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| 1 | Mucin and phospholipids determine viscosity of gallbladder bile in patients with gallstones显示文摘AIM An increased viscosity of gallbladder bile has been considered an important factor in the pathogenesis of gallstone disease. Besides lipids and proteins, mucin has been suggested to affect the viscosity of bile. To further clarify these issues we compared mucin, protein and the lipid components of hepatic and gallbladder bile and its viscosity in patients with gallstones.METHODS Viscosity of bile ( mpa. s ) wasmeasured using rotation viscosimetry in regard to the non-Newtonian property of bile at law shear rates.RESULTS Biliary viscosity was markedly higher in gallbladder bile of patients with cholesterol (5.00 ± 0.60 mpa. s, mean ± SEM, n --28) and mixed stones (3.50±0.68 mPa. s; n =8) compared to hepatic bile (0.92 ± 0.06 mpa. s,n -6). A positive correlation between mucin and viscosity was found in gallbladder biles (r=0.65; P<0.001) but not in hepatic biles. The addition of physiologic and supraphysiologic amounts of mucin to gallbladder bile resulted in a dose dependent non linear increase of its viscosity. A positive correlation was determined between phospholipid concentration and viscosity (r = 0.34, P<0.005) in gallbladder biles. However, no correlation was found between total protein or the other lipid concentrations and viscosity in both gallbladder and hepatic biles.CONCLUSION The viscosity of gallbladder bile is markedly higher than that of hepatic bile in patients with gallstones. The concentration of mucin is the major determinant of biliary viscosity and may contribute by this mechanism to the role of mucin in the pathogenesis of gallstones. | Dieter Jüngst Anna Niemeyer Iris Müller Benedikta Zündt Günther Meyer Martin Wilhelmi Reginalddel Pozo | 2001 | World Journal of Gastroenterology2001，7，2： | 2 |
| 2 | SPQD14120800011178显示文摘 | Kordes Claus Sawitza Iris G?tze Silke Herebian Diran H?ussinger Dieter | 2014 | Journal of Clinical Investigation2014，，12： | 2 |
| 3 | Salicylic Acid Alleviates the Cadmium Toxicity in Barley Saedlings显示文摘 | Ashraf M Iris F Manfred G | 2003 | Plant Physiology2003，132，： | 1 |
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| 6 | Natural frequencies of in-plane vibration of annular plates显示文摘 | Irie T Yamada G Muramoto Y | 1984 | Journal of Sound and Vibration1984，97，1： | 1 |
| 7 | Free vibration ofjoined conical- cylindrical shells显示文摘 | IRIE T YAMADA G MURAMOTO Y | 1984 | Journal of Soundand Vibration1984，95，1： | 1 |
| 8 | Sex hormones originating from different livestock production systems: fate and potential disrupting activity in the environment显示文摘 | Iris G Lange Andreas Daxenberger Bettina Schiffer Hilda Witters Dolores Ibarreta Heinrich H.D Meyer | 2002 | Analytica Chimica Acta2002，，1： | 1 |
| 9 | Salicylic Acid Alleviates the Cadmium Toxicity in Barley Seedlings显示文摘 | Ashraf M Iris F Manfred G | 2003 | Plant Physiol2003，132，： | 1 |
| 10 | Lack of Association Between the MEF2A Gene and Myocardial Infarction显示文摘 | Wolfgang Lieb Bj?rn Mayer Inke R. K?nig Iris Borwitzky Anika G?tz Silke Kain Christian Hengstenberg Patrick Linsel-Nitschke Marcus Fischer Angela D?ring H -Erich Wichmann Thomas Meitinger Reinhold Kreutz Andreas Ziegler Heribert Schunkert Jeanette Erdmann | 2008 | Circulation2008，，2： | 1 |
| 11 | Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity显示文摘 | Irie Y Li D J | 2005 | Bioorg Med Chem2005，13，15： | 1 |
| 12 | Both metabolic inhibition and mitochondrial KATP channel opening are myoprotective and initiate a compensatory sarcolemmal outward membrane current 显示文摘 | Irie H Gao J Gaudette G R | 2003 | Circulation2003，，： | 1 |
| 13 | Detection of the effects of dopamine receptor supersensitivity using pharmacological MRI and correlations with PET显示文摘 | Nguyen T V Brownell A L Iris Chen Y C Livni E Coyle J T Rosen B R Cavagna F Jenkins B G | | 0，，01： | 1 |
| 14 | Travel route recom- mendation using geo-tagged photos 显示文摘 | KURASHIMA T IWATA T IRIE G | 2013 | Knowledge and Information Systems2013，37，1： | 1 |
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| 16 | Preparation of 2,2-bis(p-fluorophenyl)-1,1,1-trichloroethane and proof of the position of the fluorine in the compound显示文摘 | Colorado Iris R Mendizabal G D | 1947 | Rev Inst Salubr Enferm Trop (Mex)1947，8，： | 1 |
| 17 | Evaluation of matrix effect in determination of some bioflavonoids in food samples by LC-MS/MS method 显示文摘 | G IRI A PROSEN H JELIKI C-STANKOV M | 2012 | Talanta2012，99，： | 1 |
| 18 | Vibration and stability of a non-uniform Timoshenko beam subjected to a flower force显示文摘 | IRIE T YAMADA G TAKAHASHI I | 1980 | Journal of Sound and Vibration1980，70，： | 1 |
| 19 | Both metabolic inhibition and mitochondrial K(ATP) channel opening are myoprotective and initiate a compensatory sarcolemmal outward membrane current显示文摘 | IRIE H GAO J GAUDETTE G R | 2003 | Circulation2003，108，1： | 1 |
| 20 | Caveolin-1 expression in advanced-stage ovarian carcinoma-a clinicopathologic study显示文摘 | Ben D Jahn MN Iris G | 2001 | Gynecologic Oncology2001，81，： | 1 |
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