|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials显示文摘Retinal and optic nerve diseases are degenerative ocular pathologies which lead to irreversible visual loss. Since the advanced therapies availability, cell-based therapies offer a new all-encompassing approach. Advances in the knowledge of neuroprotection, immunomodulation and regenerative properties of mesenchymal stem cells(MSCs) have been obtained by several preclinical studies of various neurodegenerative diseases. It has provided the opportunity to perform the translation of this knowledge to prospective treatment approaches for clinical practice. Since 2008, several first steps projecting new treatment approaches, have been taken regarding the use of cell therapy in patients with neurodegenerative pathologies of optic nerve and retina. Most of the clinical trials using MSCs are in Ⅰ/Ⅱ phase, recruiting patients or ongoing, and they have as main objective the safety assessment of MSCs using various routes of administration. However, it is important to recognize that, there is still a long way to go to reach clinical trials phase Ⅲ-Ⅳ. Hence, it is necessary to continue preclinical and clinical studies to improve this new therapeutic tool. This paper reviews the latest progress of MSCs in human clinical trials for retinal and optic nerve diseases. | Sonia Labrador-Velandia María Luz Alonso-Alonso Sara Alvarez-Sanchez Jorge González-Zamora Irene Carretero-Barrio José Carlos Pastor Iván Fernandez-Bueno Girish Kumar Srivastava | 2016 | World Journal of Stem Cells2016，8，11： | 5 |
| 3 | Early-onset colorectal cancer:A separate subset of colorectal cancer显示文摘Colorectal cancer(CRC)has a great impact on the world population.With increasing frequency,CRC is described according to the presenting phenotype,based on its molecular characteristics.Classification of CRC tumors according to their genetic and/or epigenetic alterations is not only important for establishing the molecular bases of the disease,but also for predicting patient outcomes and developing more individualized treatments.Early-onset CRC is a heterogeneous disease,with a strong familial component,although the disease is sporadic in an important proportion of cases.Different molecular alterations appear to contribute to the apparent heterogeneity of the early-onset population and subgroups can be distinguished with distinct histopathologic and familial characteristics.Moreover,compared with late-onset CRC,there are characteristicsthat suggest that early-onset CRC may have a different molecular basis.The purpose of this review was to analyze the current state of knowledge about earlyonset CRC with respect to clinicopathologic,familial and molecular features.Together,these features make it increasingly clear that this subset of CRC may be a separate disease,although it has much in common with late-onset CRC. | Irene Osorio Silla Daniel Rueda Yolanda Rodríguez Juan Luis García Felipe de la Cruz Vigo José Perea | 2014 | World Journal of Gastroenterology2014，20，46： | 4 |
| 4 | Neuroprotective effects of meloxicam on transient brain ischemia in rats:the two faces of anti-inflammatory treatments显示文摘The inflammato ry response plays an important role in neuroprotection and regeneration after ischemic insult.The use of non-ste roidal anti-inflammatory drugs has been a matter of debate as to whether they have beneficial or detrimental effects.In this context,the effects of the anti-inflammatory agent meloxicam have been scarcely documented after stro ke,but its ability to inhibit both cyclooxygenase isoforms(1 and 2) could be a promising strategy to modulate postischemic inflammation.This study analyzed the effect of meloxicam in a transient focal cerebral ischemia model in rats,measuring its neuroprotective effect after 48 hours and 7 days of reperfusion and the effects of the treatment on the glial scar and regenerative events such as the generation of new progenitors in the subventricular zone and axonal sprouting at the edge of the damaged area.We show that meloxicam’s neuroprotective effects remained after 7 days of reperfusion even if its administration was restricted to the two first days after ischemia.Moreover,meloxicam treatment modulated glial scar reactivity,which matched with an increase in axonal sprouting.However,this treatment decreased the formation of neuronal progenitor cells.This study discusses the dual role of anti-inflammatory treatments after stro ke and encourages the careful analysis of both the neuroprotective and the regenerative effects in preclinical studies. | Irene Fernández Ugidos Paloma González-Rodríguez María Santos-Galdiano Enrique Font-Belmonte Berta Anuncibay-Soto Diego Pérez-Rodríguez JoséManuel Gonzalo-Orden Arsenio Fernández-López | 2023 | Neural Regeneration Research2023，18，9： | 3 |
| 5 | Mitochondrial markers for the detection of four duck species and the specific identification of Muscovy duck in meat mixtures using the polymerase chain reaction显示文摘 | Irene Martín Teresa García Violeta Fajardo Inés López-Calleja María Rojas Pablo E. Hernández Isabel González Rosario Martín | 2007 | Meat Science2007，，4： | 2 |
| 6 | Design and development of a satellite constellation using collaborative optimization显示文摘 | Irene A B John R O | | 0，，06： | 1 |
| 7 | Influence of some parameters on the germination assessment of myeopesticides 显示文摘 | Rog6rio B Lopes Irene Martins Daniela A Souza | 2013 | Journal of Invertebrate Pathology2013，112，3： | 1 |
| 8 | The importance of shallow sediments in the recruitment of Anabaena and Aphanizomenon ( Cyanophyceae ) 显示文摘 | Irene K E Brunberg A K | 2004 | Journal of phycology2004，40，： | 1 |
| 9 | Re - engineering the toilet for sustainable wastewater management 显示文摘 | Tove AL Irene P Alfredo A | 2001 | ES&T2001，35，9： | 1 |
| 10 | Chemical vapor desposition of AlxOyNz films 显示文摘 | Jsilvestri V Irene E A Zirinsky S | 1975 | J Electron Mater1975，4，3： | 1 |
| 11 | Logistics ServiceQuality:a New Way to Loyalty显示文摘 | Irene Gil Saura David Servera France's GloriaBerenguer Contr- Mar-'a Fuentes Blasco | 2008 | Industrial Management &Data Systems2008，，5： | 1 |
| 12 | Crystal Growth and Transport Rates of GeSe and GeTe in Micro-gravity Environment 显示文摘 | Wiedemeir H Klaessing F C Irene E A | 1975 | Journal of Crystal Growth1975，31，： | 1 |
| 13 | High pressure processing of Australian navel orange juices: sensory analysis and volatile flavor profiling显示文摘 | IRENE A B KERRY E KATHERINE S | 2005 | Innovative Food Science and Emerging Technologies2005，，6： | 1 |
| 14 | Growth of Hgl CdxTe Epitaxial Layers on (100)CdTe by Chemical Vapor Transport under Normal and Re- duced Gravity Conditions 显示文摘 | Wiedemeir H Klaessing F C Irene E A | 1995 | Journal of Crystal Growth1995，146，1： | 1 |
| 15 | Survival of patients with BRCAl-assoeiated breast cancer diagnosed in an MRI-based surveillance program显示文摘 | Stormorken Christoffer Jonsrud Marit Muri Holmen Anne Irene Hagen Neal Clark Anita Sun Steven A Narod Lovise | 2013 | Breast cancer research and treatment2013，139，1： | 1 |
| 16 | Endocrine disruption caused by oral administration of atrazine in European quail (Coturnix coturnix coturnix)显示文摘 | Irene de la C R Valdehita A Soler F | 2012 | Comparative Biochemistry and Physiology2012，156，： | 1 |
| 17 | The occur- rence and identification of C30, C31 and C3z alkan-1, 15-diols and alkan-15-one-l-ols in Unit I and Unit II Black Sea sedi- ments 显示文摘 | de Leeuw J W Irene W Rijpstra C Schenck P A | 1981 | Geochim Cosmochim Acta1981，45，11： | 1 |
| 18 | Metabolic modeling of fumaric acid production by Rhizopus arrhizus 显示文摘 | Irene C G William A W Frenerick A K | 1991 | Applied Biochemistry and Biotechnoiogy1991，28，29： | 1 |
| 19 | School-based participatory health education for malaria control in Ghana= engaging children as health messengers显示文摘 | Irene A Daisuke N Josiah KA | 2010 | Malar J2010，9，： | 1 |
| 20 | Toward clean and crackless transfer of graphene显示文摘 | Liang Xuelei Sperling B A Irene C | 2011 | ACS Nano2011，，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员