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| 1 | Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients显示文摘AIM To investigate the clinical utility of serum annexin A2(ANXA2) as a diagnostic marker for early hepatocellular carcinoma(HCC).METHODS This study was performed in HCC Clinic of Ain Shams University Hospitals, Cairo, Egypt and included: Group 1: Fifty patients with early stage HCC(Barcelona Clinic Liver Cancer stage A); Group 2: Twenty five patients with chronic liver disease; and Control Group: Fifteen healthy, age-and sex-matched subjects who were seronegative for viral hepatitis markers. The followinglaboratory investigations were done: Viral hepatitis markers [hepatitis B surface antigen and hepatitis C virus(HCV) antibodies], HCV RNA in HCV antibody-positive patients, serum alpha fetoprotein(AFP), and serum ANXA2 levels.RESULTS In this study, 88% of HCC patients(n = 44) were HCVpositive, while HBV infection represented only 8% of all HCC patients(n = 4); and two patients were negative for both viral markers. A highly significant difference was found between patients with HCC and chronic liver disease as well as controls with regard to serum ANXA2 levels(130, IQR 15-240; 15, IQR 15-17; and 17, IQR 15-30 ng/m L, respectively). The area under the curve of ANXA2 was 0.865; the cut-off value was established to be 18 ng/mL with a diagnostic sensitivity of 74% and a specificity of 88%, while the sensitivity and specificity of AFP at the cut-off value of 200 ng/dL were 20% and 100%, respectively.CONCLUSION Serum ANXA2 may serve as a biomarker for the early detection of HCC. | Mohamed K Shaker Hanzada I Abdel Fattah Ghada S Sabbour Iman F Montasser Sara M Abdelhakam Eman El Hadidy Rehab Yousry Ahmed K El Dorry | 2017 | World Journal of Hepatology2017，9，9： | 4 |
| 2 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 3 | Prostaglandin E2 induces IL-23 production in bone marrow-derived dendritic cells显示文摘 | Amir F Sheibanie Iman Tadmori Huie Jing | 2004 | FASEB Journal2004，18，11： | 1 |
| 4 | lnvitro evaluation and modification of pectinate gel beads containing trimethyl chitosan, as a multi-particulate system for delivery of water-soluble macromolecules to colon显示文摘 | Atyabi F Majzoob S Iman M | 2005 | Carbohydrate Polymers2005，61，： | 1 |
| 5 | Reinforcing epoxy polymer composites through covalent integration of functionalized nanotubes 显示文摘 | Zhu J Peng H Q Rodriguez-Macias F Margrave J L Khabashesku V N Iman A M Lozano K Barrera E V | 2004 | Adv Funct Mater2004，14，7： | 1 |
| 6 | Site ordering of dopant ions in microporous aluminophosphates size effects显示文摘 | Iman Saadoune Catlow C R A Cora F | 2003 | Microporous and Mesoporous Materials2003，59，： | 1 |
| 7 | The teratogenic effects of poly- chlorinated naphthalenes (PCNs) on early development of the zebrafish (Danio rerio) 显示文摘 | $iman T Geyikolu F | 2008 | Environ Toxicol Phar2008，25，1： | 1 |
| 8 | In vitro evaluation and modification of pectinate gel beads containing trimethyl chitosan, as a muhi-particulate system for delivery of water-soluble macro- molecules to colon显示文摘 | ATYABI F MAJZOOB S IMAN M | 2005 | Carbohydrate Polymers2005，61，1： | 1 |
| 9 | Design of a multiplex PCR method for detection of toxigenic-pathogenic in vibrio cholera显示文摘 | IMANI F A A IMAN I D HOSSEINI D R | 2013 | Asian Pacific Journal of Trc^rical Medicine2013，6，2： | 1 |
| 10 | Non-linear Free Vibration of Piezoelectric NanobeamsIncorporating Surface Effects显示文摘 | Shahrokh H-H Iman N? Mahmood F | 2014 | Smart Materialsand Structures2014，23，03： | 1 |
| 11 | In vitro evaluation and modification of pcctinate gel beads containing trimethyl chitosan, as a muhi-particulate system for delivery of water-soluble macro- molecules to colon 显示文摘 | ATYABI F MAJZOOB S IMAN M | 2005 | Carbohydr Polym2005，61，1： | 1 |
| 12 | Giant mediastinal chordoma显示文摘 | Rahamn A M Iman G F Waef A A | 2002 | Ann Thorac Surg2002，73，： | 1 |
| 13 | A comprehensive slagging and fouling prediction tool for coal-fired boilers and its validation/application显示文摘 | Ma Z Iman F Lu P | | 0，，11： | 1 |
| 14 | Low-velocity impact response of woven Kevlar/epoxy laminated composites reinforced with multi-walled carbon nanotubes at ambient and low temperatures 显示文摘 | IMAN T ABDOLHOSSEIN F FATHOLLAH TB | 2014 | Materialsand design2014，53，1： | 1 |
| 15 | A comprehensiveslagging and fouling prediction tool for coal-fired boilersand its validation/application 显示文摘 | MA Zhan-hua IMAN F LU P | 2007 | Fuel Processing Tech-nology2007，88，1112： | 1 |
| 16 | A comparative study of slab deformation under heavy width reduction by sizing press and vertical rolling using FE analysis 显示文摘 | MOHAMMAD R F IMAN S AMIR H A | 2009 | Journal of Materials Processing Technology2009，209，2： | 1 |
| 17 | Synthesis and antimicrobial activity of some polymers derived from modified amino polyacrylamide by reacting it with benzoate esters and benzaldehyde derivatives 显示文摘 | E1-Refaie Kenawy Abdel-Hay F Iman Ahmed Abou El- Magd Yehia Mahmoud | 2006 | Journal of Applied Polymer Science2006，99，5： | 1 |
| 18 | Bacterial infections post-living-donor liver transplantation in Egyptian hepatitis C virus-cirrhotic patients: A singlecenter study显示文摘AIM To determine risk factors, causative organisms and antimicrobial resistance of bacterial infections following living-donor liver transplantation(LDLT) in cirrhotic patients.METHODS This prospective study included 45 patients with hepatitis C virus-related end-stage liver disease who underwent LDLT at Ain Shams Center for Organ Transplant, Cairo, Egypt from January 2014 to November 2015. Patients were followed-up for the first 3 mo after LDLT for detection of bacterial infections. All patients were examined for the possible risk factors suggestive of acquiring infection pre-, intra-and post-operatively. Positive cultures based on clinical suspicion and patterns of antimicrobial resistance were identified. RESULTS Thirty-three patients(73.3%) suffered from bacterial infections; 21 of them had a single infection episode, and 12 had repeated infection episodes. Bile was the most common site for both single and repeated episodes of infection(28.6% and 27.8%, respectively). The most common isolated organisms were gramnegative bacteria. Acinetobacter baumannii was the most common organism isolated from both single and repeated infection episodes(19% and 33.3%, respectively), followed by Escherichia coli for repeated infections(11.1%), and Pseudomonas aeruginosa for single infections(19%). Levofloxacin showed high sensitivity against repeated infection episodes(P = 0.03). Klebsiella, Acinetobacter and Pseudomonas were multi-drug resistant(MDR). Pre-transplant hepatocellular carcinoma(HCC) and duration of drain insertion(in days) were independent risk factors for the occurrence of repeated infection episodes(P = 0.024).CONCLUSION MDR gram-negative bacterial infections are common post-LDLT. Pre-transplant HCC and duration of drain insertion were independent risk factors for the occurrence of repeated infection episodes. | Mohamed F Montasser Nadia A Abdelkader Sara M Abdelhakam Hany Dabbous Iman F Montasser Yasmine M Massoud Waleed Abdelmoaty Shereen A Saleh Mohamed Bahaa Hany Said Mahmoud El-Meteini | 2017 | World Journal of Hepatology2017，9，20： | 0 |
| 19 | A potpourri of pancreatic issues显示文摘自体免疫的胰腺炎从一个建议概念出现在最后 40 年到一个很好确定并且认出的实体。作为胰腺的癌的一个有效模仿别人的人,它的早、适当的识别是关键的。与装它的致病和自然科学的理解,重要进展在自体免疫的胰腺炎的诊断被做了。在自体免疫的胰腺炎看见的典型实验室特征和成像与一些建议诊断标准和处理算法一起被考察。 | Iman Zandieh Michael F Byrne | 2007 | World Journal of Gastroenterology2007，13，47： | 0 |
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