension and well-compensated liver function with a 5-year survival rate of 50%.Surgery also offers good long-term result in selected patients with multiple or large HCCs with a reported 5-year survival rate of over 50%and 40%,respectively.Although macrovascular invasion is associated with a poor prognosis,liver resection provides better long-term results than palliative therapies or best supportive care.Recently,researchers have identified several genes whose altered expression influences the prognosis of patients with HCC.These genes may be useful for classifying the biological behaviour of different tumours.A revision of the BCLC classification should be introduced to provide the best treatment strategy and to ensure the best prognosis in patients with HCC. | Alfredo Guglielmi rea Ruzzenente Simone Conci Alessro Valdegamberi Marco Vitali Francesca Bertuzzo Michela De Angelis Guido Mantovani Calogero Iacono | 2014 | World Journal of Gastroenterology2014，20，24： | 16 |
| 3 | Large Brunner's gland adenoma:Case report and literature review显示文摘Brunner 的腺腺瘤(BGA ) 是十二指肠的一个很稀罕的良性的瘤,它在内视镜检查法顺便说一下通常无征状、发现。偶尔,这损害可能大,引起上面的胃肠的出血或肠梗阻。盒子有大 Brunner 的腺腺瘤,介绍被内视镜的切除管理的│黑粪症。 | Alba Rocco PasqualeBorriello Debora Compare Patrizia DeColibus LoredanaPica GerardoNardone Alessandro Iacono | 2006 | World Journal of Gastroenterology2006，12，12： | 16 |
| 4 | Central pancreatectomy: The Dagradi Serio Iacono operation. Evolution of a surgical technique from the pioneers to the robotic approach显示文摘Central pancreatectomy(CP) is a parenchyma-sparing surgical procedure. The aims are to clarify the history and the development of CP and to give credits to those from whom it came. Ehrhardt, in 1908, described segmental neck resection(SNR) followed, in 1910, by Finney without reconstructive part. In 1950 Honjyo described two cases of SNR combined with gastrectomy for gastric cancer infiltrating the neck of the pancreas. Guillemin and Bessot(1957) and Letton and Wilson(1959) dealt only with the reconstructive aspect of CP. Dagradi and Serio, in 1982, performed the first CP including the resective and reconstructive aspects. Subsequently Iacono has validated it with functional endocrine and exocrine tests and popularized it worldwide. In 2003, Baca and Bokan performed laparoscopic CP and, In 2004, Giulianotti et al performed a robotic assisted CP. CP is performed worldwide either by open surgery or by using minimally-invasive or robotic approaches. This confirms that the operation does not belong to whom introduced it but to everyone who carries out it; however credit must be given to those from whom it came. | Calogero Iacono Andrea Ruzzenente Luca Bortolasi Alfredo Guglielmi | 2014 | World Journal of Gastroenterology2014，20，42： | 13 |
| 5 | Hyperferritinemia is a risk factor for steatosis in chronic liver disease显示文摘AIM: To investigate the relationship between ferritin and steatosis in patients with chronically abnormal liver function tests (LFTs) and high ferritin level. METHODS: One hundred and twenty-four consecutive patients with hyperferritinemia (male > 300 ng/mL, female > 200 ng/mL) were evaluated; clinical, biochemical and serological data, iron status parameters, HFE gene mutations and homeostasis model assessment score were obtained. Steatosis was graded by ultrasound as absent or present. Histology was available in 53 patients only. RESULTS: Mean level of ferritin was 881 ± 77 ng/mL in men and 549 ± 82 ng/mL in women. The diagnosis was chronic hepatitis C in 53 (42.7%), non-alcoholic fatty liver disease/non-alcoholic steatohepatitis in 57 (45.9%), and cryptogenic liver damage in 14 (11.3%). None was diagnosed as hereditary hemochromatosis (HH). Hepatic siderosis on liver biopsy was present in 17 of 54 (32%) patients; grade 1 in eight and grade 2 in nine. Overall, 92 patients (74.2%) had steatosis. By logistic regression, ferritin and γ-glutamyltransferase were independent predictors of steatosis. Ferritin levels were signifi cantly related to low platelet count, steatosis and hepatitis C virus infection. CONCLUSION: In a non-obese cohort of non-alcoholic patients with chronically abnormal LFTs without HH, high serum ferritin level is a risk factor for steatosis. | Anna Licata Maria Elena Nebbia Giuseppe Cabibbo Giovanna Lo Iacono Francesco Barbaria Virna Brucato Nicola Alessi Salvatore Porrovecchio Vito Di Marco Antonio Craxì Calogero Cammà | 2009 | World Journal of Gastroenterology2009，15，17： | 6 |
| 6 | Elevated fibrinogen plasma level is not an independent predictor of poor prognosis in a large cohort of Western patients undergoing surgery for colorectal cancer显示文摘AIM To evaluate the clinical significance of the preoperative fibrinogen plasma level as a prognostic marker after surgery for colorectal cancer.METHODS This retrospective study analysed 652 patients undergoing surgery for stage Ⅰ-Ⅳ colorectal cancer between January 2005 and December 2012, at the Division of General Surgery A, University of Verona Hospital Trust, in whom preoperative fibrinogen plasma values were assessed at baseline. Fibrinogen is involved in tumourigenesis as well as tumour progression in several malignancies. Correlations between preoperative plasma fibrinogen values and clinicopathological characteristics were investigated. Univariate and multivariate survival analyses were performed to identify factors associated with overall and tumour-related survival.RESULTS Among the 652 patients, the fibrinogen value was higher than the threshold of 400 mg/dL in 345 patients(53%). The preoperative mean ± SD of fibrinogen was 426.2 ± 23.2 mg/dL(median: 409 mg/dL; range: 143-1045 mg/d L). Preoperative fibrinogen values correlated with age(P = 0.003), completeness of tumour resection, potentially curative vs palliative(P < 0.001), presence of systemic metastasis(P < 0.001), depth of tumour invasion p T(P < 0.001), nodes involvement p N(P = 0.001) and CEA serum level(P < 0.001). The mean fibrinogen value(± SD) was 395.6 ± 120.4 mg/d L in G1 tumours, 424.1 ± 121.4 mg/dL in G2 tumours and 453.4 ± 131.6 mg/dL in G3 tumours(P = 0.045). The overall survival and tumourrelated survival were significantly higher in patients with fibrinogen values ≤ 400 mg/d L(P < 0.001). However, hyperfibrinogenemia did not retain statistical significance regarding either overall(P = 0.313) or tumour-related survival(P = 0.355) after controlling for other risk factors in a multivariate analysis.CONCLUSION Preoperative fibrinogen levels correlate with cancer severity but do not help in predicting patient prognosis after colorectal cancer surgery. | Corrado Pedrazzani Guido Mantovani Gian Luca Salvagno Elisabeth Baldiotti Andrea Ruzzenente Calogero Iacono Giuseppe Lippi Alfredo Guglielmi | 2016 | World Journal of Gastroenterology2016，22，45： | 5 |
| 7 | Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms显示文摘 | Anna Iacono Giuseppina Mattace Raso Roberto Berni Canani Antonio Calignano Rosaria Meli | 2011 | The Journal of Nutritional Biochemistry2011，，8： | 4 |
| 8 | Surgical Resection Versus Local Ablation for HCC on Cirrhosis: Results from a Propensity Case-Matched Study显示文摘 | Andrea Ruzzenente Alfredo Guglielmi Marco Sandri Tommaso Campagnaro Alessandro Valdegamberi Simone Conci Fabio Bagante Gianni Turcato Mirko D’Onofrio Calogero Iacono | 2012 | Journal of Gastrointestinal Surgery2012，，2： | 3 |
| 9 | Intrahepatic Cholangiocarcinoma: Prognostic Factors After Surgical Resection显示文摘 | Alfredo Guglielmi Andrea Ruzzenente Tommaso Campagnaro Silvia Pachera Alessandro Valdegamberi Paola Nicoli Alessandro Cappellani Giulio Malfermoni Calogero Iacono | 2009 | World Journal of Surgery2009，，6： | 3 |
| 10 | Is there a place for central pancreatectomy in pancreatic surgery?显示文摘 | Calogero Iacono M.D. Luca Bortolasi M.D. Giovanni Serio M.D | 1998 | Journal of Gastrointestinal Surgery1998，，6： | 2 |
| 11 | Radiofrequency Ablation Versus Surgical Resection for the Treatment of Hepatocellular Carcinoma in Cirrhosis显示文摘 | Alfredo Guglielmi Andrea Ruzzenente Alessandro Valdegamberi Silvia Pachera Tommaso Campagnaro Mirko D'Onofrio Enrico Martone Paola Nicoli Calogero Iacono | 2008 | Journal of Gastrointestinal Surgery2008，，1： | 2 |
| 12 | The Dagradi-Serio-Iacono Operation Central Pancreatectomy显示文摘 | Calogero Iacono Luca Bortolasi Enrico Facci Filippo Nifosì Silvia Pachera Andrea Ruzzenente Alfredo Guglielmi | 2007 | Journal of Gastrointestinal Surgery2007，，3： | 2 |
| 13 | Gastrointestinal symptoms in infancy: A population-based prospective study显示文摘 | G. Iacono R. Merolla D. D’Amico E. Bonci F. Cavataio L. Di Prima C. Scalici L. Indinnimeo M.R. Averna A. Carroccio | 2005 | Digestive and Liver Disease2005，，6： | 2 |
| 14 | A regulatory feedback loop involving p63 and IRF6 links the pa'thogenesis of 2 genetically different human ectodermal dysplasias显示文摘 | Moretti F Marinari g go Iacono N | 2010 | J Clin Invest2010，120，5： | 1 |
| 15 | CD147 imrnuno- globulin superfamily receptor function and role in pathology显示文摘 | IACONO K T BROWN L A GREENE M I | 2007 | Exp Mol Pathol2007，83，3： | 1 |
| 16 | Knowledge creation and inter-organizational relationships: the development of innovation in the railway industry显示文摘 | Mario Pezzillo Iacono Marcello Martinez Gianluigi Mangia | 2012 | Jour- nal of Knowledge Management2012，16，4： | 1 |
| 17 | Exploring the guidelines for the management of severe head injury显示文摘 | Iacono L A | | 0，，01： | 1 |
| 18 | The Identification of Concealed Memories Using the Event - Related Potential and Implicit Behavioral Measures: A Methodology for Prediction in the Face of Individual Differences显示文摘 | Allen J J Iacono W G Danielson K D | 1992 | Psychophysiology1992，29，5： | 1 |
| 19 | Human Wharton’s Jelly Mesenchymal Stem Cells Maintain the Expression of Key Immunomodulatory Molecules When Subjected to Osteogenic, Adipogenic and Chondrogenic Differentiation In Vitro: New Perspectives for Cellular Therapy显示文摘 | Giampiero La Rocca Melania Lo Iacono Tiziana Corsello Simona Corrao Felicia Farina Rita Anzalone | 2013 | Current Stem Cell Research & Therapy2013，，： | 1 |
| 20 | Water stress and rootstock influence on leaf gas exchange of grafted and ungrafted grapevines 显示文摘 | Iacono F Buccella A Petelunger E | 1998 | Sci Hortic1998，75，： | 1 |
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