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| 1 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 2 | Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model显示文摘 | Janaiah Kota Raghu R. Chivukula Kathryn A. O’Donnell Erik A. Wentzel Chrystal L. Montgomery Hun-Way Hwang Tsung-Cheng Chang Perumal Vivekanandan Michael Torbenson K. Reed Clark Jerry R. Mendell Joshua T. Mendell | 2009 | Cell2009，，6： | 2 |
| 3 | Incidence and prognostic impact of KRAS and BRAF mutation in patients undergoing liver surgery for colorectal metastases显示文摘 | Georgios Karagkounis Michael S. Torbenson Hubert D. Daniel Nilofer S. Azad Luis A. Diaz Ross C. Donehower Kenzo Hirose Nita Ahuja Timothy M. Pawlik Michael A. Choti | 2013 | Cancer2013，，23： | 2 |
| 4 | Occult hepatitis B显示文摘 | Michael Torbenson David L Thomas | 2002 | The Lancet Infectious Diseases2002，，8： | 2 |
| 5 | Occult hepatitis B显示文摘 | Michael Torbenson David L Thomas | 2002 | Lancet Infect Dis2002，2，： | 1 |
| 6 | Limited effectiveness of antiviral treatment for hepatitis C in an urban HIV clinic显示文摘 | Shruti H Mehta Gregory M Lucas Lisa B Mirel Michael Torbenson Yvonne Higgins Richard D Moore David L Thomas Mark S Sulkowski | 2006 | AIDS2006，，18： | 1 |
| 7 | Incidence and prognostic impact of KRAS and BRAF mutation in patients undergoing liver surgery for colorectal metastases显示文摘 | Georgios Karagkounis Michael S. Torbenson Hubert D. Daniel Nilofer S. Azad Luis A. Diaz Ross C. Donehower Kenzo Hirose Nita Ahuja Timothy M. Pawlik Michael A. Choti | 2013 | Cancer2013，，23： | 1 |
| 8 | Anterior gradient-2 is overexpressed by fibrolamellar carcinomas显示文摘 | Perumal Vivekanandan Shien T.L. Micchelli Michael Torbenson | 2009 | Human Pathology2009，，： | 1 |
| 9 | Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP显示文摘 | Young H. Ko Barbara L. Smith Yuchuan Wang Martin G. Pomper David A. Rini Michael S. Torbenson Joanne Hullihen Peter L. Pedersen | 2004 | Biochemical and Biophysical Research Communications2004，，1： | 1 |
| 10 | Hepatitis C and hepatitis B nucleic acids are present in intrahepatic cholangiocarcinomas from the United States显示文摘 | Vivekanandan Perumal Jianzhou Wang Paul Thuluvath Michael Choti Michael Torbenson | 2006 | Human Pathology2006，，9： | 1 |
| 11 | Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model显示文摘 | Janaiah Kota Raghu R. Chivukula Kathryn A. O’Donnell Erik A. Wentzel Chrystal L. Montgomery Hun-Way Hwang Tsung-Cheng Chang Perumal Vivekanandan Michael Torbenson K. Reed Clark Jerry R. Mendell Joshua T. Mendell | 2009 | Cell2009，，6： | 1 |
| 12 | Bile Ducts and Ductules Are Positive for CD56 (N-CAM) in Most Cases of Extrahepatic Biliary Atresia显示文摘 | Michael Torbenson Jianzhou Wang Susan Abraham Anirban Maitra John Boitnott | 2003 | The American Journal of Surgical Pathology2003，，11： | 1 |
| 13 | Differences in characteristics of patients with and without known risk factors for hepatocellular carcinoma in the United States显示文摘AIM: To examine the clinical characteristics of a subgroup of patients with hepatocellular carcinoma (HCC) and compare them to those with known risk factors.METHODS: We used the HCC database of 306 patients seen at our institution from January 1, 1995 to December 31, 2001. Of the 306 patients, 63 (20%, group 1) had no known risk factors (hepatitis C virus, hepatitis B virus, alcohol, hemochromatosis or cirrhosis from any cause) and 243 (group 2) had one or more risk factors.RESULTS: The median age was similar in both groups, but there were disproportionate numbers of younger (< 30 years old), older (> 80 years) patients, women (33% vs 18%), and Caucasians (81% vs 52%) in group 1 as compared to group 2. There were fewer Asians (2% vs 11%) and African Americans (13% vs 27%) in group 1. Abdominal pain (70% vs 37%) was more common while gastrointestinal bleeding (0% vs 11%) and ascites (4% vs 17%) were less common in group 1 compared to group 2. Group 1 had larger tumor burden (median size 9.4 cm vs 5.7 cm) at the time of presentation, but there were no differences in the site (right, left or bilateral lesions), or number of tumors between the two groups.CONCLUSION: HCC patients without identifiable risk factors have different characteristics and clinical presentation compared to those with known risk factors.Absence of cirrhosis and larger tumor burden may explain the differences in the presenting symptoms. | Jon D Dorfman Richard Schulick Michael A Choti Jean-Francois H Geschwind Ihab Kamel Michael Torbenson Paul J Thuluvath | 2007 | World Journal of Gastroenterology2007，13，5： | 1 |
| 14 | Survivin overexpression in hepatocellular carcinoma is associated with p53 dysregulation显示文摘 | Rajesh Kannangai Jianzhou Wang Qiong Z. Liu Fikret Sahin Michael Torbenson MD | 2005 | International Journal of Gastrointestinal Cancer2005，，1： | 1 |
| 15 | LIVER TRANSPLANTATION FOR ALCOHOLIC CIRRHOSIS: LONG TERM FOLLOW-UP AND IMPACT OF DISEASE RECURRENCE1显示文摘 | Christopher O.C. Bellamy Andrea M. DiMartini Kris Ruppert Ashok Jain Forrest Dodson Michael Torbenson Thomas E. Starzl John J. Fung Anthony J. Demetris | 2001 | Transplantation2001，，4： | 1 |
| 16 | Limited effectiveness of antiviral treatment for hepatitis C in an urban HIV clinic显示文摘 | Shruti H Mehta Gregory M Lucas Lisa B Mirel Michael Torbenson Yvonne Higgins Richard D Moore David L Thomas Mark S Sulkowski | 2006 | AIDS2006，，18： | 1 |
| 17 | Preoperative Chemotherapy for Colorectal Liver Metastases: Impact on Hepatic Histology and Postoperative Outcome显示文摘 | Timothy M. Pawlik Kelly Olino Ana Luiza Gleisner Michael Torbenson Richard Schulick Michael A. Choti | 2007 | Journal of Gastrointestinal Surgery2007，，7： | 1 |
| 18 | Survivin overexpression in hepatocellular carcinoma is associated with p53 dysregulation显示文摘 | Rajesh Kannangai Jianzhou Wang Qiong Z. Liu Fikret Sahin Michael Torbenson MD | 2005 | International Journal of Gastrointestinal Cancer2005，，1： | 1 |
| 19 | 从木材解剖学视角看公元6世纪中期晚古小冰期的开始时间显示文摘公元536~540年间的大规模火山喷发使得晚古小冰期成为过去两千年最为寒冷的时期.然而,受限于现有气候代用资料的时间分辨率和空间覆盖度,晚古小冰期的开始时间和空间范围仍存有争议.本文分析了全球23个森林样点、20个树种的106个树轮样本资料,从细胞尺度揭示了公元530~550年间北半球发生的短暂夏季冷却现象.经过交叉定年和染色处理后,在北半球的树轮样品中共识别出89个蓝轮(缺失细胞壁木质化过程)、9个霜轮(细胞分裂受阻)和93个浅轮(细胞壁增厚减弱).研究结果表明,公元536年7月中旬至8月初期间整个北美和欧亚大陆均发生了最剧烈的温度下降,而更多的区域性“冷夏”出现于公元532年、540~543年和548年.然而,本研究在南半球的树轮资料中并未发现异常的解剖结构,其原因可能与南半球的海洋热惯性减缓了火山降温效应有关,也或与南半球其时正值非生长季有关.相较于传统的树轮年代学方法,本研究的木材解剖学的方法能为地球系统模式提供更为精细的参考标准,有望服务于气候与人类历史交叉学科研究,同时对“全球气候平均”概念的使用提出质疑. | Ulf Büntgen Alan Crivellaro Dominique Arseneault Mike Baillie David Barclay Mauro Bernabei Jarno Bontadi Gretel Boswijk David Brown Duncan AChristie Olga VChurakova Edward RCook Rosanne D’Arrigo Nicole Davi Jan Esper Patrick Fonti Ciara Greaves Rashit MHantemirov Malcolm KHughes Alexander VKirdyanov Paul JKrusic Carlos Le Quesne Fredrik CLjungqvist Michael McCormick Vladimir SMyglan Kurt Nicolussi Clive Oppenheimer Jonathan Palmer 秦春 Frederick Reinig Matthew Salzer Markus Stoffel Max Torbenson Mirek Trnka Ricardo Villalba Nick Wiesenberg Greg Wiles 杨保 Alma Piermattei | 2022 | Science Bulletin2022，67，22： | 0 |
| 20 | Juxta-caval hepatic angiomyolipoma masquerading as hepatocellular carcinoma显示文摘ABSTRACT: Hepatic angiomyolipoma is an uncommon primary benign epithelial liver neoplasm. Mostpatients with angiomyolipomas are middle-aged women who commonly present with epigastric fullness orpain. Angiomyolipomas are tumors consisting of three tissue types: blood vessels, smooth muscle, and fat.Hepatic angiomyolipomas may be difficult to differentiate from other liver neoplasms by noninvasiveimaging. We report a 58-year-old asymptomatic woman with a mass in the right lobe of the liver, foundincidentally on routine abdominal sonography. Preoperative radiographic evaluation revealed a 6.5-cmhypervascular lesion abutting the inferior vena cava. Preoperative histologic study demonstrated anepithelial neoplasm suspicious for hepatocellular carcinoma. Metastatic workup was negative. Atresection, the tumor was found to be an angiomyolipoma composed of lipoid, vascular and smooth musclecells. Further staining was positive for HMB-45. Resection margins were negative. The woman had anuneventful recovery and was discharged on postoperative day seven. She currently remains well severalmonths after her right hepatectomy. | Alan M Hawxby Michael Torbenson Elliot Fishman Leo Lawler Luis M Arrazola Andrew S Klein | 2003 | Hepatobiliary & Pancreatic Diseases International2003，2，4： | 0 |
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