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| 1 | Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis:Does it really save lives?显示文摘The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery(CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules present in the first surgery (70% probability of developing PC), ovarian metastases(60%), perforated tumor onset or intraoperative tumor rupture(50%). Current clinical, biological and imaging techniques still lack sufficient sensitivity to diagnose PC in its initial stages, when CRS plus HIPEC has a greater impact and a higher cure rate. Second-look surgery with HIPEC or prophylactic HIPEC at the time of the first intervention have been proposed as means of preventing and/or anticipating clinical or radiological relapse in at-risk patients. Both techniques have shown a significant decrease in peritoneal relapses and should be considered essential weapons in the management of colorectal cancer. | Delia Cortes-Guiral Dominique Elias Pedro Antonio Cascales-Campos Alfredo Badía Yébenes Ismael Guijo Castellano Ana Isabel León Carbonero JoséIgnacio Martín Valadés Jesus Garcia-Foncillas Damian Garcia-Olmo | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 2 | Generation of planar and helical elliptical gears by application of rack-cutter, hob, and shaper 显示文摘 | Litvin F L Ignacio G P Kenji Y | 2007 | Comput Methods Appl Mech Engrg2007，196，： | 1 |
| 3 | Health informatics design for assisted diagnosis of subclinical atherosclerosis,structural,and functional arterial age calculus and patient-specific cardiovascular risk evaluation显示文摘 | DANIEL B S Z’OCALO Y A IGNACIO F V | 2012 | IEEE Transactions on Information Technology in Biomedicine2012，16，5： | 1 |
| 4 | Coherent Population Transfer in Three -level A Systems by Chirped Laser Pulses: Minimization of the Intermediate-level Population显示文摘 | Ignacio R S Vladimir S M Chang B Y | 1999 | Phys Rev A1999，59，： | 1 |
| 5 | Fast supercritical fluid extrac- tion of low and high density polyethylene additives, comparison with conventional reflux and automatic soxhlet extraction 显示文摘 | Monica A Ignacio P Fredy Y | 2009 | Supererlti- cal Fluids2009，50，： | 1 |
| 6 | Dynamic modeling and classical control theory for supply chain management显示文摘 | Edgar P Ignacio G Erik Y | 2000 | Computers and Chemical Engineering2000，24，27： | 1 |
| 7 | Generation of Planar and Helical Elliptical Gears by Application of Rackcutter, Hob, and Shaper显示文摘 | FAYDOR L L IGNACIO G P KENJI Y | 2007 | Computer Methods in Applied Mechanics and Engineering2007，196，4144： | 1 |
| 8 | Comprehensive Functional Assessment of MLH1 Variants of Unknown Significance显示文摘 | Ester Borràs Marta Pineda Angela Brieger Inga Hinrichsen Carolina Gómez Matilde Navarro Judit Balma?a Teresa Ramón y Cajal Asunción Torres Joan Brunet Ignacio Blanco Guido Plotz Conxi Lázaro Gabriel Capellá | 2012 | Human Mutation2012，，1： | 1 |
| 9 | Design,simulation of meshing,and contact stresses for an improved worm gear drive显示文摘 | LITVIN F L IGNACIO G P KENJI Y | | 0，，： | 1 |
| 10 | Per- formance assessment of a novel fault diagnosis system based on support vector machines 显示文摘 | IGNACIO Y GERARD E MOISES G LUIS P | 2009 | Computers and Chemical Engineering2009，33，： | 1 |
| 11 | Performance assessment of a novel fault diagnosis system based on support vector machines显示文摘 | IGNACIO Y GERARD E MOISES G | 2009 | Computers and Chemical Engineering2009，33，1： | 1 |
| 12 | A systematic modeling framework of superstructure optimization in process synthesis 显示文摘 | HECTOR Y IGNACIO E GROSSMANN | 1999 | Computers and Chemical Engineering1999，23，： | 1 |
| 13 | Generation of planar and helical elliptical gears by application of rack-cutter,hob,and shaper显示文摘 | LITVIN F L IGNACIO G P KENJI Y | 2007 | Computer Methods in Applied Mechanics and Engineering2007，196，4144： | 1 |
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