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| 1 | Radiation therapy for portal venous invasion by hepatocellular carcinoma显示文摘AIM: To clarify the efficacy and safety of three-dimensional conformal radiotherapy (3-D CRT) for this disease and to specify patient subgroups suitable for this treatment.METHODS: Fifty-two patients with HCC received PVI-targeted radiation therapy from January 1995 through December 2003. Portal venous invasion (PVI) was found in the second or lower order branches of the portal vein in 6 patients, in the first branch in 24 patients and in the main trunk in 22 patients. Child classifications of liver function before radiation therapy were A, B, and C for 19, 24 and 2 patients, respectively. All patients received three-dimensional conformal radiotherapy with a total dose ranging from 39 to 60 Gy (57.0 Gy in average).RESULTS: Overall survival rates at 1, 2, 3, 4, and 5 years were 45.1%, 25.3%, 15.2%, 10.1%, and 5.1%, respectively. Univariate analysis revealed that Child status, the number of tumor foci, tumor type,transcatheter arterial embolization (TAE) after radiation therapy were statistically significant prognostic factors.Multivariate analysis showed that the number of tumor foci and TAE after radiation therapy were statistically significant.CONCLUSION: The results of this study strongly suggest the efficacy of 3-D CRT as treatment for PVI in HCC. 3-D CRT is recommended in combination with postradiation TAE for PVI of HCC with 5 tumor foci or less in the liver and with Child A liver function. | Keiichi Nakagawa Hideomi Yamashita Kenshiro Shiraishi Naoki Nakamura Masao Tago Hiroshi Igaki Yoshio Hosoi Shuichiro Shiina Masao Omata Masatoshi Makuuchi Kuni Ohtomo | 2005 | World Journal of Gastroenterology2005，11，46： | 14 |
| 2 | Evidence‐based C linical P ractice G uidelines for H epatocellular C arcinoma: The J apan S ociety of H epatology 2013 update (3rd JSH‐HCC G uidelines)显示文摘 | Norihiro Kokudo Kiyoshi Hasegawa Masaaki Akahane Hiroshi Igaki Namiki Izumi Takafumi Ichida Shinji Uemoto Shuichi Kaneko Seiji Kawasaki Yonson Ku Masatoshi Kudo Shoji Kubo Tadatoshi Takayama Ryosuke Tateishi Takashi Fukuda Osamu Matsui Yutaka Matsuyama Ta | 2015 | Hepatol Res2015，，2： | 2 |
| 3 | Improved Survival for Patients With Upper and/or Middle Mediastinal Lymph Node Metastasis of Squamous Cell Carcinoma of the Lower Thoracic Esophagus Treated With 3-Field Dissection显示文摘 | Hiroyasu Igaki Yuji Tachimori Hoichi Kato | 2004 | Annals of Surgery2004，，4： | 2 |
| 4 | Extended cancer-free survival after palliative chemoradiation for metastatic esophageal cancer显示文摘We report on a patient who remained cancer-free for an extended time after palliative radiotherapy(RT) and chemotherapy(nedaplatin plus 5-fluorouracil) treatment for stage Ⅳ(cT3N3M1) esophageal squamous cell carcinoma. Although multiple lymph nodes outside the RT field recurred, the local primary tumor within the RT field did not recur, even 17 mo after palliative RT of 30 Gy in 10 fractions. In this case, acute toxicity, such as myelosuppression or esophagitis, was not enhanced by increasing the fraction dose from 1.8-2.0 Gy to 3.0 Gy. Because 30 Gy in 10 fractions can be completed within a shorter time and is less expensive than 50.4 Gy in 28 fractions, we think that 30 Gy without oblique beams is a more favorable RT method for patients. | Hideomi Yamashita Kae Okuma Akihiro Nomoto Mami Yamashita Hiroshi Igaki Keiichi Nakagawa | 2014 | World Journal of Gastrointestinal Oncology2014，6，2： | 2 |
| 5 | Initial and 6-Month results of biodegradable Poly-l-Lactic acid coronary stents in humans显示文摘 | Hidel Tamai Keiji Igaki Eisho Kyo | 2000 | Circulation2000，25，： | 1 |
| 6 | Establishment and validation of a new semi-chronic dextran sulfate sodium- induced model of colitis in mice 显示文摘 | Sha T Igaki K Yamasaki M | 2013 | Int Immunopharmacol2013，15，1： | 1 |
| 7 | Clinicopathologic characteristics and surwival of patients with clinical stage I squamous cell carcinomas of the thoracic esophagus treated with three-field lymph node dissection 显示文摘 | Igaki H Kato H Tachimori Y | 2001 | Eur J Cardiothorac Surg2001，20，6： | 1 |
| 8 | Clinical results of proton beam therapy for skull base chordoma显示文摘 | Igaki H Tokuuye K Okumura T | 2004 | Int J Radiat Oncol Biol Phys2004，60，4： | 1 |
| 9 | Assessment of cervical lymph node metastasis in the staging of thoracic esophageal carcinoma 显示文摘 | Kato H Igaki H Tachimori Y | 2000 | J Surg Oncol2000，74，4： | 1 |
| 10 | Surgery for clinical 23 carcinomas of the upper thoracic oesophagus and the need for new strategies 显示文摘 | Igaki H Kato H Tachimori Y | 2005 | The British Journal of Surgery2005，92，10： | 1 |
| 11 | Long-Term (>10 Years) clin- ical outcomes of first-in-human biodegradable poly-l-lactic acid coronary stents: Igaki-Tamai stents 显示文摘 | Nishio S Kosuga K Igaki K | 2012 | Circulation2012，125，19： | 1 |
| 12 | Phase I/II trial of hy- perfractionated concomitant boost proton radiotherapy for su- pratentorial glioblastomarnultiforme显示文摘 | MizumotoM K Tsuboi H Igaki | 2010 | Int J RadiatOncol Biol Phys2010，77，1： | 1 |
| 13 | Highly frequent homozygous deletion of the p16 gene in esophageal cancer cell lines 显示文摘 | Igaki H Sasaki H Kishi T | 1994 | Biochem Biophys Res Commun1994，203，2： | 1 |
| 14 | Improved survival for pa- tients with upper and/or middle mediastinal lymph node metastasis of squamous cell carcinoma of the lower tho- racic esophagus treated with 3-field disseetion显示文摘 | Igaki H Taehimori Y Kato H | 2004 | AnnSurg2004，239，4： | 1 |
| 15 | Three-arm phase III trial comparing cisplatin plus 5-FU (CF) versus docetaxel, cisplatin plus 5-FU (DCF) versus radiotherapy with CF (CF-RT) as preoperative therapy for locally advanced esophageal cancer (JCOG1109, NExT study)显示文摘 | Nakamura K Kato K Igaki H | 2013 | Japanese journal of clinical oncology2013，43，7： | 1 |
| 16 | Initial and 6-month results of biodegradable poly-l-lactic acid coronary stents in humans显示文摘 | Tamai H Igaki K Kyo E | 2000 | Circulation2000，102，： | 1 |
| 17 | Initial and 6-month results of biodegradable poly-1-lactic acid coronary stents in humans显示文摘 | Tamai H Igaki K Kyo E | 2000 | Circulation2000，102，： | 1 |
| 18 | Evaluation of safety profile of thoracoscopic esophagectomy for TlbNOM0 cancer using data from JCOG0502: a prospective multicenter study 显示文摘 | Nozaki I Kato K Igaki H | 2015 | Surg Endosc2015，，： | 1 |
| 19 | 显示文摘 | Huang X M Igaki K | 1986 | Journal of Crystal Growth1986，78，1： | 1 |
| 20 | Improved surrival for patients with upper and/or middle mediastinal lymph node metastasis of squamous cell carcinoma of the lower thoracic esophagus treated with 3-field dissection显示文摘 | Igaki H Tachimori Y Kato H | 2004 | Ann Surg2004，39，4： | 1 |
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