|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Evaluation of the antioxidant properties of diarylamines in the benzo[b]thiophene series by free radical scavenging activity and reducing power显示文摘 | Isabel C F R Ferreira Maria-Jo(a)o R P Queiroz Miguel Vilas-Boas | | 0，，： | 1 |
| 4 | Analysis of octyl - and nonylphenol and their ethoxylates in water and sediments by liquid chromatography/tandem mass spectrometry 显示文摘 | Jorge E L R Isabelle S A Clifford P R | 2003 | Analytical Chemistry2003，75，18： | 1 |
| 5 | Specificity and nucleotyping studies of a gpSO - based polymerase chain reaction assay for detection of Pseudorabies virus 显示文摘 | HARDING M J ISABELLE P H JERZY R | 1997 | Can J Vet Res1997，61，： | 1 |
| 6 | Dynamics of rural landscapes and their main driving factors: A case study in the Seine Valley, Normandy, France 显示文摘 | Isabelle P Sabine V R | 1997 | Larutscape and Urban Planning1997，，： | 1 |
| 7 | Breast cancer,lactation history, and serum organochlorines显示文摘 | Isabelle R Mauricio H A Eduardo L P | 2000 | American Journal of Epidemiology2000，152，4： | 1 |
| 8 | The SDF-1-CXCR4 signaling pathway:a molecular hub modulating neo-angiogenesis显示文摘 | ISABELLE P DAVID J SHAHIN R | | 0，，07： | 1 |
| 9 | The Demand-Control-Sup-port model, locus of control and job dissatisfaction: a longitudinal study显示文摘 | Isabel R M J Bravo Jose M P | 2001 | Work & Stress2001，15，2： | 1 |
| 10 | Chromosomal polymorphism,morphometric traits and matingsuccess in Leptysma argentina Brunet (Orthoptem) Genetica显示文摘 | Pensel S Isabel R M | 2004 | Genetica2004，121，： | 1 |
| 11 | The effect of phosphate concentration on growth and agar content of Gelidium robustum(Gelideaceae,Rhodophyta) in culture显示文摘 | Isabel S P Lewis R Fuller M P | 1996 | Hydrobiologia1996，，： | 1 |
| 12 | Development and validation of a fast high-performance liquid chromatography method for the determination of microcncapsulated pyrethroid pesticides显示文摘 | ISABEL P R GIL-ALEGRE M E ANA ISABEL T S | 2006 | Analytica Chirnica Acta2006，557，12： | 1 |
| 13 | Effects of ohmic andconventional heating on anthocyanin degradation during the pro- cessing of blueberry pulp 显示文摘 | Julia R S Debora P J Isabel C T | 2013 | LWT- Food Science and Tech- nology2013，51，： | 1 |
| 14 | The SDF - 1/CXCR4 signaling pathway : a molecular hub modulating neo - angiogenesis 显示文摘 | Isabelle P David J Shahin R | 2007 | Trends Immunol2007，28，： | 1 |
| 15 | The SDF-1/CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis 显示文摘 | Isabelle P David J Shahin R | 2007 | Trends Immnnol2007，28，7： | 1 |
| 16 | Evaluation of the antimicrobial activities of Plant oxylipins supports their involvement in defense against pathogens 显示文摘 | Isabelle P Sandrine D Grit R | 2005 | Plant Physiol2005，39，： | 1 |
| 17 | Nonlinear internal model control using neural networks: Application to processes with delay and design issues显示文摘 | Isabelle R Leon P | 2000 | IEEE Trans on Neural Networks2000，11，1： | 1 |
| 18 | The SDF-1 /CXCR4 signaling pathway:a molecular hub modulating neo-angiogenesis显示文摘 | Isabelle P David J Shahin R | 2007 | Trends Inmunol2007，28，7： | 1 |
| 19 | Antioxidant activities of the extracts from chestnut flower, leaf, skins and fruit显示文摘 | JOAO C M BARREIRA ISABEL C F R FERREIRA M BEATRIZ P P OLIVEIRA | 2008 | FoodChemistry2008，107，： | 1 |
| 20 | Renal artery stenosis evaluation in chronic kidney disease patients:nonenhanced time-spatial labeling inversion-pulse three-dimensional MR angiography with regulated breathing versus DSA显示文摘 | Isabelle P Guy R Francis J | 2012 | Radiology2012，2，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员