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| 1 | Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice显示文摘AIM: To study isolation and chemical characterization of pectin derived from the common cranberry Vaccinium oxycoccos L. (oxycoccusan OP) and the testing of its preventive effect on experimental colitis.METHODS: Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS: In the mice treated with OP, colonic macroscopic scores (1.1 ± 0.4 vs 2.7, P < 0.01) and the total square area of damage (10 ± 2 vs 21 ± 7, P < 0.01) were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons (42 ± 11 vs 112 ± 40, P < 0.01) and enhance the amount of mucus of colitis mice (0.9 ± 0.1 vs 0.4 ± 0.1, P < 0.01). The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice (3.6 ± 0.7 vs 5.1 ± 0.8, P < 0.01). OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability (161 ± 34 vs 241 ± 21, P < 0.01). Adhesionof peritoneal neutrophils and macrophages was also shown to decrease after administration of OP (141 ± 50 vs 235 ± 37, P < 0.05).CONCLUSION: Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan. | Sergey V Popov Pavel A Markov Ida R Nikitina Sergey Petrishev Vasily Smirnov Yury S Ovodov | 2006 | World Journal of Gastroenterology2006，12，41： | 9 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Differential control of CD22 ligand expression on B and T lymphocytes,and enhanced expression in murine systemic lupus显示文摘 | Lajaunias F Ida A Kikuchi S | 2003 | Arthritis Rheum2003，48，6： | 1 |
| 4 | Incremental value ofT2-we i gh t ed and d i f f us i on-weighted MRI for predictionof biochemical recurrenceafter radical prostatectomy inclinically localized prostatecancer 显示文摘 | N i sh ida K Yuen S Kamo i K et a 1 | 2011 | Acta Radiol2011，52，2： | 1 |
| 5 | Kinetics of carbon dioxide sorption on potassium-doped lithium zirconate 显示文摘 | Xiong R T Ida J I Lin Y S | 2003 | Chem Eng Sci2003，58，19： | 1 |
| 6 | 查看详情显示文摘 | Lin Y S Yang Q Ida J | | 0，，03： | 1 |
| 7 | Optimisation of soybean hydrothermal treatment for the conversion ofβ-glucoside isoflavones to aglycones显示文摘 | Lima F S Idae I | 2014 | Food Science and Technology2014，56，2： | 1 |
| 8 | Synthesis and CO2 sorption properties of pure and modified lithium zireonate 显示文摘 | Ida J I Xiong R T Lin Y S | 2004 | Sepa ration and Purification Technol ogy2004，36，1： | 1 |
| 9 | Synthesis and CO_2 sorption properties of pure and modified lithium zirconate显示文摘 | Ida J Xiong R T Lin V S | | 0，，01： | 1 |
| 10 | The isolation of multiple forms and product specificity of rice lipoxygenase 显示文摘 | Ida S Masaki Y Morita Y | 1983 | Agric Biol Chem1983，47，3： | 1 |
| 11 | Kinetics of carbon dioxide sorption on potassium-doped lithium zirconate显示文摘 | Xiong R Ida J Lin Y S | | 0，，19： | 1 |
| 12 | Kinetics of carbon dioxide sorption on potassium-doped lithium zirconate 显示文摘 | XIONG R IDA J I LIN Y S | 2003 | Chemical Engineering Science2003，58，19： | 1 |
| 13 | Adult intestinal intussusception caused by an inflammatory myofibroblastic tumor显示文摘 | Ida S Matsuzaki H Kawashima S | | 0，，2： | 1 |
| 14 | Synthesis and C02 sorption properties of pure and modified lithium zirconate 显示文摘 | IDA J I XIONG R LIN Y S | 2004 | Sep- aration and Purification Technology2004，36，1： | 1 |
| 15 | Catalytic activity of PAN-based active carbon fibre (PAN-ACF) activated with sulphuric acid for reduction of nitric oxide with ammonia显示文摘 | Komatsumara Y Ida S Fujitsu H | 1984 | Fuel1984，63，12： | 1 |
| 16 | Lunar accretion from an impact-generated disk显示文摘 | Ida S Canup R M Stewart G R | 1997 | Nature1997，389，： | 1 |
| 17 | Synthesis and CO2 sorption properties of pure and modified lithium zirconate显示文摘 | Ida J I Xiong R T Lin Y S | 2004 | Separation and Purification Technology2004，36，1： | 1 |
| 18 | Characterization of polypeptides that accumulate in cultured Nicotiana tabacum cells显示文摘 | Takeda S Sato F Ida K | 1990 | Plant Cell Physiology1990，31，： | 1 |
| 19 | Reverse relationship between beta-amyloid precursor protein and beta-amyloid peptide plaques in Down's syndrome versus sporadic/familial Alzheimer's disease显示文摘 | Egensperger R Weggen S Ida N | 1999 | Acta Neuropathol (Berl)1999，97，2： | 1 |
| 20 | Pharmacokinetic interaction between praziquantel and albendazole in Sudanese men显示文摘 | Home ida M Leahy W Copeland S | 1994 | Ann Trop Med Parasitol1994，，： | 1 |
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