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| 1 | Experimental obstructive jaundice alters claudin-4 expression in intestinal mucosa: Effect of bombesin and neurotensin显示文摘瞄准:调查试验性的妨碍的黄疸和外长的 bombesin 和 neurotensin (NT )(BBS ) 的影响紧密的连接(TJ ) 的表示上的管理在老鼠的肠上皮的蛋白质 claudin-4。方法:四十只男 Wistar 老鼠随机被划分成五个组:我 = 控制, II = 假冒操作, III = 胆汁管结扎(BDL ) , IV = BDL+BBS (30 microg/kg 每 d ) , V = BDL+NT (300 microg/kg 每 d ) 。在 d 的实验的结束 10,内毒素在门和大动脉的血被测量。终端回肠的织物节组织学地被检验并且免疫组织化学地为在肠上皮的 claudin-4 表示的评估。结果:妨碍的黄疸导致了重要的门和大动脉的 endotoxemia 表明的肠的障碍失败。Claudin-4 表示显著地被增加在上面在 jaundiced 老鼠的第三根绒毛并且一起来它的侧面的分发的规定被注意。BBS 或 NT 的管理恢复了 claudin-4 表示到控制状态并且显著地减少了门和大动脉的 endotoxemia。结论:在肠上皮的试验性的妨碍的黄疸增加 claudin-4 表示,它可以是贡献粘膜障碍的混乱的一个关键因素。毁坏规章的肽 BBS, NT 能阻止这扇改变和还原剂门和全身的 endotoxemia。 | Stelios F Assimakopoulos Constantine E Vagianos Aristides S Charonis Ilias H Alexandris Iris Spiliopoulou Konstantinos C Thomopoulos Vassiliki N Nikolopoulou Chrisoula D Scopa | 2006 | World Journal of Gastroenterology2006，12，21： | 21 |
| 2 | Detection of the effects of dopamine receptor supersensitivity using pharmacological MRI and correlations with PET显示文摘 | Nguyen T V Brownell A L Iris Chen Y C Livni E Coyle J T Rosen B R Cavagna F Jenkins B G | | 0，，01： | 1 |
| 3 | Characterizing water and solute Movement by Time Domain Reflectometry显示文摘 | Iris V Brent E C Steven R G | 1996 | Soil Sci Soc Am J1996，60，： | 1 |
| 4 | Myelin Water Imaging in Multiple Sclerosis: Quantitative Correlations with Histopathology显示文摘 | Laule C Leung E Iris DK | 2006 | Mult Scler2006，12，6： | 1 |
| 5 | 查看详情显示文摘 | Wagner T Burrows J P Deutschmann T Dix B Friedeburg C Frie?U Hendrick F Heue K P Irie H Iwabuchi H Kanaya Y Keller J McLin- den C A Oetjen H Palazzi E Petritoli A Platt U Postylyakovo O Pukite J Richter A van Roozendael M Rozanov A Roza | | 0，，： | 1 |
| 6 | Students' evolving beliefs about nursing:from entry to graduation in a four-year baccalaureate programme显示文摘 | RENE A D PEGGY A F IRIS E C | 2005 | Nurse Education Today2005，25，： | 1 |
| 7 | Inhibition of neisseria gonorrhoeae by lactobacillus species that are commonly Isolated from the female genital tract显示文摘 | Diane C Amant ST Iris E | 2002 | Infection and Immunity2002，70，12： | 1 |
| 8 | Severe hypogammaglobulinemia persisting for 6 years after treatment with rituximab combined chemotherapy due to arrest of B lymphocyte differentiation together with alteration of T lymphocyte homeostasis显示文摘 | Irie E Shirota Y Suzuki C | 2010 | Int J Hematol2010，91，3： | 1 |
| 9 | Severe hypogammaglobulinemia persisting for 6 years after treatment with rituximab combined che- motherapy due to arrest of B lymphocyte differentiation together with alteration of T lymphocyte homeostasis 显示文摘 | Irie E Shirota Y Suzuki C | 2010 | Int J Hematol2010，91，3： | 1 |
| 10 | Inhibition of neisseria gonorrhoeae by lactobacillus species that are commonly isolated from the female genital tract显示文摘 | Diane C Amant ST Iris E | 2002 | Infection and Immunity2002，70，12： | 1 |
| 11 | Taking care of volunteers in a stroke trial: a new assisted-management strategy显示文摘Background and purpose:Providing participants with evidence-based care for secondary prevention is an ethical and scientific priority for trials in stroke therapy.The optimal strategy,however,is uncertain.We report the performance of a new approach for delivering preventive care to trial participants.Methods:Participants were enrolled in the Insulin Resistance Intervention after Stroke trial,which examined the insulin sensitiser,pioglitazone versus placebo for prevention of stroke and myocardial infarction after ischaemic stroke or transient ischaemic attack.Preventive care was the responsibility of the participants’personal healthcare providers,but investigators monitored care and provided feedback annually.We studied achievement of 8 prevention goals at baseline and 3 annual visits,with a focus on 3 priority goals:blood pressure<140/90 mm Hg,lowdensity lipoprotein(LDL)cholesterol<2.59 mmol/L and antithrombotic therapy.Results:The proportion of participants achieving the priority goals was highest for antithrombotic use(96–99%in each year)and similar for blood pressure(66–72%in each year)and LDL(68–70%in each year).All 3 priority goals were achieved by 47–52%of participants in any given year.However,only 22%of participants achieved all 3 goals in each year.Conclusions:A strategy of monitoring care and providing feedback was associated with high average yearly achievement of 3 priority secondary prevention goals,but the majority of trial participants did not persist in being at goal over time.Trial registration number:NCT00091949. | Amber C Stuart Jason J Sico Catherine M Viscoli Ashis H Tayal Silvio E Inzucchi Gary A Ford Karen L Furie Robert Cote J David Spence David Tanne Walter N Kernan on behalf of the IRIS Trial Investigators | 2016 | Stroke & Vascular Neurology2016，1，3： | 0 |
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